Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease

The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classi...
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Gespeichert in:

Autor*in:	D. Rincón-Riaño [verfasserIn] D.G. Fernández-Ávila [verfasserIn] D. Acero-Molina [verfasserIn] J.M. Bello Gualtero [verfasserIn] C. Romero-Sánchez [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Italienisch

Erschienen:	2022

Schlagwörter:	UCTD ANA anti-nuclear antibodies anti-DFS70 antibodies.

Übergeordnetes Werk:	In: Reumatismo - PAGEPress Publications, 2012, 74(2022), 2
Übergeordnetes Werk:	volume:74 ; year:2022 ; number:2

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4081/reumatismo.2022.1420

Katalog-ID:	DOAJ084401613

Internformat


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allfields	10.4081/reumatismo.2022.1420 doi (DE-627)DOAJ084401613 (DE-599)DOAJ13e75585964147c4ba732fa2463352c8 DE-627 ger DE-627 rakwb eng ita RC31-1245 D. Rincón-Riaño verfasserin aut Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease. UCTD ANA anti-nuclear antibodies anti-DFS70 antibodies. Medicine R Internal medicine D.G. Fernández-Ávila verfasserin aut D. Acero-Molina verfasserin aut J.M. Bello Gualtero verfasserin aut C. Romero-Sánchez verfasserin aut In Reumatismo PAGEPress Publications, 2012 74(2022), 2 (DE-627)355986361 (DE-600)2091202-X 22402683 nnns volume:74 year:2022 number:2 https://doi.org/10.4081/reumatismo.2022.1420 kostenfrei https://doaj.org/article/13e75585964147c4ba732fa2463352c8 kostenfrei https://www.reumatismo.org/index.php/reuma/article/view/1420 kostenfrei https://doaj.org/toc/0048-7449 Journal toc kostenfrei https://doaj.org/toc/2240-2683 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 74 2022 2
spelling	10.4081/reumatismo.2022.1420 doi (DE-627)DOAJ084401613 (DE-599)DOAJ13e75585964147c4ba732fa2463352c8 DE-627 ger DE-627 rakwb eng ita RC31-1245 D. Rincón-Riaño verfasserin aut Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease. UCTD ANA anti-nuclear antibodies anti-DFS70 antibodies. Medicine R Internal medicine D.G. Fernández-Ávila verfasserin aut D. Acero-Molina verfasserin aut J.M. Bello Gualtero verfasserin aut C. Romero-Sánchez verfasserin aut In Reumatismo PAGEPress Publications, 2012 74(2022), 2 (DE-627)355986361 (DE-600)2091202-X 22402683 nnns volume:74 year:2022 number:2 https://doi.org/10.4081/reumatismo.2022.1420 kostenfrei https://doaj.org/article/13e75585964147c4ba732fa2463352c8 kostenfrei https://www.reumatismo.org/index.php/reuma/article/view/1420 kostenfrei https://doaj.org/toc/0048-7449 Journal toc kostenfrei https://doaj.org/toc/2240-2683 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 74 2022 2
allfields_unstemmed	10.4081/reumatismo.2022.1420 doi (DE-627)DOAJ084401613 (DE-599)DOAJ13e75585964147c4ba732fa2463352c8 DE-627 ger DE-627 rakwb eng ita RC31-1245 D. Rincón-Riaño verfasserin aut Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease. UCTD ANA anti-nuclear antibodies anti-DFS70 antibodies. Medicine R Internal medicine D.G. Fernández-Ávila verfasserin aut D. Acero-Molina verfasserin aut J.M. Bello Gualtero verfasserin aut C. Romero-Sánchez verfasserin aut In Reumatismo PAGEPress Publications, 2012 74(2022), 2 (DE-627)355986361 (DE-600)2091202-X 22402683 nnns volume:74 year:2022 number:2 https://doi.org/10.4081/reumatismo.2022.1420 kostenfrei https://doaj.org/article/13e75585964147c4ba732fa2463352c8 kostenfrei https://www.reumatismo.org/index.php/reuma/article/view/1420 kostenfrei https://doaj.org/toc/0048-7449 Journal toc kostenfrei https://doaj.org/toc/2240-2683 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 74 2022 2
allfieldsGer	10.4081/reumatismo.2022.1420 doi (DE-627)DOAJ084401613 (DE-599)DOAJ13e75585964147c4ba732fa2463352c8 DE-627 ger DE-627 rakwb eng ita RC31-1245 D. Rincón-Riaño verfasserin aut Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease. UCTD ANA anti-nuclear antibodies anti-DFS70 antibodies. Medicine R Internal medicine D.G. Fernández-Ávila verfasserin aut D. Acero-Molina verfasserin aut J.M. Bello Gualtero verfasserin aut C. Romero-Sánchez verfasserin aut In Reumatismo PAGEPress Publications, 2012 74(2022), 2 (DE-627)355986361 (DE-600)2091202-X 22402683 nnns volume:74 year:2022 number:2 https://doi.org/10.4081/reumatismo.2022.1420 kostenfrei https://doaj.org/article/13e75585964147c4ba732fa2463352c8 kostenfrei https://www.reumatismo.org/index.php/reuma/article/view/1420 kostenfrei https://doaj.org/toc/0048-7449 Journal toc kostenfrei https://doaj.org/toc/2240-2683 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 74 2022 2
allfieldsSound	10.4081/reumatismo.2022.1420 doi (DE-627)DOAJ084401613 (DE-599)DOAJ13e75585964147c4ba732fa2463352c8 DE-627 ger DE-627 rakwb eng ita RC31-1245 D. Rincón-Riaño verfasserin aut Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease. UCTD ANA anti-nuclear antibodies anti-DFS70 antibodies. Medicine R Internal medicine D.G. Fernández-Ávila verfasserin aut D. Acero-Molina verfasserin aut J.M. Bello Gualtero verfasserin aut C. Romero-Sánchez verfasserin aut In Reumatismo PAGEPress Publications, 2012 74(2022), 2 (DE-627)355986361 (DE-600)2091202-X 22402683 nnns volume:74 year:2022 number:2 https://doi.org/10.4081/reumatismo.2022.1420 kostenfrei https://doaj.org/article/13e75585964147c4ba732fa2463352c8 kostenfrei https://www.reumatismo.org/index.php/reuma/article/view/1420 kostenfrei https://doaj.org/toc/0048-7449 Journal toc kostenfrei https://doaj.org/toc/2240-2683 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 74 2022 2
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spellingShingle	D. Rincón-Riaño misc RC31-1245 misc UCTD misc ANA misc anti-nuclear antibodies misc anti-DFS70 antibodies. misc Medicine misc R misc Internal medicine Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease
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topic_title	RC31-1245 Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease UCTD ANA anti-nuclear antibodies anti-DFS70 antibodies
topic	misc RC31-1245 misc UCTD misc ANA misc anti-nuclear antibodies misc anti-DFS70 antibodies. misc Medicine misc R misc Internal medicine
topic_unstemmed	misc RC31-1245 misc UCTD misc ANA misc anti-nuclear antibodies misc anti-DFS70 antibodies. misc Medicine misc R misc Internal medicine
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title	Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease
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title_full	Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease
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title_sort	frequency of ana/dfs70 autoantibodies in colombian patients with undifferentiated connective tissue disease
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title_auth	Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease
abstract	The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease.
abstractGer	The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease.
abstract_unstemmed	The objective was to describe the clinical characteristics and the frequency of the ANA/DFS70 autoantibodies in patients affected by undifferentiated connective tissue disease (UCTD) in a tertiary hospital in Colombia. This descriptive cross-sectional study enrolled patients who fulfilled the classification criteria for UCTD. ANAHEp- 2 test and the modified assay for ANA/DFS70 autoantibodies were performed through the indirect immunofluorescence technique. Erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, and the antibodies to anti-extractable nuclear antigens, DNA, phospholipids (IgG, IgM, IgA), and cyclic citrullinated peptide were also evaluated. Fifty-three patients were studied; 42/53 (79%) tested positive for ANA and 5/42 (11.9%) for ANA/DFS70 antibodies with a dense fine speckled fluorescent pattern (AC-2) in ANA HEp-2 test that was confirmed by a modified HEp-2-DFS70 assay. Patients had arthralgia (87%, n=47), non-erosive arthritis (66%, n=34), xerostomia (64%, n=34), xerophthalmia (42%, n=22), and Raynaud’s phenomenon (17%, n=9). Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. More studies are required to support the predictive role of this antibody to the absence of progression to a well-defined connective tissue disease.
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title_short	Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease
url	https://doi.org/10.4081/reumatismo.2022.1420 https://doaj.org/article/13e75585964147c4ba732fa2463352c8 https://www.reumatismo.org/index.php/reuma/article/view/1420 https://doaj.org/toc/0048-7449 https://doaj.org/toc/2240-2683
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author2	D.G. Fernández-Ávila D. Acero-Molina J.M. Bello Gualtero C. Romero-Sánchez
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Arthralgia, xerophthalmia, xeroderma, and absence of disease evolution to a specific disease over five years were more frequent in patients with a positive result for the anti-DFS70 antibodies. The ANA/DFS70 autoantibodies were more frequent in patients with UCTD compared to other rheumatic diseases for which they were initially evaluated. 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Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease

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