Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy

Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still i...
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Autor*in:	Lei Chen [verfasserIn] Jinghui Zhang [verfasserIn] Lihua Xu [verfasserIn] Luchao Zhu [verfasserIn] Jinpeng Jing [verfasserIn] Yushuo Feng [verfasserIn] Zongzhang Wang [verfasserIn] Peifei Liu [verfasserIn] Wenjing Sun [verfasserIn] Xiangmei Liu [verfasserIn] Yimin Li [verfasserIn] Hongmin Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Radiosensitizers Semiconductors Reactive oxygen species Composition tunability X-ray induced photodynamic therapy

Übergeordnetes Werk:	In: Journal of Nanobiotechnology - BMC, 2003, 20(2022), 1, Seite 11
Übergeordnetes Werk:	volume:20 ; year:2022 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12951-022-01494-7

Katalog-ID:	DOAJ085084786

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allfields	10.1186/s12951-022-01494-7 doi (DE-627)DOAJ085084786 (DE-599)DOAJ28b192066bf0432abd8c3827d1b2337a DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Lei Chen verfasserin aut Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors. Radiosensitizers Semiconductors Reactive oxygen species Composition tunability X-ray induced photodynamic therapy Biotechnology Medical technology Jinghui Zhang verfasserin aut Lihua Xu verfasserin aut Luchao Zhu verfasserin aut Jinpeng Jing verfasserin aut Yushuo Feng verfasserin aut Zongzhang Wang verfasserin aut Peifei Liu verfasserin aut Wenjing Sun verfasserin aut Xiangmei Liu verfasserin aut Yimin Li verfasserin aut Hongmin Chen verfasserin aut In Journal of Nanobiotechnology BMC, 2003 20(2022), 1, Seite 11 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/article/28b192066bf0432abd8c3827d1b2337a kostenfrei https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
spelling	10.1186/s12951-022-01494-7 doi (DE-627)DOAJ085084786 (DE-599)DOAJ28b192066bf0432abd8c3827d1b2337a DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Lei Chen verfasserin aut Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors. Radiosensitizers Semiconductors Reactive oxygen species Composition tunability X-ray induced photodynamic therapy Biotechnology Medical technology Jinghui Zhang verfasserin aut Lihua Xu verfasserin aut Luchao Zhu verfasserin aut Jinpeng Jing verfasserin aut Yushuo Feng verfasserin aut Zongzhang Wang verfasserin aut Peifei Liu verfasserin aut Wenjing Sun verfasserin aut Xiangmei Liu verfasserin aut Yimin Li verfasserin aut Hongmin Chen verfasserin aut In Journal of Nanobiotechnology BMC, 2003 20(2022), 1, Seite 11 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/article/28b192066bf0432abd8c3827d1b2337a kostenfrei https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
allfields_unstemmed	10.1186/s12951-022-01494-7 doi (DE-627)DOAJ085084786 (DE-599)DOAJ28b192066bf0432abd8c3827d1b2337a DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Lei Chen verfasserin aut Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors. Radiosensitizers Semiconductors Reactive oxygen species Composition tunability X-ray induced photodynamic therapy Biotechnology Medical technology Jinghui Zhang verfasserin aut Lihua Xu verfasserin aut Luchao Zhu verfasserin aut Jinpeng Jing verfasserin aut Yushuo Feng verfasserin aut Zongzhang Wang verfasserin aut Peifei Liu verfasserin aut Wenjing Sun verfasserin aut Xiangmei Liu verfasserin aut Yimin Li verfasserin aut Hongmin Chen verfasserin aut In Journal of Nanobiotechnology BMC, 2003 20(2022), 1, Seite 11 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/article/28b192066bf0432abd8c3827d1b2337a kostenfrei https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
allfieldsGer	10.1186/s12951-022-01494-7 doi (DE-627)DOAJ085084786 (DE-599)DOAJ28b192066bf0432abd8c3827d1b2337a DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Lei Chen verfasserin aut Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors. Radiosensitizers Semiconductors Reactive oxygen species Composition tunability X-ray induced photodynamic therapy Biotechnology Medical technology Jinghui Zhang verfasserin aut Lihua Xu verfasserin aut Luchao Zhu verfasserin aut Jinpeng Jing verfasserin aut Yushuo Feng verfasserin aut Zongzhang Wang verfasserin aut Peifei Liu verfasserin aut Wenjing Sun verfasserin aut Xiangmei Liu verfasserin aut Yimin Li verfasserin aut Hongmin Chen verfasserin aut In Journal of Nanobiotechnology BMC, 2003 20(2022), 1, Seite 11 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/article/28b192066bf0432abd8c3827d1b2337a kostenfrei https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
allfieldsSound	10.1186/s12951-022-01494-7 doi (DE-627)DOAJ085084786 (DE-599)DOAJ28b192066bf0432abd8c3827d1b2337a DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Lei Chen verfasserin aut Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors. Radiosensitizers Semiconductors Reactive oxygen species Composition tunability X-ray induced photodynamic therapy Biotechnology Medical technology Jinghui Zhang verfasserin aut Lihua Xu verfasserin aut Luchao Zhu verfasserin aut Jinpeng Jing verfasserin aut Yushuo Feng verfasserin aut Zongzhang Wang verfasserin aut Peifei Liu verfasserin aut Wenjing Sun verfasserin aut Xiangmei Liu verfasserin aut Yimin Li verfasserin aut Hongmin Chen verfasserin aut In Journal of Nanobiotechnology BMC, 2003 20(2022), 1, Seite 11 (DE-627)362770328 (DE-600)2100022-0 14773155 nnns volume:20 year:2022 number:1 pages:11 https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/article/28b192066bf0432abd8c3827d1b2337a kostenfrei https://doi.org/10.1186/s12951-022-01494-7 kostenfrei https://doaj.org/toc/1477-3155 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022 1 11
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callnumber-first	T - Technology
author	Lei Chen
spellingShingle	Lei Chen misc TP248.13-248.65 misc R855-855.5 misc Radiosensitizers misc Semiconductors misc Reactive oxygen species misc Composition tunability misc X-ray induced photodynamic therapy misc Biotechnology misc Medical technology Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy
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topic_title	TP248.13-248.65 R855-855.5 Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy Radiosensitizers Semiconductors Reactive oxygen species Composition tunability X-ray induced photodynamic therapy
topic	misc TP248.13-248.65 misc R855-855.5 misc Radiosensitizers misc Semiconductors misc Reactive oxygen species misc Composition tunability misc X-ray induced photodynamic therapy misc Biotechnology misc Medical technology
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title	Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy
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title_sort	composition tunability of semiconductor radiosensitizers for low-dose x-ray induced photodynamic therapy
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title_auth	Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy
abstract	Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors.
abstractGer	Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors.
abstract_unstemmed	Abstract Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we designed Bi-doped titanium dioxide nanosensitizers in which high-Z Bi ions with adjustable valence state (Bi3+ or Bi4+) replaced some positions of Ti4+ of anatase TiO2, increasing both X-rays absorption and oxygen vacancies. The as-prepared TiO2:Bi nanosensitizers indicated high ionizing radiation energy-transfer efficiency and photocatalytic activity, resulting in efficient electron–hole pair separation and reactive oxygen species production. After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors.
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title_short	Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy
url	https://doi.org/10.1186/s12951-022-01494-7 https://doaj.org/article/28b192066bf0432abd8c3827d1b2337a https://doaj.org/toc/1477-3155
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up_date	2024-07-04T01:46:56.721Z
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After further modification with cancer cell targeting peptide, the obtained nanoplatform demonstrated good performance in U87MG cell uptakes and intracellular radicals-generation, severely damaging the vital subcellular organs of U87MG cells, such as mitochondrion, membrane lipid, and nuclei etc. These combined therapeutic actions mediated by the composition-tunable nanosensitizers significantly inhibited the U87MG tumor growth, providing a refreshing strategy for X-ray induced dynamic therapy of malignant tumors.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Radiosensitizers</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Semiconductors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Reactive oxygen species</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Composition tunability</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield 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Composition tunability of semiconductor radiosensitizers for low-dose X-ray induced photodynamic therapy

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