Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury

Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (<i<n</i<-3) fatty a...
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Autor*in:	Myrna J. V. Brandt [verfasserIn] Cora H. Nijboer [verfasserIn] Isabell Nessel [verfasserIn] Tatenda R. Mutshiya [verfasserIn] Adina T. Michael-Titus [verfasserIn] Danielle S. Counotte [verfasserIn] Lidewij Schipper [verfasserIn] Niek E. van der Aa [verfasserIn] Manon J. N. L. Benders [verfasserIn] Caroline G. M. de Theije [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	hypoxic-ischemic encephalopathy neonate fish oil DHA EPA UMP

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 14(2021), 1, p 176
Übergeordnetes Werk:	volume:14 ; year:2021 ; number:1, p 176

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu14010176

Katalog-ID:	DOAJ084827661

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spelling	10.3390/nu14010176 doi (DE-627)DOAJ084827661 (DE-599)DOAJcff598e2c8fc4c1a9a05ef02deddf2fe DE-627 ger DE-627 rakwb eng TX341-641 Myrna J. V. Brandt verfasserin aut Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (<i<n</i<-3) fatty acids docosahexaenoic acid (DHA, 22:6<i<n</i<-3) and eicosapentaenoic acid (EPA, 20:5<i<n</i<-3), uridine monophosphate (UMP) and choline have previously been shown in rodents to synergistically enhance brain phospholipids, synaptic components and cognitive performance. The objective of this study was to test the efficacy of an experimental diet containing DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 in a mouse model of perinatal HI. Male and female C57Bl/6 mice received the experimental diet or an isocaloric control diet from birth. Hypoxic ischemic encephalopathy was induced on postnatal day 9 by ligation of the right common carotid artery and systemic hypoxia. To assess the effects of the experimental diet on long-term motor and cognitive outcome, mice were subjected to a behavioral test battery. Lesion size, neuroinflammation, brain fatty acids and phospholipids were analyzed at 15 weeks after HI. The experimental diet reduced lesion size and neuroinflammation specifically in males. In both sexes, brain <i<n</i<-3 fatty acids were increased after receiving the experimental diet. The experimental diet also improved novel object recognition, but no significant effects on motor performance were observed. Current data indicates that early life nutritional supplementation with a combination of DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 may provide neuroprotection after perinatal HI. hypoxic-ischemic encephalopathy neonate fish oil DHA EPA UMP Nutrition. Foods and food supply Cora H. Nijboer verfasserin aut Isabell Nessel verfasserin aut Tatenda R. Mutshiya verfasserin aut Adina T. Michael-Titus verfasserin aut Danielle S. Counotte verfasserin aut Lidewij Schipper verfasserin aut Niek E. van der Aa verfasserin aut Manon J. N. L. Benders verfasserin aut Caroline G. M. de Theije verfasserin aut In Nutrients MDPI AG, 2009 14(2021), 1, p 176 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2021 number:1, p 176 https://doi.org/10.3390/nu14010176 kostenfrei https://doaj.org/article/cff598e2c8fc4c1a9a05ef02deddf2fe kostenfrei https://www.mdpi.com/2072-6643/14/1/176 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1, p 176
allfields_unstemmed	10.3390/nu14010176 doi (DE-627)DOAJ084827661 (DE-599)DOAJcff598e2c8fc4c1a9a05ef02deddf2fe DE-627 ger DE-627 rakwb eng TX341-641 Myrna J. V. Brandt verfasserin aut Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (<i<n</i<-3) fatty acids docosahexaenoic acid (DHA, 22:6<i<n</i<-3) and eicosapentaenoic acid (EPA, 20:5<i<n</i<-3), uridine monophosphate (UMP) and choline have previously been shown in rodents to synergistically enhance brain phospholipids, synaptic components and cognitive performance. The objective of this study was to test the efficacy of an experimental diet containing DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 in a mouse model of perinatal HI. Male and female C57Bl/6 mice received the experimental diet or an isocaloric control diet from birth. Hypoxic ischemic encephalopathy was induced on postnatal day 9 by ligation of the right common carotid artery and systemic hypoxia. To assess the effects of the experimental diet on long-term motor and cognitive outcome, mice were subjected to a behavioral test battery. Lesion size, neuroinflammation, brain fatty acids and phospholipids were analyzed at 15 weeks after HI. The experimental diet reduced lesion size and neuroinflammation specifically in males. In both sexes, brain <i<n</i<-3 fatty acids were increased after receiving the experimental diet. The experimental diet also improved novel object recognition, but no significant effects on motor performance were observed. Current data indicates that early life nutritional supplementation with a combination of DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 may provide neuroprotection after perinatal HI. hypoxic-ischemic encephalopathy neonate fish oil DHA EPA UMP Nutrition. Foods and food supply Cora H. Nijboer verfasserin aut Isabell Nessel verfasserin aut Tatenda R. Mutshiya verfasserin aut Adina T. Michael-Titus verfasserin aut Danielle S. Counotte verfasserin aut Lidewij Schipper verfasserin aut Niek E. van der Aa verfasserin aut Manon J. N. L. Benders verfasserin aut Caroline G. M. de Theije verfasserin aut In Nutrients MDPI AG, 2009 14(2021), 1, p 176 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2021 number:1, p 176 https://doi.org/10.3390/nu14010176 kostenfrei https://doaj.org/article/cff598e2c8fc4c1a9a05ef02deddf2fe kostenfrei https://www.mdpi.com/2072-6643/14/1/176 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1, p 176
allfieldsGer	10.3390/nu14010176 doi (DE-627)DOAJ084827661 (DE-599)DOAJcff598e2c8fc4c1a9a05ef02deddf2fe DE-627 ger DE-627 rakwb eng TX341-641 Myrna J. V. Brandt verfasserin aut Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (<i<n</i<-3) fatty acids docosahexaenoic acid (DHA, 22:6<i<n</i<-3) and eicosapentaenoic acid (EPA, 20:5<i<n</i<-3), uridine monophosphate (UMP) and choline have previously been shown in rodents to synergistically enhance brain phospholipids, synaptic components and cognitive performance. The objective of this study was to test the efficacy of an experimental diet containing DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 in a mouse model of perinatal HI. Male and female C57Bl/6 mice received the experimental diet or an isocaloric control diet from birth. Hypoxic ischemic encephalopathy was induced on postnatal day 9 by ligation of the right common carotid artery and systemic hypoxia. To assess the effects of the experimental diet on long-term motor and cognitive outcome, mice were subjected to a behavioral test battery. Lesion size, neuroinflammation, brain fatty acids and phospholipids were analyzed at 15 weeks after HI. The experimental diet reduced lesion size and neuroinflammation specifically in males. In both sexes, brain <i<n</i<-3 fatty acids were increased after receiving the experimental diet. The experimental diet also improved novel object recognition, but no significant effects on motor performance were observed. Current data indicates that early life nutritional supplementation with a combination of DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 may provide neuroprotection after perinatal HI. hypoxic-ischemic encephalopathy neonate fish oil DHA EPA UMP Nutrition. Foods and food supply Cora H. Nijboer verfasserin aut Isabell Nessel verfasserin aut Tatenda R. Mutshiya verfasserin aut Adina T. Michael-Titus verfasserin aut Danielle S. Counotte verfasserin aut Lidewij Schipper verfasserin aut Niek E. van der Aa verfasserin aut Manon J. N. L. Benders verfasserin aut Caroline G. M. de Theije verfasserin aut In Nutrients MDPI AG, 2009 14(2021), 1, p 176 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:14 year:2021 number:1, p 176 https://doi.org/10.3390/nu14010176 kostenfrei https://doaj.org/article/cff598e2c8fc4c1a9a05ef02deddf2fe kostenfrei https://www.mdpi.com/2072-6643/14/1/176 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2021 1, p 176
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source	In Nutrients 14(2021), 1, p 176 volume:14 year:2021 number:1, p 176
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topic_title	TX341-641 Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury hypoxic-ischemic encephalopathy neonate fish oil DHA EPA UMP
topic	misc TX341-641 misc hypoxic-ischemic encephalopathy misc neonate misc fish oil misc DHA misc EPA misc UMP misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc hypoxic-ischemic encephalopathy misc neonate misc fish oil misc DHA misc EPA misc UMP misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc hypoxic-ischemic encephalopathy misc neonate misc fish oil misc DHA misc EPA misc UMP misc Nutrition. Foods and food supply
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title	Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury
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title_full	Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury
author_sort	Myrna J. V. Brandt
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author_browse	Myrna J. V. Brandt Cora H. Nijboer Isabell Nessel Tatenda R. Mutshiya Adina T. Michael-Titus Danielle S. Counotte Lidewij Schipper Niek E. van der Aa Manon J. N. L. Benders Caroline G. M. de Theije
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title_sort	nutritional supplementation reduces lesion size and neuroinflammation in a sex-dependent manner in a mouse model of perinatal hypoxic-ischemic brain injury
callnumber	TX341-641
title_auth	Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury
abstract	Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (<i<n</i<-3) fatty acids docosahexaenoic acid (DHA, 22:6<i<n</i<-3) and eicosapentaenoic acid (EPA, 20:5<i<n</i<-3), uridine monophosphate (UMP) and choline have previously been shown in rodents to synergistically enhance brain phospholipids, synaptic components and cognitive performance. The objective of this study was to test the efficacy of an experimental diet containing DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 in a mouse model of perinatal HI. Male and female C57Bl/6 mice received the experimental diet or an isocaloric control diet from birth. Hypoxic ischemic encephalopathy was induced on postnatal day 9 by ligation of the right common carotid artery and systemic hypoxia. To assess the effects of the experimental diet on long-term motor and cognitive outcome, mice were subjected to a behavioral test battery. Lesion size, neuroinflammation, brain fatty acids and phospholipids were analyzed at 15 weeks after HI. The experimental diet reduced lesion size and neuroinflammation specifically in males. In both sexes, brain <i<n</i<-3 fatty acids were increased after receiving the experimental diet. The experimental diet also improved novel object recognition, but no significant effects on motor performance were observed. Current data indicates that early life nutritional supplementation with a combination of DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 may provide neuroprotection after perinatal HI.
abstractGer	Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (<i<n</i<-3) fatty acids docosahexaenoic acid (DHA, 22:6<i<n</i<-3) and eicosapentaenoic acid (EPA, 20:5<i<n</i<-3), uridine monophosphate (UMP) and choline have previously been shown in rodents to synergistically enhance brain phospholipids, synaptic components and cognitive performance. The objective of this study was to test the efficacy of an experimental diet containing DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 in a mouse model of perinatal HI. Male and female C57Bl/6 mice received the experimental diet or an isocaloric control diet from birth. Hypoxic ischemic encephalopathy was induced on postnatal day 9 by ligation of the right common carotid artery and systemic hypoxia. To assess the effects of the experimental diet on long-term motor and cognitive outcome, mice were subjected to a behavioral test battery. Lesion size, neuroinflammation, brain fatty acids and phospholipids were analyzed at 15 weeks after HI. The experimental diet reduced lesion size and neuroinflammation specifically in males. In both sexes, brain <i<n</i<-3 fatty acids were increased after receiving the experimental diet. The experimental diet also improved novel object recognition, but no significant effects on motor performance were observed. Current data indicates that early life nutritional supplementation with a combination of DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 may provide neuroprotection after perinatal HI.
abstract_unstemmed	Perinatal hypoxia-ischemia (HI) is a major cause of neonatal brain injury, leading to long-term neurological impairments. Medical nutrition can be rapidly implemented in the clinic, making it a viable intervention to improve neurodevelopment after injury. The omega-3 (<i<n</i<-3) fatty acids docosahexaenoic acid (DHA, 22:6<i<n</i<-3) and eicosapentaenoic acid (EPA, 20:5<i<n</i<-3), uridine monophosphate (UMP) and choline have previously been shown in rodents to synergistically enhance brain phospholipids, synaptic components and cognitive performance. The objective of this study was to test the efficacy of an experimental diet containing DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 in a mouse model of perinatal HI. Male and female C57Bl/6 mice received the experimental diet or an isocaloric control diet from birth. Hypoxic ischemic encephalopathy was induced on postnatal day 9 by ligation of the right common carotid artery and systemic hypoxia. To assess the effects of the experimental diet on long-term motor and cognitive outcome, mice were subjected to a behavioral test battery. Lesion size, neuroinflammation, brain fatty acids and phospholipids were analyzed at 15 weeks after HI. The experimental diet reduced lesion size and neuroinflammation specifically in males. In both sexes, brain <i<n</i<-3 fatty acids were increased after receiving the experimental diet. The experimental diet also improved novel object recognition, but no significant effects on motor performance were observed. Current data indicates that early life nutritional supplementation with a combination of DHA, EPA, UMP, choline, iodide, zinc, and vitamin B12 may provide neuroprotection after perinatal HI.
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title_short	Nutritional Supplementation Reduces Lesion Size and Neuroinflammation in a Sex-Dependent Manner in a Mouse Model of Perinatal Hypoxic-Ischemic Brain Injury
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