ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758)
<i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano...
Ausführliche Beschreibung
Autor*in: |
Jie Gao [verfasserIn] Mingjian Liu [verfasserIn] Huayang Guo [verfasserIn] Kecheng Zhu [verfasserIn] Bo Liu [verfasserIn] Baosuo Liu [verfasserIn] Nan Zhang [verfasserIn] Dianchang Zhang [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Antioxidants - MDPI AG, 2013, 11(2022), 9, p 1809 |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:9, p 1809 |
Links: |
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DOI / URN: |
10.3390/antiox11091809 |
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Katalog-ID: |
DOAJ084836423 |
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245 | 1 | 0 | |a ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758) |
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520 | |a <i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. | ||
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700 | 0 | |a Dianchang Zhang |e verfasserin |4 aut | |
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10.3390/antiox11091809 doi (DE-627)DOAJ084836423 (DE-599)DOAJ9c41f15bf1124080a85157ee7aa175d8 DE-627 ger DE-627 rakwb eng RM1-950 Jie Gao verfasserin aut ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. <i<Trachinotus ovatus</i< pathogenic bacterial infection histopathology immune-related genes inflammatory response Therapeutics. Pharmacology Mingjian Liu verfasserin aut Huayang Guo verfasserin aut Kecheng Zhu verfasserin aut Bo Liu verfasserin aut Baosuo Liu verfasserin aut Nan Zhang verfasserin aut Dianchang Zhang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 9, p 1809 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:9, p 1809 https://doi.org/10.3390/antiox11091809 kostenfrei https://doaj.org/article/9c41f15bf1124080a85157ee7aa175d8 kostenfrei https://www.mdpi.com/2076-3921/11/9/1809 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 9, p 1809 |
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10.3390/antiox11091809 doi (DE-627)DOAJ084836423 (DE-599)DOAJ9c41f15bf1124080a85157ee7aa175d8 DE-627 ger DE-627 rakwb eng RM1-950 Jie Gao verfasserin aut ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. <i<Trachinotus ovatus</i< pathogenic bacterial infection histopathology immune-related genes inflammatory response Therapeutics. Pharmacology Mingjian Liu verfasserin aut Huayang Guo verfasserin aut Kecheng Zhu verfasserin aut Bo Liu verfasserin aut Baosuo Liu verfasserin aut Nan Zhang verfasserin aut Dianchang Zhang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 9, p 1809 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:9, p 1809 https://doi.org/10.3390/antiox11091809 kostenfrei https://doaj.org/article/9c41f15bf1124080a85157ee7aa175d8 kostenfrei https://www.mdpi.com/2076-3921/11/9/1809 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 9, p 1809 |
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10.3390/antiox11091809 doi (DE-627)DOAJ084836423 (DE-599)DOAJ9c41f15bf1124080a85157ee7aa175d8 DE-627 ger DE-627 rakwb eng RM1-950 Jie Gao verfasserin aut ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. <i<Trachinotus ovatus</i< pathogenic bacterial infection histopathology immune-related genes inflammatory response Therapeutics. Pharmacology Mingjian Liu verfasserin aut Huayang Guo verfasserin aut Kecheng Zhu verfasserin aut Bo Liu verfasserin aut Baosuo Liu verfasserin aut Nan Zhang verfasserin aut Dianchang Zhang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 9, p 1809 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:9, p 1809 https://doi.org/10.3390/antiox11091809 kostenfrei https://doaj.org/article/9c41f15bf1124080a85157ee7aa175d8 kostenfrei https://www.mdpi.com/2076-3921/11/9/1809 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 9, p 1809 |
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10.3390/antiox11091809 doi (DE-627)DOAJ084836423 (DE-599)DOAJ9c41f15bf1124080a85157ee7aa175d8 DE-627 ger DE-627 rakwb eng RM1-950 Jie Gao verfasserin aut ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758) 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. <i<Trachinotus ovatus</i< pathogenic bacterial infection histopathology immune-related genes inflammatory response Therapeutics. Pharmacology Mingjian Liu verfasserin aut Huayang Guo verfasserin aut Kecheng Zhu verfasserin aut Bo Liu verfasserin aut Baosuo Liu verfasserin aut Nan Zhang verfasserin aut Dianchang Zhang verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 9, p 1809 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:9, p 1809 https://doi.org/10.3390/antiox11091809 kostenfrei https://doaj.org/article/9c41f15bf1124080a85157ee7aa175d8 kostenfrei https://www.mdpi.com/2076-3921/11/9/1809 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 9, p 1809 |
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ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758) |
abstract |
<i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. |
abstractGer |
<i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. |
abstract_unstemmed |
<i<Streptococcus agalactiae</i< is common pathogenic bacteria in aquaculture and can cause mass mortality after fish infection. This study aimed to investigate the effects of <i<S. agalactiae</i< infection on the immune and antioxidant regulatory mechanisms of golden pompano (<i<Trachinotus ovatus</i<). Serum and liver samples were obtained at 0, 6, 12, 24, 48, 96, and 120 h after golden pompano infection with <i<S. agalactiae</i< for enzyme activity and gene expression analyses. After infection with <i<S. agalactiae</i<, the content of reactive oxygen species (ROS) in serum was significantly increased (<i<p</i< < 0.05). Serum levels of glucose (GLU), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) increased and then decreased (<i<p</i< < 0.05), reaching a maximum at 6 h. Serum antioxidant enzyme (LZM) activity increased significantly (<i<p</i< < 0.05) and reached a maximum at 120 h. In addition, the mRNA expression levels of antioxidant genes (<i<SOD</i<, <i<CAT</i<, and <i<GPx</i<) in the liver increased and then decreased, reaching the maximum at 24 h, 48 h, and 24 h, respectively. During the experimental period, the mRNA expression levels of NF-κB-related genes of the inflammatory signaling pathway inhibitory κB (<i<IκB</i<) showed an overall decreasing trend (<i<p</i< < 0.05) and the lowest expression at 120 h, whereas the mRNA expression levels of tumor necrosis factor α (<i<TNF-α</i<), interleukin-1β (<i<IL-1β</i<), IκB kinase (<i<IKK</i<), and nuclear factor NF-κB increased significantly (<i<p</i< < 0.05) and the highest expression was at 120 h. In conclusion, these results showed that <i<S. agalactiae</i< could activate internal regulatory signaling in the liver of golden pompano to induce defense and immune responses. This study is expected to lay a foundation to develop the healthy aquaculture of golden pompano and promote a more comprehensive understanding of its disease resistance mechanisms. |
collection_details |
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container_issue |
9, p 1809 |
title_short |
ROS Induced by <i<Streptococcus agalactiae</i< Activate Inflammatory Responses via the TNF-α/NF-κB Signaling Pathway in Golden Pompano <i<Trachinotus ovatus</i< (Linnaeus, 1758) |
url |
https://doi.org/10.3390/antiox11091809 https://doaj.org/article/9c41f15bf1124080a85157ee7aa175d8 https://www.mdpi.com/2076-3921/11/9/1809 https://doaj.org/toc/2076-3921 |
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Mingjian Liu Huayang Guo Kecheng Zhu Bo Liu Baosuo Liu Nan Zhang Dianchang Zhang |
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Mingjian Liu Huayang Guo Kecheng Zhu Bo Liu Baosuo Liu Nan Zhang Dianchang Zhang |
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doi_str |
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up_date |
2024-07-04T00:45:36.895Z |
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