Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

Slow waves and cognitive output have been modulated in humans by phase-targeted auditory stimulation. However, to advance its technical development and further our understanding, implementation of the method in animal models is indispensable. Here, we report the successful employment of slow waves’...
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Autor*in:	Carlos G Moreira [verfasserIn] Christian R Baumann [verfasserIn] Maurizio Scandella [verfasserIn] Sergio I Nemirovsky [verfasserIn] Sven Leach [verfasserIn] Reto Huber [verfasserIn] Daniela Noain [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	closed-loop auditory stimulation sleep slow waves motor learning sleep modulation

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 10(2021)
Übergeordnetes Werk:	volume:10 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.68043

Katalog-ID:	DOAJ084192305

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source	In eLife 10(2021) volume:10 year:2021
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topic_facet	closed-loop auditory stimulation sleep slow waves motor learning sleep modulation Medicine R Science Q Biology (General)
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container_title	eLife
authorswithroles_txt_mv	Carlos G Moreira @@aut@@ Christian R Baumann @@aut@@ Maurizio Scandella @@aut@@ Sergio I Nemirovsky @@aut@@ Sven Leach @@aut@@ Reto Huber @@aut@@ Daniela Noain @@aut@@
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callnumber-first	Q - Science
author	Carlos G Moreira
spellingShingle	Carlos G Moreira misc QH301-705.5 misc closed-loop auditory stimulation misc sleep slow waves misc motor learning misc sleep modulation misc Medicine misc R misc Science misc Q misc Biology (General) Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats
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topic_title	QH301-705.5 Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats closed-loop auditory stimulation sleep slow waves motor learning sleep modulation
topic	misc QH301-705.5 misc closed-loop auditory stimulation misc sleep slow waves misc motor learning misc sleep modulation misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc closed-loop auditory stimulation misc sleep slow waves misc motor learning misc sleep modulation misc Medicine misc R misc Science misc Q misc Biology (General)
topic_browse	misc QH301-705.5 misc closed-loop auditory stimulation misc sleep slow waves misc motor learning misc sleep modulation misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats
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title_full	Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats
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author_browse	Carlos G Moreira Christian R Baumann Maurizio Scandella Sergio I Nemirovsky Sven Leach Reto Huber Daniela Noain
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title_sort	closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats
callnumber	QH301-705.5
title_auth	Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats
abstract	Slow waves and cognitive output have been modulated in humans by phase-targeted auditory stimulation. However, to advance its technical development and further our understanding, implementation of the method in animal models is indispensable. Here, we report the successful employment of slow waves’ phase-targeted closed-loop auditory stimulation (CLAS) in rats. To validate this new tool both conceptually and functionally, we tested the effects of up- and down-phase CLAS on proportions and spectral characteristics of sleep, and on learning performance in the single-pellet reaching task, respectively. Without affecting 24 hr sleep-wake behavior, CLAS specifically altered delta (slow waves) and sigma (sleep spindles) power persistently over chronic periods of stimulation. While up-phase CLAS does not elicit a significant change in behavioral performance, down-phase CLAS exerted a detrimental effect on overall engagement and success rate in the behavioral test. Overall CLAS-dependent spectral changes were positively correlated with learning performance. Altogether, our results provide proof-of-principle evidence that phase-targeted CLAS of slow waves in rodents is efficient, safe, and stable over chronic experimental periods, enabling the use of this high-specificity tool for basic and preclinical translational sleep research.
abstractGer	Slow waves and cognitive output have been modulated in humans by phase-targeted auditory stimulation. However, to advance its technical development and further our understanding, implementation of the method in animal models is indispensable. Here, we report the successful employment of slow waves’ phase-targeted closed-loop auditory stimulation (CLAS) in rats. To validate this new tool both conceptually and functionally, we tested the effects of up- and down-phase CLAS on proportions and spectral characteristics of sleep, and on learning performance in the single-pellet reaching task, respectively. Without affecting 24 hr sleep-wake behavior, CLAS specifically altered delta (slow waves) and sigma (sleep spindles) power persistently over chronic periods of stimulation. While up-phase CLAS does not elicit a significant change in behavioral performance, down-phase CLAS exerted a detrimental effect on overall engagement and success rate in the behavioral test. Overall CLAS-dependent spectral changes were positively correlated with learning performance. Altogether, our results provide proof-of-principle evidence that phase-targeted CLAS of slow waves in rodents is efficient, safe, and stable over chronic experimental periods, enabling the use of this high-specificity tool for basic and preclinical translational sleep research.
abstract_unstemmed	Slow waves and cognitive output have been modulated in humans by phase-targeted auditory stimulation. However, to advance its technical development and further our understanding, implementation of the method in animal models is indispensable. Here, we report the successful employment of slow waves’ phase-targeted closed-loop auditory stimulation (CLAS) in rats. To validate this new tool both conceptually and functionally, we tested the effects of up- and down-phase CLAS on proportions and spectral characteristics of sleep, and on learning performance in the single-pellet reaching task, respectively. Without affecting 24 hr sleep-wake behavior, CLAS specifically altered delta (slow waves) and sigma (sleep spindles) power persistently over chronic periods of stimulation. While up-phase CLAS does not elicit a significant change in behavioral performance, down-phase CLAS exerted a detrimental effect on overall engagement and success rate in the behavioral test. Overall CLAS-dependent spectral changes were positively correlated with learning performance. Altogether, our results provide proof-of-principle evidence that phase-targeted CLAS of slow waves in rodents is efficient, safe, and stable over chronic experimental periods, enabling the use of this high-specificity tool for basic and preclinical translational sleep research.
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title_short	Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats
url	https://doi.org/10.7554/eLife.68043 https://doaj.org/article/efd980e27132463da10a94611bb61108 https://elifesciences.org/articles/68043 https://doaj.org/toc/2050-084X
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Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

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