Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies

Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silic...
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Autor*in:	Md Moniruzzaman [verfasserIn] Mst Maskera Jinnah [verfasserIn] Shirmin Islam [verfasserIn] Jui Biswas [verfasserIn] Al-Imran [verfasserIn] Md Joy Pramanik [verfasserIn] Md Salah Uddin [verfasserIn] Md Abu Saleh [verfasserIn] Shahriar Zaman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking

Übergeordnetes Werk:	In: Informatics in Medicine Unlocked - Elsevier, 2017, 33(2022), Seite 101089-
Übergeordnetes Werk:	volume:33 ; year:2022 ; pages:101089-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.imu.2022.101089

Katalog-ID:	DOAJ084444657

Internformat


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allfields	10.1016/j.imu.2022.101089 doi (DE-627)DOAJ084444657 (DE-599)DOAJ04544744a8cc4142a377d9a9cf1309cd DE-627 ger DE-627 rakwb eng R858-859.7 Md Moniruzzaman verfasserin aut Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs. Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking Computer applications to medicine. Medical informatics Mst Maskera Jinnah verfasserin aut Shirmin Islam verfasserin aut Jui Biswas verfasserin aut Al-Imran verfasserin aut Md Joy Pramanik verfasserin aut Md Salah Uddin verfasserin aut Md Abu Saleh verfasserin aut Shahriar Zaman verfasserin aut In Informatics in Medicine Unlocked Elsevier, 2017 33(2022), Seite 101089- (DE-627)857725165 (DE-600)2854226-5 23529148 nnns volume:33 year:2022 pages:101089- https://doi.org/10.1016/j.imu.2022.101089 kostenfrei https://doaj.org/article/04544744a8cc4142a377d9a9cf1309cd kostenfrei http://www.sciencedirect.com/science/article/pii/S2352914822002258 kostenfrei https://doaj.org/toc/2352-9148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 101089-
spelling	10.1016/j.imu.2022.101089 doi (DE-627)DOAJ084444657 (DE-599)DOAJ04544744a8cc4142a377d9a9cf1309cd DE-627 ger DE-627 rakwb eng R858-859.7 Md Moniruzzaman verfasserin aut Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs. Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking Computer applications to medicine. Medical informatics Mst Maskera Jinnah verfasserin aut Shirmin Islam verfasserin aut Jui Biswas verfasserin aut Al-Imran verfasserin aut Md Joy Pramanik verfasserin aut Md Salah Uddin verfasserin aut Md Abu Saleh verfasserin aut Shahriar Zaman verfasserin aut In Informatics in Medicine Unlocked Elsevier, 2017 33(2022), Seite 101089- (DE-627)857725165 (DE-600)2854226-5 23529148 nnns volume:33 year:2022 pages:101089- https://doi.org/10.1016/j.imu.2022.101089 kostenfrei https://doaj.org/article/04544744a8cc4142a377d9a9cf1309cd kostenfrei http://www.sciencedirect.com/science/article/pii/S2352914822002258 kostenfrei https://doaj.org/toc/2352-9148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 101089-
allfields_unstemmed	10.1016/j.imu.2022.101089 doi (DE-627)DOAJ084444657 (DE-599)DOAJ04544744a8cc4142a377d9a9cf1309cd DE-627 ger DE-627 rakwb eng R858-859.7 Md Moniruzzaman verfasserin aut Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs. Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking Computer applications to medicine. Medical informatics Mst Maskera Jinnah verfasserin aut Shirmin Islam verfasserin aut Jui Biswas verfasserin aut Al-Imran verfasserin aut Md Joy Pramanik verfasserin aut Md Salah Uddin verfasserin aut Md Abu Saleh verfasserin aut Shahriar Zaman verfasserin aut In Informatics in Medicine Unlocked Elsevier, 2017 33(2022), Seite 101089- (DE-627)857725165 (DE-600)2854226-5 23529148 nnns volume:33 year:2022 pages:101089- https://doi.org/10.1016/j.imu.2022.101089 kostenfrei https://doaj.org/article/04544744a8cc4142a377d9a9cf1309cd kostenfrei http://www.sciencedirect.com/science/article/pii/S2352914822002258 kostenfrei https://doaj.org/toc/2352-9148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 101089-
allfieldsGer	10.1016/j.imu.2022.101089 doi (DE-627)DOAJ084444657 (DE-599)DOAJ04544744a8cc4142a377d9a9cf1309cd DE-627 ger DE-627 rakwb eng R858-859.7 Md Moniruzzaman verfasserin aut Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs. Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking Computer applications to medicine. Medical informatics Mst Maskera Jinnah verfasserin aut Shirmin Islam verfasserin aut Jui Biswas verfasserin aut Al-Imran verfasserin aut Md Joy Pramanik verfasserin aut Md Salah Uddin verfasserin aut Md Abu Saleh verfasserin aut Shahriar Zaman verfasserin aut In Informatics in Medicine Unlocked Elsevier, 2017 33(2022), Seite 101089- (DE-627)857725165 (DE-600)2854226-5 23529148 nnns volume:33 year:2022 pages:101089- https://doi.org/10.1016/j.imu.2022.101089 kostenfrei https://doaj.org/article/04544744a8cc4142a377d9a9cf1309cd kostenfrei http://www.sciencedirect.com/science/article/pii/S2352914822002258 kostenfrei https://doaj.org/toc/2352-9148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 101089-
allfieldsSound	10.1016/j.imu.2022.101089 doi (DE-627)DOAJ084444657 (DE-599)DOAJ04544744a8cc4142a377d9a9cf1309cd DE-627 ger DE-627 rakwb eng R858-859.7 Md Moniruzzaman verfasserin aut Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs. Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking Computer applications to medicine. Medical informatics Mst Maskera Jinnah verfasserin aut Shirmin Islam verfasserin aut Jui Biswas verfasserin aut Al-Imran verfasserin aut Md Joy Pramanik verfasserin aut Md Salah Uddin verfasserin aut Md Abu Saleh verfasserin aut Shahriar Zaman verfasserin aut In Informatics in Medicine Unlocked Elsevier, 2017 33(2022), Seite 101089- (DE-627)857725165 (DE-600)2854226-5 23529148 nnns volume:33 year:2022 pages:101089- https://doi.org/10.1016/j.imu.2022.101089 kostenfrei https://doaj.org/article/04544744a8cc4142a377d9a9cf1309cd kostenfrei http://www.sciencedirect.com/science/article/pii/S2352914822002258 kostenfrei https://doaj.org/toc/2352-9148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 33 2022 101089-
language	English
source	In Informatics in Medicine Unlocked 33(2022), Seite 101089- volume:33 year:2022 pages:101089-
sourceStr	In Informatics in Medicine Unlocked 33(2022), Seite 101089- volume:33 year:2022 pages:101089-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking Computer applications to medicine. Medical informatics
isfreeaccess_bool	true
container_title	Informatics in Medicine Unlocked
authorswithroles_txt_mv	Md Moniruzzaman @@aut@@ Mst Maskera Jinnah @@aut@@ Shirmin Islam @@aut@@ Jui Biswas @@aut@@ Al-Imran @@aut@@ Md Joy Pramanik @@aut@@ Md Salah Uddin @@aut@@ Md Abu Saleh @@aut@@ Shahriar Zaman @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	857725165
id	DOAJ084444657
language_de	englisch
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author	Md Moniruzzaman
spellingShingle	Md Moniruzzaman misc R858-859.7 misc Cucurbita maxima misc Momordica charantia, antimicrobial activity misc Antioxidant activity misc Biofilm inhibition misc Molecular docking misc Computer applications to medicine. Medical informatics Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies
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topic_title	R858-859.7 Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies Cucurbita maxima Momordica charantia, antimicrobial activity Antioxidant activity Biofilm inhibition Molecular docking
topic	misc R858-859.7 misc Cucurbita maxima misc Momordica charantia, antimicrobial activity misc Antioxidant activity misc Biofilm inhibition misc Molecular docking misc Computer applications to medicine. Medical informatics
topic_unstemmed	misc R858-859.7 misc Cucurbita maxima misc Momordica charantia, antimicrobial activity misc Antioxidant activity misc Biofilm inhibition misc Molecular docking misc Computer applications to medicine. Medical informatics
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title	Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies
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title_full	Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies
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title_sort	biological activity of cucurbita maxima and momordica charantia seed extracts against the biofilm-associated protein of staphylococcus aureus: an in vitro and in silico studies
callnumber	R858-859.7
title_auth	Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies
abstract	Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs.
abstractGer	Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs.
abstract_unstemmed	Nowadays, it is necessary to find new and effective antimicrobial drugs because of rising drug-resistance microbes. Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. Thus, two selected plants’ seed extracts could be utilized to combat antibiotic-resistant bacteria as a natural source of drugs.
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title_short	Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies
url	https://doi.org/10.1016/j.imu.2022.101089 https://doaj.org/article/04544744a8cc4142a377d9a9cf1309cd http://www.sciencedirect.com/science/article/pii/S2352914822002258 https://doaj.org/toc/2352-9148
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up_date	2024-07-03T23:02:57.996Z
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Through in vitro analysis, two selected plants' seed (Cucurbita maxima, and Momordica charantia) extracts were evaluated to determine their antibacterial activity, and an in silico screening was used to identify potential compounds of the two selected plants' seed extracts that could be used in developing new drugs against Staphylococcus aureus. Despite an inhibitory zone being seen against all bacteria in the antibacterial activity test, the highest inhibition zone of the seed extracts from the selected plants was identified against Staphylococcus aureus at the dose of 200 μg/disc. Particular plant seed extracts also demonstrated significant antioxidant content and low risk of negative impacts. The two selected plant seed extracts exhibited remarkable biofilm inhibition ability. The binding interaction was investigated using molecular docking to identify bioactive components against Staphylococcal BAP protein (7C7U) that are responsible for biofilm formation. The binding energies of the D1 (CID- 620905), D2 (CID- 66760004), and D3 (CID- 5379220) compound from Cucurbita maxima had binding energy of −8.6 kcal/mol, −7.5 kcal/mol, and −7.1 kcal/mol, respectively. The D1 (CID- 123409), D2 (CID- 5280435), and D3 (CID- 541568) compound from Momordica charantia had an energy of −6.1 kcal/mol, −6.0 kcal/mol, and −5.9 kcal/mol, respectively. 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Biological activity of Cucurbita maxima and Momordica charantia seed extracts against the biofilm-associated protein of Staphylococcus aureus: An in vitro and in silico studies

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