Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor

Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pat...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kran Suknuntha [verfasserIn] Kritika Subramanian [verfasserIn] Joelle Racchumi [verfasserIn] Wayne Tam [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5

Übergeordnetes Werk:	In: Human Pathology Reports - Elsevier, 2022, 29(2022), Seite 300672-
Übergeordnetes Werk:	volume:29 ; year:2022 ; pages:300672-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.hpr.2022.300672

Katalog-ID:	DOAJ085115606

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ085115606
003	DE-627
005	20230502122920.0
007	cr uuu---uuuuu
008	230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1016/j.hpr.2022.300672 \|2 doi
035			\|a (DE-627)DOAJ085115606
035			\|a (DE-599)DOAJ1a381ca137a741069279ca51f1a93b56
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RB1-214
100	0		\|a Kran Suknuntha \|e verfasserin \|4 aut
245	1	0	\|a Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor
264		1	\|c 2022
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC.
650		4	\|a Merkel cell carcinoma
650		4	\|a Follicular lymphoma
650		4	\|a Collision tumor
650		4	\|a PAX5
653		0	\|a Pathology
700	0		\|a Kritika Subramanian \|e verfasserin \|4 aut
700	0		\|a Joelle Racchumi \|e verfasserin \|4 aut
700	0		\|a Wayne Tam \|e verfasserin \|4 aut
773	0	8	\|i In \|t Human Pathology Reports \|d Elsevier, 2022 \|g 29(2022), Seite 300672- \|w (DE-627)1805497138 \|x 2772736X \|7 nnns
773	1	8	\|g volume:29 \|g year:2022 \|g pages:300672-
856	4	0	\|u https://doi.org/10.1016/j.hpr.2022.300672 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/1a381ca137a741069279ca51f1a93b56 \|z kostenfrei
856	4	0	\|u http://www.sciencedirect.com/science/article/pii/S2772736X22000846 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2772-736X \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 29 \|j 2022 \|h 300672-

Indexfelder

author_variant	k s ks k s ks j r jr w t wt
matchkey_str	article:2772736X:2022----::eklelacnmadolclrypoahgluu
hierarchy_sort_str	2022
callnumber-subject-code	RB
publishDate	2022
allfields	10.1016/j.hpr.2022.300672 doi (DE-627)DOAJ085115606 (DE-599)DOAJ1a381ca137a741069279ca51f1a93b56 DE-627 ger DE-627 rakwb eng RB1-214 Kran Suknuntha verfasserin aut Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC. Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5 Pathology Kritika Subramanian verfasserin aut Joelle Racchumi verfasserin aut Wayne Tam verfasserin aut In Human Pathology Reports Elsevier, 2022 29(2022), Seite 300672- (DE-627)1805497138 2772736X nnns volume:29 year:2022 pages:300672- https://doi.org/10.1016/j.hpr.2022.300672 kostenfrei https://doaj.org/article/1a381ca137a741069279ca51f1a93b56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2772736X22000846 kostenfrei https://doaj.org/toc/2772-736X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2022 300672-
spelling	10.1016/j.hpr.2022.300672 doi (DE-627)DOAJ085115606 (DE-599)DOAJ1a381ca137a741069279ca51f1a93b56 DE-627 ger DE-627 rakwb eng RB1-214 Kran Suknuntha verfasserin aut Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC. Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5 Pathology Kritika Subramanian verfasserin aut Joelle Racchumi verfasserin aut Wayne Tam verfasserin aut In Human Pathology Reports Elsevier, 2022 29(2022), Seite 300672- (DE-627)1805497138 2772736X nnns volume:29 year:2022 pages:300672- https://doi.org/10.1016/j.hpr.2022.300672 kostenfrei https://doaj.org/article/1a381ca137a741069279ca51f1a93b56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2772736X22000846 kostenfrei https://doaj.org/toc/2772-736X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2022 300672-
allfields_unstemmed	10.1016/j.hpr.2022.300672 doi (DE-627)DOAJ085115606 (DE-599)DOAJ1a381ca137a741069279ca51f1a93b56 DE-627 ger DE-627 rakwb eng RB1-214 Kran Suknuntha verfasserin aut Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC. Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5 Pathology Kritika Subramanian verfasserin aut Joelle Racchumi verfasserin aut Wayne Tam verfasserin aut In Human Pathology Reports Elsevier, 2022 29(2022), Seite 300672- (DE-627)1805497138 2772736X nnns volume:29 year:2022 pages:300672- https://doi.org/10.1016/j.hpr.2022.300672 kostenfrei https://doaj.org/article/1a381ca137a741069279ca51f1a93b56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2772736X22000846 kostenfrei https://doaj.org/toc/2772-736X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2022 300672-
allfieldsGer	10.1016/j.hpr.2022.300672 doi (DE-627)DOAJ085115606 (DE-599)DOAJ1a381ca137a741069279ca51f1a93b56 DE-627 ger DE-627 rakwb eng RB1-214 Kran Suknuntha verfasserin aut Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC. Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5 Pathology Kritika Subramanian verfasserin aut Joelle Racchumi verfasserin aut Wayne Tam verfasserin aut In Human Pathology Reports Elsevier, 2022 29(2022), Seite 300672- (DE-627)1805497138 2772736X nnns volume:29 year:2022 pages:300672- https://doi.org/10.1016/j.hpr.2022.300672 kostenfrei https://doaj.org/article/1a381ca137a741069279ca51f1a93b56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2772736X22000846 kostenfrei https://doaj.org/toc/2772-736X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2022 300672-
allfieldsSound	10.1016/j.hpr.2022.300672 doi (DE-627)DOAJ085115606 (DE-599)DOAJ1a381ca137a741069279ca51f1a93b56 DE-627 ger DE-627 rakwb eng RB1-214 Kran Suknuntha verfasserin aut Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC. Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5 Pathology Kritika Subramanian verfasserin aut Joelle Racchumi verfasserin aut Wayne Tam verfasserin aut In Human Pathology Reports Elsevier, 2022 29(2022), Seite 300672- (DE-627)1805497138 2772736X nnns volume:29 year:2022 pages:300672- https://doi.org/10.1016/j.hpr.2022.300672 kostenfrei https://doaj.org/article/1a381ca137a741069279ca51f1a93b56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2772736X22000846 kostenfrei https://doaj.org/toc/2772-736X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2022 300672-
language	English
source	In Human Pathology Reports 29(2022), Seite 300672- volume:29 year:2022 pages:300672-
sourceStr	In Human Pathology Reports 29(2022), Seite 300672- volume:29 year:2022 pages:300672-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5 Pathology
isfreeaccess_bool	true
container_title	Human Pathology Reports
authorswithroles_txt_mv	Kran Suknuntha @@aut@@ Kritika Subramanian @@aut@@ Joelle Racchumi @@aut@@ Wayne Tam @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	1805497138
id	DOAJ085115606
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ085115606</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502122920.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.hpr.2022.300672</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ085115606</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ1a381ca137a741069279ca51f1a93b56</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RB1-214</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Kran Suknuntha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Merkel cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Follicular lymphoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Collision tumor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">PAX5</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pathology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kritika Subramanian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joelle Racchumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wayne Tam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Human Pathology Reports</subfield><subfield code="d">Elsevier, 2022</subfield><subfield code="g">29(2022), Seite 300672-</subfield><subfield code="w">(DE-627)1805497138</subfield><subfield code="x">2772736X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:2022</subfield><subfield code="g">pages:300672-</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.hpr.2022.300672</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/1a381ca137a741069279ca51f1a93b56</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S2772736X22000846</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2772-736X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">2022</subfield><subfield code="h">300672-</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Kran Suknuntha
spellingShingle	Kran Suknuntha misc RB1-214 misc Merkel cell carcinoma misc Follicular lymphoma misc Collision tumor misc PAX5 misc Pathology Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor
authorStr	Kran Suknuntha
ppnlink_with_tag_str_mv	@@773@@(DE-627)1805497138
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RB1-214
illustrated	Not Illustrated
issn	2772736X
topic_title	RB1-214 Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor Merkel cell carcinoma Follicular lymphoma Collision tumor PAX5
topic	misc RB1-214 misc Merkel cell carcinoma misc Follicular lymphoma misc Collision tumor misc PAX5 misc Pathology
topic_unstemmed	misc RB1-214 misc Merkel cell carcinoma misc Follicular lymphoma misc Collision tumor misc PAX5 misc Pathology
topic_browse	misc RB1-214 misc Merkel cell carcinoma misc Follicular lymphoma misc Collision tumor misc PAX5 misc Pathology
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Human Pathology Reports
hierarchy_parent_id	1805497138
hierarchy_top_title	Human Pathology Reports
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)1805497138
title	Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor
ctrlnum	(DE-627)DOAJ085115606 (DE-599)DOAJ1a381ca137a741069279ca51f1a93b56
title_full	Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor
author_sort	Kran Suknuntha
journal	Human Pathology Reports
journalStr	Human Pathology Reports
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2022
contenttype_str_mv	txt
container_start_page	300672
author_browse	Kran Suknuntha Kritika Subramanian Joelle Racchumi Wayne Tam
container_volume	29
class	RB1-214
format_se	Elektronische Aufsätze
author-letter	Kran Suknuntha
doi_str_mv	10.1016/j.hpr.2022.300672
author2-role	verfasserin
title_sort	merkel cell carcinoma and follicular lymphoma: a highly unusual collision tumor
callnumber	RB1-214
title_auth	Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor
abstract	Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC.
abstractGer	Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC.
abstract_unstemmed	Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700
title_short	Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor
url	https://doi.org/10.1016/j.hpr.2022.300672 https://doaj.org/article/1a381ca137a741069279ca51f1a93b56 http://www.sciencedirect.com/science/article/pii/S2772736X22000846 https://doaj.org/toc/2772-736X
remote_bool	true
author2	Kritika Subramanian Joelle Racchumi Wayne Tam
author2Str	Kritika Subramanian Joelle Racchumi Wayne Tam
ppnlink	1805497138
callnumber-subject	RB - Pathology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1016/j.hpr.2022.300672
callnumber-a	RB1-214
up_date	2024-07-04T01:54:21.195Z
_version_	1803611601577705472
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ085115606</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502122920.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.hpr.2022.300672</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ085115606</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ1a381ca137a741069279ca51f1a93b56</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RB1-214</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Kran Suknuntha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Merkel cell carcinoma (MCC), a rare and aggressive skin tumor, has a tendency to occur in association with hematologic malignancies, in particular chronic lymphocytic leukemia (CLL). The permissive immunologic environment and Merkel cell polyoma virus infection has been postulated as part of MCC pathogenesis. A collision tumor consisting of follicular lymphoma (FL) and MCC has never been described. Here we report an unusual case of nodal MCC of unknown primary arising in an immunocompetent patient who had FL involving multiple lymph nodes. Similar to the FL, PAX-5 and BCL2 were also expressed in the MCC. Cytogenetic and molecular studies showed that the two neoplastic processes are clonally unrelated. We also demonstrated a pathogenic PTEN mutation that has not been previously reported in MCC, associated with loss of heterozygosity due to monosomy 10. Our mutation data suggests that MCC of unknown primary may be pathogenetically related to typical cutaneous MCC.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Merkel cell carcinoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Follicular lymphoma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Collision tumor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">PAX5</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pathology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kritika Subramanian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joelle Racchumi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wayne Tam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Human Pathology Reports</subfield><subfield code="d">Elsevier, 2022</subfield><subfield code="g">29(2022), Seite 300672-</subfield><subfield code="w">(DE-627)1805497138</subfield><subfield code="x">2772736X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:2022</subfield><subfield code="g">pages:300672-</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.hpr.2022.300672</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/1a381ca137a741069279ca51f1a93b56</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S2772736X22000846</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2772-736X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">2022</subfield><subfield code="h">300672-</subfield></datafield></record></collection>
score	7.398781

Nicht das Richtige dabei?

Schreiben Sie uns!

Merkel cell carcinoma and follicular lymphoma: A highly unusual collision tumor

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?