A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease

Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte migh...
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Autor*in:	Fulei Zhao [verfasserIn] Chen Zhang [verfasserIn] Guolin Li [verfasserIn] Huaping Zheng [verfasserIn] Linna Gu [verfasserIn] Hong Zhou [verfasserIn] Yuanyuan Xiao [verfasserIn] Zhen Wang [verfasserIn] Jiadong Yu [verfasserIn] Yawen Hu [verfasserIn] Fanlian Zeng [verfasserIn] Xiaoyan Wang [verfasserIn] Qixiang Zhao [verfasserIn] Jing Hu [verfasserIn] Chengcheng Yue [verfasserIn] Pei Zhou [verfasserIn] Nongyu Huang [verfasserIn] Yan Hao [verfasserIn] Wenling Wu [verfasserIn] Kaijun Cui [verfasserIn] Wei Li [verfasserIn] Jiong Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	psoriasis keratinocytes WFDC12 inflammation retinoic acid

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.873720

Katalog-ID:	DOAJ08496619X

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520			\|a Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice.
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allfields	10.3389/fimmu.2022.873720 doi (DE-627)DOAJ08496619X (DE-599)DOAJ882328759e0243609ace96bdeda93ecf DE-627 ger DE-627 rakwb eng RC581-607 Fulei Zhao verfasserin aut A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice. psoriasis keratinocytes WFDC12 inflammation retinoic acid Immunologic diseases. Allergy Chen Zhang verfasserin aut Guolin Li verfasserin aut Huaping Zheng verfasserin aut Linna Gu verfasserin aut Hong Zhou verfasserin aut Yuanyuan Xiao verfasserin aut Yuanyuan Xiao verfasserin aut Zhen Wang verfasserin aut Jiadong Yu verfasserin aut Yawen Hu verfasserin aut Fanlian Zeng verfasserin aut Xiaoyan Wang verfasserin aut Qixiang Zhao verfasserin aut Jing Hu verfasserin aut Chengcheng Yue verfasserin aut Pei Zhou verfasserin aut Nongyu Huang verfasserin aut Yan Hao verfasserin aut Wenling Wu verfasserin aut Kaijun Cui verfasserin aut Wei Li verfasserin aut Jiong Li verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.873720 kostenfrei https://doaj.org/article/882328759e0243609ace96bdeda93ecf kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.873720/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fimmu.2022.873720 doi (DE-627)DOAJ08496619X (DE-599)DOAJ882328759e0243609ace96bdeda93ecf DE-627 ger DE-627 rakwb eng RC581-607 Fulei Zhao verfasserin aut A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice. psoriasis keratinocytes WFDC12 inflammation retinoic acid Immunologic diseases. Allergy Chen Zhang verfasserin aut Guolin Li verfasserin aut Huaping Zheng verfasserin aut Linna Gu verfasserin aut Hong Zhou verfasserin aut Yuanyuan Xiao verfasserin aut Yuanyuan Xiao verfasserin aut Zhen Wang verfasserin aut Jiadong Yu verfasserin aut Yawen Hu verfasserin aut Fanlian Zeng verfasserin aut Xiaoyan Wang verfasserin aut Qixiang Zhao verfasserin aut Jing Hu verfasserin aut Chengcheng Yue verfasserin aut Pei Zhou verfasserin aut Nongyu Huang verfasserin aut Yan Hao verfasserin aut Wenling Wu verfasserin aut Kaijun Cui verfasserin aut Wei Li verfasserin aut Jiong Li verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.873720 kostenfrei https://doaj.org/article/882328759e0243609ace96bdeda93ecf kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.873720/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfields_unstemmed	10.3389/fimmu.2022.873720 doi (DE-627)DOAJ08496619X (DE-599)DOAJ882328759e0243609ace96bdeda93ecf DE-627 ger DE-627 rakwb eng RC581-607 Fulei Zhao verfasserin aut A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice. psoriasis keratinocytes WFDC12 inflammation retinoic acid Immunologic diseases. Allergy Chen Zhang verfasserin aut Guolin Li verfasserin aut Huaping Zheng verfasserin aut Linna Gu verfasserin aut Hong Zhou verfasserin aut Yuanyuan Xiao verfasserin aut Yuanyuan Xiao verfasserin aut Zhen Wang verfasserin aut Jiadong Yu verfasserin aut Yawen Hu verfasserin aut Fanlian Zeng verfasserin aut Xiaoyan Wang verfasserin aut Qixiang Zhao verfasserin aut Jing Hu verfasserin aut Chengcheng Yue verfasserin aut Pei Zhou verfasserin aut Nongyu Huang verfasserin aut Yan Hao verfasserin aut Wenling Wu verfasserin aut Kaijun Cui verfasserin aut Wei Li verfasserin aut Jiong Li verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.873720 kostenfrei https://doaj.org/article/882328759e0243609ace96bdeda93ecf kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.873720/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsGer	10.3389/fimmu.2022.873720 doi (DE-627)DOAJ08496619X (DE-599)DOAJ882328759e0243609ace96bdeda93ecf DE-627 ger DE-627 rakwb eng RC581-607 Fulei Zhao verfasserin aut A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice. psoriasis keratinocytes WFDC12 inflammation retinoic acid Immunologic diseases. Allergy Chen Zhang verfasserin aut Guolin Li verfasserin aut Huaping Zheng verfasserin aut Linna Gu verfasserin aut Hong Zhou verfasserin aut Yuanyuan Xiao verfasserin aut Yuanyuan Xiao verfasserin aut Zhen Wang verfasserin aut Jiadong Yu verfasserin aut Yawen Hu verfasserin aut Fanlian Zeng verfasserin aut Xiaoyan Wang verfasserin aut Qixiang Zhao verfasserin aut Jing Hu verfasserin aut Chengcheng Yue verfasserin aut Pei Zhou verfasserin aut Nongyu Huang verfasserin aut Yan Hao verfasserin aut Wenling Wu verfasserin aut Kaijun Cui verfasserin aut Wei Li verfasserin aut Jiong Li verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.873720 kostenfrei https://doaj.org/article/882328759e0243609ace96bdeda93ecf kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.873720/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fimmu.2022.873720 doi (DE-627)DOAJ08496619X (DE-599)DOAJ882328759e0243609ace96bdeda93ecf DE-627 ger DE-627 rakwb eng RC581-607 Fulei Zhao verfasserin aut A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice. psoriasis keratinocytes WFDC12 inflammation retinoic acid Immunologic diseases. Allergy Chen Zhang verfasserin aut Guolin Li verfasserin aut Huaping Zheng verfasserin aut Linna Gu verfasserin aut Hong Zhou verfasserin aut Yuanyuan Xiao verfasserin aut Yuanyuan Xiao verfasserin aut Zhen Wang verfasserin aut Jiadong Yu verfasserin aut Yawen Hu verfasserin aut Fanlian Zeng verfasserin aut Xiaoyan Wang verfasserin aut Qixiang Zhao verfasserin aut Jing Hu verfasserin aut Chengcheng Yue verfasserin aut Pei Zhou verfasserin aut Nongyu Huang verfasserin aut Yan Hao verfasserin aut Wenling Wu verfasserin aut Kaijun Cui verfasserin aut Wei Li verfasserin aut Jiong Li verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.873720 kostenfrei https://doaj.org/article/882328759e0243609ace96bdeda93ecf kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.873720/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
language	English
source	In Frontiers in Immunology 13(2022) volume:13 year:2022
sourceStr	In Frontiers in Immunology 13(2022) volume:13 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	psoriasis keratinocytes WFDC12 inflammation retinoic acid Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Frontiers in Immunology
authorswithroles_txt_mv	Fulei Zhao @@aut@@ Chen Zhang @@aut@@ Guolin Li @@aut@@ Huaping Zheng @@aut@@ Linna Gu @@aut@@ Hong Zhou @@aut@@ Yuanyuan Xiao @@aut@@ Zhen Wang @@aut@@ Jiadong Yu @@aut@@ Yawen Hu @@aut@@ Fanlian Zeng @@aut@@ Xiaoyan Wang @@aut@@ Qixiang Zhao @@aut@@ Jing Hu @@aut@@ Chengcheng Yue @@aut@@ Pei Zhou @@aut@@ Nongyu Huang @@aut@@ Yan Hao @@aut@@ Wenling Wu @@aut@@ Kaijun Cui @@aut@@ Wei Li @@aut@@ Jiong Li @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	657998354
id	DOAJ08496619X
language_de	englisch
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callnumber-first	R - Medicine
author	Fulei Zhao
spellingShingle	Fulei Zhao misc RC581-607 misc psoriasis misc keratinocytes misc WFDC12 misc inflammation misc retinoic acid misc Immunologic diseases. Allergy A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease
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topic_title	RC581-607 A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease psoriasis keratinocytes WFDC12 inflammation retinoic acid
topic	misc RC581-607 misc psoriasis misc keratinocytes misc WFDC12 misc inflammation misc retinoic acid misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc psoriasis misc keratinocytes misc WFDC12 misc inflammation misc retinoic acid misc Immunologic diseases. Allergy
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title	A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease
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title_full	A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease
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author_browse	Fulei Zhao Chen Zhang Guolin Li Huaping Zheng Linna Gu Hong Zhou Yuanyuan Xiao Zhen Wang Jiadong Yu Yawen Hu Fanlian Zeng Xiaoyan Wang Qixiang Zhao Jing Hu Chengcheng Yue Pei Zhou Nongyu Huang Yan Hao Wenling Wu Kaijun Cui Wei Li Jiong Li
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title_sort	role for whey acidic protein four-disulfide-core 12 (wfdc12) in the pathogenesis and development of psoriasis disease
callnumber	RC581-607
title_auth	A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease
abstract	Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice.
abstractGer	Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice.
abstract_unstemmed	Whey acidic protein four-disulfide core domain protein 12 (WFDC12) has been implicated in the pathogenesis of psoriasis but the specific molecular mechanism is not clearly defined. In this study, we found the expression of WFDC12 protein closely correlated with psoriasis. WFDC12 in keratinocyte might increase infiltration of Langerhans cells (LCs) and monocyte-derived dendritic cells (moDDCs), up-regulating the co-stimulation molecular CD40/CD86. Th1 cells in lymph nodes were higher in K14-WFDC12 transgenic psoiasis-like mice. Meanwhile, the mRNA of IL-12 and IFN-γ in the lesion skin was significantly increased in transgenic mice. Moreover, we found that the expression of the proteins that participated in the retinoic acid–related pathway and immune signaling pathway was more changed in the lesion skin of K14-WFDC12 transgenic psoriasis-like mice. Collectively, the results implied that WFDC12 might affect the activation of the retinoic acid signaling pathway and regulate the infiltration of DC cells in the skin lesions and lymph nodes, thereby inducing Th1 cells differentiation and increasing the secretion of IFN-γ to exacerbate psoriasis in mice.
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title_short	A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease
url	https://doi.org/10.3389/fimmu.2022.873720 https://doaj.org/article/882328759e0243609ace96bdeda93ecf https://www.frontiersin.org/articles/10.3389/fimmu.2022.873720/full https://doaj.org/toc/1664-3224
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author2	Chen Zhang Guolin Li Huaping Zheng Linna Gu Hong Zhou Yuanyuan Xiao Zhen Wang Jiadong Yu Yawen Hu Fanlian Zeng Xiaoyan Wang Qixiang Zhao Jing Hu Chengcheng Yue Pei Zhou Nongyu Huang Yan Hao Wenling Wu Kaijun Cui Wei Li Jiong Li
author2Str	Chen Zhang Guolin Li Huaping Zheng Linna Gu Hong Zhou Yuanyuan Xiao Zhen Wang Jiadong Yu Yawen Hu Fanlian Zeng Xiaoyan Wang Qixiang Zhao Jing Hu Chengcheng Yue Pei Zhou Nongyu Huang Yan Hao Wenling Wu Kaijun Cui Wei Li Jiong Li
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up_date	2024-07-04T01:17:44.512Z
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A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease

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