The role of mucosal-associated invariant T cells in visceral leishmaniasis
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited...
Ausführliche Beschreibung
Autor*in: |
Marcela de Lima Moreira [verfasserIn] Luana Oliveira Borges-Fernandes [verfasserIn] Marcelo Antônio Pascoal-Xavier [verfasserIn] Ágata Lopes Ribeiro [verfasserIn] Victória Hellena Silva Pereira [verfasserIn] Troi Pediongco [verfasserIn] Márcio Sobreira da Silva Araújo [verfasserIn] Andréa Teixeira-Carvalho [verfasserIn] Andrea Lucchesi de Carvalho [verfasserIn] Maria Vitória Assumpção Mourão [verfasserIn] Flávia Alves Campos [verfasserIn] Marineide Borges [verfasserIn] Mariângela Carneiro [verfasserIn] Zhenjun Chen [verfasserIn] Eleanor Saunders [verfasserIn] Malcolm McConville [verfasserIn] Moriya Tsuji [verfasserIn] James McCluskey [verfasserIn] Olindo Assis Martins-Filho [verfasserIn] Sidonia Barbara Guiomar Eckle [verfasserIn] Jordana Grazziela Alves Coelho-dos-Reis [verfasserIn] Vanessa Peruhype-Magalhães [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022) |
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Übergeordnetes Werk: |
volume:13 ; year:2022 |
Links: |
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DOI / URN: |
10.3389/fimmu.2022.926446 |
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Katalog-ID: |
DOAJ084879009 |
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520 | |a Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. | ||
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10.3389/fimmu.2022.926446 doi (DE-627)DOAJ084879009 (DE-599)DOAJb8b6f2ab6e20411fa6f6ce956f5a0121 DE-627 ger DE-627 rakwb eng RC581-607 Marcela de Lima Moreira verfasserin aut The role of mucosal-associated invariant T cells in visceral leishmaniasis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. MAIT Leishmania anti-parasitic activity MR1 IL-17+MAIT IFN-γ+ MAIT Immunologic diseases. Allergy Marcela de Lima Moreira verfasserin aut Luana Oliveira Borges-Fernandes verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Ágata Lopes Ribeiro verfasserin aut Victória Hellena Silva Pereira verfasserin aut Troi Pediongco verfasserin aut Márcio Sobreira da Silva Araújo verfasserin aut Andréa Teixeira-Carvalho verfasserin aut Andrea Lucchesi de Carvalho verfasserin aut Maria Vitória Assumpção Mourão verfasserin aut Flávia Alves Campos verfasserin aut Marineide Borges verfasserin aut Mariângela Carneiro verfasserin aut Zhenjun Chen verfasserin aut Eleanor Saunders verfasserin aut Malcolm McConville verfasserin aut Moriya Tsuji verfasserin aut James McCluskey verfasserin aut Olindo Assis Martins-Filho verfasserin aut Sidonia Barbara Guiomar Eckle verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Vanessa Peruhype-Magalhães verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.926446 kostenfrei https://doaj.org/article/b8b6f2ab6e20411fa6f6ce956f5a0121 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.926446/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.926446 doi (DE-627)DOAJ084879009 (DE-599)DOAJb8b6f2ab6e20411fa6f6ce956f5a0121 DE-627 ger DE-627 rakwb eng RC581-607 Marcela de Lima Moreira verfasserin aut The role of mucosal-associated invariant T cells in visceral leishmaniasis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. MAIT Leishmania anti-parasitic activity MR1 IL-17+MAIT IFN-γ+ MAIT Immunologic diseases. Allergy Marcela de Lima Moreira verfasserin aut Luana Oliveira Borges-Fernandes verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Ágata Lopes Ribeiro verfasserin aut Victória Hellena Silva Pereira verfasserin aut Troi Pediongco verfasserin aut Márcio Sobreira da Silva Araújo verfasserin aut Andréa Teixeira-Carvalho verfasserin aut Andrea Lucchesi de Carvalho verfasserin aut Maria Vitória Assumpção Mourão verfasserin aut Flávia Alves Campos verfasserin aut Marineide Borges verfasserin aut Mariângela Carneiro verfasserin aut Zhenjun Chen verfasserin aut Eleanor Saunders verfasserin aut Malcolm McConville verfasserin aut Moriya Tsuji verfasserin aut James McCluskey verfasserin aut Olindo Assis Martins-Filho verfasserin aut Sidonia Barbara Guiomar Eckle verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Vanessa Peruhype-Magalhães verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.926446 kostenfrei https://doaj.org/article/b8b6f2ab6e20411fa6f6ce956f5a0121 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.926446/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
allfields_unstemmed |
10.3389/fimmu.2022.926446 doi (DE-627)DOAJ084879009 (DE-599)DOAJb8b6f2ab6e20411fa6f6ce956f5a0121 DE-627 ger DE-627 rakwb eng RC581-607 Marcela de Lima Moreira verfasserin aut The role of mucosal-associated invariant T cells in visceral leishmaniasis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. MAIT Leishmania anti-parasitic activity MR1 IL-17+MAIT IFN-γ+ MAIT Immunologic diseases. Allergy Marcela de Lima Moreira verfasserin aut Luana Oliveira Borges-Fernandes verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Ágata Lopes Ribeiro verfasserin aut Victória Hellena Silva Pereira verfasserin aut Troi Pediongco verfasserin aut Márcio Sobreira da Silva Araújo verfasserin aut Andréa Teixeira-Carvalho verfasserin aut Andrea Lucchesi de Carvalho verfasserin aut Maria Vitória Assumpção Mourão verfasserin aut Flávia Alves Campos verfasserin aut Marineide Borges verfasserin aut Mariângela Carneiro verfasserin aut Zhenjun Chen verfasserin aut Eleanor Saunders verfasserin aut Malcolm McConville verfasserin aut Moriya Tsuji verfasserin aut James McCluskey verfasserin aut Olindo Assis Martins-Filho verfasserin aut Sidonia Barbara Guiomar Eckle verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Vanessa Peruhype-Magalhães verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.926446 kostenfrei https://doaj.org/article/b8b6f2ab6e20411fa6f6ce956f5a0121 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.926446/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.926446 doi (DE-627)DOAJ084879009 (DE-599)DOAJb8b6f2ab6e20411fa6f6ce956f5a0121 DE-627 ger DE-627 rakwb eng RC581-607 Marcela de Lima Moreira verfasserin aut The role of mucosal-associated invariant T cells in visceral leishmaniasis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. MAIT Leishmania anti-parasitic activity MR1 IL-17+MAIT IFN-γ+ MAIT Immunologic diseases. Allergy Marcela de Lima Moreira verfasserin aut Luana Oliveira Borges-Fernandes verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Marcelo Antônio Pascoal-Xavier verfasserin aut Ágata Lopes Ribeiro verfasserin aut Victória Hellena Silva Pereira verfasserin aut Troi Pediongco verfasserin aut Márcio Sobreira da Silva Araújo verfasserin aut Andréa Teixeira-Carvalho verfasserin aut Andrea Lucchesi de Carvalho verfasserin aut Maria Vitória Assumpção Mourão verfasserin aut Flávia Alves Campos verfasserin aut Marineide Borges verfasserin aut Mariângela Carneiro verfasserin aut Zhenjun Chen verfasserin aut Eleanor Saunders verfasserin aut Malcolm McConville verfasserin aut Moriya Tsuji verfasserin aut James McCluskey verfasserin aut Olindo Assis Martins-Filho verfasserin aut Sidonia Barbara Guiomar Eckle verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Jordana Grazziela Alves Coelho-dos-Reis verfasserin aut Vanessa Peruhype-Magalhães verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.926446 kostenfrei https://doaj.org/article/b8b6f2ab6e20411fa6f6ce956f5a0121 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.926446/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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Marcela de Lima Moreira @@aut@@ Luana Oliveira Borges-Fernandes @@aut@@ Marcelo Antônio Pascoal-Xavier @@aut@@ Ágata Lopes Ribeiro @@aut@@ Victória Hellena Silva Pereira @@aut@@ Troi Pediongco @@aut@@ Márcio Sobreira da Silva Araújo @@aut@@ Andréa Teixeira-Carvalho @@aut@@ Andrea Lucchesi de Carvalho @@aut@@ Maria Vitória Assumpção Mourão @@aut@@ Flávia Alves Campos @@aut@@ Marineide Borges @@aut@@ Mariângela Carneiro @@aut@@ Zhenjun Chen @@aut@@ Eleanor Saunders @@aut@@ Malcolm McConville @@aut@@ Moriya Tsuji @@aut@@ James McCluskey @@aut@@ Olindo Assis Martins-Filho @@aut@@ Sidonia Barbara Guiomar Eckle @@aut@@ Jordana Grazziela Alves Coelho-dos-Reis @@aut@@ Vanessa Peruhype-Magalhães @@aut@@ |
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RC581-607 The role of mucosal-associated invariant T cells in visceral leishmaniasis MAIT Leishmania anti-parasitic activity MR1 IL-17+MAIT IFN-γ+ MAIT |
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Marcela de Lima Moreira Luana Oliveira Borges-Fernandes Marcelo Antônio Pascoal-Xavier Ágata Lopes Ribeiro Victória Hellena Silva Pereira Troi Pediongco Márcio Sobreira da Silva Araújo Andréa Teixeira-Carvalho Andrea Lucchesi de Carvalho Maria Vitória Assumpção Mourão Flávia Alves Campos Marineide Borges Mariângela Carneiro Zhenjun Chen Eleanor Saunders Malcolm McConville Moriya Tsuji James McCluskey Olindo Assis Martins-Filho Sidonia Barbara Guiomar Eckle Jordana Grazziela Alves Coelho-dos-Reis Vanessa Peruhype-Magalhães |
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role of mucosal-associated invariant t cells in visceral leishmaniasis |
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The role of mucosal-associated invariant T cells in visceral leishmaniasis |
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Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. |
abstractGer |
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. |
abstract_unstemmed |
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by protozoan parasites of Leishmania donovani, is limited. This study showed that in response to L. infantum, human peripheral blood MAIT cells from children with leishmaniasis produced TNF and IFN-γ in an MR1-dependent manner. The overall frequency of MAIT cells was inversely correlated with alanine aminotransferase levels, a specific marker of liver damage strongly associated with severe hepatic involvement in VL. In addition, there was a positive correlation between total protein levels and the frequency of IL-17A+ CD8+ MAIT cells, whereby reduced total protein levels are a marker of liver and kidney damage. Furthermore, the frequencies of IFN-γ+ and IL-10+ MAIT cells were inversely correlated with hemoglobin levels, a marker of severe anemia. In asymptomatic individuals and VL patients after treatment, MAIT cells also produced IL-17A, a cytokine signature associated with resistance to visceral leishmaniasis, suggesting that MAIT cells play important role in protecting against VL. In summary, these results broaden our understanding of MAIT-cell immunity to include protection against parasitic infections, with implications for MAIT-cell-based therapeutics and vaccines. At last, this study paves the way for the investigation of putative MAIT cell antigens that could exist in the context of Leishmania infection. |
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title_short |
The role of mucosal-associated invariant T cells in visceral leishmaniasis |
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