Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System

Titanium dioxide (TiO<sub<2</sub<) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO<sub<2</sub< and recent insi...
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Autor*in:	Nicolaj S. Bischoff [verfasserIn] Theo M. de Kok [verfasserIn] Dick T.H.M. Sijm [verfasserIn] Simone G. van Breda [verfasserIn] Jacco J. Briedé [verfasserIn] Jacqueline J.M. Castenmiller [verfasserIn] Antoon Opperhuizen [verfasserIn] Yolanda I. Chirino [verfasserIn] Hubert Dirven [verfasserIn] David Gott [verfasserIn] Eric Houdeau [verfasserIn] Agnes G. Oomen [verfasserIn] Morten Poulsen [verfasserIn] Gerhard Rogler [verfasserIn] Henk van Loveren [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	titanium dioxide TiO E171 food additive food safety nanomaterial

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 22(2020), 1, p 207
Übergeordnetes Werk:	volume:22 ; year:2020 ; number:1, p 207

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms22010207

Katalog-ID:	DOAJ084852534

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allfieldsSound	10.3390/ijms22010207 doi (DE-627)DOAJ084852534 (DE-599)DOAJd05aa8da7d244bc0ba673df0f24ca93c DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Nicolaj S. Bischoff verfasserin aut Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Titanium dioxide (TiO<sub<2</sub<) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO<sub<2</sub< and recent insights into its potentially hazardous properties, there are concerns about its application in commercially available products. Especially the nano-sized particle fraction (<100 nm) of TiO<sub<2</sub< warrants a more detailed evaluation of potential adverse health effects after ingestion. A workshop organized by the Dutch Office for Risk Assessment and Research (BuRO) identified uncertainties and knowledge gaps regarding the gastrointestinal absorption of TiO<sub<2</sub<, its distribution, the potential for accumulation, and induction of adverse health effects such as inflammation, DNA damage, and tumor promotion. This review aims to identify and evaluate recent toxicological studies on food-grade TiO<sub<2</sub< and nano-sized TiO<sub<2</sub< in ex-vivo, in-vitro, and in-vivo experiments along the gastrointestinal route, and to postulate an Adverse Outcome Pathway (AOP) following ingestion. Additionally, this review summarizes recommendations and outcomes of the expert meeting held by the BuRO in 2018, in order to contribute to the hazard identification and risk assessment process of ingested TiO<sub<2</sub<. titanium dioxide TiO<sub<2</sub< E171 food additive food safety nanomaterial Biology (General) Chemistry Theo M. de Kok verfasserin aut Dick T.H.M. Sijm verfasserin aut Simone G. van Breda verfasserin aut Jacco J. Briedé verfasserin aut Jacqueline J.M. Castenmiller verfasserin aut Antoon Opperhuizen verfasserin aut Yolanda I. Chirino verfasserin aut Hubert Dirven verfasserin aut David Gott verfasserin aut Eric Houdeau verfasserin aut Agnes G. Oomen verfasserin aut Morten Poulsen verfasserin aut Gerhard Rogler verfasserin aut Henk van Loveren verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2020), 1, p 207 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2020 number:1, p 207 https://doi.org/10.3390/ijms22010207 kostenfrei https://doaj.org/article/d05aa8da7d244bc0ba673df0f24ca93c kostenfrei https://www.mdpi.com/1422-0067/22/1/207 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2020 1, p 207
language	English
source	In International Journal of Molecular Sciences 22(2020), 1, p 207 volume:22 year:2020 number:1, p 207
sourceStr	In International Journal of Molecular Sciences 22(2020), 1, p 207 volume:22 year:2020 number:1, p 207
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	titanium dioxide TiO<sub<2</sub< E171 food additive food safety nanomaterial Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Nicolaj S. Bischoff @@aut@@ Theo M. de Kok @@aut@@ Dick T.H.M. Sijm @@aut@@ Simone G. van Breda @@aut@@ Jacco J. Briedé @@aut@@ Jacqueline J.M. Castenmiller @@aut@@ Antoon Opperhuizen @@aut@@ Yolanda I. Chirino @@aut@@ Hubert Dirven @@aut@@ David Gott @@aut@@ Eric Houdeau @@aut@@ Agnes G. Oomen @@aut@@ Morten Poulsen @@aut@@ Gerhard Rogler @@aut@@ Henk van Loveren @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ084852534
language_de	englisch
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callnumber-first	Q - Science
author	Nicolaj S. Bischoff
spellingShingle	Nicolaj S. Bischoff misc QH301-705.5 misc QD1-999 misc titanium dioxide misc TiO<sub<2</sub< misc E171 misc food additive misc food safety misc nanomaterial misc Biology (General) misc Chemistry Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System
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topic_title	QH301-705.5 QD1-999 Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System titanium dioxide TiO<sub<2</sub< E171 food additive food safety nanomaterial
topic	misc QH301-705.5 misc QD1-999 misc titanium dioxide misc TiO<sub<2</sub< misc E171 misc food additive misc food safety misc nanomaterial misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc titanium dioxide misc TiO<sub<2</sub< misc E171 misc food additive misc food safety misc nanomaterial misc Biology (General) misc Chemistry
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title	Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System
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title_full	Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System
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author_browse	Nicolaj S. Bischoff Theo M. de Kok Dick T.H.M. Sijm Simone G. van Breda Jacco J. Briedé Jacqueline J.M. Castenmiller Antoon Opperhuizen Yolanda I. Chirino Hubert Dirven David Gott Eric Houdeau Agnes G. Oomen Morten Poulsen Gerhard Rogler Henk van Loveren
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author-letter	Nicolaj S. Bischoff
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title_sort	possible adverse effects of food additive e171 (titanium dioxide) related to particle specific human toxicity, including the immune system
callnumber	QH301-705.5
title_auth	Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System
abstract	Titanium dioxide (TiO<sub<2</sub<) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO<sub<2</sub< and recent insights into its potentially hazardous properties, there are concerns about its application in commercially available products. Especially the nano-sized particle fraction (<100 nm) of TiO<sub<2</sub< warrants a more detailed evaluation of potential adverse health effects after ingestion. A workshop organized by the Dutch Office for Risk Assessment and Research (BuRO) identified uncertainties and knowledge gaps regarding the gastrointestinal absorption of TiO<sub<2</sub<, its distribution, the potential for accumulation, and induction of adverse health effects such as inflammation, DNA damage, and tumor promotion. This review aims to identify and evaluate recent toxicological studies on food-grade TiO<sub<2</sub< and nano-sized TiO<sub<2</sub< in ex-vivo, in-vitro, and in-vivo experiments along the gastrointestinal route, and to postulate an Adverse Outcome Pathway (AOP) following ingestion. Additionally, this review summarizes recommendations and outcomes of the expert meeting held by the BuRO in 2018, in order to contribute to the hazard identification and risk assessment process of ingested TiO<sub<2</sub<.
abstractGer	Titanium dioxide (TiO<sub<2</sub<) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO<sub<2</sub< and recent insights into its potentially hazardous properties, there are concerns about its application in commercially available products. Especially the nano-sized particle fraction (<100 nm) of TiO<sub<2</sub< warrants a more detailed evaluation of potential adverse health effects after ingestion. A workshop organized by the Dutch Office for Risk Assessment and Research (BuRO) identified uncertainties and knowledge gaps regarding the gastrointestinal absorption of TiO<sub<2</sub<, its distribution, the potential for accumulation, and induction of adverse health effects such as inflammation, DNA damage, and tumor promotion. This review aims to identify and evaluate recent toxicological studies on food-grade TiO<sub<2</sub< and nano-sized TiO<sub<2</sub< in ex-vivo, in-vitro, and in-vivo experiments along the gastrointestinal route, and to postulate an Adverse Outcome Pathway (AOP) following ingestion. Additionally, this review summarizes recommendations and outcomes of the expert meeting held by the BuRO in 2018, in order to contribute to the hazard identification and risk assessment process of ingested TiO<sub<2</sub<.
abstract_unstemmed	Titanium dioxide (TiO<sub<2</sub<) is used as a food additive (E171) and can be found in sauces, icings, and chewing gums, as well as in personal care products such as toothpaste and pharmaceutical tablets. Along with the ubiquitous presence of TiO<sub<2</sub< and recent insights into its potentially hazardous properties, there are concerns about its application in commercially available products. Especially the nano-sized particle fraction (<100 nm) of TiO<sub<2</sub< warrants a more detailed evaluation of potential adverse health effects after ingestion. A workshop organized by the Dutch Office for Risk Assessment and Research (BuRO) identified uncertainties and knowledge gaps regarding the gastrointestinal absorption of TiO<sub<2</sub<, its distribution, the potential for accumulation, and induction of adverse health effects such as inflammation, DNA damage, and tumor promotion. This review aims to identify and evaluate recent toxicological studies on food-grade TiO<sub<2</sub< and nano-sized TiO<sub<2</sub< in ex-vivo, in-vitro, and in-vivo experiments along the gastrointestinal route, and to postulate an Adverse Outcome Pathway (AOP) following ingestion. Additionally, this review summarizes recommendations and outcomes of the expert meeting held by the BuRO in 2018, in order to contribute to the hazard identification and risk assessment process of ingested TiO<sub<2</sub<.
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container_issue	1, p 207
title_short	Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System
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Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System

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