Obesity in mothers and metabolic disorders in both mothers and children: possible influences
Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
S. A. Smetanina [verfasserIn] L. A. Suplotova [verfasserIn] E. B. Khramova [verfasserIn] Y. V. Girsh [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Бюллетень сибирской медицины - Siberian State Medical University (Tomsk), 2016, 17(2018), 2, Seite 93-99 |
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| Übergeordnetes Werk: |
volume:17 ; year:2018 ; number:2 ; pages:93-99 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.20538/1682-0363-2018-2-93-99 |
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| Katalog-ID: |
DOAJ084317388 |
|---|
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| 520 | |a Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. | ||
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10.20538/1682-0363-2018-2-93-99 doi (DE-627)DOAJ084317388 (DE-599)DOAJd13e790d77e04b41a756c48024019e02 DE-627 ger DE-627 rakwb eng rus S. A. Smetanina verfasserin aut Obesity in mothers and metabolic disorders in both mothers and children: possible influences 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. ожирение метаболический синдром предгестационный индекс массы тела макросомия микросомия Medicine R L. A. Suplotova verfasserin aut E. B. Khramova verfasserin aut Y. V. Girsh verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 17(2018), 2, Seite 93-99 (DE-627)1760628204 18193684 nnns volume:17 year:2018 number:2 pages:93-99 https://doi.org/10.20538/1682-0363-2018-2-93-99 kostenfrei https://doaj.org/article/d13e790d77e04b41a756c48024019e02 kostenfrei https://bulletin.ssmu.ru/jour/article/view/1207 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 17 2018 2 93-99 |
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10.20538/1682-0363-2018-2-93-99 doi (DE-627)DOAJ084317388 (DE-599)DOAJd13e790d77e04b41a756c48024019e02 DE-627 ger DE-627 rakwb eng rus S. A. Smetanina verfasserin aut Obesity in mothers and metabolic disorders in both mothers and children: possible influences 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. ожирение метаболический синдром предгестационный индекс массы тела макросомия микросомия Medicine R L. A. Suplotova verfasserin aut E. B. Khramova verfasserin aut Y. V. Girsh verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 17(2018), 2, Seite 93-99 (DE-627)1760628204 18193684 nnns volume:17 year:2018 number:2 pages:93-99 https://doi.org/10.20538/1682-0363-2018-2-93-99 kostenfrei https://doaj.org/article/d13e790d77e04b41a756c48024019e02 kostenfrei https://bulletin.ssmu.ru/jour/article/view/1207 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 17 2018 2 93-99 |
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10.20538/1682-0363-2018-2-93-99 doi (DE-627)DOAJ084317388 (DE-599)DOAJd13e790d77e04b41a756c48024019e02 DE-627 ger DE-627 rakwb eng rus S. A. Smetanina verfasserin aut Obesity in mothers and metabolic disorders in both mothers and children: possible influences 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. ожирение метаболический синдром предгестационный индекс массы тела макросомия микросомия Medicine R L. A. Suplotova verfasserin aut E. B. Khramova verfasserin aut Y. V. Girsh verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 17(2018), 2, Seite 93-99 (DE-627)1760628204 18193684 nnns volume:17 year:2018 number:2 pages:93-99 https://doi.org/10.20538/1682-0363-2018-2-93-99 kostenfrei https://doaj.org/article/d13e790d77e04b41a756c48024019e02 kostenfrei https://bulletin.ssmu.ru/jour/article/view/1207 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 17 2018 2 93-99 |
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10.20538/1682-0363-2018-2-93-99 doi (DE-627)DOAJ084317388 (DE-599)DOAJd13e790d77e04b41a756c48024019e02 DE-627 ger DE-627 rakwb eng rus S. A. Smetanina verfasserin aut Obesity in mothers and metabolic disorders in both mothers and children: possible influences 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. ожирение метаболический синдром предгестационный индекс массы тела макросомия микросомия Medicine R L. A. Suplotova verfasserin aut E. B. Khramova verfasserin aut Y. V. Girsh verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 17(2018), 2, Seite 93-99 (DE-627)1760628204 18193684 nnns volume:17 year:2018 number:2 pages:93-99 https://doi.org/10.20538/1682-0363-2018-2-93-99 kostenfrei https://doaj.org/article/d13e790d77e04b41a756c48024019e02 kostenfrei https://bulletin.ssmu.ru/jour/article/view/1207 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 17 2018 2 93-99 |
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10.20538/1682-0363-2018-2-93-99 doi (DE-627)DOAJ084317388 (DE-599)DOAJd13e790d77e04b41a756c48024019e02 DE-627 ger DE-627 rakwb eng rus S. A. Smetanina verfasserin aut Obesity in mothers and metabolic disorders in both mothers and children: possible influences 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. ожирение метаболический синдром предгестационный индекс массы тела макросомия микросомия Medicine R L. A. Suplotova verfasserin aut E. B. Khramova verfasserin aut Y. V. Girsh verfasserin aut In Бюллетень сибирской медицины Siberian State Medical University (Tomsk), 2016 17(2018), 2, Seite 93-99 (DE-627)1760628204 18193684 nnns volume:17 year:2018 number:2 pages:93-99 https://doi.org/10.20538/1682-0363-2018-2-93-99 kostenfrei https://doaj.org/article/d13e790d77e04b41a756c48024019e02 kostenfrei https://bulletin.ssmu.ru/jour/article/view/1207 kostenfrei https://doaj.org/toc/1682-0363 Journal toc kostenfrei https://doaj.org/toc/1819-3684 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 17 2018 2 93-99 |
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A. Smetanina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Obesity in mothers and metabolic disorders in both mothers and children: possible influences</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p &lt; 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p &lt; 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. 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Obesity in mothers and metabolic disorders in both mothers and children: possible influences ожирение метаболический синдром предгестационный индекс массы тела макросомия микросомия |
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Obesity in mothers and metabolic disorders in both mothers and children: possible influences |
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Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. |
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Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. |
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Aim. To study the relationship between obesity of the mother, the body weight of the newborn and the formation of metabolic disturbances in subsequent periods of life.Materials and methods. A prospective study was conducted in which 1,000 women of reproductive age and their newborns were included by the random number method. The mean age is 29.5 [25.0; 33.5] years. The examination included the collection of anamnesis, measurement of body height and body weight, blood pressure, waist circumference and body mass index determination. Micro- and macrosomia in term infants was diagnosed with a birth weight less than 15 and more than 97 percentiles (WHO, 2005). The laboratory study included the determination of glucose, cholesterol, triglycerides, high and low density lipoproteins, insulin and C-peptides of basal and stimulated levels, leptin, adiponectin, determination of insulin resistance indices (HOMA-IR) and pancreatic β-cell function (HOMA-β). The statistical analysis of the material was carried out using the Statistica 10 software package, SPSS 13.0. Statistically significant differences were taken into account at a level of p < 0.05.Results. It was found that when pregnancy occurs, 41.0% of women are overweight or obese. In the study, the pathological mass of the body in the neonatal period was detected in every fourth newborn (24.8%), including microsomia (11.3%) and macrosomia (13.5%). As a result, differences in the body weight of newborns were found, depending on the maternal pregestational BMI. For example, women with obesity of the first degree were more likely to have children with macrosomia in 33.3% of cases than women with normal body weight, whose incidence of children with macrosomia was detected in 12.0% of cases (OR 6.8; 95% CI 2.66–17.56; p < 0.001). In women in the reproductive period, macrosomia at birth was more characteristic for people with a metabolic syndrome, and was associated with hormone-metabolic changes.Conclusion. Тhe results demonstrate the effect of pre-gestational body weight in women with obesity on the body weight of offspring at birth. Both macrosomia and microsomia at birth can be risk factors for the development of the metabolic syndrome in the long term, which confirms the importance of preventing overweight and obesity in women of childbearing age in the pre-gestational period. |
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