The Role of Autophagy in Osteoarthritic Cartilage

Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules an...
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Autor*in:	Wei-Chun Kao [verfasserIn] Jian-Chih Chen [verfasserIn] Ping-Cheng Liu [verfasserIn] Cheng-Chang Lu [verfasserIn] Sung-Yen Lin [verfasserIn] Shu-Chun Chuang [verfasserIn] Shun-Cheng Wu [verfasserIn] Ling-hua Chang [verfasserIn] Mon-Juan Lee [verfasserIn] Chung-Da Yang [verfasserIn] Tien-Ching Lee [verfasserIn] Ying-Chun Wang [verfasserIn] Jhong-You Li [verfasserIn] Chun-Wang Wei [verfasserIn] Chung-Hwan Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	AMP-activated protein kinase (AMPK) Autophagy circular RNAs microRNAs long non-coding RNAs non-coding RNAs

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 12(2022), 10, p 1357
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:10, p 1357

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom12101357

Katalog-ID:	DOAJ083689796

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author	Wei-Chun Kao
spellingShingle	Wei-Chun Kao misc QR1-502 misc AMP-activated protein kinase (AMPK) misc Autophagy misc circular RNAs misc microRNAs misc long non-coding RNAs misc non-coding RNAs misc Microbiology The Role of Autophagy in Osteoarthritic Cartilage
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title	The Role of Autophagy in Osteoarthritic Cartilage
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title_auth	The Role of Autophagy in Osteoarthritic Cartilage
abstract	Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources.
abstractGer	Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources.
abstract_unstemmed	Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources.
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title_short	The Role of Autophagy in Osteoarthritic Cartilage
url	https://doi.org/10.3390/biom12101357 https://doaj.org/article/bb2dd98baf13424880f484da267b9b41 https://www.mdpi.com/2218-273X/12/10/1357 https://doaj.org/toc/2218-273X
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up_date	2024-07-03T18:53:35.667Z
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Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. 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The Role of Autophagy in Osteoarthritic Cartilage

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