Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity

Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were...
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Autor*in:	Julius Nückel [verfasserIn] Elisa Planatscher [verfasserIn] Anne Wiebe Mohr [verfasserIn] Karolin Deichl [verfasserIn] Hrvoje Mijočević [verfasserIn] Martin Feuerherd [verfasserIn] Lisa Wolff [verfasserIn] Johanna Erber [verfasserIn] Jochen Schneider [verfasserIn] Michael Quante [verfasserIn] Christoph Winter [verfasserIn] Jürgen Ruland [verfasserIn] Alexander Hapfelmeier [verfasserIn] Wolfgang Hammerschmidt [verfasserIn] Andreas Moosmann [verfasserIn] Ulrike Protzer [verfasserIn] Uta Behrends [verfasserIn] Josef Mautner [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.889836

Katalog-ID:	DOAJ084585641

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allfields	10.3389/fimmu.2022.889836 doi (DE-627)DOAJ084585641 (DE-599)DOAJfe87ee6f674d43778acc467d3a27c4c1 DE-627 ger DE-627 rakwb eng RC581-607 Julius Nückel verfasserin aut Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals. SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein Immunologic diseases. Allergy Julius Nückel verfasserin aut Elisa Planatscher verfasserin aut Anne Wiebe Mohr verfasserin aut Anne Wiebe Mohr verfasserin aut Karolin Deichl verfasserin aut Hrvoje Mijočević verfasserin aut Martin Feuerherd verfasserin aut Lisa Wolff verfasserin aut Johanna Erber verfasserin aut Jochen Schneider verfasserin aut Michael Quante verfasserin aut Christoph Winter verfasserin aut Christoph Winter verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Alexander Hapfelmeier verfasserin aut Wolfgang Hammerschmidt verfasserin aut Andreas Moosmann verfasserin aut Andreas Moosmann verfasserin aut Ulrike Protzer verfasserin aut Ulrike Protzer verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.889836 kostenfrei https://doaj.org/article/fe87ee6f674d43778acc467d3a27c4c1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.889836/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fimmu.2022.889836 doi (DE-627)DOAJ084585641 (DE-599)DOAJfe87ee6f674d43778acc467d3a27c4c1 DE-627 ger DE-627 rakwb eng RC581-607 Julius Nückel verfasserin aut Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals. SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein Immunologic diseases. Allergy Julius Nückel verfasserin aut Elisa Planatscher verfasserin aut Anne Wiebe Mohr verfasserin aut Anne Wiebe Mohr verfasserin aut Karolin Deichl verfasserin aut Hrvoje Mijočević verfasserin aut Martin Feuerherd verfasserin aut Lisa Wolff verfasserin aut Johanna Erber verfasserin aut Jochen Schneider verfasserin aut Michael Quante verfasserin aut Christoph Winter verfasserin aut Christoph Winter verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Alexander Hapfelmeier verfasserin aut Wolfgang Hammerschmidt verfasserin aut Andreas Moosmann verfasserin aut Andreas Moosmann verfasserin aut Ulrike Protzer verfasserin aut Ulrike Protzer verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.889836 kostenfrei https://doaj.org/article/fe87ee6f674d43778acc467d3a27c4c1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.889836/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfields_unstemmed	10.3389/fimmu.2022.889836 doi (DE-627)DOAJ084585641 (DE-599)DOAJfe87ee6f674d43778acc467d3a27c4c1 DE-627 ger DE-627 rakwb eng RC581-607 Julius Nückel verfasserin aut Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals. SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein Immunologic diseases. Allergy Julius Nückel verfasserin aut Elisa Planatscher verfasserin aut Anne Wiebe Mohr verfasserin aut Anne Wiebe Mohr verfasserin aut Karolin Deichl verfasserin aut Hrvoje Mijočević verfasserin aut Martin Feuerherd verfasserin aut Lisa Wolff verfasserin aut Johanna Erber verfasserin aut Jochen Schneider verfasserin aut Michael Quante verfasserin aut Christoph Winter verfasserin aut Christoph Winter verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Alexander Hapfelmeier verfasserin aut Wolfgang Hammerschmidt verfasserin aut Andreas Moosmann verfasserin aut Andreas Moosmann verfasserin aut Ulrike Protzer verfasserin aut Ulrike Protzer verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.889836 kostenfrei https://doaj.org/article/fe87ee6f674d43778acc467d3a27c4c1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.889836/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsGer	10.3389/fimmu.2022.889836 doi (DE-627)DOAJ084585641 (DE-599)DOAJfe87ee6f674d43778acc467d3a27c4c1 DE-627 ger DE-627 rakwb eng RC581-607 Julius Nückel verfasserin aut Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals. SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein Immunologic diseases. Allergy Julius Nückel verfasserin aut Elisa Planatscher verfasserin aut Anne Wiebe Mohr verfasserin aut Anne Wiebe Mohr verfasserin aut Karolin Deichl verfasserin aut Hrvoje Mijočević verfasserin aut Martin Feuerherd verfasserin aut Lisa Wolff verfasserin aut Johanna Erber verfasserin aut Jochen Schneider verfasserin aut Michael Quante verfasserin aut Christoph Winter verfasserin aut Christoph Winter verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Alexander Hapfelmeier verfasserin aut Wolfgang Hammerschmidt verfasserin aut Andreas Moosmann verfasserin aut Andreas Moosmann verfasserin aut Ulrike Protzer verfasserin aut Ulrike Protzer verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.889836 kostenfrei https://doaj.org/article/fe87ee6f674d43778acc467d3a27c4c1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.889836/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fimmu.2022.889836 doi (DE-627)DOAJ084585641 (DE-599)DOAJfe87ee6f674d43778acc467d3a27c4c1 DE-627 ger DE-627 rakwb eng RC581-607 Julius Nückel verfasserin aut Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals. SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein Immunologic diseases. Allergy Julius Nückel verfasserin aut Elisa Planatscher verfasserin aut Anne Wiebe Mohr verfasserin aut Anne Wiebe Mohr verfasserin aut Karolin Deichl verfasserin aut Hrvoje Mijočević verfasserin aut Martin Feuerherd verfasserin aut Lisa Wolff verfasserin aut Johanna Erber verfasserin aut Jochen Schneider verfasserin aut Michael Quante verfasserin aut Christoph Winter verfasserin aut Christoph Winter verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Jürgen Ruland verfasserin aut Alexander Hapfelmeier verfasserin aut Wolfgang Hammerschmidt verfasserin aut Andreas Moosmann verfasserin aut Andreas Moosmann verfasserin aut Ulrike Protzer verfasserin aut Ulrike Protzer verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Uta Behrends verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut Josef Mautner verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.889836 kostenfrei https://doaj.org/article/fe87ee6f674d43778acc467d3a27c4c1 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.889836/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
language	English
source	In Frontiers in Immunology 13(2022) volume:13 year:2022
sourceStr	In Frontiers in Immunology 13(2022) volume:13 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Frontiers in Immunology
authorswithroles_txt_mv	Julius Nückel @@aut@@ Elisa Planatscher @@aut@@ Anne Wiebe Mohr @@aut@@ Karolin Deichl @@aut@@ Hrvoje Mijočević @@aut@@ Martin Feuerherd @@aut@@ Lisa Wolff @@aut@@ Johanna Erber @@aut@@ Jochen Schneider @@aut@@ Michael Quante @@aut@@ Christoph Winter @@aut@@ Jürgen Ruland @@aut@@ Alexander Hapfelmeier @@aut@@ Wolfgang Hammerschmidt @@aut@@ Andreas Moosmann @@aut@@ Ulrike Protzer @@aut@@ Uta Behrends @@aut@@ Josef Mautner @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	657998354
id	DOAJ084585641
language_de	englisch
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callnumber-first	R - Medicine
author	Julius Nückel
spellingShingle	Julius Nückel misc RC581-607 misc SARS-CoV-2 misc multiplex serology misc COVID-19 misc coronavirus misc nucleocapsid protein misc Immunologic diseases. Allergy Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity
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topic_title	RC581-607 Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity SARS-CoV-2 multiplex serology COVID-19 coronavirus nucleocapsid protein
topic	misc RC581-607 misc SARS-CoV-2 misc multiplex serology misc COVID-19 misc coronavirus misc nucleocapsid protein misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc SARS-CoV-2 misc multiplex serology misc COVID-19 misc coronavirus misc nucleocapsid protein misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc SARS-CoV-2 misc multiplex serology misc COVID-19 misc coronavirus misc nucleocapsid protein misc Immunologic diseases. Allergy
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title	Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity
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title_full	Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity
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author_browse	Julius Nückel Elisa Planatscher Anne Wiebe Mohr Karolin Deichl Hrvoje Mijočević Martin Feuerherd Lisa Wolff Johanna Erber Jochen Schneider Michael Quante Christoph Winter Jürgen Ruland Alexander Hapfelmeier Wolfgang Hammerschmidt Andreas Moosmann Ulrike Protzer Uta Behrends Josef Mautner
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title_sort	association between igg responses against the nucleocapsid proteins of alphacoronaviruses and covid-19 severity
callnumber	RC581-607
title_auth	Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity
abstract	Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.
abstractGer	Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.
abstract_unstemmed	Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.
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title_short	Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity
url	https://doi.org/10.3389/fimmu.2022.889836 https://doaj.org/article/fe87ee6f674d43778acc467d3a27c4c1 https://www.frontiersin.org/articles/10.3389/fimmu.2022.889836/full https://doaj.org/toc/1664-3224
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author2	Julius Nückel Elisa Planatscher Anne Wiebe Mohr Karolin Deichl Hrvoje Mijočević Martin Feuerherd Lisa Wolff Johanna Erber Jochen Schneider Michael Quante Christoph Winter Jürgen Ruland Alexander Hapfelmeier Wolfgang Hammerschmidt Andreas Moosmann Ulrike Protzer Uta Behrends Josef Mautner
author2Str	Julius Nückel Elisa Planatscher Anne Wiebe Mohr Karolin Deichl Hrvoje Mijočević Martin Feuerherd Lisa Wolff Johanna Erber Jochen Schneider Michael Quante Christoph Winter Jürgen Ruland Alexander Hapfelmeier Wolfgang Hammerschmidt Andreas Moosmann Ulrike Protzer Uta Behrends Josef Mautner
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doi_str	10.3389/fimmu.2022.889836
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up_date	2024-07-03T23:42:12.364Z
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