Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation

Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation. Here, we show that transcription termination is an important driving force for codon usage bias in eukaryotes....
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Autor*in:	Zhipeng Zhou [verfasserIn] Yunkun Dang [verfasserIn] Mian Zhou [verfasserIn] Haiyan Yuan [verfasserIn] Yi Liu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	codon usage transcription termination Neurospora

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 7(2018)
Übergeordnetes Werk:	volume:7 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.33569

Katalog-ID:	DOAJ08420835X

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520			\|a Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation. Here, we show that transcription termination is an important driving force for codon usage bias in eukaryotes. Using Neurospora crassa as a model organism, we demonstrated that introduction of rare codons results in premature transcription termination (PTT) within open reading frames and abolishment of full-length mRNA. PTT is a wide-spread phenomenon in Neurospora, and there is a strong negative correlation between codon usage bias and PTT events. Rare codons lead to the formation of putative poly(A) signals and PTT. A similar role for codon usage bias was also observed in mouse cells. Together, these results suggest that codon usage biases co-evolve with the transcription termination machinery to suppress premature termination of transcription and thus allow for optimal gene expression.
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author	Zhipeng Zhou
spellingShingle	Zhipeng Zhou misc QH301-705.5 misc codon usage misc transcription termination misc Neurospora misc Medicine misc R misc Science misc Q misc Biology (General) Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
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topic_title	QH301-705.5 Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation codon usage transcription termination Neurospora
topic	misc QH301-705.5 misc codon usage misc transcription termination misc Neurospora misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
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title_full	Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
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title_sort	codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
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title_auth	Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
abstract	Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation. Here, we show that transcription termination is an important driving force for codon usage bias in eukaryotes. Using Neurospora crassa as a model organism, we demonstrated that introduction of rare codons results in premature transcription termination (PTT) within open reading frames and abolishment of full-length mRNA. PTT is a wide-spread phenomenon in Neurospora, and there is a strong negative correlation between codon usage bias and PTT events. Rare codons lead to the formation of putative poly(A) signals and PTT. A similar role for codon usage bias was also observed in mouse cells. Together, these results suggest that codon usage biases co-evolve with the transcription termination machinery to suppress premature termination of transcription and thus allow for optimal gene expression.
abstractGer	Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation. Here, we show that transcription termination is an important driving force for codon usage bias in eukaryotes. Using Neurospora crassa as a model organism, we demonstrated that introduction of rare codons results in premature transcription termination (PTT) within open reading frames and abolishment of full-length mRNA. PTT is a wide-spread phenomenon in Neurospora, and there is a strong negative correlation between codon usage bias and PTT events. Rare codons lead to the formation of putative poly(A) signals and PTT. A similar role for codon usage bias was also observed in mouse cells. Together, these results suggest that codon usage biases co-evolve with the transcription termination machinery to suppress premature termination of transcription and thus allow for optimal gene expression.
abstract_unstemmed	Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation. Here, we show that transcription termination is an important driving force for codon usage bias in eukaryotes. Using Neurospora crassa as a model organism, we demonstrated that introduction of rare codons results in premature transcription termination (PTT) within open reading frames and abolishment of full-length mRNA. PTT is a wide-spread phenomenon in Neurospora, and there is a strong negative correlation between codon usage bias and PTT events. Rare codons lead to the formation of putative poly(A) signals and PTT. A similar role for codon usage bias was also observed in mouse cells. Together, these results suggest that codon usage biases co-evolve with the transcription termination machinery to suppress premature termination of transcription and thus allow for optimal gene expression.
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title_short	Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
url	https://doi.org/10.7554/eLife.33569 https://doaj.org/article/a4e2c0fdd33d43e3a47b504de9bb6738 https://elifesciences.org/articles/33569 https://doaj.org/toc/2050-084X
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