Neoantigens in precision cancer immunotherapy: from identification to clinical applications

Abstract. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Qiao Zhang [verfasserIn] Qingzhu Jia [verfasserIn] Jing Zhang [verfasserIn] Bo Zhu [verfasserIn] Peifang Wei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Chinese Medical Journal - Wolters Kluwer, 2004, 135(2022), 11, Seite 1285-1298
Übergeordnetes Werk:	volume:135 ; year:2022 ; number:11 ; pages:1285-1298

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1097/CM9.0000000000002181

Katalog-ID:	DOAJ084895756

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spelling	10.1097/CM9.0000000000002181 doi (DE-627)DOAJ084895756 (DE-599)DOAJfcec5a764a774e389f82d711d9e52e22 DE-627 ger DE-627 rakwb eng Qiao Zhang verfasserin aut Neoantigens in precision cancer immunotherapy: from identification to clinical applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy. Medicine R Qingzhu Jia verfasserin aut Jing Zhang verfasserin aut Bo Zhu verfasserin aut Peifang Wei verfasserin aut In Chinese Medical Journal Wolters Kluwer, 2004 135(2022), 11, Seite 1285-1298 (DE-627)363772693 (DE-600)2108782-9 25425641 nnns volume:135 year:2022 number:11 pages:1285-1298 https://doi.org/10.1097/CM9.0000000000002181 kostenfrei https://doaj.org/article/fcec5a764a774e389f82d711d9e52e22 kostenfrei http://journals.lww.com/10.1097/CM9.0000000000002181 kostenfrei https://doaj.org/toc/0366-6999 Journal toc kostenfrei https://doaj.org/toc/2542-5641 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 135 2022 11 1285-1298
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allfieldsGer	10.1097/CM9.0000000000002181 doi (DE-627)DOAJ084895756 (DE-599)DOAJfcec5a764a774e389f82d711d9e52e22 DE-627 ger DE-627 rakwb eng Qiao Zhang verfasserin aut Neoantigens in precision cancer immunotherapy: from identification to clinical applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy. Medicine R Qingzhu Jia verfasserin aut Jing Zhang verfasserin aut Bo Zhu verfasserin aut Peifang Wei verfasserin aut In Chinese Medical Journal Wolters Kluwer, 2004 135(2022), 11, Seite 1285-1298 (DE-627)363772693 (DE-600)2108782-9 25425641 nnns volume:135 year:2022 number:11 pages:1285-1298 https://doi.org/10.1097/CM9.0000000000002181 kostenfrei https://doaj.org/article/fcec5a764a774e389f82d711d9e52e22 kostenfrei http://journals.lww.com/10.1097/CM9.0000000000002181 kostenfrei https://doaj.org/toc/0366-6999 Journal toc kostenfrei https://doaj.org/toc/2542-5641 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 135 2022 11 1285-1298
allfieldsSound	10.1097/CM9.0000000000002181 doi (DE-627)DOAJ084895756 (DE-599)DOAJfcec5a764a774e389f82d711d9e52e22 DE-627 ger DE-627 rakwb eng Qiao Zhang verfasserin aut Neoantigens in precision cancer immunotherapy: from identification to clinical applications 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy. Medicine R Qingzhu Jia verfasserin aut Jing Zhang verfasserin aut Bo Zhu verfasserin aut Peifang Wei verfasserin aut In Chinese Medical Journal Wolters Kluwer, 2004 135(2022), 11, Seite 1285-1298 (DE-627)363772693 (DE-600)2108782-9 25425641 nnns volume:135 year:2022 number:11 pages:1285-1298 https://doi.org/10.1097/CM9.0000000000002181 kostenfrei https://doaj.org/article/fcec5a764a774e389f82d711d9e52e22 kostenfrei http://journals.lww.com/10.1097/CM9.0000000000002181 kostenfrei https://doaj.org/toc/0366-6999 Journal toc kostenfrei https://doaj.org/toc/2542-5641 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 135 2022 11 1285-1298
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source	In Chinese Medical Journal 135(2022), 11, Seite 1285-1298 volume:135 year:2022 number:11 pages:1285-1298
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authorswithroles_txt_mv	Qiao Zhang @@aut@@ Qingzhu Jia @@aut@@ Jing Zhang @@aut@@ Bo Zhu @@aut@@ Peifang Wei @@aut@@
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author	Qiao Zhang
spellingShingle	Qiao Zhang misc Medicine misc R Neoantigens in precision cancer immunotherapy: from identification to clinical applications
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title	Neoantigens in precision cancer immunotherapy: from identification to clinical applications
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title_sort	neoantigens in precision cancer immunotherapy: from identification to clinical applications
title_auth	Neoantigens in precision cancer immunotherapy: from identification to clinical applications
abstract	Abstract. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy.
abstractGer	Abstract. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy.
abstract_unstemmed	Abstract. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy.
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title_short	Neoantigens in precision cancer immunotherapy: from identification to clinical applications
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