PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish

PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosom...
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Autor*in:	Xin Zhao [verfasserIn] Wenji Huang [verfasserIn] Yanjie Shi [verfasserIn] Jiahong Guo [verfasserIn] Hehe Xiao [verfasserIn] Ning Ji [verfasserIn] Jianhua Feng [verfasserIn] Huifeng Dang [verfasserIn] Jun Zou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	PLAAT1 IRF3 IRF7 interferon autophagy virus

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.979919

Katalog-ID:	DOAJ085025631

Internformat


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allfields	10.3389/fimmu.2022.979919 doi (DE-627)DOAJ085025631 (DE-599)DOAJd32b4abfc6be48c09b9c3be761b8818f DE-627 ger DE-627 rakwb eng RC581-607 Xin Zhao verfasserin aut PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection. PLAAT1 IRF3 IRF7 interferon autophagy virus Immunologic diseases. Allergy Xin Zhao verfasserin aut Xin Zhao verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.979919 kostenfrei https://doaj.org/article/d32b4abfc6be48c09b9c3be761b8818f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.979919/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fimmu.2022.979919 doi (DE-627)DOAJ085025631 (DE-599)DOAJd32b4abfc6be48c09b9c3be761b8818f DE-627 ger DE-627 rakwb eng RC581-607 Xin Zhao verfasserin aut PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection. PLAAT1 IRF3 IRF7 interferon autophagy virus Immunologic diseases. Allergy Xin Zhao verfasserin aut Xin Zhao verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.979919 kostenfrei https://doaj.org/article/d32b4abfc6be48c09b9c3be761b8818f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.979919/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
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allfieldsGer	10.3389/fimmu.2022.979919 doi (DE-627)DOAJ085025631 (DE-599)DOAJd32b4abfc6be48c09b9c3be761b8818f DE-627 ger DE-627 rakwb eng RC581-607 Xin Zhao verfasserin aut PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection. PLAAT1 IRF3 IRF7 interferon autophagy virus Immunologic diseases. Allergy Xin Zhao verfasserin aut Xin Zhao verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.979919 kostenfrei https://doaj.org/article/d32b4abfc6be48c09b9c3be761b8818f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.979919/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fimmu.2022.979919 doi (DE-627)DOAJ085025631 (DE-599)DOAJd32b4abfc6be48c09b9c3be761b8818f DE-627 ger DE-627 rakwb eng RC581-607 Xin Zhao verfasserin aut PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection. PLAAT1 IRF3 IRF7 interferon autophagy virus Immunologic diseases. Allergy Xin Zhao verfasserin aut Xin Zhao verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Wenji Huang verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Yanjie Shi verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Jiahong Guo verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Hehe Xiao verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Ning Ji verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Jianhua Feng verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Huifeng Dang verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut Jun Zou verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.979919 kostenfrei https://doaj.org/article/d32b4abfc6be48c09b9c3be761b8818f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.979919/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
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authorswithroles_txt_mv	Xin Zhao @@aut@@ Wenji Huang @@aut@@ Yanjie Shi @@aut@@ Jiahong Guo @@aut@@ Hehe Xiao @@aut@@ Ning Ji @@aut@@ Jianhua Feng @@aut@@ Huifeng Dang @@aut@@ Jun Zou @@aut@@
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callnumber-first	R - Medicine
author	Xin Zhao
spellingShingle	Xin Zhao misc RC581-607 misc PLAAT1 misc IRF3 misc IRF7 misc interferon misc autophagy misc virus misc Immunologic diseases. Allergy PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
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topic_title	RC581-607 PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish PLAAT1 IRF3 IRF7 interferon autophagy virus
topic	misc RC581-607 misc PLAAT1 misc IRF3 misc IRF7 misc interferon misc autophagy misc virus misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc PLAAT1 misc IRF3 misc IRF7 misc interferon misc autophagy misc virus misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc PLAAT1 misc IRF3 misc IRF7 misc interferon misc autophagy misc virus misc Immunologic diseases. Allergy
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title	PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
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title_full	PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
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author_browse	Xin Zhao Wenji Huang Yanjie Shi Jiahong Guo Hehe Xiao Ning Ji Jianhua Feng Huifeng Dang Jun Zou
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title_sort	plaat1 inhibits type i interferon response via degradation of irf3 and irf7 in zebrafish
callnumber	RC581-607
title_auth	PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
abstract	PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection.
abstractGer	PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection.
abstract_unstemmed	PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation and peroxisomal biogenesis. Recently, PLAAT1 has been shown to promote degradation of p53 protein and cellular organelles such as mitochondria, endoplasmic reticulum and lysosome. In this study, we show that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Overexpression of Plaat1 in zebrafish cells suppresses antiviral responses and promotes virus replication. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection.
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title_short	PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
url	https://doi.org/10.3389/fimmu.2022.979919 https://doaj.org/article/d32b4abfc6be48c09b9c3be761b8818f https://www.frontiersin.org/articles/10.3389/fimmu.2022.979919/full https://doaj.org/toc/1664-3224
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up_date	2024-07-04T01:32:40.157Z
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PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish

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