A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wi...
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Autor*in:	Alyson Ashe [verfasserIn] Tony Bélicard [verfasserIn] Jérémie Le Pen [verfasserIn] Peter Sarkies [verfasserIn] Lise Frézal [verfasserIn] Nicolas J Lehrbach [verfasserIn] Marie-Anne Félix [verfasserIn] Eric A Miska [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	RNA interference immunity virus infection

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 2(2013)
Übergeordnetes Werk:	volume:2 ; year:2013

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.00994

Katalog-ID:	DOAJ084180625

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allfieldsSound	10.7554/eLife.00994 doi (DE-627)DOAJ084180625 (DE-599)DOAJf3bad0c18c67455bb24d7eae7bb1d867 DE-627 ger DE-627 rakwb eng QH301-705.5 Alyson Ashe verfasserin aut A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wild populations and quantitative trait locus mapping, we identify a 159 base-pair deletion in the conserved drh-1 gene (encoding a RIG-I-like helicase) as a major determinant of viral sensitivity. We show that DRH-1 is required for the initiation of an antiviral RNAi pathway and the generation of virus-derived siRNAs (viRNAs). In mammals, RIG-I-domain containing proteins trigger an interferon-based innate immunity pathway in response to RNA virus infection. Our work in C. elegans demonstrates that the RIG-I domain has an ancient role in viral recognition. We propose that RIG-I acts as modular viral recognition factor that couples viral recognition to different effector pathways including RNAi and interferon responses. RNA interference immunity virus infection Medicine R Science Q Biology (General) Tony Bélicard verfasserin aut Jérémie Le Pen verfasserin aut Peter Sarkies verfasserin aut Lise Frézal verfasserin aut Nicolas J Lehrbach verfasserin aut Marie-Anne Félix verfasserin aut Eric A Miska verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 2(2013) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:2 year:2013 https://doi.org/10.7554/eLife.00994 kostenfrei https://doaj.org/article/f3bad0c18c67455bb24d7eae7bb1d867 kostenfrei https://elifesciences.org/articles/00994 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013
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authorswithroles_txt_mv	Alyson Ashe @@aut@@ Tony Bélicard @@aut@@ Jérémie Le Pen @@aut@@ Peter Sarkies @@aut@@ Lise Frézal @@aut@@ Nicolas J Lehrbach @@aut@@ Marie-Anne Félix @@aut@@ Eric A Miska @@aut@@
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callnumber-first	Q - Science
author	Alyson Ashe
spellingShingle	Alyson Ashe misc QH301-705.5 misc RNA interference misc immunity misc virus infection misc Medicine misc R misc Science misc Q misc Biology (General) A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity
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topic_title	QH301-705.5 A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity RNA interference immunity virus infection
topic	misc QH301-705.5 misc RNA interference misc immunity misc virus infection misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc RNA interference misc immunity misc virus infection misc Medicine misc R misc Science misc Q misc Biology (General)
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title	A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity
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title_full	A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity
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title_sort	deletion polymorphism in the caenorhabditis elegans rig-i homolog disables viral rna dicing and antiviral immunity
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title_auth	A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity
abstract	RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wild populations and quantitative trait locus mapping, we identify a 159 base-pair deletion in the conserved drh-1 gene (encoding a RIG-I-like helicase) as a major determinant of viral sensitivity. We show that DRH-1 is required for the initiation of an antiviral RNAi pathway and the generation of virus-derived siRNAs (viRNAs). In mammals, RIG-I-domain containing proteins trigger an interferon-based innate immunity pathway in response to RNA virus infection. Our work in C. elegans demonstrates that the RIG-I domain has an ancient role in viral recognition. We propose that RIG-I acts as modular viral recognition factor that couples viral recognition to different effector pathways including RNAi and interferon responses.
abstractGer	RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wild populations and quantitative trait locus mapping, we identify a 159 base-pair deletion in the conserved drh-1 gene (encoding a RIG-I-like helicase) as a major determinant of viral sensitivity. We show that DRH-1 is required for the initiation of an antiviral RNAi pathway and the generation of virus-derived siRNAs (viRNAs). In mammals, RIG-I-domain containing proteins trigger an interferon-based innate immunity pathway in response to RNA virus infection. Our work in C. elegans demonstrates that the RIG-I domain has an ancient role in viral recognition. We propose that RIG-I acts as modular viral recognition factor that couples viral recognition to different effector pathways including RNAi and interferon responses.
abstract_unstemmed	RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand RNA virus Orsay, have recently emerged as a new animal model of host-virus interaction. Using a genome-wide association study in C. elegans wild populations and quantitative trait locus mapping, we identify a 159 base-pair deletion in the conserved drh-1 gene (encoding a RIG-I-like helicase) as a major determinant of viral sensitivity. We show that DRH-1 is required for the initiation of an antiviral RNAi pathway and the generation of virus-derived siRNAs (viRNAs). In mammals, RIG-I-domain containing proteins trigger an interferon-based innate immunity pathway in response to RNA virus infection. Our work in C. elegans demonstrates that the RIG-I domain has an ancient role in viral recognition. We propose that RIG-I acts as modular viral recognition factor that couples viral recognition to different effector pathways including RNAi and interferon responses.
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title_short	A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity
url	https://doi.org/10.7554/eLife.00994 https://doaj.org/article/f3bad0c18c67455bb24d7eae7bb1d867 https://elifesciences.org/articles/00994 https://doaj.org/toc/2050-084X
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A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

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