T Cell/B Cell Interactions in the Establishment of Protective Immunity

Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review, we will discuss how the generation of Tfh cells...
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Gespeichert in:

Autor*in:	Julia Ritzau-Jost [verfasserIn] Andreas Hutloff [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	follicular helper T cells peripheral helper T cells germinal center reaction vaccination inflamed tissues cytokines

Übergeordnetes Werk:	In: Vaccines - MDPI AG, 2013, 9(2021), 10, p 1074
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:10, p 1074

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/vaccines9101074

Katalog-ID:	DOAJ084307390

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spelling	10.3390/vaccines9101074 doi (DE-627)DOAJ084307390 (DE-599)DOAJ78df6cd50279436a88deec12c02859af DE-627 ger DE-627 rakwb eng Julia Ritzau-Jost verfasserin aut T Cell/B Cell Interactions in the Establishment of Protective Immunity 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review, we will discuss how the generation of Tfh cells and their interaction with B cells in secondary lymphoid organs can be optimized for therapeutic purposes. We will summarize different T cell subsets including Tfh-like peripheral helper T cells (Tph) capable of providing B cell help. In particular, we will highlight the novel concept of T cell/B cell interaction in non-lymphoid tissues as an important element for the generation of protective antibodies directly at the site of pathogen invasion. follicular helper T cells peripheral helper T cells germinal center reaction vaccination inflamed tissues cytokines Medicine R Andreas Hutloff verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 10, p 1074 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:10, p 1074 https://doi.org/10.3390/vaccines9101074 kostenfrei https://doaj.org/article/78df6cd50279436a88deec12c02859af kostenfrei https://www.mdpi.com/2076-393X/9/10/1074 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 10, p 1074
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language	English
source	In Vaccines 9(2021), 10, p 1074 volume:9 year:2021 number:10, p 1074
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topic_facet	follicular helper T cells peripheral helper T cells germinal center reaction vaccination inflamed tissues cytokines Medicine R
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author	Julia Ritzau-Jost
spellingShingle	Julia Ritzau-Jost misc follicular helper T cells misc peripheral helper T cells misc germinal center reaction misc vaccination misc inflamed tissues misc cytokines misc Medicine misc R T Cell/B Cell Interactions in the Establishment of Protective Immunity
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topic_title	T Cell/B Cell Interactions in the Establishment of Protective Immunity follicular helper T cells peripheral helper T cells germinal center reaction vaccination inflamed tissues cytokines
topic	misc follicular helper T cells misc peripheral helper T cells misc germinal center reaction misc vaccination misc inflamed tissues misc cytokines misc Medicine misc R
topic_unstemmed	misc follicular helper T cells misc peripheral helper T cells misc germinal center reaction misc vaccination misc inflamed tissues misc cytokines misc Medicine misc R
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title	T Cell/B Cell Interactions in the Establishment of Protective Immunity
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title_full	T Cell/B Cell Interactions in the Establishment of Protective Immunity
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title_sort	cell/b cell interactions in the establishment of protective immunity
title_auth	T Cell/B Cell Interactions in the Establishment of Protective Immunity
abstract	Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review, we will discuss how the generation of Tfh cells and their interaction with B cells in secondary lymphoid organs can be optimized for therapeutic purposes. We will summarize different T cell subsets including Tfh-like peripheral helper T cells (Tph) capable of providing B cell help. In particular, we will highlight the novel concept of T cell/B cell interaction in non-lymphoid tissues as an important element for the generation of protective antibodies directly at the site of pathogen invasion.
abstractGer	Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review, we will discuss how the generation of Tfh cells and their interaction with B cells in secondary lymphoid organs can be optimized for therapeutic purposes. We will summarize different T cell subsets including Tfh-like peripheral helper T cells (Tph) capable of providing B cell help. In particular, we will highlight the novel concept of T cell/B cell interaction in non-lymphoid tissues as an important element for the generation of protective antibodies directly at the site of pathogen invasion.
abstract_unstemmed	Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review, we will discuss how the generation of Tfh cells and their interaction with B cells in secondary lymphoid organs can be optimized for therapeutic purposes. We will summarize different T cell subsets including Tfh-like peripheral helper T cells (Tph) capable of providing B cell help. In particular, we will highlight the novel concept of T cell/B cell interaction in non-lymphoid tissues as an important element for the generation of protective antibodies directly at the site of pathogen invasion.
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title_short	T Cell/B Cell Interactions in the Establishment of Protective Immunity
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up_date	2024-07-03T22:19:42.122Z
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