Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients

Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to d...
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Autor*in:	Valmiki Maharaj [verfasserIn] Arianne C. Agdamag [verfasserIn] Sue Duval [verfasserIn] Jonathan Edmiston [verfasserIn] Victoria Charpentier [verfasserIn] Meg Fraser [verfasserIn] Alexandra Hall [verfasserIn] Jessica Schultz [verfasserIn] Ranjit John [verfasserIn] Andrew Shaffer [verfasserIn] Cindy M. Martin [verfasserIn] Thenappan Thenappan [verfasserIn] Gary S. Francis [verfasserIn] Rebecca Cogswell [verfasserIn] Tamas Alexy [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure

Übergeordnetes Werk:	In: ESC Heart Failure - Wiley, 2015, 9(2022), 5, Seite 3496-3504
Übergeordnetes Werk:	volume:9 ; year:2022 ; number:5 ; pages:3496-3504

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/ehf2.14099

Katalog-ID:	DOAJ08380000X

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245	1	0	\|a Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients
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520			\|a Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed.
650		4	\|a Cardiopulmonary exercise stress test
650		4	\|a Left ventricular assist device
650		4	\|a Hypotension
650		4	\|a Heart failure
653		0	\|a Diseases of the circulatory (Cardiovascular) system
700	0		\|a Arianne C. Agdamag \|e verfasserin \|4 aut
700	0		\|a Sue Duval \|e verfasserin \|4 aut
700	0		\|a Jonathan Edmiston \|e verfasserin \|4 aut
700	0		\|a Victoria Charpentier \|e verfasserin \|4 aut
700	0		\|a Meg Fraser \|e verfasserin \|4 aut
700	0		\|a Alexandra Hall \|e verfasserin \|4 aut
700	0		\|a Jessica Schultz \|e verfasserin \|4 aut
700	0		\|a Ranjit John \|e verfasserin \|4 aut
700	0		\|a Andrew Shaffer \|e verfasserin \|4 aut
700	0		\|a Cindy M. Martin \|e verfasserin \|4 aut
700	0		\|a Thenappan Thenappan \|e verfasserin \|4 aut
700	0		\|a Gary S. Francis \|e verfasserin \|4 aut
700	0		\|a Rebecca Cogswell \|e verfasserin \|4 aut
700	0		\|a Tamas Alexy \|e verfasserin \|4 aut
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allfields	10.1002/ehf2.14099 doi (DE-627)DOAJ08380000X (DE-599)DOAJ4fedd7c1255248cbaab46f09360bad80 DE-627 ger DE-627 rakwb eng RC666-701 Valmiki Maharaj verfasserin aut Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed. Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure Diseases of the circulatory (Cardiovascular) system Arianne C. Agdamag verfasserin aut Sue Duval verfasserin aut Jonathan Edmiston verfasserin aut Victoria Charpentier verfasserin aut Meg Fraser verfasserin aut Alexandra Hall verfasserin aut Jessica Schultz verfasserin aut Ranjit John verfasserin aut Andrew Shaffer verfasserin aut Cindy M. Martin verfasserin aut Thenappan Thenappan verfasserin aut Gary S. Francis verfasserin aut Rebecca Cogswell verfasserin aut Tamas Alexy verfasserin aut In ESC Heart Failure Wiley, 2015 9(2022), 5, Seite 3496-3504 (DE-627)820686506 (DE-600)2814355-3 20555822 nnns volume:9 year:2022 number:5 pages:3496-3504 https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/article/4fedd7c1255248cbaab46f09360bad80 kostenfrei https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/toc/2055-5822 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 5 3496-3504
spelling	10.1002/ehf2.14099 doi (DE-627)DOAJ08380000X (DE-599)DOAJ4fedd7c1255248cbaab46f09360bad80 DE-627 ger DE-627 rakwb eng RC666-701 Valmiki Maharaj verfasserin aut Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed. Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure Diseases of the circulatory (Cardiovascular) system Arianne C. Agdamag verfasserin aut Sue Duval verfasserin aut Jonathan Edmiston verfasserin aut Victoria Charpentier verfasserin aut Meg Fraser verfasserin aut Alexandra Hall verfasserin aut Jessica Schultz verfasserin aut Ranjit John verfasserin aut Andrew Shaffer verfasserin aut Cindy M. Martin verfasserin aut Thenappan Thenappan verfasserin aut Gary S. Francis verfasserin aut Rebecca Cogswell verfasserin aut Tamas Alexy verfasserin aut In ESC Heart Failure Wiley, 2015 9(2022), 5, Seite 3496-3504 (DE-627)820686506 (DE-600)2814355-3 20555822 nnns volume:9 year:2022 number:5 pages:3496-3504 https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/article/4fedd7c1255248cbaab46f09360bad80 kostenfrei https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/toc/2055-5822 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 5 3496-3504
allfields_unstemmed	10.1002/ehf2.14099 doi (DE-627)DOAJ08380000X (DE-599)DOAJ4fedd7c1255248cbaab46f09360bad80 DE-627 ger DE-627 rakwb eng RC666-701 Valmiki Maharaj verfasserin aut Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed. Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure Diseases of the circulatory (Cardiovascular) system Arianne C. Agdamag verfasserin aut Sue Duval verfasserin aut Jonathan Edmiston verfasserin aut Victoria Charpentier verfasserin aut Meg Fraser verfasserin aut Alexandra Hall verfasserin aut Jessica Schultz verfasserin aut Ranjit John verfasserin aut Andrew Shaffer verfasserin aut Cindy M. Martin verfasserin aut Thenappan Thenappan verfasserin aut Gary S. Francis verfasserin aut Rebecca Cogswell verfasserin aut Tamas Alexy verfasserin aut In ESC Heart Failure Wiley, 2015 9(2022), 5, Seite 3496-3504 (DE-627)820686506 (DE-600)2814355-3 20555822 nnns volume:9 year:2022 number:5 pages:3496-3504 https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/article/4fedd7c1255248cbaab46f09360bad80 kostenfrei https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/toc/2055-5822 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 5 3496-3504
allfieldsGer	10.1002/ehf2.14099 doi (DE-627)DOAJ08380000X (DE-599)DOAJ4fedd7c1255248cbaab46f09360bad80 DE-627 ger DE-627 rakwb eng RC666-701 Valmiki Maharaj verfasserin aut Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed. Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure Diseases of the circulatory (Cardiovascular) system Arianne C. Agdamag verfasserin aut Sue Duval verfasserin aut Jonathan Edmiston verfasserin aut Victoria Charpentier verfasserin aut Meg Fraser verfasserin aut Alexandra Hall verfasserin aut Jessica Schultz verfasserin aut Ranjit John verfasserin aut Andrew Shaffer verfasserin aut Cindy M. Martin verfasserin aut Thenappan Thenappan verfasserin aut Gary S. Francis verfasserin aut Rebecca Cogswell verfasserin aut Tamas Alexy verfasserin aut In ESC Heart Failure Wiley, 2015 9(2022), 5, Seite 3496-3504 (DE-627)820686506 (DE-600)2814355-3 20555822 nnns volume:9 year:2022 number:5 pages:3496-3504 https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/article/4fedd7c1255248cbaab46f09360bad80 kostenfrei https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/toc/2055-5822 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 5 3496-3504
allfieldsSound	10.1002/ehf2.14099 doi (DE-627)DOAJ08380000X (DE-599)DOAJ4fedd7c1255248cbaab46f09360bad80 DE-627 ger DE-627 rakwb eng RC666-701 Valmiki Maharaj verfasserin aut Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed. Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure Diseases of the circulatory (Cardiovascular) system Arianne C. Agdamag verfasserin aut Sue Duval verfasserin aut Jonathan Edmiston verfasserin aut Victoria Charpentier verfasserin aut Meg Fraser verfasserin aut Alexandra Hall verfasserin aut Jessica Schultz verfasserin aut Ranjit John verfasserin aut Andrew Shaffer verfasserin aut Cindy M. Martin verfasserin aut Thenappan Thenappan verfasserin aut Gary S. Francis verfasserin aut Rebecca Cogswell verfasserin aut Tamas Alexy verfasserin aut In ESC Heart Failure Wiley, 2015 9(2022), 5, Seite 3496-3504 (DE-627)820686506 (DE-600)2814355-3 20555822 nnns volume:9 year:2022 number:5 pages:3496-3504 https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/article/4fedd7c1255248cbaab46f09360bad80 kostenfrei https://doi.org/10.1002/ehf2.14099 kostenfrei https://doaj.org/toc/2055-5822 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022 5 3496-3504
language	English
source	In ESC Heart Failure 9(2022), 5, Seite 3496-3504 volume:9 year:2022 number:5 pages:3496-3504
sourceStr	In ESC Heart Failure 9(2022), 5, Seite 3496-3504 volume:9 year:2022 number:5 pages:3496-3504
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure Diseases of the circulatory (Cardiovascular) system
isfreeaccess_bool	true
container_title	ESC Heart Failure
authorswithroles_txt_mv	Valmiki Maharaj @@aut@@ Arianne C. Agdamag @@aut@@ Sue Duval @@aut@@ Jonathan Edmiston @@aut@@ Victoria Charpentier @@aut@@ Meg Fraser @@aut@@ Alexandra Hall @@aut@@ Jessica Schultz @@aut@@ Ranjit John @@aut@@ Andrew Shaffer @@aut@@ Cindy M. Martin @@aut@@ Thenappan Thenappan @@aut@@ Gary S. Francis @@aut@@ Rebecca Cogswell @@aut@@ Tamas Alexy @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	820686506
id	DOAJ08380000X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ08380000X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501182835.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/ehf2.14099</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ08380000X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ4fedd7c1255248cbaab46f09360bad80</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC666-701</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Valmiki Maharaj</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cardiopulmonary exercise stress test</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Left ventricular assist device</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hypotension</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Heart failure</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the circulatory (Cardiovascular) system</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Arianne C. 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callnumber-first	R - Medicine
author	Valmiki Maharaj
spellingShingle	Valmiki Maharaj misc RC666-701 misc Cardiopulmonary exercise stress test misc Left ventricular assist device misc Hypotension misc Heart failure misc Diseases of the circulatory (Cardiovascular) system Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients
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topic_title	RC666-701 Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients Cardiopulmonary exercise stress test Left ventricular assist device Hypotension Heart failure
topic	misc RC666-701 misc Cardiopulmonary exercise stress test misc Left ventricular assist device misc Hypotension misc Heart failure misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc Cardiopulmonary exercise stress test misc Left ventricular assist device misc Hypotension misc Heart failure misc Diseases of the circulatory (Cardiovascular) system
topic_browse	misc RC666-701 misc Cardiopulmonary exercise stress test misc Left ventricular assist device misc Hypotension misc Heart failure misc Diseases of the circulatory (Cardiovascular) system
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title	Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients
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title_full	Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients
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author_browse	Valmiki Maharaj Arianne C. Agdamag Sue Duval Jonathan Edmiston Victoria Charpentier Meg Fraser Alexandra Hall Jessica Schultz Ranjit John Andrew Shaffer Cindy M. Martin Thenappan Thenappan Gary S. Francis Rebecca Cogswell Tamas Alexy
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doi_str_mv	10.1002/ehf2.14099
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title_sort	hypotension on cardiopulmonary stress test predicts 90 day mortality after lvad implantation in intermacs 3–6 patients
callnumber	RC666-701
title_auth	Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients
abstract	Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed.
abstractGer	Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed.
abstract_unstemmed	Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. Additional studies are needed to determine the mechanism of increased mortality observed.
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title_short	Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients
url	https://doi.org/10.1002/ehf2.14099 https://doaj.org/article/4fedd7c1255248cbaab46f09360bad80 https://doaj.org/toc/2055-5822
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author2	Arianne C. Agdamag Sue Duval Jonathan Edmiston Victoria Charpentier Meg Fraser Alexandra Hall Jessica Schultz Ranjit John Andrew Shaffer Cindy M. Martin Thenappan Thenappan Gary S. Francis Rebecca Cogswell Tamas Alexy
author2Str	Arianne C. Agdamag Sue Duval Jonathan Edmiston Victoria Charpentier Meg Fraser Alexandra Hall Jessica Schultz Ranjit John Andrew Shaffer Cindy M. Martin Thenappan Thenappan Gary S. Francis Rebecca Cogswell Tamas Alexy
ppnlink	820686506
callnumber-subject	RC - Internal Medicine
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doi_str	10.1002/ehf2.14099
callnumber-a	RC666-701
up_date	2024-07-03T19:30:37.786Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ08380000X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501182835.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/ehf2.14099</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ08380000X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ4fedd7c1255248cbaab46f09360bad80</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC666-701</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Valmiki Maharaj</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Aims Cardiopulmonary stress test (CPX) is routinely performed when evaluating patient candidacy for left ventricular assist device (LVAD) implantation. The predictive value of hypotensive systolic blood pressure (SBP) response during CPX on clinical outcomes is unknown. This study aims to determine the effect of hypotensive SBP response during to clinical outcomes among patients who underwent LVAD implantation. Methods and results This was a retrospective single center study enrolling consecutive patients implanted with a continuous flow LVAD between 2011 and 2022. Hypotensive SBP response was defined as peak exercise SBP below the resting value. Multivariable Cox‐regression analysis was performed to evaluate the relationship between hypotensive SBP response and all‐cause mortality within 30 and 90 days of LVAD implantation. A subgroup analysis was performed for patients implanted with a HeartMate III (HM III) device. Four hundred thirty‐two patients underwent LVAD implantation during the pre‐defined period and 156 with INTERMACS profiles 3–6 met our inclusion criteria. The median age was 63 years (IQR 54–69), and 52% had ischaemic cardiomyopathy. Hypotensive SBP response was present in 35% of patients and was associated with increased 90 day all‐cause mortality (unadjusted HR 9.16, 95% CI 1.98–42; P = 0.0046). Hazard ratio remained significant after adjusting for age, INTERMACS profile, serum creatinine, and total bilirubin. Findings were similar in the HM III subgroup. Conclusions Hypotensive SBP response on pre‐LVAD CPX is associated with increased perioperative and 90 day mortality after LVAD implantation. 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Hypotension on cardiopulmonary stress test predicts 90 day mortality after LVAD implantation in INTERMACS 3–6 patients

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