In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia

Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (...
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Autor*in:	Mohammad Abavisani [verfasserIn] Karim Rahimian [verfasserIn] Mansoor Kodori [verfasserIn] Reza Khayami [verfasserIn] Mahsa Mollapour Sisakht [verfasserIn] Mohammadamin Mahmanzar [verfasserIn] Zahra Meshkat [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2

Übergeordnetes Werk:	In: Iranian Journal of Basic Medical Sciences - Mashhad University of Medical Sciences, 2009, 25(2022), 11, Seite 1299-1307
Übergeordnetes Werk:	volume:25 ; year:2022 ; number:11 ; pages:1299-1307

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.22038/ijbms.2022.66649.14620

Katalog-ID:	DOAJ08391613X

Internformat


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245	1	0	\|a In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia
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allfields	10.22038/ijbms.2022.66649.14620 doi (DE-627)DOAJ08391613X (DE-599)DOAJ35c0079245784db2b26a0aaa27f92ea7 DE-627 ger DE-627 rakwb eng Mohammad Abavisani verfasserin aut In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools. asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2 Medicine R Karim Rahimian verfasserin aut Mansoor Kodori verfasserin aut Reza Khayami verfasserin aut Mahsa Mollapour Sisakht verfasserin aut Mohammadamin Mahmanzar verfasserin aut Zahra Meshkat verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 11, Seite 1299-1307 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:11 pages:1299-1307 https://doi.org/10.22038/ijbms.2022.66649.14620 kostenfrei https://doaj.org/article/35c0079245784db2b26a0aaa27f92ea7 kostenfrei https://ijbms.mums.ac.ir/article_21109_e932424ac90508b5b3885839f8f8cb33.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 11 1299-1307
spelling	10.22038/ijbms.2022.66649.14620 doi (DE-627)DOAJ08391613X (DE-599)DOAJ35c0079245784db2b26a0aaa27f92ea7 DE-627 ger DE-627 rakwb eng Mohammad Abavisani verfasserin aut In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools. asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2 Medicine R Karim Rahimian verfasserin aut Mansoor Kodori verfasserin aut Reza Khayami verfasserin aut Mahsa Mollapour Sisakht verfasserin aut Mohammadamin Mahmanzar verfasserin aut Zahra Meshkat verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 11, Seite 1299-1307 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:11 pages:1299-1307 https://doi.org/10.22038/ijbms.2022.66649.14620 kostenfrei https://doaj.org/article/35c0079245784db2b26a0aaa27f92ea7 kostenfrei https://ijbms.mums.ac.ir/article_21109_e932424ac90508b5b3885839f8f8cb33.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 11 1299-1307
allfields_unstemmed	10.22038/ijbms.2022.66649.14620 doi (DE-627)DOAJ08391613X (DE-599)DOAJ35c0079245784db2b26a0aaa27f92ea7 DE-627 ger DE-627 rakwb eng Mohammad Abavisani verfasserin aut In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools. asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2 Medicine R Karim Rahimian verfasserin aut Mansoor Kodori verfasserin aut Reza Khayami verfasserin aut Mahsa Mollapour Sisakht verfasserin aut Mohammadamin Mahmanzar verfasserin aut Zahra Meshkat verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 11, Seite 1299-1307 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:11 pages:1299-1307 https://doi.org/10.22038/ijbms.2022.66649.14620 kostenfrei https://doaj.org/article/35c0079245784db2b26a0aaa27f92ea7 kostenfrei https://ijbms.mums.ac.ir/article_21109_e932424ac90508b5b3885839f8f8cb33.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 11 1299-1307
allfieldsGer	10.22038/ijbms.2022.66649.14620 doi (DE-627)DOAJ08391613X (DE-599)DOAJ35c0079245784db2b26a0aaa27f92ea7 DE-627 ger DE-627 rakwb eng Mohammad Abavisani verfasserin aut In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools. asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2 Medicine R Karim Rahimian verfasserin aut Mansoor Kodori verfasserin aut Reza Khayami verfasserin aut Mahsa Mollapour Sisakht verfasserin aut Mohammadamin Mahmanzar verfasserin aut Zahra Meshkat verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 11, Seite 1299-1307 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:11 pages:1299-1307 https://doi.org/10.22038/ijbms.2022.66649.14620 kostenfrei https://doaj.org/article/35c0079245784db2b26a0aaa27f92ea7 kostenfrei https://ijbms.mums.ac.ir/article_21109_e932424ac90508b5b3885839f8f8cb33.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 11 1299-1307
allfieldsSound	10.22038/ijbms.2022.66649.14620 doi (DE-627)DOAJ08391613X (DE-599)DOAJ35c0079245784db2b26a0aaa27f92ea7 DE-627 ger DE-627 rakwb eng Mohammad Abavisani verfasserin aut In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools. asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2 Medicine R Karim Rahimian verfasserin aut Mansoor Kodori verfasserin aut Reza Khayami verfasserin aut Mahsa Mollapour Sisakht verfasserin aut Mohammadamin Mahmanzar verfasserin aut Zahra Meshkat verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 11, Seite 1299-1307 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:11 pages:1299-1307 https://doi.org/10.22038/ijbms.2022.66649.14620 kostenfrei https://doaj.org/article/35c0079245784db2b26a0aaa27f92ea7 kostenfrei https://ijbms.mums.ac.ir/article_21109_e932424ac90508b5b3885839f8f8cb33.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 11 1299-1307
language	English
source	In Iranian Journal of Basic Medical Sciences 25(2022), 11, Seite 1299-1307 volume:25 year:2022 number:11 pages:1299-1307
sourceStr	In Iranian Journal of Basic Medical Sciences 25(2022), 11, Seite 1299-1307 volume:25 year:2022 number:11 pages:1299-1307
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institution	findex.gbv.de
topic_facet	asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2 Medicine R
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container_title	Iranian Journal of Basic Medical Sciences
authorswithroles_txt_mv	Mohammad Abavisani @@aut@@ Karim Rahimian @@aut@@ Mansoor Kodori @@aut@@ Reza Khayami @@aut@@ Mahsa Mollapour Sisakht @@aut@@ Mohammadamin Mahmanzar @@aut@@ Zahra Meshkat @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
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author	Mohammad Abavisani
spellingShingle	Mohammad Abavisani misc asia misc covid-19 misc evolutionary analysis misc genome-wide mutations misc mutations misc sars-cov-2 misc Medicine misc R In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia
authorStr	Mohammad Abavisani
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topic_title	In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia asia covid-19 evolutionary analysis genome-wide mutations mutations sars-cov-2
topic	misc asia misc covid-19 misc evolutionary analysis misc genome-wide mutations misc mutations misc sars-cov-2 misc Medicine misc R
topic_unstemmed	misc asia misc covid-19 misc evolutionary analysis misc genome-wide mutations misc mutations misc sars-cov-2 misc Medicine misc R
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title	In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia
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title_full	In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia
author_sort	Mohammad Abavisani
journal	Iranian Journal of Basic Medical Sciences
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author_browse	Mohammad Abavisani Karim Rahimian Mansoor Kodori Reza Khayami Mahsa Mollapour Sisakht Mohammadamin Mahmanzar Zahra Meshkat
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author-letter	Mohammad Abavisani
doi_str_mv	10.22038/ijbms.2022.66649.14620
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title_sort	in silico analysis of the substitution mutations and evolutionary trends of the sars-cov-2 structural proteins in asia
title_auth	In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia
abstract	Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools.
abstractGer	Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools.
abstract_unstemmed	Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and Methods: We investigated the Asian and worldwide samples of amino-acid sequences (AASs) for envelope (E), membrane (M), nucleocapsid (N), and spike (S) proteins from the announcement of the new coronavirus 2019 (COVID-19) up to January 2022. Sequence alignment to the Wuhan-2019 virus permits tracking mutations in Asian and global samples. Furthermore, we explored the evolutionary tendencies of structural protein mutations and compared the results between Asia and the globe.Results: The mutation analyses indicated that 5.81%, 70.63%, 26.59%, and 3.36% of Asian S, E, M, and N samples did not display any mutation. Additionally, the most relative mutations among the S, E, M, and N AASs occurred in the regions of 508 to 635 AA, 7 to 14 AA, 66 to 88 AA, and 164 to 205 AA in both Asian and total samples. D614G, T9I, I82T, and R203M were inferred as the most frequent mutations in S, E, M, and N AASs. Timeline research showed that substitution mutation in the location of 614 among Asian and total S AASs was detected from January 2020.Conclusion: N protein was the most non-conserved protein, and the most prevalent mutations in S, E, M, and N AASs were D614G, T9I, I82T, and R203M. Screening structural protein mutations is a robust approach for developing drugs, vaccines, and more specific diagnostic tools.
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title_short	In silico analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia
url	https://doi.org/10.22038/ijbms.2022.66649.14620 https://doaj.org/article/35c0079245784db2b26a0aaa27f92ea7 https://ijbms.mums.ac.ir/article_21109_e932424ac90508b5b3885839f8f8cb33.pdf https://doaj.org/toc/2008-3866 https://doaj.org/toc/2008-3874
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author2	Karim Rahimian Mansoor Kodori Reza Khayami Mahsa Mollapour Sisakht Mohammadamin Mahmanzar Zahra Meshkat
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up_date	2024-07-03T20:08:57.390Z
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