Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis

Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary...
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Autor*in:	Dimitrios A. Vrachatis [verfasserIn] Konstantinos A. Papathanasiou [verfasserIn] Dimitrios Kazantzis [verfasserIn] Jorge Sanz-Sánchez [verfasserIn] Sotiria G. Giotaki [verfasserIn] Konstantinos Raisakis [verfasserIn] Andreas Kaoukis [verfasserIn] Charalampos Kossyvakis [verfasserIn] Gerasimos Deftereos [verfasserIn] Bernhard Reimers [verfasserIn] Dimitrios Avramides [verfasserIn] Gerasimos Siasos [verfasserIn] Michael Cleman [verfasserIn] George Giannopoulos [verfasserIn] Alexandra Lansky [verfasserIn] Spyridon Deftereos [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio

Übergeordnetes Werk:	In: Diagnostics - MDPI AG, 2012, 12(2022), 5, p 1026
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:5, p 1026

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/diagnostics12051026

Katalog-ID:	DOAJ085011304

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allfields	10.3390/diagnostics12051026 doi (DE-627)DOAJ085011304 (DE-599)DOAJf460e1d0aaa8453f9fbda2b1a58a73e6 DE-627 ger DE-627 rakwb eng R5-920 Dimitrios A. Vrachatis verfasserin aut Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation. coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio Medicine (General) Konstantinos A. Papathanasiou verfasserin aut Dimitrios Kazantzis verfasserin aut Jorge Sanz-Sánchez verfasserin aut Sotiria G. Giotaki verfasserin aut Konstantinos Raisakis verfasserin aut Andreas Kaoukis verfasserin aut Charalampos Kossyvakis verfasserin aut Gerasimos Deftereos verfasserin aut Bernhard Reimers verfasserin aut Dimitrios Avramides verfasserin aut Gerasimos Siasos verfasserin aut Michael Cleman verfasserin aut George Giannopoulos verfasserin aut Alexandra Lansky verfasserin aut Spyridon Deftereos verfasserin aut In Diagnostics MDPI AG, 2012 12(2022), 5, p 1026 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:12 year:2022 number:5, p 1026 https://doi.org/10.3390/diagnostics12051026 kostenfrei https://doaj.org/article/f460e1d0aaa8453f9fbda2b1a58a73e6 kostenfrei https://www.mdpi.com/2075-4418/12/5/1026 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 5, p 1026
spelling	10.3390/diagnostics12051026 doi (DE-627)DOAJ085011304 (DE-599)DOAJf460e1d0aaa8453f9fbda2b1a58a73e6 DE-627 ger DE-627 rakwb eng R5-920 Dimitrios A. Vrachatis verfasserin aut Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation. coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio Medicine (General) Konstantinos A. Papathanasiou verfasserin aut Dimitrios Kazantzis verfasserin aut Jorge Sanz-Sánchez verfasserin aut Sotiria G. Giotaki verfasserin aut Konstantinos Raisakis verfasserin aut Andreas Kaoukis verfasserin aut Charalampos Kossyvakis verfasserin aut Gerasimos Deftereos verfasserin aut Bernhard Reimers verfasserin aut Dimitrios Avramides verfasserin aut Gerasimos Siasos verfasserin aut Michael Cleman verfasserin aut George Giannopoulos verfasserin aut Alexandra Lansky verfasserin aut Spyridon Deftereos verfasserin aut In Diagnostics MDPI AG, 2012 12(2022), 5, p 1026 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:12 year:2022 number:5, p 1026 https://doi.org/10.3390/diagnostics12051026 kostenfrei https://doaj.org/article/f460e1d0aaa8453f9fbda2b1a58a73e6 kostenfrei https://www.mdpi.com/2075-4418/12/5/1026 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 5, p 1026
allfields_unstemmed	10.3390/diagnostics12051026 doi (DE-627)DOAJ085011304 (DE-599)DOAJf460e1d0aaa8453f9fbda2b1a58a73e6 DE-627 ger DE-627 rakwb eng R5-920 Dimitrios A. Vrachatis verfasserin aut Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation. coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio Medicine (General) Konstantinos A. Papathanasiou verfasserin aut Dimitrios Kazantzis verfasserin aut Jorge Sanz-Sánchez verfasserin aut Sotiria G. Giotaki verfasserin aut Konstantinos Raisakis verfasserin aut Andreas Kaoukis verfasserin aut Charalampos Kossyvakis verfasserin aut Gerasimos Deftereos verfasserin aut Bernhard Reimers verfasserin aut Dimitrios Avramides verfasserin aut Gerasimos Siasos verfasserin aut Michael Cleman verfasserin aut George Giannopoulos verfasserin aut Alexandra Lansky verfasserin aut Spyridon Deftereos verfasserin aut In Diagnostics MDPI AG, 2012 12(2022), 5, p 1026 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:12 year:2022 number:5, p 1026 https://doi.org/10.3390/diagnostics12051026 kostenfrei https://doaj.org/article/f460e1d0aaa8453f9fbda2b1a58a73e6 kostenfrei https://www.mdpi.com/2075-4418/12/5/1026 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 5, p 1026
allfieldsGer	10.3390/diagnostics12051026 doi (DE-627)DOAJ085011304 (DE-599)DOAJf460e1d0aaa8453f9fbda2b1a58a73e6 DE-627 ger DE-627 rakwb eng R5-920 Dimitrios A. Vrachatis verfasserin aut Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation. coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio Medicine (General) Konstantinos A. Papathanasiou verfasserin aut Dimitrios Kazantzis verfasserin aut Jorge Sanz-Sánchez verfasserin aut Sotiria G. Giotaki verfasserin aut Konstantinos Raisakis verfasserin aut Andreas Kaoukis verfasserin aut Charalampos Kossyvakis verfasserin aut Gerasimos Deftereos verfasserin aut Bernhard Reimers verfasserin aut Dimitrios Avramides verfasserin aut Gerasimos Siasos verfasserin aut Michael Cleman verfasserin aut George Giannopoulos verfasserin aut Alexandra Lansky verfasserin aut Spyridon Deftereos verfasserin aut In Diagnostics MDPI AG, 2012 12(2022), 5, p 1026 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:12 year:2022 number:5, p 1026 https://doi.org/10.3390/diagnostics12051026 kostenfrei https://doaj.org/article/f460e1d0aaa8453f9fbda2b1a58a73e6 kostenfrei https://www.mdpi.com/2075-4418/12/5/1026 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 5, p 1026
allfieldsSound	10.3390/diagnostics12051026 doi (DE-627)DOAJ085011304 (DE-599)DOAJf460e1d0aaa8453f9fbda2b1a58a73e6 DE-627 ger DE-627 rakwb eng R5-920 Dimitrios A. Vrachatis verfasserin aut Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation. coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio Medicine (General) Konstantinos A. Papathanasiou verfasserin aut Dimitrios Kazantzis verfasserin aut Jorge Sanz-Sánchez verfasserin aut Sotiria G. Giotaki verfasserin aut Konstantinos Raisakis verfasserin aut Andreas Kaoukis verfasserin aut Charalampos Kossyvakis verfasserin aut Gerasimos Deftereos verfasserin aut Bernhard Reimers verfasserin aut Dimitrios Avramides verfasserin aut Gerasimos Siasos verfasserin aut Michael Cleman verfasserin aut George Giannopoulos verfasserin aut Alexandra Lansky verfasserin aut Spyridon Deftereos verfasserin aut In Diagnostics MDPI AG, 2012 12(2022), 5, p 1026 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:12 year:2022 number:5, p 1026 https://doi.org/10.3390/diagnostics12051026 kostenfrei https://doaj.org/article/f460e1d0aaa8453f9fbda2b1a58a73e6 kostenfrei https://www.mdpi.com/2075-4418/12/5/1026 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 5, p 1026
language	English
source	In Diagnostics 12(2022), 5, p 1026 volume:12 year:2022 number:5, p 1026
sourceStr	In Diagnostics 12(2022), 5, p 1026 volume:12 year:2022 number:5, p 1026
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio Medicine (General)
isfreeaccess_bool	true
container_title	Diagnostics
authorswithroles_txt_mv	Dimitrios A. Vrachatis @@aut@@ Konstantinos A. Papathanasiou @@aut@@ Dimitrios Kazantzis @@aut@@ Jorge Sanz-Sánchez @@aut@@ Sotiria G. Giotaki @@aut@@ Konstantinos Raisakis @@aut@@ Andreas Kaoukis @@aut@@ Charalampos Kossyvakis @@aut@@ Gerasimos Deftereos @@aut@@ Bernhard Reimers @@aut@@ Dimitrios Avramides @@aut@@ Gerasimos Siasos @@aut@@ Michael Cleman @@aut@@ George Giannopoulos @@aut@@ Alexandra Lansky @@aut@@ Spyridon Deftereos @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	718627814
id	DOAJ085011304
language_de	englisch
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callnumber-first	R - Medicine
author	Dimitrios A. Vrachatis
spellingShingle	Dimitrios A. Vrachatis misc R5-920 misc coronary artery ectasia misc inflammation misc biomarkers misc neutrophil lymphocyte ratio misc Medicine (General) Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis
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topic_title	R5-920 Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio
topic	misc R5-920 misc coronary artery ectasia misc inflammation misc biomarkers misc neutrophil lymphocyte ratio misc Medicine (General)
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title	Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis
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title_full	Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis
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author_browse	Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Dimitrios Kazantzis Jorge Sanz-Sánchez Sotiria G. Giotaki Konstantinos Raisakis Andreas Kaoukis Charalampos Kossyvakis Gerasimos Deftereos Bernhard Reimers Dimitrios Avramides Gerasimos Siasos Michael Cleman George Giannopoulos Alexandra Lansky Spyridon Deftereos
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title_sort	inflammatory biomarkers in coronary artery ectasia: a systematic review and meta-analysis
callnumber	R5-920
title_auth	Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis
abstract	Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation.
abstractGer	Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation.
abstract_unstemmed	Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation.
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title_short	Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis
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