MDN brain descending neurons coordinately activate backward and inhibit forward locomotion

Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define ‘command-like neuron’ as a neuron whose activation elicits or ‘commands’ a specific behavior). In most animals, it remains unknown how neural circuit...
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Autor*in:	Arnaldo Carreira-Rosario [verfasserIn] Aref Arzan Zarin [verfasserIn] Matthew Q Clark [verfasserIn] Laurina Manning [verfasserIn] Richard D Fetter [verfasserIn] Albert Cardona [verfasserIn] Chris Q Doe [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	neural circuit locomotor command neuron behavior backward crawl descending neuron

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 7(2018)
Übergeordnetes Werk:	volume:7 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.38554

Katalog-ID:	DOAJ084523077

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spelling	10.7554/eLife.38554 doi (DE-627)DOAJ084523077 (DE-599)DOAJf037d67d170a4ad28f2bc0f0943f2e3b DE-627 ger DE-627 rakwb eng QH301-705.5 Arnaldo Carreira-Rosario verfasserin aut MDN brain descending neurons coordinately activate backward and inhibit forward locomotion 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define ‘command-like neuron’ as a neuron whose activation elicits or ‘commands’ a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval ‘mooncrawler descending neurons’ (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals. neural circuit locomotor command neuron behavior backward crawl descending neuron Medicine R Science Q Biology (General) Aref Arzan Zarin verfasserin aut Matthew Q Clark verfasserin aut Laurina Manning verfasserin aut Richard D Fetter verfasserin aut Albert Cardona verfasserin aut Chris Q Doe verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 7(2018) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:7 year:2018 https://doi.org/10.7554/eLife.38554 kostenfrei https://doaj.org/article/f037d67d170a4ad28f2bc0f0943f2e3b kostenfrei https://elifesciences.org/articles/38554 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018
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allfieldsGer	10.7554/eLife.38554 doi (DE-627)DOAJ084523077 (DE-599)DOAJf037d67d170a4ad28f2bc0f0943f2e3b DE-627 ger DE-627 rakwb eng QH301-705.5 Arnaldo Carreira-Rosario verfasserin aut MDN brain descending neurons coordinately activate backward and inhibit forward locomotion 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define ‘command-like neuron’ as a neuron whose activation elicits or ‘commands’ a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval ‘mooncrawler descending neurons’ (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals. neural circuit locomotor command neuron behavior backward crawl descending neuron Medicine R Science Q Biology (General) Aref Arzan Zarin verfasserin aut Matthew Q Clark verfasserin aut Laurina Manning verfasserin aut Richard D Fetter verfasserin aut Albert Cardona verfasserin aut Chris Q Doe verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 7(2018) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:7 year:2018 https://doi.org/10.7554/eLife.38554 kostenfrei https://doaj.org/article/f037d67d170a4ad28f2bc0f0943f2e3b kostenfrei https://elifesciences.org/articles/38554 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018
allfieldsSound	10.7554/eLife.38554 doi (DE-627)DOAJ084523077 (DE-599)DOAJf037d67d170a4ad28f2bc0f0943f2e3b DE-627 ger DE-627 rakwb eng QH301-705.5 Arnaldo Carreira-Rosario verfasserin aut MDN brain descending neurons coordinately activate backward and inhibit forward locomotion 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define ‘command-like neuron’ as a neuron whose activation elicits or ‘commands’ a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval ‘mooncrawler descending neurons’ (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals. neural circuit locomotor command neuron behavior backward crawl descending neuron Medicine R Science Q Biology (General) Aref Arzan Zarin verfasserin aut Matthew Q Clark verfasserin aut Laurina Manning verfasserin aut Richard D Fetter verfasserin aut Albert Cardona verfasserin aut Chris Q Doe verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 7(2018) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:7 year:2018 https://doi.org/10.7554/eLife.38554 kostenfrei https://doaj.org/article/f037d67d170a4ad28f2bc0f0943f2e3b kostenfrei https://elifesciences.org/articles/38554 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018
language	English
source	In eLife 7(2018) volume:7 year:2018
sourceStr	In eLife 7(2018) volume:7 year:2018
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topic_facet	neural circuit locomotor command neuron behavior backward crawl descending neuron Medicine R Science Q Biology (General)
isfreeaccess_bool	true
container_title	eLife
authorswithroles_txt_mv	Arnaldo Carreira-Rosario @@aut@@ Aref Arzan Zarin @@aut@@ Matthew Q Clark @@aut@@ Laurina Manning @@aut@@ Richard D Fetter @@aut@@ Albert Cardona @@aut@@ Chris Q Doe @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
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callnumber-first	Q - Science
author	Arnaldo Carreira-Rosario
spellingShingle	Arnaldo Carreira-Rosario misc QH301-705.5 misc neural circuit misc locomotor misc command neuron misc behavior misc backward crawl misc descending neuron misc Medicine misc R misc Science misc Q misc Biology (General) MDN brain descending neurons coordinately activate backward and inhibit forward locomotion
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topic_title	QH301-705.5 MDN brain descending neurons coordinately activate backward and inhibit forward locomotion neural circuit locomotor command neuron behavior backward crawl descending neuron
topic	misc QH301-705.5 misc neural circuit misc locomotor misc command neuron misc behavior misc backward crawl misc descending neuron misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc neural circuit misc locomotor misc command neuron misc behavior misc backward crawl misc descending neuron misc Medicine misc R misc Science misc Q misc Biology (General)
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title	MDN brain descending neurons coordinately activate backward and inhibit forward locomotion
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title_full	MDN brain descending neurons coordinately activate backward and inhibit forward locomotion
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author_browse	Arnaldo Carreira-Rosario Aref Arzan Zarin Matthew Q Clark Laurina Manning Richard D Fetter Albert Cardona Chris Q Doe
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title_sort	mdn brain descending neurons coordinately activate backward and inhibit forward locomotion
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title_auth	MDN brain descending neurons coordinately activate backward and inhibit forward locomotion
abstract	Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define ‘command-like neuron’ as a neuron whose activation elicits or ‘commands’ a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval ‘mooncrawler descending neurons’ (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals.
abstractGer	Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define ‘command-like neuron’ as a neuron whose activation elicits or ‘commands’ a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval ‘mooncrawler descending neurons’ (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals.
abstract_unstemmed	Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define ‘command-like neuron’ as a neuron whose activation elicits or ‘commands’ a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval ‘mooncrawler descending neurons’ (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals.
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title_short	MDN brain descending neurons coordinately activate backward and inhibit forward locomotion
url	https://doi.org/10.7554/eLife.38554 https://doaj.org/article/f037d67d170a4ad28f2bc0f0943f2e3b https://elifesciences.org/articles/38554 https://doaj.org/toc/2050-084X
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MDN brain descending neurons coordinately activate backward and inhibit forward locomotion

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