Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel

Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a va...
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Autor*in:	Léo Michel [verfasserIn] Karina Palma [verfasserIn] Mauricio Cerda [verfasserIn] Ronan Lagadec [verfasserIn] Hélène Mayeur [verfasserIn] Michaël Fuentès [verfasserIn] Laurence Besseau [verfasserIn] Patrick Martin [verfasserIn] Elodie Magnanou [verfasserIn] Patrick Blader [verfasserIn] Miguel L. Concha [verfasserIn] Sylvie Mazan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	habenula asymmetry Atlantic salmon European eel pax6 sox1

Übergeordnetes Werk:	In: Frontiers in Cell and Developmental Biology - Frontiers Media S.A., 2014, 10(2022)
Übergeordnetes Werk:	volume:10 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcell.2022.1015074

Katalog-ID:	DOAJ084035501

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spelling	10.3389/fcell.2022.1015074 doi (DE-627)DOAJ084035501 (DE-599)DOAJ14c3135c51ee40bfaa89207b2694050c DE-627 ger DE-627 rakwb eng QH301-705.5 Léo Michel verfasserin aut Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a variety of organismal adaptive responses. However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. Taken together, our data raise novel questions about the variability of asymmetries across teleosts and their biological significance depending on ecological contexts. habenula asymmetry Atlantic salmon European eel pax6 sox1 Biology (General) Karina Palma verfasserin aut Karina Palma verfasserin aut Mauricio Cerda verfasserin aut Mauricio Cerda verfasserin aut Mauricio Cerda verfasserin aut Ronan Lagadec verfasserin aut Hélène Mayeur verfasserin aut Michaël Fuentès verfasserin aut Laurence Besseau verfasserin aut Patrick Martin verfasserin aut Elodie Magnanou verfasserin aut Patrick Blader verfasserin aut Miguel L. Concha verfasserin aut Miguel L. Concha verfasserin aut Miguel L. Concha verfasserin aut Sylvie Mazan verfasserin aut In Frontiers in Cell and Developmental Biology Frontiers Media S.A., 2014 10(2022) (DE-627)770398138 (DE-600)2737824-X 2296634X nnns volume:10 year:2022 https://doi.org/10.3389/fcell.2022.1015074 kostenfrei https://doaj.org/article/14c3135c51ee40bfaa89207b2694050c kostenfrei https://www.frontiersin.org/articles/10.3389/fcell.2022.1015074/full kostenfrei https://doaj.org/toc/2296-634X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022
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callnumber-first	Q - Science
author	Léo Michel
spellingShingle	Léo Michel misc QH301-705.5 misc habenula misc asymmetry misc Atlantic salmon misc European eel misc pax6 misc sox1 misc Biology (General) Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
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topic_title	QH301-705.5 Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel habenula asymmetry Atlantic salmon European eel pax6 sox1
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title	Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
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title_full	Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
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title_sort	diversification of habenular organization and asymmetries in teleosts: insights from the atlantic salmon and european eel
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title_auth	Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
abstract	Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a variety of organismal adaptive responses. However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. Taken together, our data raise novel questions about the variability of asymmetries across teleosts and their biological significance depending on ecological contexts.
abstractGer	Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a variety of organismal adaptive responses. However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. Taken together, our data raise novel questions about the variability of asymmetries across teleosts and their biological significance depending on ecological contexts.
abstract_unstemmed	Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a variety of organismal adaptive responses. However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. Taken together, our data raise novel questions about the variability of asymmetries across teleosts and their biological significance depending on ecological contexts.
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title_short	Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
url	https://doi.org/10.3389/fcell.2022.1015074 https://doaj.org/article/14c3135c51ee40bfaa89207b2694050c https://www.frontiersin.org/articles/10.3389/fcell.2022.1015074/full https://doaj.org/toc/2296-634X
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However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. 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Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel

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