The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4

Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder without a recognized cause. Aquaporins (AQPs) are transmembrane channels that carry water through cell membranes and are critical for cerebrospinal fluid circulation and cerebral water balance. The function of AQPs in develop...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zitong Zhao [verfasserIn] Jian He [verfasserIn] Yibing Chen [verfasserIn] Yuchang Wang [verfasserIn] Chuansen Wang [verfasserIn] Changwu Tan [verfasserIn] Junbo Liao [verfasserIn] Gelei Xiao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	iNPH AQP1 AQP4 hydrocephalus pathogenesis

Übergeordnetes Werk:	In: Frontiers in Molecular Neuroscience - Frontiers Media S.A., 2008, 15(2022)
Übergeordnetes Werk:	volume:15 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnmol.2022.952036

Katalog-ID:	DOAJ084415835

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author	Zitong Zhao
spellingShingle	Zitong Zhao misc RC321-571 misc iNPH misc AQP1 misc AQP4 misc hydrocephalus misc pathogenesis misc Neurosciences. Biological psychiatry. Neuropsychiatry The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
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topic_title	RC321-571 The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4 iNPH AQP1 AQP4 hydrocephalus pathogenesis
topic	misc RC321-571 misc iNPH misc AQP1 misc AQP4 misc hydrocephalus misc pathogenesis misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc iNPH misc AQP1 misc AQP4 misc hydrocephalus misc pathogenesis misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc iNPH misc AQP1 misc AQP4 misc hydrocephalus misc pathogenesis misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
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title_full	The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
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title_sort	pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of aqp1 and aqp4
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title_auth	The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
abstract	Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder without a recognized cause. Aquaporins (AQPs) are transmembrane channels that carry water through cell membranes and are critical for cerebrospinal fluid circulation and cerebral water balance. The function of AQPs in developing and maintaining hydrocephalus should be studied in greater detail as a possible diagnostic and therapeutic tool. Recent research indicates that patients with iNPH exhibited high levels of aquaporin 1 and low levels of aquaporin 4 expression, suggesting that these AQPs are essential in iNPH pathogenesis. To determine the source of iNPH and diagnose and treat it, it is necessary to examine and appreciate their function in the genesis and maintenance of hydrocephalus. The expression, function, and regulation of AQPs in iNPH are reviewed in this article, in order to provide fresh targets and suggestions for future research.
abstractGer	Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder without a recognized cause. Aquaporins (AQPs) are transmembrane channels that carry water through cell membranes and are critical for cerebrospinal fluid circulation and cerebral water balance. The function of AQPs in developing and maintaining hydrocephalus should be studied in greater detail as a possible diagnostic and therapeutic tool. Recent research indicates that patients with iNPH exhibited high levels of aquaporin 1 and low levels of aquaporin 4 expression, suggesting that these AQPs are essential in iNPH pathogenesis. To determine the source of iNPH and diagnose and treat it, it is necessary to examine and appreciate their function in the genesis and maintenance of hydrocephalus. The expression, function, and regulation of AQPs in iNPH are reviewed in this article, in order to provide fresh targets and suggestions for future research.
abstract_unstemmed	Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder without a recognized cause. Aquaporins (AQPs) are transmembrane channels that carry water through cell membranes and are critical for cerebrospinal fluid circulation and cerebral water balance. The function of AQPs in developing and maintaining hydrocephalus should be studied in greater detail as a possible diagnostic and therapeutic tool. Recent research indicates that patients with iNPH exhibited high levels of aquaporin 1 and low levels of aquaporin 4 expression, suggesting that these AQPs are essential in iNPH pathogenesis. To determine the source of iNPH and diagnose and treat it, it is necessary to examine and appreciate their function in the genesis and maintenance of hydrocephalus. The expression, function, and regulation of AQPs in iNPH are reviewed in this article, in order to provide fresh targets and suggestions for future research.
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title_short	The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4
url	https://doi.org/10.3389/fnmol.2022.952036 https://doaj.org/article/a8826dc72f254ae9b1994e37b6ab678b https://www.frontiersin.org/articles/10.3389/fnmol.2022.952036/full https://doaj.org/toc/1662-5099
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up_date	2024-07-03T22:53:17.827Z
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Aquaporins (AQPs) are transmembrane channels that carry water through cell membranes and are critical for cerebrospinal fluid circulation and cerebral water balance. The function of AQPs in developing and maintaining hydrocephalus should be studied in greater detail as a possible diagnostic and therapeutic tool. Recent research indicates that patients with iNPH exhibited high levels of aquaporin 1 and low levels of aquaporin 4 expression, suggesting that these AQPs are essential in iNPH pathogenesis. To determine the source of iNPH and diagnose and treat it, it is necessary to examine and appreciate their function in the genesis and maintenance of hydrocephalus. 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The pathogenesis of idiopathic normal pressure hydrocephalus based on the understanding of AQP1 and AQP4

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