Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study

Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with ac...
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Autor*in:	Giovanna Chidini [verfasserIn] Daniele De Luca [verfasserIn] Edoardo Calderini [verfasserIn] Stefano Scalia Catenacci [verfasserIn] Tiziana Marchesi [verfasserIn] Thomas Langer [verfasserIn] Cesare Gregoretti [verfasserIn] Giorgio Conti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation

Übergeordnetes Werk:	In: Journal of Anesthesia, Analgesia and Critical Care - BMC, 2022, 1(2021), 1, Seite 9
Übergeordnetes Werk:	volume:1 ; year:2021 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s44158-021-00005-8

Katalog-ID:	DOAJ083713875

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520			\|a Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data.
650		4	\|a Acute respiratory failure
650		4	\|a Children
650		4	\|a Neurally adjusted ventilatory assist
650		4	\|a Noninvasive ventilation
653		0	\|a Anesthesiology
653		0	\|a Medical emergencies. Critical care. Intensive care. First aid
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700	0		\|a Tiziana Marchesi \|e verfasserin \|4 aut
700	0		\|a Thomas Langer \|e verfasserin \|4 aut
700	0		\|a Cesare Gregoretti \|e verfasserin \|4 aut
700	0		\|a Giorgio Conti \|e verfasserin \|4 aut
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allfields	10.1186/s44158-021-00005-8 doi (DE-627)DOAJ083713875 (DE-599)DOAJc21f3c36ecaf40f8b1a8a94321277b82 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC86-88.9 Giovanna Chidini verfasserin aut Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data. Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation Anesthesiology Medical emergencies. Critical care. Intensive care. First aid Daniele De Luca verfasserin aut Edoardo Calderini verfasserin aut Stefano Scalia Catenacci verfasserin aut Tiziana Marchesi verfasserin aut Thomas Langer verfasserin aut Cesare Gregoretti verfasserin aut Giorgio Conti verfasserin aut In Journal of Anesthesia, Analgesia and Critical Care BMC, 2022 1(2021), 1, Seite 9 (DE-627)1774283131 27313786 nnns volume:1 year:2021 number:1 pages:9 https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/article/c21f3c36ecaf40f8b1a8a94321277b82 kostenfrei https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/toc/2731-3786 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2021 1 9
spelling	10.1186/s44158-021-00005-8 doi (DE-627)DOAJ083713875 (DE-599)DOAJc21f3c36ecaf40f8b1a8a94321277b82 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC86-88.9 Giovanna Chidini verfasserin aut Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data. Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation Anesthesiology Medical emergencies. Critical care. Intensive care. First aid Daniele De Luca verfasserin aut Edoardo Calderini verfasserin aut Stefano Scalia Catenacci verfasserin aut Tiziana Marchesi verfasserin aut Thomas Langer verfasserin aut Cesare Gregoretti verfasserin aut Giorgio Conti verfasserin aut In Journal of Anesthesia, Analgesia and Critical Care BMC, 2022 1(2021), 1, Seite 9 (DE-627)1774283131 27313786 nnns volume:1 year:2021 number:1 pages:9 https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/article/c21f3c36ecaf40f8b1a8a94321277b82 kostenfrei https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/toc/2731-3786 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2021 1 9
allfields_unstemmed	10.1186/s44158-021-00005-8 doi (DE-627)DOAJ083713875 (DE-599)DOAJc21f3c36ecaf40f8b1a8a94321277b82 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC86-88.9 Giovanna Chidini verfasserin aut Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data. Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation Anesthesiology Medical emergencies. Critical care. Intensive care. First aid Daniele De Luca verfasserin aut Edoardo Calderini verfasserin aut Stefano Scalia Catenacci verfasserin aut Tiziana Marchesi verfasserin aut Thomas Langer verfasserin aut Cesare Gregoretti verfasserin aut Giorgio Conti verfasserin aut In Journal of Anesthesia, Analgesia and Critical Care BMC, 2022 1(2021), 1, Seite 9 (DE-627)1774283131 27313786 nnns volume:1 year:2021 number:1 pages:9 https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/article/c21f3c36ecaf40f8b1a8a94321277b82 kostenfrei https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/toc/2731-3786 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2021 1 9
allfieldsGer	10.1186/s44158-021-00005-8 doi (DE-627)DOAJ083713875 (DE-599)DOAJc21f3c36ecaf40f8b1a8a94321277b82 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC86-88.9 Giovanna Chidini verfasserin aut Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data. Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation Anesthesiology Medical emergencies. Critical care. Intensive care. First aid Daniele De Luca verfasserin aut Edoardo Calderini verfasserin aut Stefano Scalia Catenacci verfasserin aut Tiziana Marchesi verfasserin aut Thomas Langer verfasserin aut Cesare Gregoretti verfasserin aut Giorgio Conti verfasserin aut In Journal of Anesthesia, Analgesia and Critical Care BMC, 2022 1(2021), 1, Seite 9 (DE-627)1774283131 27313786 nnns volume:1 year:2021 number:1 pages:9 https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/article/c21f3c36ecaf40f8b1a8a94321277b82 kostenfrei https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/toc/2731-3786 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2021 1 9
allfieldsSound	10.1186/s44158-021-00005-8 doi (DE-627)DOAJ083713875 (DE-599)DOAJc21f3c36ecaf40f8b1a8a94321277b82 DE-627 ger DE-627 rakwb eng RD78.3-87.3 RC86-88.9 Giovanna Chidini verfasserin aut Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data. Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation Anesthesiology Medical emergencies. Critical care. Intensive care. First aid Daniele De Luca verfasserin aut Edoardo Calderini verfasserin aut Stefano Scalia Catenacci verfasserin aut Tiziana Marchesi verfasserin aut Thomas Langer verfasserin aut Cesare Gregoretti verfasserin aut Giorgio Conti verfasserin aut In Journal of Anesthesia, Analgesia and Critical Care BMC, 2022 1(2021), 1, Seite 9 (DE-627)1774283131 27313786 nnns volume:1 year:2021 number:1 pages:9 https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/article/c21f3c36ecaf40f8b1a8a94321277b82 kostenfrei https://doi.org/10.1186/s44158-021-00005-8 kostenfrei https://doaj.org/toc/2731-3786 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2021 1 9
language	English
source	In Journal of Anesthesia, Analgesia and Critical Care 1(2021), 1, Seite 9 volume:1 year:2021 number:1 pages:9
sourceStr	In Journal of Anesthesia, Analgesia and Critical Care 1(2021), 1, Seite 9 volume:1 year:2021 number:1 pages:9
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation Anesthesiology Medical emergencies. Critical care. Intensive care. First aid
isfreeaccess_bool	true
container_title	Journal of Anesthesia, Analgesia and Critical Care
authorswithroles_txt_mv	Giovanna Chidini @@aut@@ Daniele De Luca @@aut@@ Edoardo Calderini @@aut@@ Stefano Scalia Catenacci @@aut@@ Tiziana Marchesi @@aut@@ Thomas Langer @@aut@@ Cesare Gregoretti @@aut@@ Giorgio Conti @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1774283131
id	DOAJ083713875
language_de	englisch
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Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). 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callnumber-first	R - Medicine
author	Giovanna Chidini
spellingShingle	Giovanna Chidini misc RD78.3-87.3 misc RC86-88.9 misc Acute respiratory failure misc Children misc Neurally adjusted ventilatory assist misc Noninvasive ventilation misc Anesthesiology misc Medical emergencies. Critical care. Intensive care. First aid Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study
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topic_title	RD78.3-87.3 RC86-88.9 Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study Acute respiratory failure Children Neurally adjusted ventilatory assist Noninvasive ventilation
topic	misc RD78.3-87.3 misc RC86-88.9 misc Acute respiratory failure misc Children misc Neurally adjusted ventilatory assist misc Noninvasive ventilation misc Anesthesiology misc Medical emergencies. Critical care. Intensive care. First aid
topic_unstemmed	misc RD78.3-87.3 misc RC86-88.9 misc Acute respiratory failure misc Children misc Neurally adjusted ventilatory assist misc Noninvasive ventilation misc Anesthesiology misc Medical emergencies. Critical care. Intensive care. First aid
topic_browse	misc RD78.3-87.3 misc RC86-88.9 misc Acute respiratory failure misc Children misc Neurally adjusted ventilatory assist misc Noninvasive ventilation misc Anesthesiology misc Medical emergencies. Critical care. Intensive care. First aid
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title	Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study
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title_full	Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study
author_sort	Giovanna Chidini
journal	Journal of Anesthesia, Analgesia and Critical Care
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author_browse	Giovanna Chidini Daniele De Luca Edoardo Calderini Stefano Scalia Catenacci Tiziana Marchesi Thomas Langer Cesare Gregoretti Giorgio Conti
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author-letter	Giovanna Chidini
doi_str_mv	10.1186/s44158-021-00005-8
author2-role	verfasserin
title_sort	implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study
callnumber	RD78.3-87.3
title_auth	Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study
abstract	Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data.
abstractGer	Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data.
abstract_unstemmed	Abstract Backgrounds Pediatric noninvasive neurally adjusted ventilatory assist (NIV-NAVA) has been shown to improve patient-ventilator interaction but no data on clinical outcomes are available. Aim of this study was to compare NIV-NAVA with noninvasive pressure support (NIV-PS) in children with acute hypoxemic respiratory failure (AHRF), in a single-center before-after study. A cohort of thirty-four NIV-PS patients (before group) admitted to our PICU within the 2 years prior NAVA introduction was compared with a cohort of thirty children treated with NIV-NAVA during implementation phase (after group). The primary end-point was intubation rate between groups. Days on mechanical ventilation, number of invasive devices, nosocomial infections, PICU/hospital length of stay (LOS), and physiological parameters at 2 and 24 h after admission were considered. Results Intubation rate was lower in the NIV-NAVA group as compared to the NIV-PS group (p = 0.006). Patients treated with NIV-NAVA required fewer invasive devices (p = 0.032) and had lower incidence of ventilator-acquired pneumonia (p = 0.004) and shorter PICU (p = 0.032) and hospital LOS (p = 0.013). At 2 h, NIV-NAVA compared with NIV-PS resulted in higher paO2:FIO2 (p = 0.017), lower paCO2 (p = 0.002), RR (p = 0.026), and HR (p = 0.009). Conclusions Early NIV-NAVA vs NIV-PS was associated to lower intubation rate and shorter PICU and hospital LOS. Further studies are needed in order to confirm these preliminary data.
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title_short	Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study
url	https://doi.org/10.1186/s44158-021-00005-8 https://doaj.org/article/c21f3c36ecaf40f8b1a8a94321277b82 https://doaj.org/toc/2731-3786
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author2	Daniele De Luca Edoardo Calderini Stefano Scalia Catenacci Tiziana Marchesi Thomas Langer Cesare Gregoretti Giorgio Conti
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Implementation of noninvasive neurally adjusted ventilatory assist in pediatric acute respiratory failure: a controlled before-after quality improvement study

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