Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer
Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yu-Xin Yang [verfasserIn] Chun-Ying Li [verfasserIn] Wen-Jie Yin [verfasserIn] Xia Chen [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: Journal of Oncology - Hindawi Limited, 2008, (2022) |
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| Übergeordnetes Werk: |
year:2022 |
| Links: |
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| DOI / URN: |
10.1155/2022/8762647 |
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| Katalog-ID: |
DOAJ084409304 |
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| 245 | 1 | 0 | |a Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer |
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| 520 | |a Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. | ||
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10.1155/2022/8762647 doi (DE-627)DOAJ084409304 (DE-599)DOAJ155974e9269d47559ba27ad26e848bb7 DE-627 ger DE-627 rakwb eng RC254-282 Yu-Xin Yang verfasserin aut Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chun-Ying Li verfasserin aut Wen-Jie Yin verfasserin aut Xia Chen verfasserin aut In Journal of Oncology Hindawi Limited, 2008 (2022) (DE-627)584401353 (DE-600)2461349-6 16878469 nnns year:2022 https://doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/article/155974e9269d47559ba27ad26e848bb7 kostenfrei http://dx.doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/toc/1687-8469 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 |
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10.1155/2022/8762647 doi (DE-627)DOAJ084409304 (DE-599)DOAJ155974e9269d47559ba27ad26e848bb7 DE-627 ger DE-627 rakwb eng RC254-282 Yu-Xin Yang verfasserin aut Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chun-Ying Li verfasserin aut Wen-Jie Yin verfasserin aut Xia Chen verfasserin aut In Journal of Oncology Hindawi Limited, 2008 (2022) (DE-627)584401353 (DE-600)2461349-6 16878469 nnns year:2022 https://doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/article/155974e9269d47559ba27ad26e848bb7 kostenfrei http://dx.doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/toc/1687-8469 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 |
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10.1155/2022/8762647 doi (DE-627)DOAJ084409304 (DE-599)DOAJ155974e9269d47559ba27ad26e848bb7 DE-627 ger DE-627 rakwb eng RC254-282 Yu-Xin Yang verfasserin aut Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chun-Ying Li verfasserin aut Wen-Jie Yin verfasserin aut Xia Chen verfasserin aut In Journal of Oncology Hindawi Limited, 2008 (2022) (DE-627)584401353 (DE-600)2461349-6 16878469 nnns year:2022 https://doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/article/155974e9269d47559ba27ad26e848bb7 kostenfrei http://dx.doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/toc/1687-8469 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 |
| allfieldsGer |
10.1155/2022/8762647 doi (DE-627)DOAJ084409304 (DE-599)DOAJ155974e9269d47559ba27ad26e848bb7 DE-627 ger DE-627 rakwb eng RC254-282 Yu-Xin Yang verfasserin aut Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chun-Ying Li verfasserin aut Wen-Jie Yin verfasserin aut Xia Chen verfasserin aut In Journal of Oncology Hindawi Limited, 2008 (2022) (DE-627)584401353 (DE-600)2461349-6 16878469 nnns year:2022 https://doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/article/155974e9269d47559ba27ad26e848bb7 kostenfrei http://dx.doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/toc/1687-8469 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 |
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10.1155/2022/8762647 doi (DE-627)DOAJ084409304 (DE-599)DOAJ155974e9269d47559ba27ad26e848bb7 DE-627 ger DE-627 rakwb eng RC254-282 Yu-Xin Yang verfasserin aut Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chun-Ying Li verfasserin aut Wen-Jie Yin verfasserin aut Xia Chen verfasserin aut In Journal of Oncology Hindawi Limited, 2008 (2022) (DE-627)584401353 (DE-600)2461349-6 16878469 nnns year:2022 https://doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/article/155974e9269d47559ba27ad26e848bb7 kostenfrei http://dx.doi.org/10.1155/2022/8762647 kostenfrei https://doaj.org/toc/1687-8469 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2022 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Yu-Xin Yang @@aut@@ Chun-Ying Li @@aut@@ Wen-Jie Yin @@aut@@ Xia Chen @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ084409304</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502203730.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1155/2022/8762647</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ084409304</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ155974e9269d47559ba27ad26e848bb7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Yu-Xin Yang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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R - Medicine |
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Yu-Xin Yang |
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Yu-Xin Yang misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer |
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RC254-282 Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer |
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misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer |
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Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer |
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Yu-Xin Yang |
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efficacy of trastuzumab + cisplatin combined with irinotecan on the quality of life of patients with advanced her-2 positive gastric cancer |
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RC254-282 |
| title_auth |
Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer |
| abstract |
Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. |
| abstractGer |
Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. |
| abstract_unstemmed |
Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects. |
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Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer |
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https://doi.org/10.1155/2022/8762647 https://doaj.org/article/155974e9269d47559ba27ad26e848bb7 http://dx.doi.org/10.1155/2022/8762647 https://doaj.org/toc/1687-8469 |
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Chun-Ying Li Wen-Jie Yin Xia Chen |
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Chun-Ying Li Wen-Jie Yin Xia Chen |
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584401353 |
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RC - Internal Medicine |
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10.1155/2022/8762647 |
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RC254-282 |
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2024-07-03T22:51:01.438Z |
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To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (P<0.05). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (P<0.05), and the reduction in the joint group after treatment was more evident as compared with the control group (P<0.05). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (P<0.05), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (P<0.05). The occurrence of side effects was not statistically different between the two groups of patients (P<0.05). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (P<0.05), the difference in PFS between the groups was significant (t = 9.013, P<0.001), and the difference in OS between the groups was not significant (t = 1.236, P=0.219). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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