Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i<

Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the...
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Autor*in:	Meseret Gebre [verfasserIn] Kassa Haile [verfasserIn] Trevor Duke [verfasserIn] Md. Tanveer Faruk [verfasserIn] Mehnaz Kamal [verfasserIn] Md Farhad Kabir [verfasserIn] Md. Fakhar Uddin [verfasserIn] Muluye Shimelis [verfasserIn] Bethelhem Solomon [verfasserIn] Abebe Genetu Bayih [verfasserIn] Alemseged Abdissa [verfasserIn] Taye Tolera Balcha [verfasserIn] Rahel Argaw [verfasserIn] Asrat Demtse [verfasserIn] Abate Yeshidenber [verfasserIn] Abayneh Girma [verfasserIn] Bitseat W. Haile [verfasserIn] Tahmeed Ahmed [verfasserIn] John D. Clemens [verfasserIn] Mohammod Jobayer Chisti [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	bubble continuous positive airway pressure severe pneumonia hypoxemia

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2022), 17, p 4934
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:17, p 4934

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm11174934

Katalog-ID:	DOAJ084935111

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allfields	10.3390/jcm11174934 doi (DE-627)DOAJ084935111 (DE-599)DOAJ1e67c704e1a149e29b24e64e7cc95517 DE-627 ger DE-627 rakwb eng Meseret Gebre verfasserin aut Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting. bubble continuous positive airway pressure severe pneumonia hypoxemia Medicine R Kassa Haile verfasserin aut Trevor Duke verfasserin aut Md. Tanveer Faruk verfasserin aut Mehnaz Kamal verfasserin aut Md Farhad Kabir verfasserin aut Md. Fakhar Uddin verfasserin aut Muluye Shimelis verfasserin aut Bethelhem Solomon verfasserin aut Abebe Genetu Bayih verfasserin aut Alemseged Abdissa verfasserin aut Taye Tolera Balcha verfasserin aut Rahel Argaw verfasserin aut Asrat Demtse verfasserin aut Abate Yeshidenber verfasserin aut Abayneh Girma verfasserin aut Bitseat W. Haile verfasserin aut Tahmeed Ahmed verfasserin aut John D. Clemens verfasserin aut Mohammod Jobayer Chisti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 17, p 4934 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:17, p 4934 https://doi.org/10.3390/jcm11174934 kostenfrei https://doaj.org/article/1e67c704e1a149e29b24e64e7cc95517 kostenfrei https://www.mdpi.com/2077-0383/11/17/4934 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 4934
spelling	10.3390/jcm11174934 doi (DE-627)DOAJ084935111 (DE-599)DOAJ1e67c704e1a149e29b24e64e7cc95517 DE-627 ger DE-627 rakwb eng Meseret Gebre verfasserin aut Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting. bubble continuous positive airway pressure severe pneumonia hypoxemia Medicine R Kassa Haile verfasserin aut Trevor Duke verfasserin aut Md. Tanveer Faruk verfasserin aut Mehnaz Kamal verfasserin aut Md Farhad Kabir verfasserin aut Md. Fakhar Uddin verfasserin aut Muluye Shimelis verfasserin aut Bethelhem Solomon verfasserin aut Abebe Genetu Bayih verfasserin aut Alemseged Abdissa verfasserin aut Taye Tolera Balcha verfasserin aut Rahel Argaw verfasserin aut Asrat Demtse verfasserin aut Abate Yeshidenber verfasserin aut Abayneh Girma verfasserin aut Bitseat W. Haile verfasserin aut Tahmeed Ahmed verfasserin aut John D. Clemens verfasserin aut Mohammod Jobayer Chisti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 17, p 4934 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:17, p 4934 https://doi.org/10.3390/jcm11174934 kostenfrei https://doaj.org/article/1e67c704e1a149e29b24e64e7cc95517 kostenfrei https://www.mdpi.com/2077-0383/11/17/4934 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 4934
allfields_unstemmed	10.3390/jcm11174934 doi (DE-627)DOAJ084935111 (DE-599)DOAJ1e67c704e1a149e29b24e64e7cc95517 DE-627 ger DE-627 rakwb eng Meseret Gebre verfasserin aut Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting. bubble continuous positive airway pressure severe pneumonia hypoxemia Medicine R Kassa Haile verfasserin aut Trevor Duke verfasserin aut Md. Tanveer Faruk verfasserin aut Mehnaz Kamal verfasserin aut Md Farhad Kabir verfasserin aut Md. Fakhar Uddin verfasserin aut Muluye Shimelis verfasserin aut Bethelhem Solomon verfasserin aut Abebe Genetu Bayih verfasserin aut Alemseged Abdissa verfasserin aut Taye Tolera Balcha verfasserin aut Rahel Argaw verfasserin aut Asrat Demtse verfasserin aut Abate Yeshidenber verfasserin aut Abayneh Girma verfasserin aut Bitseat W. Haile verfasserin aut Tahmeed Ahmed verfasserin aut John D. Clemens verfasserin aut Mohammod Jobayer Chisti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 17, p 4934 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:17, p 4934 https://doi.org/10.3390/jcm11174934 kostenfrei https://doaj.org/article/1e67c704e1a149e29b24e64e7cc95517 kostenfrei https://www.mdpi.com/2077-0383/11/17/4934 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 4934
allfieldsGer	10.3390/jcm11174934 doi (DE-627)DOAJ084935111 (DE-599)DOAJ1e67c704e1a149e29b24e64e7cc95517 DE-627 ger DE-627 rakwb eng Meseret Gebre verfasserin aut Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting. bubble continuous positive airway pressure severe pneumonia hypoxemia Medicine R Kassa Haile verfasserin aut Trevor Duke verfasserin aut Md. Tanveer Faruk verfasserin aut Mehnaz Kamal verfasserin aut Md Farhad Kabir verfasserin aut Md. Fakhar Uddin verfasserin aut Muluye Shimelis verfasserin aut Bethelhem Solomon verfasserin aut Abebe Genetu Bayih verfasserin aut Alemseged Abdissa verfasserin aut Taye Tolera Balcha verfasserin aut Rahel Argaw verfasserin aut Asrat Demtse verfasserin aut Abate Yeshidenber verfasserin aut Abayneh Girma verfasserin aut Bitseat W. Haile verfasserin aut Tahmeed Ahmed verfasserin aut John D. Clemens verfasserin aut Mohammod Jobayer Chisti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 17, p 4934 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:17, p 4934 https://doi.org/10.3390/jcm11174934 kostenfrei https://doaj.org/article/1e67c704e1a149e29b24e64e7cc95517 kostenfrei https://www.mdpi.com/2077-0383/11/17/4934 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 4934
allfieldsSound	10.3390/jcm11174934 doi (DE-627)DOAJ084935111 (DE-599)DOAJ1e67c704e1a149e29b24e64e7cc95517 DE-627 ger DE-627 rakwb eng Meseret Gebre verfasserin aut Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting. bubble continuous positive airway pressure severe pneumonia hypoxemia Medicine R Kassa Haile verfasserin aut Trevor Duke verfasserin aut Md. Tanveer Faruk verfasserin aut Mehnaz Kamal verfasserin aut Md Farhad Kabir verfasserin aut Md. Fakhar Uddin verfasserin aut Muluye Shimelis verfasserin aut Bethelhem Solomon verfasserin aut Abebe Genetu Bayih verfasserin aut Alemseged Abdissa verfasserin aut Taye Tolera Balcha verfasserin aut Rahel Argaw verfasserin aut Asrat Demtse verfasserin aut Abate Yeshidenber verfasserin aut Abayneh Girma verfasserin aut Bitseat W. Haile verfasserin aut Tahmeed Ahmed verfasserin aut John D. Clemens verfasserin aut Mohammod Jobayer Chisti verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2022), 17, p 4934 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2022 number:17, p 4934 https://doi.org/10.3390/jcm11174934 kostenfrei https://doaj.org/article/1e67c704e1a149e29b24e64e7cc95517 kostenfrei https://www.mdpi.com/2077-0383/11/17/4934 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 4934
language	English
source	In Journal of Clinical Medicine 11(2022), 17, p 4934 volume:11 year:2022 number:17, p 4934
sourceStr	In Journal of Clinical Medicine 11(2022), 17, p 4934 volume:11 year:2022 number:17, p 4934
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	bubble continuous positive airway pressure severe pneumonia hypoxemia Medicine R
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container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Meseret Gebre @@aut@@ Kassa Haile @@aut@@ Trevor Duke @@aut@@ Md. Tanveer Faruk @@aut@@ Mehnaz Kamal @@aut@@ Md Farhad Kabir @@aut@@ Md. Fakhar Uddin @@aut@@ Muluye Shimelis @@aut@@ Bethelhem Solomon @@aut@@ Abebe Genetu Bayih @@aut@@ Alemseged Abdissa @@aut@@ Taye Tolera Balcha @@aut@@ Rahel Argaw @@aut@@ Asrat Demtse @@aut@@ Abate Yeshidenber @@aut@@ Abayneh Girma @@aut@@ Bitseat W. Haile @@aut@@ Tahmeed Ahmed @@aut@@ John D. Clemens @@aut@@ Mohammod Jobayer Chisti @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	718632478
id	DOAJ084935111
language_de	englisch
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author	Meseret Gebre
spellingShingle	Meseret Gebre misc bubble continuous positive airway pressure misc severe pneumonia misc hypoxemia misc Medicine misc R Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i<
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topic_title	Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i< bubble continuous positive airway pressure severe pneumonia hypoxemia
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title	Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i<
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title_full	Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i<
author_sort	Meseret Gebre
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author_browse	Meseret Gebre Kassa Haile Trevor Duke Md. Tanveer Faruk Mehnaz Kamal Md Farhad Kabir Md. Fakhar Uddin Muluye Shimelis Bethelhem Solomon Abebe Genetu Bayih Alemseged Abdissa Taye Tolera Balcha Rahel Argaw Asrat Demtse Abate Yeshidenber Abayneh Girma Bitseat W. Haile Tahmeed Ahmed John D. Clemens Mohammod Jobayer Chisti
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title_sort	effectiveness of bubble continuous positive airway pressure (bcpap) for treatment of children aged 1–59 months with severe pneumonia and hypoxemia in ethiopia: a <i<pragmatic cluster randomized controlled clinical trial</i<
title_auth	Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i<
abstract	Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting.
abstractGer	Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting.
abstract_unstemmed	Despite the beneficial effect of bubble continuous positive airway pressure (BCPAP) oxygen therapy for children with severe pneumonia under the supervision of physicians that has been shown in different studies, effectiveness trials in developing country settings where low-flow oxygen therapy is the standard of care are still needed. Thus, the aim of this study is to assess the effectiveness of bubble CPAP oxygen therapy compared to the WHO standard low-flow oxygen therapy among children hospitalized with severe pneumonia and hypoxemia in Ethiopia. This is a cluster randomized controlled trial where six district hospitals are randomized to BCPAP and six to standard WHO low-flow oxygen therapy. The total sample size is 620 per arm. Currently, recruitment of the patients is still ongoing where the management and follow-up of the enrolled patients are performed by general physicians and nurses under the supervision of pediatricians. The primary outcome is treatment failure and main secondary outcome is death. We anticipate to complete enrollment by September 2022 and data analysis followed by manuscript writing by December 2022. Findings will also be disseminated in December 2022. Our study will provide data on the effectiveness of BCPAP in treating childhood severe pneumonia and hypoxemia in a real-world setting.
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title_short	Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i<
url	https://doi.org/10.3390/jcm11174934 https://doaj.org/article/1e67c704e1a149e29b24e64e7cc95517 https://www.mdpi.com/2077-0383/11/17/4934 https://doaj.org/toc/2077-0383
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Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1–59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: A <i<Pragmatic Cluster Randomized Controlled Clinical Trial</i<

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