Placental galectin-3 is reduced in early-onset preeclampsia

Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lys...
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Autor*in:	Manju Kandel [verfasserIn] Stephen Tong [verfasserIn] Susan P Walker [verfasserIn] Ping Cannon [verfasserIn] Tuong-Vi Nguyen [verfasserIn] Teresa M. MacDonald [verfasserIn] Natalie J. Hannan [verfasserIn] Tu’uhevaha J. Kaitu’u-Lino [verfasserIn] Lucy A Bartho [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	placenta preeclampsia galectin-3 galectin-3 binding protein plasma

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2022.1037597

Katalog-ID:	DOAJ084270438

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allfields	10.3389/fphys.2022.1037597 doi (DE-627)DOAJ084270438 (DE-599)DOAJ6ae85dac2026490296b52890bce0f9ab DE-627 ger DE-627 rakwb eng QP1-981 Manju Kandel verfasserin aut Placental galectin-3 is reduced in early-onset preeclampsia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells. placenta preeclampsia galectin-3 galectin-3 binding protein plasma Physiology Manju Kandel verfasserin aut Stephen Tong verfasserin aut Stephen Tong verfasserin aut Susan P Walker verfasserin aut Susan P Walker verfasserin aut Ping Cannon verfasserin aut Ping Cannon verfasserin aut Tuong-Vi Nguyen verfasserin aut Tuong-Vi Nguyen verfasserin aut Teresa M. MacDonald verfasserin aut Teresa M. MacDonald verfasserin aut Natalie J. Hannan verfasserin aut Natalie J. Hannan verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Lucy A Bartho verfasserin aut Lucy A Bartho verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 13(2022) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:13 year:2022 https://doi.org/10.3389/fphys.2022.1037597 kostenfrei https://doaj.org/article/6ae85dac2026490296b52890bce0f9ab kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2022.1037597/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fphys.2022.1037597 doi (DE-627)DOAJ084270438 (DE-599)DOAJ6ae85dac2026490296b52890bce0f9ab DE-627 ger DE-627 rakwb eng QP1-981 Manju Kandel verfasserin aut Placental galectin-3 is reduced in early-onset preeclampsia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells. placenta preeclampsia galectin-3 galectin-3 binding protein plasma Physiology Manju Kandel verfasserin aut Stephen Tong verfasserin aut Stephen Tong verfasserin aut Susan P Walker verfasserin aut Susan P Walker verfasserin aut Ping Cannon verfasserin aut Ping Cannon verfasserin aut Tuong-Vi Nguyen verfasserin aut Tuong-Vi Nguyen verfasserin aut Teresa M. MacDonald verfasserin aut Teresa M. MacDonald verfasserin aut Natalie J. Hannan verfasserin aut Natalie J. Hannan verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Lucy A Bartho verfasserin aut Lucy A Bartho verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 13(2022) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:13 year:2022 https://doi.org/10.3389/fphys.2022.1037597 kostenfrei https://doaj.org/article/6ae85dac2026490296b52890bce0f9ab kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2022.1037597/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfields_unstemmed	10.3389/fphys.2022.1037597 doi (DE-627)DOAJ084270438 (DE-599)DOAJ6ae85dac2026490296b52890bce0f9ab DE-627 ger DE-627 rakwb eng QP1-981 Manju Kandel verfasserin aut Placental galectin-3 is reduced in early-onset preeclampsia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells. placenta preeclampsia galectin-3 galectin-3 binding protein plasma Physiology Manju Kandel verfasserin aut Stephen Tong verfasserin aut Stephen Tong verfasserin aut Susan P Walker verfasserin aut Susan P Walker verfasserin aut Ping Cannon verfasserin aut Ping Cannon verfasserin aut Tuong-Vi Nguyen verfasserin aut Tuong-Vi Nguyen verfasserin aut Teresa M. MacDonald verfasserin aut Teresa M. MacDonald verfasserin aut Natalie J. Hannan verfasserin aut Natalie J. Hannan verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Lucy A Bartho verfasserin aut Lucy A Bartho verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 13(2022) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:13 year:2022 https://doi.org/10.3389/fphys.2022.1037597 kostenfrei https://doaj.org/article/6ae85dac2026490296b52890bce0f9ab kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2022.1037597/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsGer	10.3389/fphys.2022.1037597 doi (DE-627)DOAJ084270438 (DE-599)DOAJ6ae85dac2026490296b52890bce0f9ab DE-627 ger DE-627 rakwb eng QP1-981 Manju Kandel verfasserin aut Placental galectin-3 is reduced in early-onset preeclampsia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells. placenta preeclampsia galectin-3 galectin-3 binding protein plasma Physiology Manju Kandel verfasserin aut Stephen Tong verfasserin aut Stephen Tong verfasserin aut Susan P Walker verfasserin aut Susan P Walker verfasserin aut Ping Cannon verfasserin aut Ping Cannon verfasserin aut Tuong-Vi Nguyen verfasserin aut Tuong-Vi Nguyen verfasserin aut Teresa M. MacDonald verfasserin aut Teresa M. MacDonald verfasserin aut Natalie J. Hannan verfasserin aut Natalie J. Hannan verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Lucy A Bartho verfasserin aut Lucy A Bartho verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 13(2022) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:13 year:2022 https://doi.org/10.3389/fphys.2022.1037597 kostenfrei https://doaj.org/article/6ae85dac2026490296b52890bce0f9ab kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2022.1037597/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fphys.2022.1037597 doi (DE-627)DOAJ084270438 (DE-599)DOAJ6ae85dac2026490296b52890bce0f9ab DE-627 ger DE-627 rakwb eng QP1-981 Manju Kandel verfasserin aut Placental galectin-3 is reduced in early-onset preeclampsia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells. placenta preeclampsia galectin-3 galectin-3 binding protein plasma Physiology Manju Kandel verfasserin aut Stephen Tong verfasserin aut Stephen Tong verfasserin aut Susan P Walker verfasserin aut Susan P Walker verfasserin aut Ping Cannon verfasserin aut Ping Cannon verfasserin aut Tuong-Vi Nguyen verfasserin aut Tuong-Vi Nguyen verfasserin aut Teresa M. MacDonald verfasserin aut Teresa M. MacDonald verfasserin aut Natalie J. Hannan verfasserin aut Natalie J. Hannan verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Tu’uhevaha J. Kaitu’u-Lino verfasserin aut Lucy A Bartho verfasserin aut Lucy A Bartho verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 13(2022) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:13 year:2022 https://doi.org/10.3389/fphys.2022.1037597 kostenfrei https://doaj.org/article/6ae85dac2026490296b52890bce0f9ab kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2022.1037597/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
language	English
source	In Frontiers in Physiology 13(2022) volume:13 year:2022
sourceStr	In Frontiers in Physiology 13(2022) volume:13 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	placenta preeclampsia galectin-3 galectin-3 binding protein plasma Physiology
isfreeaccess_bool	true
container_title	Frontiers in Physiology
authorswithroles_txt_mv	Manju Kandel @@aut@@ Stephen Tong @@aut@@ Susan P Walker @@aut@@ Ping Cannon @@aut@@ Tuong-Vi Nguyen @@aut@@ Teresa M. MacDonald @@aut@@ Natalie J. Hannan @@aut@@ Tu’uhevaha J. Kaitu’u-Lino @@aut@@ Lucy A Bartho @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	631498788
id	DOAJ084270438
language_de	englisch
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callnumber-first	Q - Science
author	Manju Kandel
spellingShingle	Manju Kandel misc QP1-981 misc placenta misc preeclampsia misc galectin-3 misc galectin-3 binding protein misc plasma misc Physiology Placental galectin-3 is reduced in early-onset preeclampsia
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topic_title	QP1-981 Placental galectin-3 is reduced in early-onset preeclampsia placenta preeclampsia galectin-3 galectin-3 binding protein plasma
topic	misc QP1-981 misc placenta misc preeclampsia misc galectin-3 misc galectin-3 binding protein misc plasma misc Physiology
topic_unstemmed	misc QP1-981 misc placenta misc preeclampsia misc galectin-3 misc galectin-3 binding protein misc plasma misc Physiology
topic_browse	misc QP1-981 misc placenta misc preeclampsia misc galectin-3 misc galectin-3 binding protein misc plasma misc Physiology
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title	Placental galectin-3 is reduced in early-onset preeclampsia
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title_full	Placental galectin-3 is reduced in early-onset preeclampsia
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author_browse	Manju Kandel Stephen Tong Susan P Walker Ping Cannon Tuong-Vi Nguyen Teresa M. MacDonald Natalie J. Hannan Tu’uhevaha J. Kaitu’u-Lino Lucy A Bartho
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title_sort	placental galectin-3 is reduced in early-onset preeclampsia
callnumber	QP1-981
title_auth	Placental galectin-3 is reduced in early-onset preeclampsia
abstract	Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells.
abstractGer	Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells.
abstract_unstemmed	Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells (hTSCs). Galectin-3 was measured in placental lysates and plasma collected from patients with early-onset preeclampsia (delivered <34 weeks’ gestation) and gestation matched controls. Placental galectin-3 protein was significantly reduced in 43 women with early-onset preeclampsia compared to 21 controls. mRNA expression of LGALS3 (galectin-3 encoding gene) was reduced in 29 women with early-onset preeclampsia, compared to 18 controls (p = 0.009). There was no significant difference in plasma galectin-3 protein in 46 women with early-onset preeclampsia compared to 20 controls. In a separate cohort of samples collected at 36 weeks’ gestation, circulating galectin-3 was not altered in 23 women who later developed preeclampsia, versus 182 who did not. In syncytialised hTSCs, hypoxia increased mRNA expression of LGALS3 (p = 0.01). Treatment with inflammatory cytokines (TNF-α and IL-6) had no effect on LGALS3 mRNA expression. However, TNF-α treatment caused an increase in mRNA expression of LGALS3BP (galectin-3 binding protein encoding gene) in hTSCs (p = 0.03). This study showed a reduction of galectin-3 in placenta from pregnancies complicated by early-onset preeclampsia. LGALS3 mRNA expression was dysregulated by hypoxia exposure in placental stem cells.
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title_short	Placental galectin-3 is reduced in early-onset preeclampsia
url	https://doi.org/10.3389/fphys.2022.1037597 https://doaj.org/article/6ae85dac2026490296b52890bce0f9ab https://www.frontiersin.org/articles/10.3389/fphys.2022.1037597/full https://doaj.org/toc/1664-042X
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up_date	2024-07-03T22:07:31.599Z
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Placental galectin-3 is reduced in early-onset preeclampsia

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