Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise
The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative...
Ausführliche Beschreibung
Autor*in: |
Dimitrios Tsikas [verfasserIn] Norbert Maassen [verfasserIn] Antonie Thorns [verfasserIn] Armin Finkel [verfasserIn] Moritz Lützow [verfasserIn] Magdalena Aleksandra Röhrig [verfasserIn] Larissa Sarah Blau [verfasserIn] Laurianne Dimina [verfasserIn] François Mariotti [verfasserIn] Bibiana Beckmann [verfasserIn] Vladimir Shushakov [verfasserIn] Mirja Jantz [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 18, p 10649 |
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Übergeordnetes Werk: |
volume:23 ; year:2022 ; number:18, p 10649 |
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DOI / URN: |
10.3390/ijms231810649 |
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Katalog-ID: |
DOAJ084819243 |
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520 | |a The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). | ||
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10.3390/ijms231810649 doi (DE-627)DOAJ084819243 (DE-599)DOAJ480d797df1f246b7ae7f80d6f68f58fb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Dimitrios Tsikas verfasserin aut Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). amino acids guanidinoacetate homoarginine inorganic nitrate malondialdehyde oxidative stress Biology (General) Chemistry Norbert Maassen verfasserin aut Antonie Thorns verfasserin aut Armin Finkel verfasserin aut Moritz Lützow verfasserin aut Magdalena Aleksandra Röhrig verfasserin aut Larissa Sarah Blau verfasserin aut Laurianne Dimina verfasserin aut François Mariotti verfasserin aut Bibiana Beckmann verfasserin aut Vladimir Shushakov verfasserin aut Mirja Jantz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 18, p 10649 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:18, p 10649 https://doi.org/10.3390/ijms231810649 kostenfrei https://doaj.org/article/480d797df1f246b7ae7f80d6f68f58fb kostenfrei https://www.mdpi.com/1422-0067/23/18/10649 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 18, p 10649 |
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10.3390/ijms231810649 doi (DE-627)DOAJ084819243 (DE-599)DOAJ480d797df1f246b7ae7f80d6f68f58fb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Dimitrios Tsikas verfasserin aut Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). amino acids guanidinoacetate homoarginine inorganic nitrate malondialdehyde oxidative stress Biology (General) Chemistry Norbert Maassen verfasserin aut Antonie Thorns verfasserin aut Armin Finkel verfasserin aut Moritz Lützow verfasserin aut Magdalena Aleksandra Röhrig verfasserin aut Larissa Sarah Blau verfasserin aut Laurianne Dimina verfasserin aut François Mariotti verfasserin aut Bibiana Beckmann verfasserin aut Vladimir Shushakov verfasserin aut Mirja Jantz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 18, p 10649 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:18, p 10649 https://doi.org/10.3390/ijms231810649 kostenfrei https://doaj.org/article/480d797df1f246b7ae7f80d6f68f58fb kostenfrei https://www.mdpi.com/1422-0067/23/18/10649 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 18, p 10649 |
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10.3390/ijms231810649 doi (DE-627)DOAJ084819243 (DE-599)DOAJ480d797df1f246b7ae7f80d6f68f58fb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Dimitrios Tsikas verfasserin aut Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). amino acids guanidinoacetate homoarginine inorganic nitrate malondialdehyde oxidative stress Biology (General) Chemistry Norbert Maassen verfasserin aut Antonie Thorns verfasserin aut Armin Finkel verfasserin aut Moritz Lützow verfasserin aut Magdalena Aleksandra Röhrig verfasserin aut Larissa Sarah Blau verfasserin aut Laurianne Dimina verfasserin aut François Mariotti verfasserin aut Bibiana Beckmann verfasserin aut Vladimir Shushakov verfasserin aut Mirja Jantz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 18, p 10649 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:18, p 10649 https://doi.org/10.3390/ijms231810649 kostenfrei https://doaj.org/article/480d797df1f246b7ae7f80d6f68f58fb kostenfrei https://www.mdpi.com/1422-0067/23/18/10649 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 18, p 10649 |
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10.3390/ijms231810649 doi (DE-627)DOAJ084819243 (DE-599)DOAJ480d797df1f246b7ae7f80d6f68f58fb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Dimitrios Tsikas verfasserin aut Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). amino acids guanidinoacetate homoarginine inorganic nitrate malondialdehyde oxidative stress Biology (General) Chemistry Norbert Maassen verfasserin aut Antonie Thorns verfasserin aut Armin Finkel verfasserin aut Moritz Lützow verfasserin aut Magdalena Aleksandra Röhrig verfasserin aut Larissa Sarah Blau verfasserin aut Laurianne Dimina verfasserin aut François Mariotti verfasserin aut Bibiana Beckmann verfasserin aut Vladimir Shushakov verfasserin aut Mirja Jantz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 18, p 10649 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:18, p 10649 https://doi.org/10.3390/ijms231810649 kostenfrei https://doaj.org/article/480d797df1f246b7ae7f80d6f68f58fb kostenfrei https://www.mdpi.com/1422-0067/23/18/10649 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 18, p 10649 |
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10.3390/ijms231810649 doi (DE-627)DOAJ084819243 (DE-599)DOAJ480d797df1f246b7ae7f80d6f68f58fb DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Dimitrios Tsikas verfasserin aut Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). amino acids guanidinoacetate homoarginine inorganic nitrate malondialdehyde oxidative stress Biology (General) Chemistry Norbert Maassen verfasserin aut Antonie Thorns verfasserin aut Armin Finkel verfasserin aut Moritz Lützow verfasserin aut Magdalena Aleksandra Röhrig verfasserin aut Larissa Sarah Blau verfasserin aut Laurianne Dimina verfasserin aut François Mariotti verfasserin aut Bibiana Beckmann verfasserin aut Vladimir Shushakov verfasserin aut Mirja Jantz verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 18, p 10649 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:18, p 10649 https://doi.org/10.3390/ijms231810649 kostenfrei https://doaj.org/article/480d797df1f246b7ae7f80d6f68f58fb kostenfrei https://www.mdpi.com/1422-0067/23/18/10649 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 18, p 10649 |
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Dimitrios Tsikas @@aut@@ Norbert Maassen @@aut@@ Antonie Thorns @@aut@@ Armin Finkel @@aut@@ Moritz Lützow @@aut@@ Magdalena Aleksandra Röhrig @@aut@@ Larissa Sarah Blau @@aut@@ Laurianne Dimina @@aut@@ François Mariotti @@aut@@ Bibiana Beckmann @@aut@@ Vladimir Shushakov @@aut@@ Mirja Jantz @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ084819243</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414203442.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/ijms231810649</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ084819243</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ480d797df1f246b7ae7f80d6f68f58fb</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD1-999</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Dimitrios Tsikas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. 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Dimitrios Tsikas |
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Dimitrios Tsikas misc QH301-705.5 misc QD1-999 misc amino acids misc guanidinoacetate misc homoarginine misc inorganic nitrate misc malondialdehyde misc oxidative stress misc Biology (General) misc Chemistry Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise |
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QH301-705.5 QD1-999 Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise amino acids guanidinoacetate homoarginine inorganic nitrate malondialdehyde oxidative stress |
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Dimitrios Tsikas Norbert Maassen Antonie Thorns Armin Finkel Moritz Lützow Magdalena Aleksandra Röhrig Larissa Sarah Blau Laurianne Dimina François Mariotti Bibiana Beckmann Vladimir Shushakov Mirja Jantz |
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short-term supplementation of sodium nitrate vs. sodium chloride increases homoarginine synthesis in young men independent of exercise |
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Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise |
abstract |
The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). |
abstractGer |
The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). |
abstract_unstemmed |
The aim of the study was to investigate the effects of short-term oral administration of inorganic nitrate (NaNO<sub<3</sub<; <i<n</i< = 8) or placebo (NaCl; <i<n</i< = 9) (each 0.1 mmol/kg body weight/d for 9 days) on plasma amino acids, creatinine, and oxidative stress in healthy young men. At baseline, the plasma concentrations of amino acids did not differ between the groups. At the end of the study, the plasma concentrations of homoarginine (hArg; by 24%, <i<p</i< = 0.0001), citrulline and ornithine (Cit/Orn; by 16%, <i<p</i< = 0.015), and glutamine/glutamate (Gln/Glu; by 6%, <i<p</i< = 0.0003) were higher in the NaNO<sub<3</sub< group compared to the NaCl group. The plasma concentrations of sarcosine (Sarc; by 28%, <i<p</i< < 0.0001), tyrosine (by 14%, <i<p</i< = 0.0051), phenylalanine (by 8%, <i<p</i< = 0.0026), and tryptophan (by 8%, <i<p</i< = 0.0047) were lower in the NaNO<sub<3</sub< group compared to the NaCl group. These results suggest that nitrate administration affects amino-acid metabolism. The arginine/glycine amidinotransferase (AGAT) catalyzes two reactions: (1) the formation of <span style="font-variant: small-caps;"<l</span<-homoarginine (hArg) and <span style="font-variant: small-caps;"<l</span<-ornithine (Orn) from <span style="font-variant: small-caps;"<l</span<-arginine (Arg) and <span style="font-variant: small-caps;"<l</span<-lysine (Lys): Arg + Lys <−< hArg + Orn, with equilibrium constant <i<K</i<<sub<harg</sub<; (2) the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly <−< GAA + Orn, with equilibrium constant <i<K</i<<sub<gaa</sub<. The plasma <i<K</i<<sub<gaa</sub</<i<K</i<<sub<hArg</sub< ratio was lower in the NaNO<sub<3</sub< group compared to the NaCl group (1.57 vs. 2.02, <i<p</i< = 0.0034). Our study suggests that supplementation of inorganic nitrate increases the AGAT-catalyzed synthesis of hArg and decreases the <i<N</i<-methyltransferase-catalyzed synthesis of GAA, the precursor of creatine. To our knowledge, this is the first study to demonstrate elevation of hArg synthesis by inorganic nitrate supplementation. Remarkably, an increase of 24% corresponds to the synthesis capacity of one kidney in healthy humans. Differences in the association between plasma concentrations of amino acids in the NaNO<sub<3</sub< and NaCl groups suggest changes in amino-acid homeostasis. Plasma concentrations of the oxidative stress marker malondialdehyde (MDA) did not change after supplementation of NaNO<sub<3</sub< or NaCl over the whole exercise time range. Plasma nitrite concentration turned out to be a more discriminant marker of NaNO<sub<3</sub< ingestion than plasma nitrate (area under the receiver operating characteristic curve: 0.951 vs. 0.866, <i<p</i< < 0.0001 each). |
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18, p 10649 |
title_short |
Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise |
url |
https://doi.org/10.3390/ijms231810649 https://doaj.org/article/480d797df1f246b7ae7f80d6f68f58fb https://www.mdpi.com/1422-0067/23/18/10649 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 |
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Norbert Maassen Antonie Thorns Armin Finkel Moritz Lützow Magdalena Aleksandra Röhrig Larissa Sarah Blau Laurianne Dimina François Mariotti Bibiana Beckmann Vladimir Shushakov Mirja Jantz |
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Norbert Maassen Antonie Thorns Armin Finkel Moritz Lützow Magdalena Aleksandra Röhrig Larissa Sarah Blau Laurianne Dimina François Mariotti Bibiana Beckmann Vladimir Shushakov Mirja Jantz |
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