Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos.

Bipolar disorder (BD) is a chronic mental disorder that affects 1-3% of the population, and is characterized by affective episodes that alternate with periods of euthymia. Although traditionally patients were thought to return to premorbid functioning levels during the inter-episode periods, recent evidence suggests that cognitive deficits persist even during periods of euthymia, and may impair patients working and functioning status.The present study aimed to characterize the neurocognitive and psychosocial functioning in a sample of Portuguese bipolar type I patients.Sixty-five BD type I patients were compared to 50 healthy controls with an extensive neuropsychological battery to assess to assess attention and mental control, speed of processing, executive functions, and verbal memory. Mood symptoms were assessed with the Hamilton Depression Rating Scale and with the Young Mania Rating Scale, and psychosocial functioning was assessed with the Global Assessment of Functioning (GAF).BD patients performed overall significantly worse on neurocognitive tests as compared to healthy controls, but especially on verbal memory and executive functions, even after controlling for educational level and mood symptomatology, showing moderate to large effect sizes on these domains. BD patients scored significantly lower on the GAF as compared to healthy controls, and psychosocial functioning was significantly correlated with performance on all neurocognitive tests. Although there were less BD patients active and working, and more patients inactive and/or retired, working status did not correlate significantly with neurocognitive performance.The results of our study support the hypothesis that BD type I patients present global cognitive deficits even whilst in euthymia, especially in the domains of verbal memory and executive functions. These cognitive deficits correlate with the functional difficulties that many patients present in the course of the disease, but their impact on working status is still not clear. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Vasco Videira Dias [verfasserIn] Sofia Brissos [verfasserIn] Anabel Martinez-Arán [verfasserIn] Flávio Kapczinski [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Portugiesisch

Erschienen:	2009

Übergeordnetes Werk:	In: Acta Médica Portuguesa - Ordem dos Médicos, 2008, 21(2009), 6
Übergeordnetes Werk:	volume:21 ; year:2009 ; number:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.20344/amp.826

Katalog-ID:	DOAJ084459026

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spelling	10.20344/amp.826 doi (DE-627)DOAJ084459026 (DE-599)DOAJ90c91594c27140fd833556afd4a8b018 DE-627 ger DE-627 rakwb eng por R5-920 Vasco Videira Dias verfasserin aut Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a chronic mental disorder that affects 1-3% of the population, and is characterized by affective episodes that alternate with periods of euthymia. Although traditionally patients were thought to return to premorbid functioning levels during the inter-episode periods, recent evidence suggests that cognitive deficits persist even during periods of euthymia, and may impair patients working and functioning status.The present study aimed to characterize the neurocognitive and psychosocial functioning in a sample of Portuguese bipolar type I patients.Sixty-five BD type I patients were compared to 50 healthy controls with an extensive neuropsychological battery to assess to assess attention and mental control, speed of processing, executive functions, and verbal memory. Mood symptoms were assessed with the Hamilton Depression Rating Scale and with the Young Mania Rating Scale, and psychosocial functioning was assessed with the Global Assessment of Functioning (GAF).BD patients performed overall significantly worse on neurocognitive tests as compared to healthy controls, but especially on verbal memory and executive functions, even after controlling for educational level and mood symptomatology, showing moderate to large effect sizes on these domains. BD patients scored significantly lower on the GAF as compared to healthy controls, and psychosocial functioning was significantly correlated with performance on all neurocognitive tests. Although there were less BD patients active and working, and more patients inactive and/or retired, working status did not correlate significantly with neurocognitive performance.The results of our study support the hypothesis that BD type I patients present global cognitive deficits even whilst in euthymia, especially in the domains of verbal memory and executive functions. These cognitive deficits correlate with the functional difficulties that many patients present in the course of the disease, but their impact on working status is still not clear. Medicine R Medicine (General) Sofia Brissos verfasserin aut Anabel Martinez-Arán verfasserin aut Flávio Kapczinski verfasserin aut In Acta Médica Portuguesa Ordem dos Médicos, 2008 21(2009), 6 (DE-627)37812935X (DE-600)2133563-1 16460758 nnns volume:21 year:2009 number:6 https://doi.org/10.20344/amp.826 kostenfrei https://doaj.org/article/90c91594c27140fd833556afd4a8b018 kostenfrei https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/826 kostenfrei https://doaj.org/toc/0870-399X Journal toc kostenfrei https://doaj.org/toc/1646-0758 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2009 6
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allfieldsGer	10.20344/amp.826 doi (DE-627)DOAJ084459026 (DE-599)DOAJ90c91594c27140fd833556afd4a8b018 DE-627 ger DE-627 rakwb eng por R5-920 Vasco Videira Dias verfasserin aut Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a chronic mental disorder that affects 1-3% of the population, and is characterized by affective episodes that alternate with periods of euthymia. Although traditionally patients were thought to return to premorbid functioning levels during the inter-episode periods, recent evidence suggests that cognitive deficits persist even during periods of euthymia, and may impair patients working and functioning status.The present study aimed to characterize the neurocognitive and psychosocial functioning in a sample of Portuguese bipolar type I patients.Sixty-five BD type I patients were compared to 50 healthy controls with an extensive neuropsychological battery to assess to assess attention and mental control, speed of processing, executive functions, and verbal memory. Mood symptoms were assessed with the Hamilton Depression Rating Scale and with the Young Mania Rating Scale, and psychosocial functioning was assessed with the Global Assessment of Functioning (GAF).BD patients performed overall significantly worse on neurocognitive tests as compared to healthy controls, but especially on verbal memory and executive functions, even after controlling for educational level and mood symptomatology, showing moderate to large effect sizes on these domains. BD patients scored significantly lower on the GAF as compared to healthy controls, and psychosocial functioning was significantly correlated with performance on all neurocognitive tests. Although there were less BD patients active and working, and more patients inactive and/or retired, working status did not correlate significantly with neurocognitive performance.The results of our study support the hypothesis that BD type I patients present global cognitive deficits even whilst in euthymia, especially in the domains of verbal memory and executive functions. These cognitive deficits correlate with the functional difficulties that many patients present in the course of the disease, but their impact on working status is still not clear. Medicine R Medicine (General) Sofia Brissos verfasserin aut Anabel Martinez-Arán verfasserin aut Flávio Kapczinski verfasserin aut In Acta Médica Portuguesa Ordem dos Médicos, 2008 21(2009), 6 (DE-627)37812935X (DE-600)2133563-1 16460758 nnns volume:21 year:2009 number:6 https://doi.org/10.20344/amp.826 kostenfrei https://doaj.org/article/90c91594c27140fd833556afd4a8b018 kostenfrei https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/826 kostenfrei https://doaj.org/toc/0870-399X Journal toc kostenfrei https://doaj.org/toc/1646-0758 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2009 6
allfieldsSound	10.20344/amp.826 doi (DE-627)DOAJ084459026 (DE-599)DOAJ90c91594c27140fd833556afd4a8b018 DE-627 ger DE-627 rakwb eng por R5-920 Vasco Videira Dias verfasserin aut Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bipolar disorder (BD) is a chronic mental disorder that affects 1-3% of the population, and is characterized by affective episodes that alternate with periods of euthymia. Although traditionally patients were thought to return to premorbid functioning levels during the inter-episode periods, recent evidence suggests that cognitive deficits persist even during periods of euthymia, and may impair patients working and functioning status.The present study aimed to characterize the neurocognitive and psychosocial functioning in a sample of Portuguese bipolar type I patients.Sixty-five BD type I patients were compared to 50 healthy controls with an extensive neuropsychological battery to assess to assess attention and mental control, speed of processing, executive functions, and verbal memory. Mood symptoms were assessed with the Hamilton Depression Rating Scale and with the Young Mania Rating Scale, and psychosocial functioning was assessed with the Global Assessment of Functioning (GAF).BD patients performed overall significantly worse on neurocognitive tests as compared to healthy controls, but especially on verbal memory and executive functions, even after controlling for educational level and mood symptomatology, showing moderate to large effect sizes on these domains. BD patients scored significantly lower on the GAF as compared to healthy controls, and psychosocial functioning was significantly correlated with performance on all neurocognitive tests. Although there were less BD patients active and working, and more patients inactive and/or retired, working status did not correlate significantly with neurocognitive performance.The results of our study support the hypothesis that BD type I patients present global cognitive deficits even whilst in euthymia, especially in the domains of verbal memory and executive functions. These cognitive deficits correlate with the functional difficulties that many patients present in the course of the disease, but their impact on working status is still not clear. Medicine R Medicine (General) Sofia Brissos verfasserin aut Anabel Martinez-Arán verfasserin aut Flávio Kapczinski verfasserin aut In Acta Médica Portuguesa Ordem dos Médicos, 2008 21(2009), 6 (DE-627)37812935X (DE-600)2133563-1 16460758 nnns volume:21 year:2009 number:6 https://doi.org/10.20344/amp.826 kostenfrei https://doaj.org/article/90c91594c27140fd833556afd4a8b018 kostenfrei https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/826 kostenfrei https://doaj.org/toc/0870-399X Journal toc kostenfrei https://doaj.org/toc/1646-0758 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2009 6
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title	Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos.
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title_auth	Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos.
abstract	Bipolar disorder (BD) is a chronic mental disorder that affects 1-3% of the population, and is characterized by affective episodes that alternate with periods of euthymia. Although traditionally patients were thought to return to premorbid functioning levels during the inter-episode periods, recent evidence suggests that cognitive deficits persist even during periods of euthymia, and may impair patients working and functioning status.The present study aimed to characterize the neurocognitive and psychosocial functioning in a sample of Portuguese bipolar type I patients.Sixty-five BD type I patients were compared to 50 healthy controls with an extensive neuropsychological battery to assess to assess attention and mental control, speed of processing, executive functions, and verbal memory. Mood symptoms were assessed with the Hamilton Depression Rating Scale and with the Young Mania Rating Scale, and psychosocial functioning was assessed with the Global Assessment of Functioning (GAF).BD patients performed overall significantly worse on neurocognitive tests as compared to healthy controls, but especially on verbal memory and executive functions, even after controlling for educational level and mood symptomatology, showing moderate to large effect sizes on these domains. BD patients scored significantly lower on the GAF as compared to healthy controls, and psychosocial functioning was significantly correlated with performance on all neurocognitive tests. Although there were less BD patients active and working, and more patients inactive and/or retired, working status did not correlate significantly with neurocognitive performance.The results of our study support the hypothesis that BD type I patients present global cognitive deficits even whilst in euthymia, especially in the domains of verbal memory and executive functions. These cognitive deficits correlate with the functional difficulties that many patients present in the course of the disease, but their impact on working status is still not clear.
abstractGer	Bipolar disorder (BD) is a chronic mental disorder that affects 1-3% of the population, and is characterized by affective episodes that alternate with periods of euthymia. Although traditionally patients were thought to return to premorbid functioning levels during the inter-episode periods, recent evidence suggests that cognitive deficits persist even during periods of euthymia, and may impair patients working and functioning status.The present study aimed to characterize the neurocognitive and psychosocial functioning in a sample of Portuguese bipolar type I patients.Sixty-five BD type I patients were compared to 50 healthy controls with an extensive neuropsychological battery to assess to assess attention and mental control, speed of processing, executive functions, and verbal memory. Mood symptoms were assessed with the Hamilton Depression Rating Scale and with the Young Mania Rating Scale, and psychosocial functioning was assessed with the Global Assessment of Functioning (GAF).BD patients performed overall significantly worse on neurocognitive tests as compared to healthy controls, but especially on verbal memory and executive functions, even after controlling for educational level and mood symptomatology, showing moderate to large effect sizes on these domains. BD patients scored significantly lower on the GAF as compared to healthy controls, and psychosocial functioning was significantly correlated with performance on all neurocognitive tests. Although there were less BD patients active and working, and more patients inactive and/or retired, working status did not correlate significantly with neurocognitive performance.The results of our study support the hypothesis that BD type I patients present global cognitive deficits even whilst in euthymia, especially in the domains of verbal memory and executive functions. These cognitive deficits correlate with the functional difficulties that many patients present in the course of the disease, but their impact on working status is still not clear.
abstract_unstemmed	Bipolar disorder (BD) is a chronic mental disorder that affects 1-3% of the population, and is characterized by affective episodes that alternate with periods of euthymia. Although traditionally patients were thought to return to premorbid functioning levels during the inter-episode periods, recent evidence suggests that cognitive deficits persist even during periods of euthymia, and may impair patients working and functioning status.The present study aimed to characterize the neurocognitive and psychosocial functioning in a sample of Portuguese bipolar type I patients.Sixty-five BD type I patients were compared to 50 healthy controls with an extensive neuropsychological battery to assess to assess attention and mental control, speed of processing, executive functions, and verbal memory. Mood symptoms were assessed with the Hamilton Depression Rating Scale and with the Young Mania Rating Scale, and psychosocial functioning was assessed with the Global Assessment of Functioning (GAF).BD patients performed overall significantly worse on neurocognitive tests as compared to healthy controls, but especially on verbal memory and executive functions, even after controlling for educational level and mood symptomatology, showing moderate to large effect sizes on these domains. BD patients scored significantly lower on the GAF as compared to healthy controls, and psychosocial functioning was significantly correlated with performance on all neurocognitive tests. Although there were less BD patients active and working, and more patients inactive and/or retired, working status did not correlate significantly with neurocognitive performance.The results of our study support the hypothesis that BD type I patients present global cognitive deficits even whilst in euthymia, especially in the domains of verbal memory and executive functions. These cognitive deficits correlate with the functional difficulties that many patients present in the course of the disease, but their impact on working status is still not clear.
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title_short	Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos.
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Funcionamento neurocognitivo em doentes bipolares tipo I eutímicos.

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