The Role of Autophagy in Osteoarthritic Cartilage
Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules an...
Ausführliche Beschreibung
Autor*in: |
Wei-Chun Kao [verfasserIn] Jian-Chih Chen [verfasserIn] Ping-Cheng Liu [verfasserIn] Cheng-Chang Lu [verfasserIn] Sung-Yen Lin [verfasserIn] Shu-Chun Chuang [verfasserIn] Shun-Cheng Wu [verfasserIn] Ling-hua Chang [verfasserIn] Mon-Juan Lee [verfasserIn] Chung-Da Yang [verfasserIn] Tien-Ching Lee [verfasserIn] Ying-Chun Wang [verfasserIn] Jhong-You Li [verfasserIn] Chun-Wang Wei [verfasserIn] Chung-Hwan Chen [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2022 |
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Übergeordnetes Werk: |
In: Biomolecules - MDPI AG, 2013, 12(2022), 10, p 1357 |
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Übergeordnetes Werk: |
volume:12 ; year:2022 ; number:10, p 1357 |
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DOI / URN: |
10.3390/biom12101357 |
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Katalog-ID: |
DOAJ083689796 |
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10.3390/biom12101357 doi (DE-627)DOAJ083689796 (DE-599)DOAJbb2dd98baf13424880f484da267b9b41 DE-627 ger DE-627 rakwb eng QR1-502 Wei-Chun Kao verfasserin aut The Role of Autophagy in Osteoarthritic Cartilage 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. AMP-activated protein kinase (AMPK) Autophagy circular RNAs microRNAs long non-coding RNAs non-coding RNAs Microbiology Jian-Chih Chen verfasserin aut Ping-Cheng Liu verfasserin aut Cheng-Chang Lu verfasserin aut Sung-Yen Lin verfasserin aut Shu-Chun Chuang verfasserin aut Shun-Cheng Wu verfasserin aut Ling-hua Chang verfasserin aut Mon-Juan Lee verfasserin aut Chung-Da Yang verfasserin aut Tien-Ching Lee verfasserin aut Ying-Chun Wang verfasserin aut Jhong-You Li verfasserin aut Chun-Wang Wei verfasserin aut Chung-Hwan Chen verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 10, p 1357 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:10, p 1357 https://doi.org/10.3390/biom12101357 kostenfrei https://doaj.org/article/bb2dd98baf13424880f484da267b9b41 kostenfrei https://www.mdpi.com/2218-273X/12/10/1357 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10, p 1357 |
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10.3390/biom12101357 doi (DE-627)DOAJ083689796 (DE-599)DOAJbb2dd98baf13424880f484da267b9b41 DE-627 ger DE-627 rakwb eng QR1-502 Wei-Chun Kao verfasserin aut The Role of Autophagy in Osteoarthritic Cartilage 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. AMP-activated protein kinase (AMPK) Autophagy circular RNAs microRNAs long non-coding RNAs non-coding RNAs Microbiology Jian-Chih Chen verfasserin aut Ping-Cheng Liu verfasserin aut Cheng-Chang Lu verfasserin aut Sung-Yen Lin verfasserin aut Shu-Chun Chuang verfasserin aut Shun-Cheng Wu verfasserin aut Ling-hua Chang verfasserin aut Mon-Juan Lee verfasserin aut Chung-Da Yang verfasserin aut Tien-Ching Lee verfasserin aut Ying-Chun Wang verfasserin aut Jhong-You Li verfasserin aut Chun-Wang Wei verfasserin aut Chung-Hwan Chen verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 10, p 1357 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:10, p 1357 https://doi.org/10.3390/biom12101357 kostenfrei https://doaj.org/article/bb2dd98baf13424880f484da267b9b41 kostenfrei https://www.mdpi.com/2218-273X/12/10/1357 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10, p 1357 |
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10.3390/biom12101357 doi (DE-627)DOAJ083689796 (DE-599)DOAJbb2dd98baf13424880f484da267b9b41 DE-627 ger DE-627 rakwb eng QR1-502 Wei-Chun Kao verfasserin aut The Role of Autophagy in Osteoarthritic Cartilage 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. AMP-activated protein kinase (AMPK) Autophagy circular RNAs microRNAs long non-coding RNAs non-coding RNAs Microbiology Jian-Chih Chen verfasserin aut Ping-Cheng Liu verfasserin aut Cheng-Chang Lu verfasserin aut Sung-Yen Lin verfasserin aut Shu-Chun Chuang verfasserin aut Shun-Cheng Wu verfasserin aut Ling-hua Chang verfasserin aut Mon-Juan Lee verfasserin aut Chung-Da Yang verfasserin aut Tien-Ching Lee verfasserin aut Ying-Chun Wang verfasserin aut Jhong-You Li verfasserin aut Chun-Wang Wei verfasserin aut Chung-Hwan Chen verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 10, p 1357 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:10, p 1357 https://doi.org/10.3390/biom12101357 kostenfrei https://doaj.org/article/bb2dd98baf13424880f484da267b9b41 kostenfrei https://www.mdpi.com/2218-273X/12/10/1357 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10, p 1357 |
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10.3390/biom12101357 doi (DE-627)DOAJ083689796 (DE-599)DOAJbb2dd98baf13424880f484da267b9b41 DE-627 ger DE-627 rakwb eng QR1-502 Wei-Chun Kao verfasserin aut The Role of Autophagy in Osteoarthritic Cartilage 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. AMP-activated protein kinase (AMPK) Autophagy circular RNAs microRNAs long non-coding RNAs non-coding RNAs Microbiology Jian-Chih Chen verfasserin aut Ping-Cheng Liu verfasserin aut Cheng-Chang Lu verfasserin aut Sung-Yen Lin verfasserin aut Shu-Chun Chuang verfasserin aut Shun-Cheng Wu verfasserin aut Ling-hua Chang verfasserin aut Mon-Juan Lee verfasserin aut Chung-Da Yang verfasserin aut Tien-Ching Lee verfasserin aut Ying-Chun Wang verfasserin aut Jhong-You Li verfasserin aut Chun-Wang Wei verfasserin aut Chung-Hwan Chen verfasserin aut In Biomolecules MDPI AG, 2013 12(2022), 10, p 1357 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:12 year:2022 number:10, p 1357 https://doi.org/10.3390/biom12101357 kostenfrei https://doaj.org/article/bb2dd98baf13424880f484da267b9b41 kostenfrei https://www.mdpi.com/2218-273X/12/10/1357 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 10, p 1357 |
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2022-01-01T00:00:00Z |
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The Role of Autophagy in Osteoarthritic Cartilage |
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Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. |
abstractGer |
Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. |
abstract_unstemmed |
Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. The database we searched in is PubMed and we used the keywords listed below to find appropriate article resources. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ083689796</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414181357.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/biom12101357</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ083689796</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJbb2dd98baf13424880f484da267b9b41</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR1-502</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Wei-Chun Kao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The Role of Autophagy in Osteoarthritic Cartilage</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Osteoarthritis (OA) is one of the most common diseases leading to physical disability, with age being the main risk factor, and degeneration of articular cartilage is the main focus for the pathogenesis of OA. Autophagy is a crucial intracellular homeostasis system recycling flawed macromolecules and cellular organelles to sustain the metabolism of cells. Growing evidences have revealed that autophagy is chondroprotective by regulating apoptosis and repairing the function of damaged chondrocytes. Then, OA is related to autophagy depending on different stages and models. In this review, we discuss the character of autophagy in OA and the process of the autophagy pathway, which can be modulated by some drugs, key molecules and non-coding RNAs (microRNAs, long non-coding RNAs and circular RNAs). More in-depth investigations of autophagy are needed to find therapeutic targets or diagnostic biomarkers through in vitro and in vivo situations, making autophagy a more effective way for OA treatment in the future. The aim of this review is to introduce the concept of autophagy and make readers realize its impact on OA. 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