Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes

The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study...
Ausführliche Beschreibung

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Autor*in:	Yang Zhao [verfasserIn] Xuesong Li [verfasserIn] Jing Wei [verfasserIn] Jaume Torres [verfasserIn] Anthony G. Fane [verfasserIn] Rong Wang [verfasserIn] Chuyang Y. Tang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol

Übergeordnetes Werk:	In: Membranes - MDPI AG, 2011, 12(2021), 1, p 32
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1, p 32

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/membranes12010032

Katalog-ID:	DOAJ084859695

Internformat


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allfields	10.3390/membranes12010032 doi (DE-627)DOAJ084859695 (DE-599)DOAJb6c0cb938e774cb38e8edcdfd2a90099 DE-627 ger DE-627 rakwb eng TP1-1185 TP155-156 Yang Zhao verfasserin aut Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production. aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol Chemical technology Chemical engineering Xuesong Li verfasserin aut Jing Wei verfasserin aut Jaume Torres verfasserin aut Anthony G. Fane verfasserin aut Rong Wang verfasserin aut Chuyang Y. Tang verfasserin aut In Membranes MDPI AG, 2011 12(2021), 1, p 32 (DE-627)662495683 (DE-600)2614641-1 20770375 nnns volume:12 year:2021 number:1, p 32 https://doi.org/10.3390/membranes12010032 kostenfrei https://doaj.org/article/b6c0cb938e774cb38e8edcdfd2a90099 kostenfrei https://www.mdpi.com/2077-0375/12/1/32 kostenfrei https://doaj.org/toc/2077-0375 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1, p 32
spelling	10.3390/membranes12010032 doi (DE-627)DOAJ084859695 (DE-599)DOAJb6c0cb938e774cb38e8edcdfd2a90099 DE-627 ger DE-627 rakwb eng TP1-1185 TP155-156 Yang Zhao verfasserin aut Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production. aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol Chemical technology Chemical engineering Xuesong Li verfasserin aut Jing Wei verfasserin aut Jaume Torres verfasserin aut Anthony G. Fane verfasserin aut Rong Wang verfasserin aut Chuyang Y. Tang verfasserin aut In Membranes MDPI AG, 2011 12(2021), 1, p 32 (DE-627)662495683 (DE-600)2614641-1 20770375 nnns volume:12 year:2021 number:1, p 32 https://doi.org/10.3390/membranes12010032 kostenfrei https://doaj.org/article/b6c0cb938e774cb38e8edcdfd2a90099 kostenfrei https://www.mdpi.com/2077-0375/12/1/32 kostenfrei https://doaj.org/toc/2077-0375 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1, p 32
allfields_unstemmed	10.3390/membranes12010032 doi (DE-627)DOAJ084859695 (DE-599)DOAJb6c0cb938e774cb38e8edcdfd2a90099 DE-627 ger DE-627 rakwb eng TP1-1185 TP155-156 Yang Zhao verfasserin aut Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production. aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol Chemical technology Chemical engineering Xuesong Li verfasserin aut Jing Wei verfasserin aut Jaume Torres verfasserin aut Anthony G. Fane verfasserin aut Rong Wang verfasserin aut Chuyang Y. Tang verfasserin aut In Membranes MDPI AG, 2011 12(2021), 1, p 32 (DE-627)662495683 (DE-600)2614641-1 20770375 nnns volume:12 year:2021 number:1, p 32 https://doi.org/10.3390/membranes12010032 kostenfrei https://doaj.org/article/b6c0cb938e774cb38e8edcdfd2a90099 kostenfrei https://www.mdpi.com/2077-0375/12/1/32 kostenfrei https://doaj.org/toc/2077-0375 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1, p 32
allfieldsGer	10.3390/membranes12010032 doi (DE-627)DOAJ084859695 (DE-599)DOAJb6c0cb938e774cb38e8edcdfd2a90099 DE-627 ger DE-627 rakwb eng TP1-1185 TP155-156 Yang Zhao verfasserin aut Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production. aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol Chemical technology Chemical engineering Xuesong Li verfasserin aut Jing Wei verfasserin aut Jaume Torres verfasserin aut Anthony G. Fane verfasserin aut Rong Wang verfasserin aut Chuyang Y. Tang verfasserin aut In Membranes MDPI AG, 2011 12(2021), 1, p 32 (DE-627)662495683 (DE-600)2614641-1 20770375 nnns volume:12 year:2021 number:1, p 32 https://doi.org/10.3390/membranes12010032 kostenfrei https://doaj.org/article/b6c0cb938e774cb38e8edcdfd2a90099 kostenfrei https://www.mdpi.com/2077-0375/12/1/32 kostenfrei https://doaj.org/toc/2077-0375 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1, p 32
allfieldsSound	10.3390/membranes12010032 doi (DE-627)DOAJ084859695 (DE-599)DOAJb6c0cb938e774cb38e8edcdfd2a90099 DE-627 ger DE-627 rakwb eng TP1-1185 TP155-156 Yang Zhao verfasserin aut Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production. aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol Chemical technology Chemical engineering Xuesong Li verfasserin aut Jing Wei verfasserin aut Jaume Torres verfasserin aut Anthony G. Fane verfasserin aut Rong Wang verfasserin aut Chuyang Y. Tang verfasserin aut In Membranes MDPI AG, 2011 12(2021), 1, p 32 (DE-627)662495683 (DE-600)2614641-1 20770375 nnns volume:12 year:2021 number:1, p 32 https://doi.org/10.3390/membranes12010032 kostenfrei https://doaj.org/article/b6c0cb938e774cb38e8edcdfd2a90099 kostenfrei https://www.mdpi.com/2077-0375/12/1/32 kostenfrei https://doaj.org/toc/2077-0375 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1, p 32
language	English
source	In Membranes 12(2021), 1, p 32 volume:12 year:2021 number:1, p 32
sourceStr	In Membranes 12(2021), 1, p 32 volume:12 year:2021 number:1, p 32
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol Chemical technology Chemical engineering
isfreeaccess_bool	true
container_title	Membranes
authorswithroles_txt_mv	Yang Zhao @@aut@@ Xuesong Li @@aut@@ Jing Wei @@aut@@ Jaume Torres @@aut@@ Anthony G. Fane @@aut@@ Rong Wang @@aut@@ Chuyang Y. Tang @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	662495683
id	DOAJ084859695
language_de	englisch
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callnumber-first	T - Technology
author	Yang Zhao
spellingShingle	Yang Zhao misc TP1-1185 misc TP155-156 misc aquaporin misc biomimetic thin-film composite membrane misc proteoliposome concentration misc protein-to-lipid ratio misc cholesterol misc Chemical technology misc Chemical engineering Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes
authorStr	Yang Zhao
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topic_title	TP1-1185 TP155-156 Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes aquaporin biomimetic thin-film composite membrane proteoliposome concentration protein-to-lipid ratio cholesterol
topic	misc TP1-1185 misc TP155-156 misc aquaporin misc biomimetic thin-film composite membrane misc proteoliposome concentration misc protein-to-lipid ratio misc cholesterol misc Chemical technology misc Chemical engineering
topic_unstemmed	misc TP1-1185 misc TP155-156 misc aquaporin misc biomimetic thin-film composite membrane misc proteoliposome concentration misc protein-to-lipid ratio misc cholesterol misc Chemical technology misc Chemical engineering
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title	Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes
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title_full	Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes
author_sort	Yang Zhao
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author_browse	Yang Zhao Xuesong Li Jing Wei Jaume Torres Anthony G. Fane Rong Wang Chuyang Y. Tang
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doi_str_mv	10.3390/membranes12010032
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title_sort	optimization of aquaporin loading for performance enhancement of aquaporin-based biomimetic thin-film composite membranes
callnumber	TP1-1185
title_auth	Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes
abstract	The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production.
abstractGer	The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production.
abstract_unstemmed	The aquaporin-based biomimetic thin-film composite membrane (ABM-TFC) has demonstrated superior separation performance and achieved successful commercialization. The larger-scale production of the ABM membrane requires an appropriate balance between the performance and manufacturing cost. This study has systematically investigated the effects of proteoliposome concentration, protein-to-lipid ratio, as well as the additive on the separation performance of ABM for the purpose of finding the optimal preparation conditions for the ABM from the perspective of industrial production. Although increasing the proteoliposome concentration or protein-to-lipid ratio within a certain range could significantly enhance the water permeability of ABMs by increasing the loading of aquaporins in the selective layer, the enhancement effect was marginal or even compromised beyond an optimal point. Alternatively, adding cholesterol in the proteoliposome could further enhance the water flux of the ABM membrane, with minor effects on the salt rejection. The optimized ABM not only achieved a nearly doubled water flux with unchanged salt rejection compared to the control, but also demonstrated satisfactory filtration stability within a wide range of operation temperatures. This study provides a practical strategy for the optimization of ABM-TFC membranes to fit within the scheme of industrial-scale production.
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title_short	Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes
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Optimization of Aquaporin Loading for Performance Enhancement of Aquaporin-Based Biomimetic Thin-Film Composite Membranes

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