Experimental Cell Line Models for Nephrotoxicity Screening
The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo studies in laboratory animals, and 19%—after phase...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
I. A. Mazerkina [verfasserIn] V. A. Evteev [verfasserIn] A. B. Prokofiev [verfasserIn] O. V. Muslimova [verfasserIn] E. Yu. Demchenkova [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Ведомости Научного центра экспертизы средств медицинского применения - NEICON ISP LLC, 2018, 11(2021), 3, Seite 160-166 |
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| Übergeordnetes Werk: |
volume:11 ; year:2021 ; number:3 ; pages:160-166 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.30895/1991-2919-2021-11-160-166 |
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DOAJ083774963 |
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10.30895/1991-2919-2021-11-160-166 doi (DE-627)DOAJ083774963 (DE-599)DOAJ79097ac83a654c18900b53f36796d3bf DE-627 ger DE-627 rakwb rus R5-920 I. A. Mazerkina verfasserin aut Experimental Cell Line Models for Nephrotoxicity Screening 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo studies in laboratory animals, and 19%—after phase 3 clinical trials. Prediction of toxicity in cell models could make drug development more cost-effective and help to reduce/avoid animal testing. At present, there are no official international guidelines for assessment of nephrotoxicity in vitro, but there is a lot of research underway. The main toxicity target in kidneys is renal proximal tubule epithelial cells, therefore the main research is focused on the development of renal proximal tubule epithelial cell lines with stable functional characteristics. Another important aspect in nephrotoxicity modeling is the choice of relevant test methods and end points which would reflect potential toxicity mechanisms. The paper reviews existing human renal proximal tubule epithelial cell lines and current test methods for assessing cytotoxicity. Promising areas for future development of cell models for nephrotoxicity assessment— are optimisation and standardisation of in vitro systems that would help to make preclinical predictions of drug nephrotoxicity in vivo. cell cultures nephrotoxicity in vitro renal proximal tubule epithelial cells nephrotoxicity prediction Medicine (General) V. A. Evteev verfasserin aut A. B. Prokofiev verfasserin aut O. V. Muslimova verfasserin aut E. Yu. Demchenkova verfasserin aut In Ведомости Научного центра экспертизы средств медицинского применения NEICON ISP LLC, 2018 11(2021), 3, Seite 160-166 (DE-627)1760611107 26191172 nnns volume:11 year:2021 number:3 pages:160-166 https://doi.org/10.30895/1991-2919-2021-11-160-166 kostenfrei https://doaj.org/article/79097ac83a654c18900b53f36796d3bf kostenfrei https://www.vedomostincesmp.ru/jour/article/view/372 kostenfrei https://doaj.org/toc/1991-2919 Journal toc kostenfrei https://doaj.org/toc/2619-1172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_39 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 3 160-166 |
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In Ведомости Научного центра экспертизы средств медицинского применения 11(2021), 3, Seite 160-166 volume:11 year:2021 number:3 pages:160-166 |
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The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo studies in laboratory animals, and 19%—after phase 3 clinical trials. Prediction of toxicity in cell models could make drug development more cost-effective and help to reduce/avoid animal testing. At present, there are no official international guidelines for assessment of nephrotoxicity in vitro, but there is a lot of research underway. The main toxicity target in kidneys is renal proximal tubule epithelial cells, therefore the main research is focused on the development of renal proximal tubule epithelial cell lines with stable functional characteristics. Another important aspect in nephrotoxicity modeling is the choice of relevant test methods and end points which would reflect potential toxicity mechanisms. The paper reviews existing human renal proximal tubule epithelial cell lines and current test methods for assessing cytotoxicity. Promising areas for future development of cell models for nephrotoxicity assessment— are optimisation and standardisation of in vitro systems that would help to make preclinical predictions of drug nephrotoxicity in vivo. |
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The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo studies in laboratory animals, and 19%—after phase 3 clinical trials. Prediction of toxicity in cell models could make drug development more cost-effective and help to reduce/avoid animal testing. At present, there are no official international guidelines for assessment of nephrotoxicity in vitro, but there is a lot of research underway. The main toxicity target in kidneys is renal proximal tubule epithelial cells, therefore the main research is focused on the development of renal proximal tubule epithelial cell lines with stable functional characteristics. Another important aspect in nephrotoxicity modeling is the choice of relevant test methods and end points which would reflect potential toxicity mechanisms. The paper reviews existing human renal proximal tubule epithelial cell lines and current test methods for assessing cytotoxicity. Promising areas for future development of cell models for nephrotoxicity assessment— are optimisation and standardisation of in vitro systems that would help to make preclinical predictions of drug nephrotoxicity in vivo. |
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