Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro

<i<Sechium edule</i< shows a wide biological diversity. Hybrids and varieties of <i<Sechium edule</i< have been created, producing fruits of different shapes, sizes, colors, tastes, and textures. These hybrids and varieties have been used as food and in traditional medicine....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jorge Cadena-Iñiguez [verfasserIn] Itzen Aguiñiga-Sánchez [verfasserIn] María Teresa Uriostegui-Arias [verfasserIn] Edelmiro Santiago-Osorio [verfasserIn] Lucero del Mar Ruiz-Posadas [verfasserIn] Marcos Soto-Hernández [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	chayote breast cancer methanol extracts hybrids

Übergeordnetes Werk:	In: Separations - MDPI AG, 2016, 9(2022), 9, p 230
Übergeordnetes Werk:	volume:9 ; year:2022 ; number:9, p 230

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/separations9090230

Katalog-ID:	DOAJ084782900

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callnumber-first	Q - Science
author	Jorge Cadena-Iñiguez
spellingShingle	Jorge Cadena-Iñiguez misc QC1-999 misc QD1-999 misc chayote misc <i<Sechium edule</i< misc breast cancer misc methanol extracts misc hybrids misc Physics misc Chemistry Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro
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topic_title	QC1-999 QD1-999 Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro chayote <i<Sechium edule</i< breast cancer methanol extracts hybrids
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title	Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro
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title_full	Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro
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title_sort	antiproliferative effect of <i<sechium edule</i< (jacq.) sw., cv. madre negra extracts on breast cancer in vitro
callnumber	QC1-999
title_auth	Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro
abstract	<i<Sechium edule</i< shows a wide biological diversity. Hybrids and varieties of <i<Sechium edule</i< have been created, producing fruits of different shapes, sizes, colors, tastes, and textures. These hybrids and varieties have been used as food and in traditional medicine. In this research, the antiproliferative activity of the Madre Negra™ genotype of <i<Sechium edule var. amarus silvestrys</i< on the MCF7 breast cancer cell line was assessed. Different extracts in hexane, methanol, and dichloromethane were obtained to perform a bio-guided study. The dichloromethane extract showed the largest significant inhibitory activity (<i<p</i< < 0.05). This extract was separated into 92 fractions, which were reduced to eight fractions by chromogenic identity. Of the eight fractions, two recorded significant antiproliferative activity (<i<p</i< < 0.05) on MCF7, an even higher activity than the total extract. The active metabolites were identified as flavonoids, tannins, and terpenes, of which cucurbitacins I, B, D, and E stood out. The present paper can be considered as preliminary results of our research work.
abstractGer	<i<Sechium edule</i< shows a wide biological diversity. Hybrids and varieties of <i<Sechium edule</i< have been created, producing fruits of different shapes, sizes, colors, tastes, and textures. These hybrids and varieties have been used as food and in traditional medicine. In this research, the antiproliferative activity of the Madre Negra™ genotype of <i<Sechium edule var. amarus silvestrys</i< on the MCF7 breast cancer cell line was assessed. Different extracts in hexane, methanol, and dichloromethane were obtained to perform a bio-guided study. The dichloromethane extract showed the largest significant inhibitory activity (<i<p</i< < 0.05). This extract was separated into 92 fractions, which were reduced to eight fractions by chromogenic identity. Of the eight fractions, two recorded significant antiproliferative activity (<i<p</i< < 0.05) on MCF7, an even higher activity than the total extract. The active metabolites were identified as flavonoids, tannins, and terpenes, of which cucurbitacins I, B, D, and E stood out. The present paper can be considered as preliminary results of our research work.
abstract_unstemmed	<i<Sechium edule</i< shows a wide biological diversity. Hybrids and varieties of <i<Sechium edule</i< have been created, producing fruits of different shapes, sizes, colors, tastes, and textures. These hybrids and varieties have been used as food and in traditional medicine. In this research, the antiproliferative activity of the Madre Negra™ genotype of <i<Sechium edule var. amarus silvestrys</i< on the MCF7 breast cancer cell line was assessed. Different extracts in hexane, methanol, and dichloromethane were obtained to perform a bio-guided study. The dichloromethane extract showed the largest significant inhibitory activity (<i<p</i< < 0.05). This extract was separated into 92 fractions, which were reduced to eight fractions by chromogenic identity. Of the eight fractions, two recorded significant antiproliferative activity (<i<p</i< < 0.05) on MCF7, an even higher activity than the total extract. The active metabolites were identified as flavonoids, tannins, and terpenes, of which cucurbitacins I, B, D, and E stood out. The present paper can be considered as preliminary results of our research work.
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title_short	Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro
url	https://doi.org/10.3390/separations9090230 https://doaj.org/article/73212399255946b0b7e1831635e7b351 https://www.mdpi.com/2297-8739/9/9/230 https://doaj.org/toc/2297-8739
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In this research, the antiproliferative activity of the Madre Negra™ genotype of <i<Sechium edule var. amarus silvestrys</i< on the MCF7 breast cancer cell line was assessed. Different extracts in hexane, methanol, and dichloromethane were obtained to perform a bio-guided study. The dichloromethane extract showed the largest significant inhibitory activity (<i<p</i< < 0.05). This extract was separated into 92 fractions, which were reduced to eight fractions by chromogenic identity. Of the eight fractions, two recorded significant antiproliferative activity (<i<p</i< < 0.05) on MCF7, an even higher activity than the total extract. The active metabolites were identified as flavonoids, tannins, and terpenes, of which cucurbitacins I, B, D, and E stood out. 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Antiproliferative Effect of <i<Sechium edule</i< (Jacq.) Sw., cv. Madre Negra Extracts on Breast Cancer In Vitro

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