Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin

Microtubules (MTs) and actin filaments (F-actin) function cooperatively to regulate plant cell morphogenesis. However, the mechanisms underlying the crosstalk between these two cytoskeletal systems, particularly in cell shape control, remain largely unknown. In this study, we show that introduction...
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Autor*in:	Juan Tian [verfasserIn] Libo Han [verfasserIn] Zhidi Feng [verfasserIn] Guangda Wang [verfasserIn] Weiwei Liu [verfasserIn] Yinping Ma [verfasserIn] Yanjun Yu [verfasserIn] Zhaosheng Kong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	cell shape determination trichome microtubules actin filament kinesin

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 4(2015)
Übergeordnetes Werk:	volume:4 ; year:2015

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.09351

Katalog-ID:	DOAJ084180064

Internformat


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language	English
source	In eLife 4(2015) volume:4 year:2015
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container_title	eLife
authorswithroles_txt_mv	Juan Tian @@aut@@ Libo Han @@aut@@ Zhidi Feng @@aut@@ Guangda Wang @@aut@@ Weiwei Liu @@aut@@ Yinping Ma @@aut@@ Yanjun Yu @@aut@@ Zhaosheng Kong @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
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callnumber-first	Q - Science
author	Juan Tian
spellingShingle	Juan Tian misc QH301-705.5 misc cell shape determination misc trichome misc microtubules misc actin filament misc kinesin misc Medicine misc R misc Science misc Q misc Biology (General) Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin
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topic_title	QH301-705.5 Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin cell shape determination trichome microtubules actin filament kinesin
topic	misc QH301-705.5 misc cell shape determination misc trichome misc microtubules misc actin filament misc kinesin misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc cell shape determination misc trichome misc microtubules misc actin filament misc kinesin misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin
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title_full	Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin
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title_sort	orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin
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title_auth	Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin
abstract	Microtubules (MTs) and actin filaments (F-actin) function cooperatively to regulate plant cell morphogenesis. However, the mechanisms underlying the crosstalk between these two cytoskeletal systems, particularly in cell shape control, remain largely unknown. In this study, we show that introduction of the MyTH4-FERM tandem into KCBP (kinesin-like calmodulin-binding protein) during evolution conferred novel functions. The MyTH4 domain and the FERM domain in the N-terminal tail of KCBP physically bind to MTs and F-actin, respectively. During trichome morphogenesis, KCBP distributes in a specific cortical gradient and concentrates at the branching sites and the apexes of elongating branches, which lack MTs but have cortical F-actin. Further, live-cell imaging and genetic analyses revealed that KCBP acts as a hub integrating MTs and actin filaments to assemble the required cytoskeletal configuration for the unique, polarized diffuse growth pattern during trichome cell morphogenesis. Our findings provide significant insights into the mechanisms underlying cytoskeletal regulation of cell shape determination.
abstractGer	Microtubules (MTs) and actin filaments (F-actin) function cooperatively to regulate plant cell morphogenesis. However, the mechanisms underlying the crosstalk between these two cytoskeletal systems, particularly in cell shape control, remain largely unknown. In this study, we show that introduction of the MyTH4-FERM tandem into KCBP (kinesin-like calmodulin-binding protein) during evolution conferred novel functions. The MyTH4 domain and the FERM domain in the N-terminal tail of KCBP physically bind to MTs and F-actin, respectively. During trichome morphogenesis, KCBP distributes in a specific cortical gradient and concentrates at the branching sites and the apexes of elongating branches, which lack MTs but have cortical F-actin. Further, live-cell imaging and genetic analyses revealed that KCBP acts as a hub integrating MTs and actin filaments to assemble the required cytoskeletal configuration for the unique, polarized diffuse growth pattern during trichome cell morphogenesis. Our findings provide significant insights into the mechanisms underlying cytoskeletal regulation of cell shape determination.
abstract_unstemmed	Microtubules (MTs) and actin filaments (F-actin) function cooperatively to regulate plant cell morphogenesis. However, the mechanisms underlying the crosstalk between these two cytoskeletal systems, particularly in cell shape control, remain largely unknown. In this study, we show that introduction of the MyTH4-FERM tandem into KCBP (kinesin-like calmodulin-binding protein) during evolution conferred novel functions. The MyTH4 domain and the FERM domain in the N-terminal tail of KCBP physically bind to MTs and F-actin, respectively. During trichome morphogenesis, KCBP distributes in a specific cortical gradient and concentrates at the branching sites and the apexes of elongating branches, which lack MTs but have cortical F-actin. Further, live-cell imaging and genetic analyses revealed that KCBP acts as a hub integrating MTs and actin filaments to assemble the required cytoskeletal configuration for the unique, polarized diffuse growth pattern during trichome cell morphogenesis. Our findings provide significant insights into the mechanisms underlying cytoskeletal regulation of cell shape determination.
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title_short	Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin
url	https://doi.org/10.7554/eLife.09351 https://doaj.org/article/884f6b243c7c4c27aa4a95cdca4985b7 https://elifesciences.org/articles/09351 https://doaj.org/toc/2050-084X
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Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin

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