Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis

Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovag...
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Autor*in:	Sean M Hughes [verfasserIn] Claire N Levy [verfasserIn] Fernanda L Calienes [verfasserIn] Katie A Martinez [verfasserIn] Stacy Selke [verfasserIn] Kenneth Tapia [verfasserIn] Bhavna H Chohan [verfasserIn] Lynda Oluoch [verfasserIn] Catherine Kiptinness [verfasserIn] Anna Wald [verfasserIn] Mimi Ghosh [verfasserIn] Liselotte Hardy [verfasserIn] Kenneth Ngure [verfasserIn] Nelly R Mugo [verfasserIn] Florian Hladik [verfasserIn] Alison C Roxby [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 11(2022)
Übergeordnetes Werk:	volume:11 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.78565

Katalog-ID:	DOAJ083705473

Internformat


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245	1	0	\|a Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis
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520			\|a Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757.
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allfields	10.7554/eLife.78565 doi (DE-627)DOAJ083705473 (DE-599)DOAJad9ba4d4c9564e9d9dd747f7c32db626 DE-627 ger DE-627 rakwb eng QH301-705.5 Sean M Hughes verfasserin aut Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757. adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity Medicine R Science Q Biology (General) Claire N Levy verfasserin aut Fernanda L Calienes verfasserin aut Katie A Martinez verfasserin aut Stacy Selke verfasserin aut Kenneth Tapia verfasserin aut Bhavna H Chohan verfasserin aut Lynda Oluoch verfasserin aut Catherine Kiptinness verfasserin aut Anna Wald verfasserin aut Mimi Ghosh verfasserin aut Liselotte Hardy verfasserin aut Kenneth Ngure verfasserin aut Nelly R Mugo verfasserin aut Florian Hladik verfasserin aut Alison C Roxby verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 11(2022) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:11 year:2022 https://doi.org/10.7554/eLife.78565 kostenfrei https://doaj.org/article/ad9ba4d4c9564e9d9dd747f7c32db626 kostenfrei https://elifesciences.org/articles/78565 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022
spelling	10.7554/eLife.78565 doi (DE-627)DOAJ083705473 (DE-599)DOAJad9ba4d4c9564e9d9dd747f7c32db626 DE-627 ger DE-627 rakwb eng QH301-705.5 Sean M Hughes verfasserin aut Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757. adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity Medicine R Science Q Biology (General) Claire N Levy verfasserin aut Fernanda L Calienes verfasserin aut Katie A Martinez verfasserin aut Stacy Selke verfasserin aut Kenneth Tapia verfasserin aut Bhavna H Chohan verfasserin aut Lynda Oluoch verfasserin aut Catherine Kiptinness verfasserin aut Anna Wald verfasserin aut Mimi Ghosh verfasserin aut Liselotte Hardy verfasserin aut Kenneth Ngure verfasserin aut Nelly R Mugo verfasserin aut Florian Hladik verfasserin aut Alison C Roxby verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 11(2022) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:11 year:2022 https://doi.org/10.7554/eLife.78565 kostenfrei https://doaj.org/article/ad9ba4d4c9564e9d9dd747f7c32db626 kostenfrei https://elifesciences.org/articles/78565 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022
allfields_unstemmed	10.7554/eLife.78565 doi (DE-627)DOAJ083705473 (DE-599)DOAJad9ba4d4c9564e9d9dd747f7c32db626 DE-627 ger DE-627 rakwb eng QH301-705.5 Sean M Hughes verfasserin aut Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757. adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity Medicine R Science Q Biology (General) Claire N Levy verfasserin aut Fernanda L Calienes verfasserin aut Katie A Martinez verfasserin aut Stacy Selke verfasserin aut Kenneth Tapia verfasserin aut Bhavna H Chohan verfasserin aut Lynda Oluoch verfasserin aut Catherine Kiptinness verfasserin aut Anna Wald verfasserin aut Mimi Ghosh verfasserin aut Liselotte Hardy verfasserin aut Kenneth Ngure verfasserin aut Nelly R Mugo verfasserin aut Florian Hladik verfasserin aut Alison C Roxby verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 11(2022) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:11 year:2022 https://doi.org/10.7554/eLife.78565 kostenfrei https://doaj.org/article/ad9ba4d4c9564e9d9dd747f7c32db626 kostenfrei https://elifesciences.org/articles/78565 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022
allfieldsGer	10.7554/eLife.78565 doi (DE-627)DOAJ083705473 (DE-599)DOAJad9ba4d4c9564e9d9dd747f7c32db626 DE-627 ger DE-627 rakwb eng QH301-705.5 Sean M Hughes verfasserin aut Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757. adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity Medicine R Science Q Biology (General) Claire N Levy verfasserin aut Fernanda L Calienes verfasserin aut Katie A Martinez verfasserin aut Stacy Selke verfasserin aut Kenneth Tapia verfasserin aut Bhavna H Chohan verfasserin aut Lynda Oluoch verfasserin aut Catherine Kiptinness verfasserin aut Anna Wald verfasserin aut Mimi Ghosh verfasserin aut Liselotte Hardy verfasserin aut Kenneth Ngure verfasserin aut Nelly R Mugo verfasserin aut Florian Hladik verfasserin aut Alison C Roxby verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 11(2022) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:11 year:2022 https://doi.org/10.7554/eLife.78565 kostenfrei https://doaj.org/article/ad9ba4d4c9564e9d9dd747f7c32db626 kostenfrei https://elifesciences.org/articles/78565 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022
allfieldsSound	10.7554/eLife.78565 doi (DE-627)DOAJ083705473 (DE-599)DOAJad9ba4d4c9564e9d9dd747f7c32db626 DE-627 ger DE-627 rakwb eng QH301-705.5 Sean M Hughes verfasserin aut Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757. adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity Medicine R Science Q Biology (General) Claire N Levy verfasserin aut Fernanda L Calienes verfasserin aut Katie A Martinez verfasserin aut Stacy Selke verfasserin aut Kenneth Tapia verfasserin aut Bhavna H Chohan verfasserin aut Lynda Oluoch verfasserin aut Catherine Kiptinness verfasserin aut Anna Wald verfasserin aut Mimi Ghosh verfasserin aut Liselotte Hardy verfasserin aut Kenneth Ngure verfasserin aut Nelly R Mugo verfasserin aut Florian Hladik verfasserin aut Alison C Roxby verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 11(2022) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:11 year:2022 https://doi.org/10.7554/eLife.78565 kostenfrei https://doaj.org/article/ad9ba4d4c9564e9d9dd747f7c32db626 kostenfrei https://elifesciences.org/articles/78565 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022
language	English
source	In eLife 11(2022) volume:11 year:2022
sourceStr	In eLife 11(2022) volume:11 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity Medicine R Science Q Biology (General)
isfreeaccess_bool	true
container_title	eLife
authorswithroles_txt_mv	Sean M Hughes @@aut@@ Claire N Levy @@aut@@ Fernanda L Calienes @@aut@@ Katie A Martinez @@aut@@ Stacy Selke @@aut@@ Kenneth Tapia @@aut@@ Bhavna H Chohan @@aut@@ Lynda Oluoch @@aut@@ Catherine Kiptinness @@aut@@ Anna Wald @@aut@@ Mimi Ghosh @@aut@@ Liselotte Hardy @@aut@@ Kenneth Ngure @@aut@@ Nelly R Mugo @@aut@@ Florian Hladik @@aut@@ Alison C Roxby @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	728518384
id	DOAJ083705473
language_de	englisch
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Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">adolescent girls and young women</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sexual intercourse</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cytokines</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mucosal immunity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">immune activation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">genital immunity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " 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callnumber-first	Q - Science
author	Sean M Hughes
spellingShingle	Sean M Hughes misc QH301-705.5 misc adolescent girls and young women misc sexual intercourse misc cytokines misc mucosal immunity misc immune activation misc genital immunity misc Medicine misc R misc Science misc Q misc Biology (General) Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis
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topic_title	QH301-705.5 Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis adolescent girls and young women sexual intercourse cytokines mucosal immunity immune activation genital immunity
topic	misc QH301-705.5 misc adolescent girls and young women misc sexual intercourse misc cytokines misc mucosal immunity misc immune activation misc genital immunity misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc adolescent girls and young women misc sexual intercourse misc cytokines misc mucosal immunity misc immune activation misc genital immunity misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis
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title_full	Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis
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author_browse	Sean M Hughes Claire N Levy Fernanda L Calienes Katie A Martinez Stacy Selke Kenneth Tapia Bhavna H Chohan Lynda Oluoch Catherine Kiptinness Anna Wald Mimi Ghosh Liselotte Hardy Kenneth Ngure Nelly R Mugo Florian Hladik Alison C Roxby
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title_sort	starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis
callnumber	QH301-705.5
title_auth	Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis
abstract	Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757.
abstractGer	Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757.
abstract_unstemmed	Background: Adolescent girls and young women (AGYW) are at high risk of sexually transmitted infections (STIs). It is unknown whether beginning to have sexual intercourse results in changes to immune mediators in the cervicovaginal tract that contribute to this risk. Methods: We collected cervicovaginal lavages from Kenyan AGYW in the months before and after first penile-vaginal sexual intercourse and measured the concentrations of 20 immune mediators. We compared concentrations pre- and post-first sex using mixed effect models. We additionally performed a systematic review to identify similar studies and combined them with our results by meta-analysis of individual participant data. Results: We included 180 samples from 95 AGYW, with 44% providing only pre-first sex samples, 35% matched pre and post, and 21% only post. We consistently detected 19/20 immune mediators, all of which increased post-first sex (p<0.05 for 13/19; Holm-Bonferroni-adjusted p<0.05 for IL-1β, IL-2, and CXCL8). Effects remained similar after excluding samples with STIs and high Nugent scores. Concentrations increased cumulatively over time after date of first sex, with an estimated doubling time of about 5 months. Conclusions: Cervicovaginal immune mediator concentrations were higher in women who reported that they started sexual activity. Results were consistent across three studies conducted on three different continents. Funding: This research was funded by R01 HD091996-01 (ACR), by P01 AI 030731-25 (Project 1) (AW), R01 AI116292 (FH), R03 AI154366 (FH) and by the Center for AIDS Research (CFAR) of the University of Washington/Fred Hutchinson Cancer Research Center AI027757.
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title_short	Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis
url	https://doi.org/10.7554/eLife.78565 https://doaj.org/article/ad9ba4d4c9564e9d9dd747f7c32db626 https://elifesciences.org/articles/78565 https://doaj.org/toc/2050-084X
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up_date	2024-07-03T18:58:59.298Z
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Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis

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