Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside

The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently...
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Autor*in:	Xiaoli Liu [verfasserIn] Yifei Wang [verfasserIn] Bonan Chen [verfasserIn] Wai Nok Chan [verfasserIn] Chun Wai Mui [verfasserIn] Alvin H.K. Cheung [verfasserIn] Jinglin Zhang [verfasserIn] Kit Yee Wong [verfasserIn] Jun Yu [verfasserIn] Wei Kang [verfasserIn] Ka Fai To [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer

Übergeordnetes Werk:	In: Biomedicines - MDPI AG, 2014, 10(2022), 10, p 2512
Übergeordnetes Werk:	volume:10 ; year:2022 ; number:10, p 2512

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biomedicines10102512

Katalog-ID:	DOAJ083693645

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allfields	10.3390/biomedicines10102512 doi (DE-627)DOAJ083693645 (DE-599)DOAJ8711c1517d47443e9f71ad1460564cb1 DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoli Liu verfasserin aut Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers. Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer Biology (General) Yifei Wang verfasserin aut Bonan Chen verfasserin aut Wai Nok Chan verfasserin aut Chun Wai Mui verfasserin aut Alvin H.K. Cheung verfasserin aut Jinglin Zhang verfasserin aut Kit Yee Wong verfasserin aut Jun Yu verfasserin aut Wei Kang verfasserin aut Ka Fai To verfasserin aut In Biomedicines MDPI AG, 2014 10(2022), 10, p 2512 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:10 year:2022 number:10, p 2512 https://doi.org/10.3390/biomedicines10102512 kostenfrei https://doaj.org/article/8711c1517d47443e9f71ad1460564cb1 kostenfrei https://www.mdpi.com/2227-9059/10/10/2512 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 10, p 2512
spelling	10.3390/biomedicines10102512 doi (DE-627)DOAJ083693645 (DE-599)DOAJ8711c1517d47443e9f71ad1460564cb1 DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoli Liu verfasserin aut Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers. Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer Biology (General) Yifei Wang verfasserin aut Bonan Chen verfasserin aut Wai Nok Chan verfasserin aut Chun Wai Mui verfasserin aut Alvin H.K. Cheung verfasserin aut Jinglin Zhang verfasserin aut Kit Yee Wong verfasserin aut Jun Yu verfasserin aut Wei Kang verfasserin aut Ka Fai To verfasserin aut In Biomedicines MDPI AG, 2014 10(2022), 10, p 2512 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:10 year:2022 number:10, p 2512 https://doi.org/10.3390/biomedicines10102512 kostenfrei https://doaj.org/article/8711c1517d47443e9f71ad1460564cb1 kostenfrei https://www.mdpi.com/2227-9059/10/10/2512 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 10, p 2512
allfields_unstemmed	10.3390/biomedicines10102512 doi (DE-627)DOAJ083693645 (DE-599)DOAJ8711c1517d47443e9f71ad1460564cb1 DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoli Liu verfasserin aut Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers. Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer Biology (General) Yifei Wang verfasserin aut Bonan Chen verfasserin aut Wai Nok Chan verfasserin aut Chun Wai Mui verfasserin aut Alvin H.K. Cheung verfasserin aut Jinglin Zhang verfasserin aut Kit Yee Wong verfasserin aut Jun Yu verfasserin aut Wei Kang verfasserin aut Ka Fai To verfasserin aut In Biomedicines MDPI AG, 2014 10(2022), 10, p 2512 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:10 year:2022 number:10, p 2512 https://doi.org/10.3390/biomedicines10102512 kostenfrei https://doaj.org/article/8711c1517d47443e9f71ad1460564cb1 kostenfrei https://www.mdpi.com/2227-9059/10/10/2512 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 10, p 2512
allfieldsGer	10.3390/biomedicines10102512 doi (DE-627)DOAJ083693645 (DE-599)DOAJ8711c1517d47443e9f71ad1460564cb1 DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoli Liu verfasserin aut Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers. Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer Biology (General) Yifei Wang verfasserin aut Bonan Chen verfasserin aut Wai Nok Chan verfasserin aut Chun Wai Mui verfasserin aut Alvin H.K. Cheung verfasserin aut Jinglin Zhang verfasserin aut Kit Yee Wong verfasserin aut Jun Yu verfasserin aut Wei Kang verfasserin aut Ka Fai To verfasserin aut In Biomedicines MDPI AG, 2014 10(2022), 10, p 2512 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:10 year:2022 number:10, p 2512 https://doi.org/10.3390/biomedicines10102512 kostenfrei https://doaj.org/article/8711c1517d47443e9f71ad1460564cb1 kostenfrei https://www.mdpi.com/2227-9059/10/10/2512 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 10, p 2512
allfieldsSound	10.3390/biomedicines10102512 doi (DE-627)DOAJ083693645 (DE-599)DOAJ8711c1517d47443e9f71ad1460564cb1 DE-627 ger DE-627 rakwb eng QH301-705.5 Xiaoli Liu verfasserin aut Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers. Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer Biology (General) Yifei Wang verfasserin aut Bonan Chen verfasserin aut Wai Nok Chan verfasserin aut Chun Wai Mui verfasserin aut Alvin H.K. Cheung verfasserin aut Jinglin Zhang verfasserin aut Kit Yee Wong verfasserin aut Jun Yu verfasserin aut Wei Kang verfasserin aut Ka Fai To verfasserin aut In Biomedicines MDPI AG, 2014 10(2022), 10, p 2512 (DE-627)750370483 (DE-600)2720867-9 22279059 nnns volume:10 year:2022 number:10, p 2512 https://doi.org/10.3390/biomedicines10102512 kostenfrei https://doaj.org/article/8711c1517d47443e9f71ad1460564cb1 kostenfrei https://www.mdpi.com/2227-9059/10/10/2512 kostenfrei https://doaj.org/toc/2227-9059 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 10, p 2512
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source	In Biomedicines 10(2022), 10, p 2512 volume:10 year:2022 number:10, p 2512
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topic_facet	Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer Biology (General)
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container_title	Biomedicines
authorswithroles_txt_mv	Xiaoli Liu @@aut@@ Yifei Wang @@aut@@ Bonan Chen @@aut@@ Wai Nok Chan @@aut@@ Chun Wai Mui @@aut@@ Alvin H.K. Cheung @@aut@@ Jinglin Zhang @@aut@@ Kit Yee Wong @@aut@@ Jun Yu @@aut@@ Wei Kang @@aut@@ Ka Fai To @@aut@@
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author	Xiaoli Liu
spellingShingle	Xiaoli Liu misc QH301-705.5 misc Hippo pathway misc YAP1 (yes-associated protein 1) misc TAZ (WW domain-containing transcription regulator 1) misc gastric cancer misc Biology (General) Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside
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topic_title	QH301-705.5 Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside Hippo pathway YAP1 (yes-associated protein 1) TAZ (WW domain-containing transcription regulator 1) gastric cancer
topic	misc QH301-705.5 misc Hippo pathway misc YAP1 (yes-associated protein 1) misc TAZ (WW domain-containing transcription regulator 1) misc gastric cancer misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Hippo pathway misc YAP1 (yes-associated protein 1) misc TAZ (WW domain-containing transcription regulator 1) misc gastric cancer misc Biology (General)
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title	Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside
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title_full	Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside
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title_sort	targeting the hippo pathway in gastric cancer and other malignancies in the digestive system: from bench to bedside
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title_auth	Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside
abstract	The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers.
abstractGer	The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers.
abstract_unstemmed	The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression. Dysregulation of the Hippo tumor suppressor signaling frequently occurs in gastric cancer (GC) and other solid tumors and contributes to cancer development through modulating multiple aspects, including cell proliferation, survival, metastasis, and oncotherapy resistance. In the clinic, Hippo components also possess diagnostic and prognostic values for cancer patients. Considering its crucial role in driving tumorigenesis, targeting the Hippo pathway may greatly benefit developing novel cancer therapies. This review summarizes the current research progress regarding the core components and regulation of the Hippo pathway, as well as the mechanism and functional roles of their dysregulation in gastrointestinal malignancies, especially in GC, and discusses the therapeutic potential of targeting the Hippo pathway against cancers.
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container_issue	10, p 2512
title_short	Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside
url	https://doi.org/10.3390/biomedicines10102512 https://doaj.org/article/8711c1517d47443e9f71ad1460564cb1 https://www.mdpi.com/2227-9059/10/10/2512 https://doaj.org/toc/2227-9059
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Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside

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