Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally. Atherosclerosis is characterized as a chronic inflammatory disease which involves inflammation and immune dysfunction. P. lactiflora Pall. is a p...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Wei Yu [verfasserIn] Iqra Ilyas [verfasserIn] Xuerui Hu [verfasserIn] Suowen Xu [verfasserIn] Hui Yu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	atherosclerosis cardiovascular disease paeoniflorin inflammation immunity

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2022.1072007

Katalog-ID:	DOAJ08507697X

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520			\|a Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally. Atherosclerosis is characterized as a chronic inflammatory disease which involves inflammation and immune dysfunction. P. lactiflora Pall. is a plant origin traditional medicine that has been widely used for the treatment of various diseases for more than a millennium in China, Japan and Korean. Paeoniflorin is a bioactive monomer extracted from P. lactiflora Pall. with anti-atherosclerosis effects. In this article, we comprehensively reviewed the potential therapeutic effects and molecular mechanism whereby paeoniflorin protects against atherosclerosis from the unique angle of inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, monocytes, macrophages, platelets and mast cells. Paeoniflorin, with multiple protective effects in atherosclerosis, has the potential to be used as a promising therapeutic agent for the treatment of atherosclerosis and its complications. We conclude with a detailed discussion of the challenges and future perspective of paeoniflorin in translational cardiovascular medicine.
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language	English
source	In Frontiers in Immunology 13(2022) volume:13 year:2022
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topic_facet	atherosclerosis cardiovascular disease paeoniflorin inflammation immunity Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Wei Yu @@aut@@ Iqra Ilyas @@aut@@ Xuerui Hu @@aut@@ Suowen Xu @@aut@@ Hui Yu @@aut@@
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callnumber-first	R - Medicine
author	Wei Yu
spellingShingle	Wei Yu misc RC581-607 misc atherosclerosis misc cardiovascular disease misc paeoniflorin misc inflammation misc immunity misc Immunologic diseases. Allergy Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective
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topic_title	RC581-607 Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective atherosclerosis cardiovascular disease paeoniflorin inflammation immunity
topic	misc RC581-607 misc atherosclerosis misc cardiovascular disease misc paeoniflorin misc inflammation misc immunity misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc atherosclerosis misc cardiovascular disease misc paeoniflorin misc inflammation misc immunity misc Immunologic diseases. Allergy
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title	Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective
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title_full	Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective
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title_auth	Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective
abstract	Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally. Atherosclerosis is characterized as a chronic inflammatory disease which involves inflammation and immune dysfunction. P. lactiflora Pall. is a plant origin traditional medicine that has been widely used for the treatment of various diseases for more than a millennium in China, Japan and Korean. Paeoniflorin is a bioactive monomer extracted from P. lactiflora Pall. with anti-atherosclerosis effects. In this article, we comprehensively reviewed the potential therapeutic effects and molecular mechanism whereby paeoniflorin protects against atherosclerosis from the unique angle of inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, monocytes, macrophages, platelets and mast cells. Paeoniflorin, with multiple protective effects in atherosclerosis, has the potential to be used as a promising therapeutic agent for the treatment of atherosclerosis and its complications. We conclude with a detailed discussion of the challenges and future perspective of paeoniflorin in translational cardiovascular medicine.
abstractGer	Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally. Atherosclerosis is characterized as a chronic inflammatory disease which involves inflammation and immune dysfunction. P. lactiflora Pall. is a plant origin traditional medicine that has been widely used for the treatment of various diseases for more than a millennium in China, Japan and Korean. Paeoniflorin is a bioactive monomer extracted from P. lactiflora Pall. with anti-atherosclerosis effects. In this article, we comprehensively reviewed the potential therapeutic effects and molecular mechanism whereby paeoniflorin protects against atherosclerosis from the unique angle of inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, monocytes, macrophages, platelets and mast cells. Paeoniflorin, with multiple protective effects in atherosclerosis, has the potential to be used as a promising therapeutic agent for the treatment of atherosclerosis and its complications. We conclude with a detailed discussion of the challenges and future perspective of paeoniflorin in translational cardiovascular medicine.
abstract_unstemmed	Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally. Atherosclerosis is characterized as a chronic inflammatory disease which involves inflammation and immune dysfunction. P. lactiflora Pall. is a plant origin traditional medicine that has been widely used for the treatment of various diseases for more than a millennium in China, Japan and Korean. Paeoniflorin is a bioactive monomer extracted from P. lactiflora Pall. with anti-atherosclerosis effects. In this article, we comprehensively reviewed the potential therapeutic effects and molecular mechanism whereby paeoniflorin protects against atherosclerosis from the unique angle of inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, monocytes, macrophages, platelets and mast cells. Paeoniflorin, with multiple protective effects in atherosclerosis, has the potential to be used as a promising therapeutic agent for the treatment of atherosclerosis and its complications. We conclude with a detailed discussion of the challenges and future perspective of paeoniflorin in translational cardiovascular medicine.
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title_short	Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective
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Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

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