The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?
Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease wit...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Übergeordnetes Werk: |
In: World Journal of Emergency Surgery - BMC, 2006, 17(2022), 1, Seite 16 |
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| Übergeordnetes Werk: |
volume:17 ; year:2022 ; number:1 ; pages:16 |
| Links: |
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| DOI / URN: |
10.1186/s13017-022-00466-4 |
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| Katalog-ID: |
DOAJ085162078 |
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| 245 | 1 | 4 | |a The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? |
| 264 | 1 | |c 2022 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract | ||
| 650 | 4 | |a Acute cholecystitis | |
| 650 | 4 | |a Cholecystectomy | |
| 650 | 4 | |a Gangrene | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Laparoscopy | |
| 653 | 0 | |a Surgery | |
| 653 | 0 | |a Medical emergencies. Critical care. Intensive care. First aid | |
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| 700 | 0 | |a Dimitrios Schizas |e verfasserin |4 aut | |
| 700 | 0 | |a Athanasios Syllaios |e verfasserin |4 aut | |
| 700 | 0 | |a Ilias Vagios |e verfasserin |4 aut | |
| 700 | 0 | |a Stavros Gourgiotis |e verfasserin |4 aut | |
| 700 | 0 | |a Nick Dai |e verfasserin |4 aut | |
| 700 | 0 | |a Rekha Gurung |e verfasserin |4 aut | |
| 700 | 0 | |a Marcus Norrey |e verfasserin |4 aut | |
| 700 | 0 | |a Antonio Pesce |e verfasserin |4 aut | |
| 700 | 0 | |a Carlo Vittorio Feo |e verfasserin |4 aut | |
| 700 | 0 | |a Nicolo’ Fabbri |e verfasserin |4 aut | |
| 700 | 0 | |a Nikolaos Machairas |e verfasserin |4 aut | |
| 700 | 0 | |a Panagiotis Dorovinis |e verfasserin |4 aut | |
| 700 | 0 | |a Myrto D. Keramida |e verfasserin |4 aut | |
| 700 | 0 | |a Francesk Mulita |e verfasserin |4 aut | |
| 700 | 0 | |a Georgios Ioannis Verras |e verfasserin |4 aut | |
| 700 | 0 | |a Michail Vailas |e verfasserin |4 aut | |
| 700 | 0 | |a Omer Yalkin |e verfasserin |4 aut | |
| 700 | 0 | |a Nidal Iflazoglu |e verfasserin |4 aut | |
| 700 | 0 | |a Direnc Yigit |e verfasserin |4 aut | |
| 700 | 0 | |a Oussama Baraket |e verfasserin |4 aut | |
| 700 | 0 | |a Karim Ayed |e verfasserin |4 aut | |
| 700 | 0 | |a Mohamed hedi Ghalloussi |e verfasserin |4 aut | |
| 700 | 0 | |a Parmenion Patias |e verfasserin |4 aut | |
| 700 | 0 | |a Georgios Ntokos |e verfasserin |4 aut | |
| 700 | 0 | |a Razrim Rahim |e verfasserin |4 aut | |
| 700 | 0 | |a Miklosh Bala |e verfasserin |4 aut | |
| 700 | 0 | |a Asaf Kedar |e verfasserin |4 aut | |
| 700 | 0 | |a Robert G. Sawyer |e verfasserin |4 aut | |
| 700 | 0 | |a Anna Trinh |e verfasserin |4 aut | |
| 700 | 0 | |a Kelsey Miller |e verfasserin |4 aut | |
| 700 | 0 | |a Ruslan Sydorchuk |e verfasserin |4 aut | |
| 700 | 0 | |a Ruslan Knut |e verfasserin |4 aut | |
| 700 | 0 | |a Oleksandr Plehutsa |e verfasserin |4 aut | |
| 700 | 0 | |a Rumeysa Kevser Liman |e verfasserin |4 aut | |
| 700 | 0 | |a Zeynep Ozkan |e verfasserin |4 aut | |
| 700 | 0 | |a Saleh Abdel Kader |e verfasserin |4 aut | |
| 700 | 0 | |a Sanjay Gupta |e verfasserin |4 aut | |
| 700 | 0 | |a Monika Gureh |e verfasserin |4 aut | |
| 700 | 0 | |a Sara Saeidi |e verfasserin |4 aut | |
| 700 | 0 | |a Mohsen Aliakbarian |e verfasserin |4 aut | |
| 700 | 0 | |a Amin Dalili |e verfasserin |4 aut | |
| 700 | 0 | |a Tomohisa Shoko |e verfasserin |4 aut | |
| 700 | 0 | |a Mitsuaki Kojima |e verfasserin |4 aut | |
| 700 | 0 | |a Raira Nakamoto |e verfasserin |4 aut | |
| 700 | 0 | |a Semra Demirli Atici |e verfasserin |4 aut | |
| 700 | 0 | |a Gizem Kilinc Tuncer |e verfasserin |4 aut | |
| 700 | 0 | |a Tayfun Kaya |e verfasserin |4 aut | |
| 700 | 0 | |a Spiros G. Delis |e verfasserin |4 aut | |
| 700 | 0 | |a Stefano Rossi |e verfasserin |4 aut | |
| 700 | 0 | |a Biagio Picardi |e verfasserin |4 aut | |
| 700 | 0 | |a Simone Rossi del Monte |e verfasserin |4 aut | |
| 700 | 0 | |a Tania Triantafyllou |e verfasserin |4 aut | |
| 700 | 0 | |a Dimitrios Theodorou |e verfasserin |4 aut | |
| 700 | 0 | |a Tadeja Pintar |e verfasserin |4 aut | |
| 700 | 0 | |a Jure Salobir |e verfasserin |4 aut | |
| 700 | 0 | |a Dimitrios K. Manatakis |e verfasserin |4 aut | |
| 700 | 0 | |a Nikolaos Tasis |e verfasserin |4 aut | |
| 700 | 0 | |a Vasileios Acheimastos |e verfasserin |4 aut | |
| 700 | 0 | |a Orestis Ioannidis |e verfasserin |4 aut | |
| 700 | 0 | |a Lydia Loutzidou |e verfasserin |4 aut | |
| 700 | 0 | |a Savvas Symeonidis |e verfasserin |4 aut | |
| 700 | 0 | |a Tiago Correia de Sá |e verfasserin |4 aut | |
| 700 | 0 | |a Mónica Rocha |e verfasserin |4 aut | |
| 700 | 0 | |a Tommaso Guagni |e verfasserin |4 aut | |
| 700 | 0 | |a Desiré Pantalone |e verfasserin |4 aut | |
| 700 | 0 | |a Gherardo Maltinti |e verfasserin |4 aut | |
| 700 | 0 | |a Vladimir Khokha |e verfasserin |4 aut | |
| 700 | 0 | |a Wafaa Abdel-elsalam |e verfasserin |4 aut | |
| 700 | 0 | |a Basma Ghoneim |e verfasserin |4 aut | |
| 700 | 0 | |a José Antonio López-Ruiz |e verfasserin |4 aut | |
| 700 | 0 | |a Yasin Kara |e verfasserin |4 aut | |
| 700 | 0 | |a Syaza Zainudin |e verfasserin |4 aut | |
| 700 | 0 | |a Firdaus Hayati |e verfasserin |4 aut | |
| 700 | 0 | |a Nornazirah Azizan |e verfasserin |4 aut | |
| 700 | 0 | |a Victoria Tan Phooi Khei |e verfasserin |4 aut | |
| 700 | 0 | |a Rebecca Choy Xin Yi |e verfasserin |4 aut | |
| 700 | 0 | |a Harivinthan Sellappan |e verfasserin |4 aut | |
| 700 | 0 | |a Zaza Demetrashvili |e verfasserin |4 aut | |
| 700 | 0 | |a Nika Lekiashvili |e verfasserin |4 aut | |
| 700 | 0 | |a Ana Tvaladze |e verfasserin |4 aut | |
| 700 | 0 | |a Caterina Froiio |e verfasserin |4 aut | |
| 700 | 0 | |a Daniele Bernardi |e verfasserin |4 aut | |
| 700 | 0 | |a Luigi Bonavina |e verfasserin |4 aut | |
| 700 | 0 | |a Angeles Gil-Olarte |e verfasserin |4 aut | |
| 700 | 0 | |a Sebastiano Grassia |e verfasserin |4 aut | |
| 700 | 0 | |a Estela Romero-Vargas |e verfasserin |4 aut | |
| 700 | 0 | |a Francesco Bianco |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew A. Gumbs |e verfasserin |4 aut | |
| 700 | 0 | |a Agron Dogjani |e verfasserin |4 aut | |
| 700 | 0 | |a Ferdinando Agresta |e verfasserin |4 aut | |
| 700 | 0 | |a Andrey Litvin |e verfasserin |4 aut | |
| 700 | 0 | |a Zsolt J. Balogh |e verfasserin |4 aut | |
| 700 | 0 | |a George Gendrikson |e verfasserin |4 aut | |
| 700 | 0 | |a Costanza Martino |e verfasserin |4 aut | |
| 700 | 0 | |a Dimitrios Damaskos |e verfasserin |4 aut | |
| 700 | 0 | |a Nikolaos Pararas |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew Kirkpatrick |e verfasserin |4 aut | |
| 700 | 0 | |a Mikhail Kurtenkov |e verfasserin |4 aut | |
| 700 | 0 | |a Felipe Couto Gomes |e verfasserin |4 aut | |
| 700 | 0 | |a Adolfo Pisanu |e verfasserin |4 aut | |
| 700 | 0 | |a Oreste Nardello |e verfasserin |4 aut | |
| 700 | 0 | |a Fabrizio Gambarini |e verfasserin |4 aut | |
| 700 | 0 | |a Hager Aref |e verfasserin |4 aut | |
| 700 | 0 | |a Nicola de’ Angelis |e verfasserin |4 aut | |
| 700 | 0 | |a Vanni Agnoletti |e verfasserin |4 aut | |
| 700 | 0 | |a Antonio Biondi |e verfasserin |4 aut | |
| 700 | 0 | |a Marco Vacante |e verfasserin |4 aut | |
| 700 | 0 | |a Giulia Griggio |e verfasserin |4 aut | |
| 700 | 0 | |a Roberta Tutino |e verfasserin |4 aut | |
| 700 | 0 | |a Marco Massani |e verfasserin |4 aut | |
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10.1186/s13017-022-00466-4 doi (DE-627)DOAJ085162078 (DE-599)DOAJ16b272a5a4204c378480f1cd29897edc DE-627 ger DE-627 rakwb eng RD1-811 RC86-88.9 Belinda De Simone verfasserin aut The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract Acute cholecystitis Cholecystectomy Gangrene COVID-19 SARS-CoV-2 Laparoscopy Surgery Medical emergencies. Critical care. Intensive care. First aid Fikri M. Abu-Zidan verfasserin aut Elie Chouillard verfasserin aut Salomone Di Saverio verfasserin aut Massimo Sartelli verfasserin aut Mauro Podda verfasserin aut Carlos Augusto Gomes verfasserin aut Ernest E. Moore verfasserin aut Susan J. Moug verfasserin aut Luca Ansaloni verfasserin aut Yoram Kluger verfasserin aut Federico Coccolini verfasserin aut Aitor Landaluce-Olavarria verfasserin aut Begoña Estraviz-Mateos verfasserin aut Ana Uriguen-Etxeberria verfasserin aut Alessio Giordano verfasserin aut Alfonso Palmieri Luna verfasserin aut Luz Adriana Hernández Amín verfasserin aut Adriana María Palmieri Hernández verfasserin aut Amanda Shabana verfasserin aut Zakaria Andee Dzulkarnaen verfasserin aut Muhammad Asyraf Othman verfasserin aut Mohamad Ikhwan Sani verfasserin aut Andrea Balla verfasserin aut Rosa Scaramuzzo verfasserin aut Pasquale Lepiane verfasserin aut Andrea Bottari verfasserin aut Fabio Staderini verfasserin aut Fabio Cianchi verfasserin aut Andrea Cavallaro verfasserin aut Antonio Zanghì verfasserin aut Alessandro Cappellani verfasserin aut Roberto Campagnacci verfasserin aut Angela Maurizi verfasserin aut Mario Martinotti verfasserin aut Annamaria Ruggieri verfasserin aut Asri Che Jusoh verfasserin aut Karim Abdul Rahman verfasserin aut Anis Suraya M. Zulkifli verfasserin aut Barbara Petronio verfasserin aut Belén Matías-García verfasserin aut Ana Quiroga-Valcárcel verfasserin aut Fernando Mendoza-Moreno verfasserin aut Boyko Atanasov verfasserin aut Fabio Cesare Campanile verfasserin aut Ilaria Vecchioni verfasserin aut Luca Cardinali verfasserin aut Grazia Travaglini verfasserin aut Elisa Sebastiani verfasserin aut Serge Chooklin verfasserin aut Serhii Chuklin verfasserin aut Pasquale Cianci verfasserin aut Enrico Restini verfasserin aut Sabino Capuzzolo verfasserin aut Giuseppe Currò verfasserin aut Rosalinda Filippo verfasserin aut Michele Rispoli verfasserin aut Daniel Aparicio-Sánchez verfasserin aut Virginia Durán Muñóz-Cruzado verfasserin aut Sandra Dios Barbeito verfasserin aut Samir Delibegovic verfasserin aut Amar Kesetovic verfasserin aut Diego Sasia verfasserin aut Felice Borghi verfasserin aut Giorgio Giraudo verfasserin aut Diego Visconti verfasserin aut Emanuele Doria verfasserin aut Mauro Santarelli verfasserin aut Davide Luppi verfasserin aut Stefano Bonilauri verfasserin aut Ugo Grossi verfasserin aut Giacomo Zanus verfasserin aut Alberto Sartori verfasserin aut Giacomo Piatto verfasserin aut Maurizio De Luca verfasserin aut Domenico Vita verfasserin aut Luigi Conti verfasserin aut Patrizio Capelli verfasserin aut Gaetano Maria Cattaneo verfasserin aut Athanasios Marinis verfasserin aut Styliani-Aikaterini Vederaki verfasserin aut Mehmet Bayrak verfasserin aut Yasemin Altıntas verfasserin aut Mustafa Yener Uzunoglu verfasserin aut Iskender Eren Demirbas verfasserin aut Yuksel Altinel verfasserin aut Serhat Meric verfasserin aut Yunus Emre Aktimur verfasserin aut Derya Salim Uymaz verfasserin aut Nail Omarov verfasserin aut Ibrahim Azamat verfasserin aut Eftychios Lostoridis verfasserin aut Eleni-Aikaterini Nagorni verfasserin aut Antonio Pujante verfasserin aut Gabriele Anania verfasserin aut Cristina Bombardini verfasserin aut Francesco Bagolini verfasserin aut Emre Gonullu verfasserin aut Baris Mantoglu verfasserin aut Recayi Capoglu verfasserin aut Stefano Cappato verfasserin aut Elena Muzio verfasserin aut Elif Colak verfasserin aut Suleyman Polat verfasserin aut Zehra Alan Koylu verfasserin aut Fatih Altintoprak verfasserin aut Zülfü Bayhan verfasserin aut Emrah Akin verfasserin aut Enrico Andolfi verfasserin aut Sulce Rezart verfasserin aut Jae Il Kim verfasserin aut Sung Won Jung verfasserin aut Yong Chan Shin verfasserin aut Octavian Enciu verfasserin aut Elena Adelina Toma verfasserin aut Fabio Medas verfasserin aut Gian Luigi Canu verfasserin aut Federico Cappellacci verfasserin aut Fabrizio D’Acapito verfasserin aut Giorgio Ercolani verfasserin aut Leonardo Solaini verfasserin aut Francesco Roscio verfasserin aut Federico Clerici verfasserin aut Roberta Gelmini verfasserin aut Francesco Serra verfasserin aut Elena Giulia Rossi verfasserin aut Francesco Fleres verfasserin aut Guglielmo Clarizia verfasserin aut Alessandro Spolini verfasserin aut Francesco Ferrara verfasserin aut Gabriela Nita verfasserin aut Jlenia Sarnari verfasserin aut Mahir Gachabayov verfasserin aut Abakar Abdullaev verfasserin aut Gaetano Poillucci verfasserin aut Gian Marco Palini verfasserin aut Simone Veneroni verfasserin aut Gianluca Garulli verfasserin aut Micaela Piccoli verfasserin aut Gianmaria Casoni Pattacini verfasserin aut Francesca Pecchini verfasserin aut Giulio Argenio verfasserin aut Mariano Fortunato Armellino verfasserin aut Giuseppe Brisinda verfasserin aut Silvia Tedesco verfasserin aut Pietro Fransvea verfasserin aut Giuseppe Ietto verfasserin aut Caterina Franchi verfasserin aut Giulio Carcano verfasserin aut Gennaro Martines verfasserin aut Giuseppe Trigiante verfasserin aut Giulia Negro verfasserin aut Gustavo Machain Vega verfasserin aut Agustín Rodríguez González verfasserin aut Leonardo Ojeda verfasserin aut Gaetano Piccolo verfasserin aut Andrea Bondurri verfasserin aut Anna Maffioli verfasserin aut Claudio Guerci verfasserin aut Boo Han Sin verfasserin aut Zamri Zuhdi verfasserin aut Azlanudin Azman verfasserin aut Hussam Mousa verfasserin aut Shadi al Bahri verfasserin aut Goran Augustin verfasserin aut Ivan Romic verfasserin aut Trpimir Moric verfasserin aut Ioannis Nikolopoulos verfasserin aut Jacopo Andreuccetti verfasserin aut Giusto Pignata verfasserin aut Rossella D’Alessio verfasserin aut Jakub Kenig verfasserin aut Urszula Skorus verfasserin aut Gustavo Pereira Fraga verfasserin aut Elcio Shiyoiti Hirano verfasserin aut Jackson Vinícius de Lima Bertuol verfasserin aut Arda Isik verfasserin aut Eray Kurnaz verfasserin aut Mohammad Sohail Asghar verfasserin aut Ameer Afzal verfasserin aut Ali Akbar verfasserin aut Taxiarchis Konstantinos Nikolouzakis verfasserin aut Konstantinos Lasithiotakis verfasserin aut Emmanuel Chrysos verfasserin aut Koray Das verfasserin aut Nazmi Özer verfasserin aut Ahmet Seker verfasserin aut Mohamed Ibrahim verfasserin aut Hytham K. S. Hamid verfasserin aut Ahmed Babiker verfasserin aut Konstantinos Bouliaris verfasserin aut George Koukoulis verfasserin aut Chrysoula-Christina Kolla verfasserin aut Andrea Lucchi verfasserin aut Laura Agostinelli verfasserin aut Antonio Taddei verfasserin aut Laura Fortuna verfasserin aut Carlotta Agostini verfasserin aut Leo Licari verfasserin aut Simona Viola verfasserin aut Cosimo Callari verfasserin aut Letizia Laface verfasserin aut Emmanuele Abate verfasserin aut Massimiliano Casati verfasserin aut Alessandro Anastasi verfasserin aut Giuseppe Canonico verfasserin aut Linda Gabellini verfasserin aut Lorenzo Tosi verfasserin aut Anna Guariniello verfasserin aut Federico Zanzi verfasserin aut Lovenish Bains verfasserin aut Larysa Sydorchuk verfasserin aut Oksana Iftoda verfasserin aut Andrii Sydorchuk verfasserin aut Michele Malerba verfasserin aut Federico Costanzo verfasserin aut Raffaele Galleano verfasserin aut Michela Monteleone verfasserin aut Andrea Costanzi verfasserin aut Carlo Riva verfasserin aut Maciej Walędziak verfasserin aut Andrzej Kwiatkowski verfasserin aut Łukasz Czyżykowski verfasserin aut Piotr Major verfasserin aut Marcin Strzałka verfasserin aut Maciej Matyja verfasserin aut Michal Natkaniec verfasserin aut Maria Rosaria Valenti verfasserin aut Maria Domenica Pia Di Vita verfasserin aut Maria Sotiropoulou verfasserin aut Stylianos Kapiris verfasserin aut Damien Massalou verfasserin aut Massimiliano Veroux verfasserin aut Alessio Volpicelli verfasserin aut Rossella Gioco verfasserin aut Matteo Uccelli verfasserin aut Marta Bonaldi verfasserin aut Stefano Olmi verfasserin aut Matteo Nardi verfasserin aut Giada Livadoti verfasserin aut Cristian Mesina verfasserin aut Theodor Viorel Dumitrescu verfasserin aut Mihai Calin Ciorbagiu verfasserin aut Michele Ammendola verfasserin aut Giorgio Ammerata verfasserin aut Roberto Romano verfasserin aut Mihail Slavchev verfasserin aut Evangelos P. Misiakos verfasserin aut Emmanouil Pikoulis verfasserin aut Dimitrios Papaconstantinou verfasserin aut Mohamed Elbahnasawy verfasserin aut Sherief Abdel-elsalam verfasserin aut Daniel M. Felsenreich verfasserin aut Julia Jedamzik verfasserin aut Nikolaos V. Michalopoulos verfasserin aut Theodoros A. Sidiropoulos verfasserin aut Maria Papadoliopoulou verfasserin aut Nicola Cillara verfasserin aut Antonello Deserra verfasserin aut Alessandro Cannavera verfasserin aut Ionuţ Negoi verfasserin aut Dimitrios Schizas verfasserin aut Athanasios Syllaios verfasserin aut Ilias Vagios verfasserin aut Stavros Gourgiotis verfasserin aut Nick Dai verfasserin aut Rekha Gurung verfasserin aut Marcus Norrey verfasserin aut Antonio Pesce verfasserin aut Carlo Vittorio Feo verfasserin aut Nicolo’ Fabbri verfasserin aut Nikolaos Machairas verfasserin aut Panagiotis Dorovinis verfasserin aut Myrto D. Keramida verfasserin aut Francesk Mulita verfasserin aut Georgios Ioannis Verras verfasserin aut Michail Vailas verfasserin aut Omer Yalkin verfasserin aut Nidal Iflazoglu verfasserin aut Direnc Yigit verfasserin aut Oussama Baraket verfasserin aut Karim Ayed verfasserin aut Mohamed hedi Ghalloussi verfasserin aut Parmenion Patias verfasserin aut Georgios Ntokos verfasserin aut Razrim Rahim verfasserin aut Miklosh Bala verfasserin aut Asaf Kedar verfasserin aut Robert G. Sawyer verfasserin aut Anna Trinh verfasserin aut Kelsey Miller verfasserin aut Ruslan Sydorchuk verfasserin aut Ruslan Knut verfasserin aut Oleksandr Plehutsa verfasserin aut Rumeysa Kevser Liman verfasserin aut Zeynep Ozkan verfasserin aut Saleh Abdel Kader verfasserin aut Sanjay Gupta verfasserin aut Monika Gureh verfasserin aut Sara Saeidi verfasserin aut Mohsen Aliakbarian verfasserin aut Amin Dalili verfasserin aut Tomohisa Shoko verfasserin aut Mitsuaki Kojima verfasserin aut Raira Nakamoto verfasserin aut Semra Demirli Atici verfasserin aut Gizem Kilinc Tuncer verfasserin aut Tayfun Kaya verfasserin aut Spiros G. Delis verfasserin aut Stefano Rossi verfasserin aut Biagio Picardi verfasserin aut Simone Rossi del Monte verfasserin aut Tania Triantafyllou verfasserin aut Dimitrios Theodorou verfasserin aut Tadeja Pintar verfasserin aut Jure Salobir verfasserin aut Dimitrios K. Manatakis verfasserin aut Nikolaos Tasis verfasserin aut Vasileios Acheimastos verfasserin aut Orestis Ioannidis verfasserin aut Lydia Loutzidou verfasserin aut Savvas Symeonidis verfasserin aut Tiago Correia de Sá verfasserin aut Mónica Rocha verfasserin aut Tommaso Guagni verfasserin aut Desiré Pantalone verfasserin aut Gherardo Maltinti verfasserin aut Vladimir Khokha verfasserin aut Wafaa Abdel-elsalam verfasserin aut Basma Ghoneim verfasserin aut José Antonio López-Ruiz verfasserin aut Yasin Kara verfasserin aut Syaza Zainudin verfasserin aut Firdaus Hayati verfasserin aut Nornazirah Azizan verfasserin aut Victoria Tan Phooi Khei verfasserin aut Rebecca Choy Xin Yi verfasserin aut Harivinthan Sellappan verfasserin aut Zaza Demetrashvili verfasserin aut Nika Lekiashvili verfasserin aut Ana Tvaladze verfasserin aut Caterina Froiio verfasserin aut Daniele Bernardi verfasserin aut Luigi Bonavina verfasserin aut Angeles Gil-Olarte verfasserin aut Sebastiano Grassia verfasserin aut Estela Romero-Vargas verfasserin aut Francesco Bianco verfasserin aut Andrew A. Gumbs verfasserin aut Agron Dogjani verfasserin aut Ferdinando Agresta verfasserin aut Andrey Litvin verfasserin aut Zsolt J. Balogh verfasserin aut George Gendrikson verfasserin aut Costanza Martino verfasserin aut Dimitrios Damaskos verfasserin aut Nikolaos Pararas verfasserin aut Andrew Kirkpatrick verfasserin aut Mikhail Kurtenkov verfasserin aut Felipe Couto Gomes verfasserin aut Adolfo Pisanu verfasserin aut Oreste Nardello verfasserin aut Fabrizio Gambarini verfasserin aut Hager Aref verfasserin aut Nicola de’ Angelis verfasserin aut Vanni Agnoletti verfasserin aut Antonio Biondi verfasserin aut Marco Vacante verfasserin aut Giulia Griggio verfasserin aut Roberta Tutino verfasserin aut Marco Massani verfasserin aut Giovanni Bisetto verfasserin aut Savino Occhionorelli verfasserin aut Dario Andreotti verfasserin aut Domenico Lacavalla verfasserin aut Walter L. Biffl verfasserin aut Fausto Catena verfasserin aut In World Journal of Emergency Surgery BMC, 2006 17(2022), 1, Seite 16 (DE-627)511639236 (DE-600)2233734-9 17497922 nnns volume:17 year:2022 number:1 pages:16 https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/article/16b272a5a4204c378480f1cd29897edc kostenfrei https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/toc/1749-7922 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 16 |
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10.1186/s13017-022-00466-4 doi (DE-627)DOAJ085162078 (DE-599)DOAJ16b272a5a4204c378480f1cd29897edc DE-627 ger DE-627 rakwb eng RD1-811 RC86-88.9 Belinda De Simone verfasserin aut The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract Acute cholecystitis Cholecystectomy Gangrene COVID-19 SARS-CoV-2 Laparoscopy Surgery Medical emergencies. Critical care. Intensive care. First aid Fikri M. Abu-Zidan verfasserin aut Elie Chouillard verfasserin aut Salomone Di Saverio verfasserin aut Massimo Sartelli verfasserin aut Mauro Podda verfasserin aut Carlos Augusto Gomes verfasserin aut Ernest E. Moore verfasserin aut Susan J. Moug verfasserin aut Luca Ansaloni verfasserin aut Yoram Kluger verfasserin aut Federico Coccolini verfasserin aut Aitor Landaluce-Olavarria verfasserin aut Begoña Estraviz-Mateos verfasserin aut Ana Uriguen-Etxeberria verfasserin aut Alessio Giordano verfasserin aut Alfonso Palmieri Luna verfasserin aut Luz Adriana Hernández Amín verfasserin aut Adriana María Palmieri Hernández verfasserin aut Amanda Shabana verfasserin aut Zakaria Andee Dzulkarnaen verfasserin aut Muhammad Asyraf Othman verfasserin aut Mohamad Ikhwan Sani verfasserin aut Andrea Balla verfasserin aut Rosa Scaramuzzo verfasserin aut Pasquale Lepiane verfasserin aut Andrea Bottari verfasserin aut Fabio Staderini verfasserin aut Fabio Cianchi verfasserin aut Andrea Cavallaro verfasserin aut Antonio Zanghì verfasserin aut Alessandro Cappellani verfasserin aut Roberto Campagnacci verfasserin aut Angela Maurizi verfasserin aut Mario Martinotti verfasserin aut Annamaria Ruggieri verfasserin aut Asri Che Jusoh verfasserin aut Karim Abdul Rahman verfasserin aut Anis Suraya M. Zulkifli verfasserin aut Barbara Petronio verfasserin aut Belén Matías-García verfasserin aut Ana Quiroga-Valcárcel verfasserin aut Fernando Mendoza-Moreno verfasserin aut Boyko Atanasov verfasserin aut Fabio Cesare Campanile verfasserin aut Ilaria Vecchioni verfasserin aut Luca Cardinali verfasserin aut Grazia Travaglini verfasserin aut Elisa Sebastiani verfasserin aut Serge Chooklin verfasserin aut Serhii Chuklin verfasserin aut Pasquale Cianci verfasserin aut Enrico Restini verfasserin aut Sabino Capuzzolo verfasserin aut Giuseppe Currò verfasserin aut Rosalinda Filippo verfasserin aut Michele Rispoli verfasserin aut Daniel Aparicio-Sánchez verfasserin aut Virginia Durán Muñóz-Cruzado verfasserin aut Sandra Dios Barbeito verfasserin aut Samir Delibegovic verfasserin aut Amar Kesetovic verfasserin aut Diego Sasia verfasserin aut Felice Borghi verfasserin aut Giorgio Giraudo verfasserin aut Diego Visconti verfasserin aut Emanuele Doria verfasserin aut Mauro Santarelli verfasserin aut Davide Luppi verfasserin aut Stefano Bonilauri verfasserin aut Ugo Grossi verfasserin aut Giacomo Zanus verfasserin aut Alberto Sartori verfasserin aut Giacomo Piatto verfasserin aut Maurizio De Luca verfasserin aut Domenico Vita verfasserin aut Luigi Conti verfasserin aut Patrizio Capelli verfasserin aut Gaetano Maria Cattaneo verfasserin aut Athanasios Marinis verfasserin aut Styliani-Aikaterini Vederaki verfasserin aut Mehmet Bayrak verfasserin aut Yasemin Altıntas verfasserin aut Mustafa Yener Uzunoglu verfasserin aut Iskender Eren Demirbas verfasserin aut Yuksel Altinel verfasserin aut Serhat Meric verfasserin aut Yunus Emre Aktimur verfasserin aut Derya Salim Uymaz verfasserin aut Nail Omarov verfasserin aut Ibrahim Azamat verfasserin aut Eftychios Lostoridis verfasserin aut Eleni-Aikaterini Nagorni verfasserin aut Antonio Pujante verfasserin aut Gabriele Anania verfasserin aut Cristina Bombardini verfasserin aut Francesco Bagolini verfasserin aut Emre Gonullu verfasserin aut Baris Mantoglu verfasserin aut Recayi Capoglu verfasserin aut Stefano Cappato verfasserin aut Elena Muzio verfasserin aut Elif Colak verfasserin aut Suleyman Polat verfasserin aut Zehra Alan Koylu verfasserin aut Fatih Altintoprak verfasserin aut Zülfü Bayhan verfasserin aut Emrah Akin verfasserin aut Enrico Andolfi verfasserin aut Sulce Rezart verfasserin aut Jae Il Kim verfasserin aut Sung Won Jung verfasserin aut Yong Chan Shin verfasserin aut Octavian Enciu verfasserin aut Elena Adelina Toma verfasserin aut Fabio Medas verfasserin aut Gian Luigi Canu verfasserin aut Federico Cappellacci verfasserin aut Fabrizio D’Acapito verfasserin aut Giorgio Ercolani verfasserin aut Leonardo Solaini verfasserin aut Francesco Roscio verfasserin aut Federico Clerici verfasserin aut Roberta Gelmini verfasserin aut Francesco Serra verfasserin aut Elena Giulia Rossi verfasserin aut Francesco Fleres verfasserin aut Guglielmo Clarizia verfasserin aut Alessandro Spolini verfasserin aut Francesco Ferrara verfasserin aut Gabriela Nita verfasserin aut Jlenia Sarnari verfasserin aut Mahir Gachabayov verfasserin aut Abakar Abdullaev verfasserin aut Gaetano Poillucci verfasserin aut Gian Marco Palini verfasserin aut Simone Veneroni verfasserin aut Gianluca Garulli verfasserin aut Micaela Piccoli verfasserin aut Gianmaria Casoni Pattacini verfasserin aut Francesca Pecchini verfasserin aut Giulio Argenio verfasserin aut Mariano Fortunato Armellino verfasserin aut Giuseppe Brisinda verfasserin aut Silvia Tedesco verfasserin aut Pietro Fransvea verfasserin aut Giuseppe Ietto verfasserin aut Caterina Franchi verfasserin aut Giulio Carcano verfasserin aut Gennaro Martines verfasserin aut Giuseppe Trigiante verfasserin aut Giulia Negro verfasserin aut Gustavo Machain Vega verfasserin aut Agustín Rodríguez González verfasserin aut Leonardo Ojeda verfasserin aut Gaetano Piccolo verfasserin aut Andrea Bondurri verfasserin aut Anna Maffioli verfasserin aut Claudio Guerci verfasserin aut Boo Han Sin verfasserin aut Zamri Zuhdi verfasserin aut Azlanudin Azman verfasserin aut Hussam Mousa verfasserin aut Shadi al Bahri verfasserin aut Goran Augustin verfasserin aut Ivan Romic verfasserin aut Trpimir Moric verfasserin aut Ioannis Nikolopoulos verfasserin aut Jacopo Andreuccetti verfasserin aut Giusto Pignata verfasserin aut Rossella D’Alessio verfasserin aut Jakub Kenig verfasserin aut Urszula Skorus verfasserin aut Gustavo Pereira Fraga verfasserin aut Elcio Shiyoiti Hirano verfasserin aut Jackson Vinícius de Lima Bertuol verfasserin aut Arda Isik verfasserin aut Eray Kurnaz verfasserin aut Mohammad Sohail Asghar verfasserin aut Ameer Afzal verfasserin aut Ali Akbar verfasserin aut Taxiarchis Konstantinos Nikolouzakis verfasserin aut Konstantinos Lasithiotakis verfasserin aut Emmanuel Chrysos verfasserin aut Koray Das verfasserin aut Nazmi Özer verfasserin aut Ahmet Seker verfasserin aut Mohamed Ibrahim verfasserin aut Hytham K. S. Hamid verfasserin aut Ahmed Babiker verfasserin aut Konstantinos Bouliaris verfasserin aut George Koukoulis verfasserin aut Chrysoula-Christina Kolla verfasserin aut Andrea Lucchi verfasserin aut Laura Agostinelli verfasserin aut Antonio Taddei verfasserin aut Laura Fortuna verfasserin aut Carlotta Agostini verfasserin aut Leo Licari verfasserin aut Simona Viola verfasserin aut Cosimo Callari verfasserin aut Letizia Laface verfasserin aut Emmanuele Abate verfasserin aut Massimiliano Casati verfasserin aut Alessandro Anastasi verfasserin aut Giuseppe Canonico verfasserin aut Linda Gabellini verfasserin aut Lorenzo Tosi verfasserin aut Anna Guariniello verfasserin aut Federico Zanzi verfasserin aut Lovenish Bains verfasserin aut Larysa Sydorchuk verfasserin aut Oksana Iftoda verfasserin aut Andrii Sydorchuk verfasserin aut Michele Malerba verfasserin aut Federico Costanzo verfasserin aut Raffaele Galleano verfasserin aut Michela Monteleone verfasserin aut Andrea Costanzi verfasserin aut Carlo Riva verfasserin aut Maciej Walędziak verfasserin aut Andrzej Kwiatkowski verfasserin aut Łukasz Czyżykowski verfasserin aut Piotr Major verfasserin aut Marcin Strzałka verfasserin aut Maciej Matyja verfasserin aut Michal Natkaniec verfasserin aut Maria Rosaria Valenti verfasserin aut Maria Domenica Pia Di Vita verfasserin aut Maria Sotiropoulou verfasserin aut Stylianos Kapiris verfasserin aut Damien Massalou verfasserin aut Massimiliano Veroux verfasserin aut Alessio Volpicelli verfasserin aut Rossella Gioco verfasserin aut Matteo Uccelli verfasserin aut Marta Bonaldi verfasserin aut Stefano Olmi verfasserin aut Matteo Nardi verfasserin aut Giada Livadoti verfasserin aut Cristian Mesina verfasserin aut Theodor Viorel Dumitrescu verfasserin aut Mihai Calin Ciorbagiu verfasserin aut Michele Ammendola verfasserin aut Giorgio Ammerata verfasserin aut Roberto Romano verfasserin aut Mihail Slavchev verfasserin aut Evangelos P. Misiakos verfasserin aut Emmanouil Pikoulis verfasserin aut Dimitrios Papaconstantinou verfasserin aut Mohamed Elbahnasawy verfasserin aut Sherief Abdel-elsalam verfasserin aut Daniel M. Felsenreich verfasserin aut Julia Jedamzik verfasserin aut Nikolaos V. Michalopoulos verfasserin aut Theodoros A. Sidiropoulos verfasserin aut Maria Papadoliopoulou verfasserin aut Nicola Cillara verfasserin aut Antonello Deserra verfasserin aut Alessandro Cannavera verfasserin aut Ionuţ Negoi verfasserin aut Dimitrios Schizas verfasserin aut Athanasios Syllaios verfasserin aut Ilias Vagios verfasserin aut Stavros Gourgiotis verfasserin aut Nick Dai verfasserin aut Rekha Gurung verfasserin aut Marcus Norrey verfasserin aut Antonio Pesce verfasserin aut Carlo Vittorio Feo verfasserin aut Nicolo’ Fabbri verfasserin aut Nikolaos Machairas verfasserin aut Panagiotis Dorovinis verfasserin aut Myrto D. Keramida verfasserin aut Francesk Mulita verfasserin aut Georgios Ioannis Verras verfasserin aut Michail Vailas verfasserin aut Omer Yalkin verfasserin aut Nidal Iflazoglu verfasserin aut Direnc Yigit verfasserin aut Oussama Baraket verfasserin aut Karim Ayed verfasserin aut Mohamed hedi Ghalloussi verfasserin aut Parmenion Patias verfasserin aut Georgios Ntokos verfasserin aut Razrim Rahim verfasserin aut Miklosh Bala verfasserin aut Asaf Kedar verfasserin aut Robert G. Sawyer verfasserin aut Anna Trinh verfasserin aut Kelsey Miller verfasserin aut Ruslan Sydorchuk verfasserin aut Ruslan Knut verfasserin aut Oleksandr Plehutsa verfasserin aut Rumeysa Kevser Liman verfasserin aut Zeynep Ozkan verfasserin aut Saleh Abdel Kader verfasserin aut Sanjay Gupta verfasserin aut Monika Gureh verfasserin aut Sara Saeidi verfasserin aut Mohsen Aliakbarian verfasserin aut Amin Dalili verfasserin aut Tomohisa Shoko verfasserin aut Mitsuaki Kojima verfasserin aut Raira Nakamoto verfasserin aut Semra Demirli Atici verfasserin aut Gizem Kilinc Tuncer verfasserin aut Tayfun Kaya verfasserin aut Spiros G. Delis verfasserin aut Stefano Rossi verfasserin aut Biagio Picardi verfasserin aut Simone Rossi del Monte verfasserin aut Tania Triantafyllou verfasserin aut Dimitrios Theodorou verfasserin aut Tadeja Pintar verfasserin aut Jure Salobir verfasserin aut Dimitrios K. Manatakis verfasserin aut Nikolaos Tasis verfasserin aut Vasileios Acheimastos verfasserin aut Orestis Ioannidis verfasserin aut Lydia Loutzidou verfasserin aut Savvas Symeonidis verfasserin aut Tiago Correia de Sá verfasserin aut Mónica Rocha verfasserin aut Tommaso Guagni verfasserin aut Desiré Pantalone verfasserin aut Gherardo Maltinti verfasserin aut Vladimir Khokha verfasserin aut Wafaa Abdel-elsalam verfasserin aut Basma Ghoneim verfasserin aut José Antonio López-Ruiz verfasserin aut Yasin Kara verfasserin aut Syaza Zainudin verfasserin aut Firdaus Hayati verfasserin aut Nornazirah Azizan verfasserin aut Victoria Tan Phooi Khei verfasserin aut Rebecca Choy Xin Yi verfasserin aut Harivinthan Sellappan verfasserin aut Zaza Demetrashvili verfasserin aut Nika Lekiashvili verfasserin aut Ana Tvaladze verfasserin aut Caterina Froiio verfasserin aut Daniele Bernardi verfasserin aut Luigi Bonavina verfasserin aut Angeles Gil-Olarte verfasserin aut Sebastiano Grassia verfasserin aut Estela Romero-Vargas verfasserin aut Francesco Bianco verfasserin aut Andrew A. Gumbs verfasserin aut Agron Dogjani verfasserin aut Ferdinando Agresta verfasserin aut Andrey Litvin verfasserin aut Zsolt J. Balogh verfasserin aut George Gendrikson verfasserin aut Costanza Martino verfasserin aut Dimitrios Damaskos verfasserin aut Nikolaos Pararas verfasserin aut Andrew Kirkpatrick verfasserin aut Mikhail Kurtenkov verfasserin aut Felipe Couto Gomes verfasserin aut Adolfo Pisanu verfasserin aut Oreste Nardello verfasserin aut Fabrizio Gambarini verfasserin aut Hager Aref verfasserin aut Nicola de’ Angelis verfasserin aut Vanni Agnoletti verfasserin aut Antonio Biondi verfasserin aut Marco Vacante verfasserin aut Giulia Griggio verfasserin aut Roberta Tutino verfasserin aut Marco Massani verfasserin aut Giovanni Bisetto verfasserin aut Savino Occhionorelli verfasserin aut Dario Andreotti verfasserin aut Domenico Lacavalla verfasserin aut Walter L. Biffl verfasserin aut Fausto Catena verfasserin aut In World Journal of Emergency Surgery BMC, 2006 17(2022), 1, Seite 16 (DE-627)511639236 (DE-600)2233734-9 17497922 nnns volume:17 year:2022 number:1 pages:16 https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/article/16b272a5a4204c378480f1cd29897edc kostenfrei https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/toc/1749-7922 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 16 |
| allfields_unstemmed |
10.1186/s13017-022-00466-4 doi (DE-627)DOAJ085162078 (DE-599)DOAJ16b272a5a4204c378480f1cd29897edc DE-627 ger DE-627 rakwb eng RD1-811 RC86-88.9 Belinda De Simone verfasserin aut The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract Acute cholecystitis Cholecystectomy Gangrene COVID-19 SARS-CoV-2 Laparoscopy Surgery Medical emergencies. Critical care. Intensive care. First aid Fikri M. Abu-Zidan verfasserin aut Elie Chouillard verfasserin aut Salomone Di Saverio verfasserin aut Massimo Sartelli verfasserin aut Mauro Podda verfasserin aut Carlos Augusto Gomes verfasserin aut Ernest E. Moore verfasserin aut Susan J. Moug verfasserin aut Luca Ansaloni verfasserin aut Yoram Kluger verfasserin aut Federico Coccolini verfasserin aut Aitor Landaluce-Olavarria verfasserin aut Begoña Estraviz-Mateos verfasserin aut Ana Uriguen-Etxeberria verfasserin aut Alessio Giordano verfasserin aut Alfonso Palmieri Luna verfasserin aut Luz Adriana Hernández Amín verfasserin aut Adriana María Palmieri Hernández verfasserin aut Amanda Shabana verfasserin aut Zakaria Andee Dzulkarnaen verfasserin aut Muhammad Asyraf Othman verfasserin aut Mohamad Ikhwan Sani verfasserin aut Andrea Balla verfasserin aut Rosa Scaramuzzo verfasserin aut Pasquale Lepiane verfasserin aut Andrea Bottari verfasserin aut Fabio Staderini verfasserin aut Fabio Cianchi verfasserin aut Andrea Cavallaro verfasserin aut Antonio Zanghì verfasserin aut Alessandro Cappellani verfasserin aut Roberto Campagnacci verfasserin aut Angela Maurizi verfasserin aut Mario Martinotti verfasserin aut Annamaria Ruggieri verfasserin aut Asri Che Jusoh verfasserin aut Karim Abdul Rahman verfasserin aut Anis Suraya M. Zulkifli verfasserin aut Barbara Petronio verfasserin aut Belén Matías-García verfasserin aut Ana Quiroga-Valcárcel verfasserin aut Fernando Mendoza-Moreno verfasserin aut Boyko Atanasov verfasserin aut Fabio Cesare Campanile verfasserin aut Ilaria Vecchioni verfasserin aut Luca Cardinali verfasserin aut Grazia Travaglini verfasserin aut Elisa Sebastiani verfasserin aut Serge Chooklin verfasserin aut Serhii Chuklin verfasserin aut Pasquale Cianci verfasserin aut Enrico Restini verfasserin aut Sabino Capuzzolo verfasserin aut Giuseppe Currò verfasserin aut Rosalinda Filippo verfasserin aut Michele Rispoli verfasserin aut Daniel Aparicio-Sánchez verfasserin aut Virginia Durán Muñóz-Cruzado verfasserin aut Sandra Dios Barbeito verfasserin aut Samir Delibegovic verfasserin aut Amar Kesetovic verfasserin aut Diego Sasia verfasserin aut Felice Borghi verfasserin aut Giorgio Giraudo verfasserin aut Diego Visconti verfasserin aut Emanuele Doria verfasserin aut Mauro Santarelli verfasserin aut Davide Luppi verfasserin aut Stefano Bonilauri verfasserin aut Ugo Grossi verfasserin aut Giacomo Zanus verfasserin aut Alberto Sartori verfasserin aut Giacomo Piatto verfasserin aut Maurizio De Luca verfasserin aut Domenico Vita verfasserin aut Luigi Conti verfasserin aut Patrizio Capelli verfasserin aut Gaetano Maria Cattaneo verfasserin aut Athanasios Marinis verfasserin aut Styliani-Aikaterini Vederaki verfasserin aut Mehmet Bayrak verfasserin aut Yasemin Altıntas verfasserin aut Mustafa Yener Uzunoglu verfasserin aut Iskender Eren Demirbas verfasserin aut Yuksel Altinel verfasserin aut Serhat Meric verfasserin aut Yunus Emre Aktimur verfasserin aut Derya Salim Uymaz verfasserin aut Nail Omarov verfasserin aut Ibrahim Azamat verfasserin aut Eftychios Lostoridis verfasserin aut Eleni-Aikaterini Nagorni verfasserin aut Antonio Pujante verfasserin aut Gabriele Anania verfasserin aut Cristina Bombardini verfasserin aut Francesco Bagolini verfasserin aut Emre Gonullu verfasserin aut Baris Mantoglu verfasserin aut Recayi Capoglu verfasserin aut Stefano Cappato verfasserin aut Elena Muzio verfasserin aut Elif Colak verfasserin aut Suleyman Polat verfasserin aut Zehra Alan Koylu verfasserin aut Fatih Altintoprak verfasserin aut Zülfü Bayhan verfasserin aut Emrah Akin verfasserin aut Enrico Andolfi verfasserin aut Sulce Rezart verfasserin aut Jae Il Kim verfasserin aut Sung Won Jung verfasserin aut Yong Chan Shin verfasserin aut Octavian Enciu verfasserin aut Elena Adelina Toma verfasserin aut Fabio Medas verfasserin aut Gian Luigi Canu verfasserin aut Federico Cappellacci verfasserin aut Fabrizio D’Acapito verfasserin aut Giorgio Ercolani verfasserin aut Leonardo Solaini verfasserin aut Francesco Roscio verfasserin aut Federico Clerici verfasserin aut Roberta Gelmini verfasserin aut Francesco Serra verfasserin aut Elena Giulia Rossi verfasserin aut Francesco Fleres verfasserin aut Guglielmo Clarizia verfasserin aut Alessandro Spolini verfasserin aut Francesco Ferrara verfasserin aut Gabriela Nita verfasserin aut Jlenia Sarnari verfasserin aut Mahir Gachabayov verfasserin aut Abakar Abdullaev verfasserin aut Gaetano Poillucci verfasserin aut Gian Marco Palini verfasserin aut Simone Veneroni verfasserin aut Gianluca Garulli verfasserin aut Micaela Piccoli verfasserin aut Gianmaria Casoni Pattacini verfasserin aut Francesca Pecchini verfasserin aut Giulio Argenio verfasserin aut Mariano Fortunato Armellino verfasserin aut Giuseppe Brisinda verfasserin aut Silvia Tedesco verfasserin aut Pietro Fransvea verfasserin aut Giuseppe Ietto verfasserin aut Caterina Franchi verfasserin aut Giulio Carcano verfasserin aut Gennaro Martines verfasserin aut Giuseppe Trigiante verfasserin aut Giulia Negro verfasserin aut Gustavo Machain Vega verfasserin aut Agustín Rodríguez González verfasserin aut Leonardo Ojeda verfasserin aut Gaetano Piccolo verfasserin aut Andrea Bondurri verfasserin aut Anna Maffioli verfasserin aut Claudio Guerci verfasserin aut Boo Han Sin verfasserin aut Zamri Zuhdi verfasserin aut Azlanudin Azman verfasserin aut Hussam Mousa verfasserin aut Shadi al Bahri verfasserin aut Goran Augustin verfasserin aut Ivan Romic verfasserin aut Trpimir Moric verfasserin aut Ioannis Nikolopoulos verfasserin aut Jacopo Andreuccetti verfasserin aut Giusto Pignata verfasserin aut Rossella D’Alessio verfasserin aut Jakub Kenig verfasserin aut Urszula Skorus verfasserin aut Gustavo Pereira Fraga verfasserin aut Elcio Shiyoiti Hirano verfasserin aut Jackson Vinícius de Lima Bertuol verfasserin aut Arda Isik verfasserin aut Eray Kurnaz verfasserin aut Mohammad Sohail Asghar verfasserin aut Ameer Afzal verfasserin aut Ali Akbar verfasserin aut Taxiarchis Konstantinos Nikolouzakis verfasserin aut Konstantinos Lasithiotakis verfasserin aut Emmanuel Chrysos verfasserin aut Koray Das verfasserin aut Nazmi Özer verfasserin aut Ahmet Seker verfasserin aut Mohamed Ibrahim verfasserin aut Hytham K. S. Hamid verfasserin aut Ahmed Babiker verfasserin aut Konstantinos Bouliaris verfasserin aut George Koukoulis verfasserin aut Chrysoula-Christina Kolla verfasserin aut Andrea Lucchi verfasserin aut Laura Agostinelli verfasserin aut Antonio Taddei verfasserin aut Laura Fortuna verfasserin aut Carlotta Agostini verfasserin aut Leo Licari verfasserin aut Simona Viola verfasserin aut Cosimo Callari verfasserin aut Letizia Laface verfasserin aut Emmanuele Abate verfasserin aut Massimiliano Casati verfasserin aut Alessandro Anastasi verfasserin aut Giuseppe Canonico verfasserin aut Linda Gabellini verfasserin aut Lorenzo Tosi verfasserin aut Anna Guariniello verfasserin aut Federico Zanzi verfasserin aut Lovenish Bains verfasserin aut Larysa Sydorchuk verfasserin aut Oksana Iftoda verfasserin aut Andrii Sydorchuk verfasserin aut Michele Malerba verfasserin aut Federico Costanzo verfasserin aut Raffaele Galleano verfasserin aut Michela Monteleone verfasserin aut Andrea Costanzi verfasserin aut Carlo Riva verfasserin aut Maciej Walędziak verfasserin aut Andrzej Kwiatkowski verfasserin aut Łukasz Czyżykowski verfasserin aut Piotr Major verfasserin aut Marcin Strzałka verfasserin aut Maciej Matyja verfasserin aut Michal Natkaniec verfasserin aut Maria Rosaria Valenti verfasserin aut Maria Domenica Pia Di Vita verfasserin aut Maria Sotiropoulou verfasserin aut Stylianos Kapiris verfasserin aut Damien Massalou verfasserin aut Massimiliano Veroux verfasserin aut Alessio Volpicelli verfasserin aut Rossella Gioco verfasserin aut Matteo Uccelli verfasserin aut Marta Bonaldi verfasserin aut Stefano Olmi verfasserin aut Matteo Nardi verfasserin aut Giada Livadoti verfasserin aut Cristian Mesina verfasserin aut Theodor Viorel Dumitrescu verfasserin aut Mihai Calin Ciorbagiu verfasserin aut Michele Ammendola verfasserin aut Giorgio Ammerata verfasserin aut Roberto Romano verfasserin aut Mihail Slavchev verfasserin aut Evangelos P. Misiakos verfasserin aut Emmanouil Pikoulis verfasserin aut Dimitrios Papaconstantinou verfasserin aut Mohamed Elbahnasawy verfasserin aut Sherief Abdel-elsalam verfasserin aut Daniel M. Felsenreich verfasserin aut Julia Jedamzik verfasserin aut Nikolaos V. Michalopoulos verfasserin aut Theodoros A. Sidiropoulos verfasserin aut Maria Papadoliopoulou verfasserin aut Nicola Cillara verfasserin aut Antonello Deserra verfasserin aut Alessandro Cannavera verfasserin aut Ionuţ Negoi verfasserin aut Dimitrios Schizas verfasserin aut Athanasios Syllaios verfasserin aut Ilias Vagios verfasserin aut Stavros Gourgiotis verfasserin aut Nick Dai verfasserin aut Rekha Gurung verfasserin aut Marcus Norrey verfasserin aut Antonio Pesce verfasserin aut Carlo Vittorio Feo verfasserin aut Nicolo’ Fabbri verfasserin aut Nikolaos Machairas verfasserin aut Panagiotis Dorovinis verfasserin aut Myrto D. Keramida verfasserin aut Francesk Mulita verfasserin aut Georgios Ioannis Verras verfasserin aut Michail Vailas verfasserin aut Omer Yalkin verfasserin aut Nidal Iflazoglu verfasserin aut Direnc Yigit verfasserin aut Oussama Baraket verfasserin aut Karim Ayed verfasserin aut Mohamed hedi Ghalloussi verfasserin aut Parmenion Patias verfasserin aut Georgios Ntokos verfasserin aut Razrim Rahim verfasserin aut Miklosh Bala verfasserin aut Asaf Kedar verfasserin aut Robert G. Sawyer verfasserin aut Anna Trinh verfasserin aut Kelsey Miller verfasserin aut Ruslan Sydorchuk verfasserin aut Ruslan Knut verfasserin aut Oleksandr Plehutsa verfasserin aut Rumeysa Kevser Liman verfasserin aut Zeynep Ozkan verfasserin aut Saleh Abdel Kader verfasserin aut Sanjay Gupta verfasserin aut Monika Gureh verfasserin aut Sara Saeidi verfasserin aut Mohsen Aliakbarian verfasserin aut Amin Dalili verfasserin aut Tomohisa Shoko verfasserin aut Mitsuaki Kojima verfasserin aut Raira Nakamoto verfasserin aut Semra Demirli Atici verfasserin aut Gizem Kilinc Tuncer verfasserin aut Tayfun Kaya verfasserin aut Spiros G. Delis verfasserin aut Stefano Rossi verfasserin aut Biagio Picardi verfasserin aut Simone Rossi del Monte verfasserin aut Tania Triantafyllou verfasserin aut Dimitrios Theodorou verfasserin aut Tadeja Pintar verfasserin aut Jure Salobir verfasserin aut Dimitrios K. Manatakis verfasserin aut Nikolaos Tasis verfasserin aut Vasileios Acheimastos verfasserin aut Orestis Ioannidis verfasserin aut Lydia Loutzidou verfasserin aut Savvas Symeonidis verfasserin aut Tiago Correia de Sá verfasserin aut Mónica Rocha verfasserin aut Tommaso Guagni verfasserin aut Desiré Pantalone verfasserin aut Gherardo Maltinti verfasserin aut Vladimir Khokha verfasserin aut Wafaa Abdel-elsalam verfasserin aut Basma Ghoneim verfasserin aut José Antonio López-Ruiz verfasserin aut Yasin Kara verfasserin aut Syaza Zainudin verfasserin aut Firdaus Hayati verfasserin aut Nornazirah Azizan verfasserin aut Victoria Tan Phooi Khei verfasserin aut Rebecca Choy Xin Yi verfasserin aut Harivinthan Sellappan verfasserin aut Zaza Demetrashvili verfasserin aut Nika Lekiashvili verfasserin aut Ana Tvaladze verfasserin aut Caterina Froiio verfasserin aut Daniele Bernardi verfasserin aut Luigi Bonavina verfasserin aut Angeles Gil-Olarte verfasserin aut Sebastiano Grassia verfasserin aut Estela Romero-Vargas verfasserin aut Francesco Bianco verfasserin aut Andrew A. Gumbs verfasserin aut Agron Dogjani verfasserin aut Ferdinando Agresta verfasserin aut Andrey Litvin verfasserin aut Zsolt J. Balogh verfasserin aut George Gendrikson verfasserin aut Costanza Martino verfasserin aut Dimitrios Damaskos verfasserin aut Nikolaos Pararas verfasserin aut Andrew Kirkpatrick verfasserin aut Mikhail Kurtenkov verfasserin aut Felipe Couto Gomes verfasserin aut Adolfo Pisanu verfasserin aut Oreste Nardello verfasserin aut Fabrizio Gambarini verfasserin aut Hager Aref verfasserin aut Nicola de’ Angelis verfasserin aut Vanni Agnoletti verfasserin aut Antonio Biondi verfasserin aut Marco Vacante verfasserin aut Giulia Griggio verfasserin aut Roberta Tutino verfasserin aut Marco Massani verfasserin aut Giovanni Bisetto verfasserin aut Savino Occhionorelli verfasserin aut Dario Andreotti verfasserin aut Domenico Lacavalla verfasserin aut Walter L. Biffl verfasserin aut Fausto Catena verfasserin aut In World Journal of Emergency Surgery BMC, 2006 17(2022), 1, Seite 16 (DE-627)511639236 (DE-600)2233734-9 17497922 nnns volume:17 year:2022 number:1 pages:16 https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/article/16b272a5a4204c378480f1cd29897edc kostenfrei https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/toc/1749-7922 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 16 |
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10.1186/s13017-022-00466-4 doi (DE-627)DOAJ085162078 (DE-599)DOAJ16b272a5a4204c378480f1cd29897edc DE-627 ger DE-627 rakwb eng RD1-811 RC86-88.9 Belinda De Simone verfasserin aut The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract Acute cholecystitis Cholecystectomy Gangrene COVID-19 SARS-CoV-2 Laparoscopy Surgery Medical emergencies. Critical care. Intensive care. First aid Fikri M. Abu-Zidan verfasserin aut Elie Chouillard verfasserin aut Salomone Di Saverio verfasserin aut Massimo Sartelli verfasserin aut Mauro Podda verfasserin aut Carlos Augusto Gomes verfasserin aut Ernest E. Moore verfasserin aut Susan J. Moug verfasserin aut Luca Ansaloni verfasserin aut Yoram Kluger verfasserin aut Federico Coccolini verfasserin aut Aitor Landaluce-Olavarria verfasserin aut Begoña Estraviz-Mateos verfasserin aut Ana Uriguen-Etxeberria verfasserin aut Alessio Giordano verfasserin aut Alfonso Palmieri Luna verfasserin aut Luz Adriana Hernández Amín verfasserin aut Adriana María Palmieri Hernández verfasserin aut Amanda Shabana verfasserin aut Zakaria Andee Dzulkarnaen verfasserin aut Muhammad Asyraf Othman verfasserin aut Mohamad Ikhwan Sani verfasserin aut Andrea Balla verfasserin aut Rosa Scaramuzzo verfasserin aut Pasquale Lepiane verfasserin aut Andrea Bottari verfasserin aut Fabio Staderini verfasserin aut Fabio Cianchi verfasserin aut Andrea Cavallaro verfasserin aut Antonio Zanghì verfasserin aut Alessandro Cappellani verfasserin aut Roberto Campagnacci verfasserin aut Angela Maurizi verfasserin aut Mario Martinotti verfasserin aut Annamaria Ruggieri verfasserin aut Asri Che Jusoh verfasserin aut Karim Abdul Rahman verfasserin aut Anis Suraya M. Zulkifli verfasserin aut Barbara Petronio verfasserin aut Belén Matías-García verfasserin aut Ana Quiroga-Valcárcel verfasserin aut Fernando Mendoza-Moreno verfasserin aut Boyko Atanasov verfasserin aut Fabio Cesare Campanile verfasserin aut Ilaria Vecchioni verfasserin aut Luca Cardinali verfasserin aut Grazia Travaglini verfasserin aut Elisa Sebastiani verfasserin aut Serge Chooklin verfasserin aut Serhii Chuklin verfasserin aut Pasquale Cianci verfasserin aut Enrico Restini verfasserin aut Sabino Capuzzolo verfasserin aut Giuseppe Currò verfasserin aut Rosalinda Filippo verfasserin aut Michele Rispoli verfasserin aut Daniel Aparicio-Sánchez verfasserin aut Virginia Durán Muñóz-Cruzado verfasserin aut Sandra Dios Barbeito verfasserin aut Samir Delibegovic verfasserin aut Amar Kesetovic verfasserin aut Diego Sasia verfasserin aut Felice Borghi verfasserin aut Giorgio Giraudo verfasserin aut Diego Visconti verfasserin aut Emanuele Doria verfasserin aut Mauro Santarelli verfasserin aut Davide Luppi verfasserin aut Stefano Bonilauri verfasserin aut Ugo Grossi verfasserin aut Giacomo Zanus verfasserin aut Alberto Sartori verfasserin aut Giacomo Piatto verfasserin aut Maurizio De Luca verfasserin aut Domenico Vita verfasserin aut Luigi Conti verfasserin aut Patrizio Capelli verfasserin aut Gaetano Maria Cattaneo verfasserin aut Athanasios Marinis verfasserin aut Styliani-Aikaterini Vederaki verfasserin aut Mehmet Bayrak verfasserin aut Yasemin Altıntas verfasserin aut Mustafa Yener Uzunoglu verfasserin aut Iskender Eren Demirbas verfasserin aut Yuksel Altinel verfasserin aut Serhat Meric verfasserin aut Yunus Emre Aktimur verfasserin aut Derya Salim Uymaz verfasserin aut Nail Omarov verfasserin aut Ibrahim Azamat verfasserin aut Eftychios Lostoridis verfasserin aut Eleni-Aikaterini Nagorni verfasserin aut Antonio Pujante verfasserin aut Gabriele Anania verfasserin aut Cristina Bombardini verfasserin aut Francesco Bagolini verfasserin aut Emre Gonullu verfasserin aut Baris Mantoglu verfasserin aut Recayi Capoglu verfasserin aut Stefano Cappato verfasserin aut Elena Muzio verfasserin aut Elif Colak verfasserin aut Suleyman Polat verfasserin aut Zehra Alan Koylu verfasserin aut Fatih Altintoprak verfasserin aut Zülfü Bayhan verfasserin aut Emrah Akin verfasserin aut Enrico Andolfi verfasserin aut Sulce Rezart verfasserin aut Jae Il Kim verfasserin aut Sung Won Jung verfasserin aut Yong Chan Shin verfasserin aut Octavian Enciu verfasserin aut Elena Adelina Toma verfasserin aut Fabio Medas verfasserin aut Gian Luigi Canu verfasserin aut Federico Cappellacci verfasserin aut Fabrizio D’Acapito verfasserin aut Giorgio Ercolani verfasserin aut Leonardo Solaini verfasserin aut Francesco Roscio verfasserin aut Federico Clerici verfasserin aut Roberta Gelmini verfasserin aut Francesco Serra verfasserin aut Elena Giulia Rossi verfasserin aut Francesco Fleres verfasserin aut Guglielmo Clarizia verfasserin aut Alessandro Spolini verfasserin aut Francesco Ferrara verfasserin aut Gabriela Nita verfasserin aut Jlenia Sarnari verfasserin aut Mahir Gachabayov verfasserin aut Abakar Abdullaev verfasserin aut Gaetano Poillucci verfasserin aut Gian Marco Palini verfasserin aut Simone Veneroni verfasserin aut Gianluca Garulli verfasserin aut Micaela Piccoli verfasserin aut Gianmaria Casoni Pattacini verfasserin aut Francesca Pecchini verfasserin aut Giulio Argenio verfasserin aut Mariano Fortunato Armellino verfasserin aut Giuseppe Brisinda verfasserin aut Silvia Tedesco verfasserin aut Pietro Fransvea verfasserin aut Giuseppe Ietto verfasserin aut Caterina Franchi verfasserin aut Giulio Carcano verfasserin aut Gennaro Martines verfasserin aut Giuseppe Trigiante verfasserin aut Giulia Negro verfasserin aut Gustavo Machain Vega verfasserin aut Agustín Rodríguez González verfasserin aut Leonardo Ojeda verfasserin aut Gaetano Piccolo verfasserin aut Andrea Bondurri verfasserin aut Anna Maffioli verfasserin aut Claudio Guerci verfasserin aut Boo Han Sin verfasserin aut Zamri Zuhdi verfasserin aut Azlanudin Azman verfasserin aut Hussam Mousa verfasserin aut Shadi al Bahri verfasserin aut Goran Augustin verfasserin aut Ivan Romic verfasserin aut Trpimir Moric verfasserin aut Ioannis Nikolopoulos verfasserin aut Jacopo Andreuccetti verfasserin aut Giusto Pignata verfasserin aut Rossella D’Alessio verfasserin aut Jakub Kenig verfasserin aut Urszula Skorus verfasserin aut Gustavo Pereira Fraga verfasserin aut Elcio Shiyoiti Hirano verfasserin aut Jackson Vinícius de Lima Bertuol verfasserin aut Arda Isik verfasserin aut Eray Kurnaz verfasserin aut Mohammad Sohail Asghar verfasserin aut Ameer Afzal verfasserin aut Ali Akbar verfasserin aut Taxiarchis Konstantinos Nikolouzakis verfasserin aut Konstantinos Lasithiotakis verfasserin aut Emmanuel Chrysos verfasserin aut Koray Das verfasserin aut Nazmi Özer verfasserin aut Ahmet Seker verfasserin aut Mohamed Ibrahim verfasserin aut Hytham K. S. Hamid verfasserin aut Ahmed Babiker verfasserin aut Konstantinos Bouliaris verfasserin aut George Koukoulis verfasserin aut Chrysoula-Christina Kolla verfasserin aut Andrea Lucchi verfasserin aut Laura Agostinelli verfasserin aut Antonio Taddei verfasserin aut Laura Fortuna verfasserin aut Carlotta Agostini verfasserin aut Leo Licari verfasserin aut Simona Viola verfasserin aut Cosimo Callari verfasserin aut Letizia Laface verfasserin aut Emmanuele Abate verfasserin aut Massimiliano Casati verfasserin aut Alessandro Anastasi verfasserin aut Giuseppe Canonico verfasserin aut Linda Gabellini verfasserin aut Lorenzo Tosi verfasserin aut Anna Guariniello verfasserin aut Federico Zanzi verfasserin aut Lovenish Bains verfasserin aut Larysa Sydorchuk verfasserin aut Oksana Iftoda verfasserin aut Andrii Sydorchuk verfasserin aut Michele Malerba verfasserin aut Federico Costanzo verfasserin aut Raffaele Galleano verfasserin aut Michela Monteleone verfasserin aut Andrea Costanzi verfasserin aut Carlo Riva verfasserin aut Maciej Walędziak verfasserin aut Andrzej Kwiatkowski verfasserin aut Łukasz Czyżykowski verfasserin aut Piotr Major verfasserin aut Marcin Strzałka verfasserin aut Maciej Matyja verfasserin aut Michal Natkaniec verfasserin aut Maria Rosaria Valenti verfasserin aut Maria Domenica Pia Di Vita verfasserin aut Maria Sotiropoulou verfasserin aut Stylianos Kapiris verfasserin aut Damien Massalou verfasserin aut Massimiliano Veroux verfasserin aut Alessio Volpicelli verfasserin aut Rossella Gioco verfasserin aut Matteo Uccelli verfasserin aut Marta Bonaldi verfasserin aut Stefano Olmi verfasserin aut Matteo Nardi verfasserin aut Giada Livadoti verfasserin aut Cristian Mesina verfasserin aut Theodor Viorel Dumitrescu verfasserin aut Mihai Calin Ciorbagiu verfasserin aut Michele Ammendola verfasserin aut Giorgio Ammerata verfasserin aut Roberto Romano verfasserin aut Mihail Slavchev verfasserin aut Evangelos P. Misiakos verfasserin aut Emmanouil Pikoulis verfasserin aut Dimitrios Papaconstantinou verfasserin aut Mohamed Elbahnasawy verfasserin aut Sherief Abdel-elsalam verfasserin aut Daniel M. Felsenreich verfasserin aut Julia Jedamzik verfasserin aut Nikolaos V. Michalopoulos verfasserin aut Theodoros A. Sidiropoulos verfasserin aut Maria Papadoliopoulou verfasserin aut Nicola Cillara verfasserin aut Antonello Deserra verfasserin aut Alessandro Cannavera verfasserin aut Ionuţ Negoi verfasserin aut Dimitrios Schizas verfasserin aut Athanasios Syllaios verfasserin aut Ilias Vagios verfasserin aut Stavros Gourgiotis verfasserin aut Nick Dai verfasserin aut Rekha Gurung verfasserin aut Marcus Norrey verfasserin aut Antonio Pesce verfasserin aut Carlo Vittorio Feo verfasserin aut Nicolo’ Fabbri verfasserin aut Nikolaos Machairas verfasserin aut Panagiotis Dorovinis verfasserin aut Myrto D. Keramida verfasserin aut Francesk Mulita verfasserin aut Georgios Ioannis Verras verfasserin aut Michail Vailas verfasserin aut Omer Yalkin verfasserin aut Nidal Iflazoglu verfasserin aut Direnc Yigit verfasserin aut Oussama Baraket verfasserin aut Karim Ayed verfasserin aut Mohamed hedi Ghalloussi verfasserin aut Parmenion Patias verfasserin aut Georgios Ntokos verfasserin aut Razrim Rahim verfasserin aut Miklosh Bala verfasserin aut Asaf Kedar verfasserin aut Robert G. Sawyer verfasserin aut Anna Trinh verfasserin aut Kelsey Miller verfasserin aut Ruslan Sydorchuk verfasserin aut Ruslan Knut verfasserin aut Oleksandr Plehutsa verfasserin aut Rumeysa Kevser Liman verfasserin aut Zeynep Ozkan verfasserin aut Saleh Abdel Kader verfasserin aut Sanjay Gupta verfasserin aut Monika Gureh verfasserin aut Sara Saeidi verfasserin aut Mohsen Aliakbarian verfasserin aut Amin Dalili verfasserin aut Tomohisa Shoko verfasserin aut Mitsuaki Kojima verfasserin aut Raira Nakamoto verfasserin aut Semra Demirli Atici verfasserin aut Gizem Kilinc Tuncer verfasserin aut Tayfun Kaya verfasserin aut Spiros G. Delis verfasserin aut Stefano Rossi verfasserin aut Biagio Picardi verfasserin aut Simone Rossi del Monte verfasserin aut Tania Triantafyllou verfasserin aut Dimitrios Theodorou verfasserin aut Tadeja Pintar verfasserin aut Jure Salobir verfasserin aut Dimitrios K. Manatakis verfasserin aut Nikolaos Tasis verfasserin aut Vasileios Acheimastos verfasserin aut Orestis Ioannidis verfasserin aut Lydia Loutzidou verfasserin aut Savvas Symeonidis verfasserin aut Tiago Correia de Sá verfasserin aut Mónica Rocha verfasserin aut Tommaso Guagni verfasserin aut Desiré Pantalone verfasserin aut Gherardo Maltinti verfasserin aut Vladimir Khokha verfasserin aut Wafaa Abdel-elsalam verfasserin aut Basma Ghoneim verfasserin aut José Antonio López-Ruiz verfasserin aut Yasin Kara verfasserin aut Syaza Zainudin verfasserin aut Firdaus Hayati verfasserin aut Nornazirah Azizan verfasserin aut Victoria Tan Phooi Khei verfasserin aut Rebecca Choy Xin Yi verfasserin aut Harivinthan Sellappan verfasserin aut Zaza Demetrashvili verfasserin aut Nika Lekiashvili verfasserin aut Ana Tvaladze verfasserin aut Caterina Froiio verfasserin aut Daniele Bernardi verfasserin aut Luigi Bonavina verfasserin aut Angeles Gil-Olarte verfasserin aut Sebastiano Grassia verfasserin aut Estela Romero-Vargas verfasserin aut Francesco Bianco verfasserin aut Andrew A. Gumbs verfasserin aut Agron Dogjani verfasserin aut Ferdinando Agresta verfasserin aut Andrey Litvin verfasserin aut Zsolt J. Balogh verfasserin aut George Gendrikson verfasserin aut Costanza Martino verfasserin aut Dimitrios Damaskos verfasserin aut Nikolaos Pararas verfasserin aut Andrew Kirkpatrick verfasserin aut Mikhail Kurtenkov verfasserin aut Felipe Couto Gomes verfasserin aut Adolfo Pisanu verfasserin aut Oreste Nardello verfasserin aut Fabrizio Gambarini verfasserin aut Hager Aref verfasserin aut Nicola de’ Angelis verfasserin aut Vanni Agnoletti verfasserin aut Antonio Biondi verfasserin aut Marco Vacante verfasserin aut Giulia Griggio verfasserin aut Roberta Tutino verfasserin aut Marco Massani verfasserin aut Giovanni Bisetto verfasserin aut Savino Occhionorelli verfasserin aut Dario Andreotti verfasserin aut Domenico Lacavalla verfasserin aut Walter L. Biffl verfasserin aut Fausto Catena verfasserin aut In World Journal of Emergency Surgery BMC, 2006 17(2022), 1, Seite 16 (DE-627)511639236 (DE-600)2233734-9 17497922 nnns volume:17 year:2022 number:1 pages:16 https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/article/16b272a5a4204c378480f1cd29897edc kostenfrei https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/toc/1749-7922 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 16 |
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10.1186/s13017-022-00466-4 doi (DE-627)DOAJ085162078 (DE-599)DOAJ16b272a5a4204c378480f1cd29897edc DE-627 ger DE-627 rakwb eng RD1-811 RC86-88.9 Belinda De Simone verfasserin aut The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract Acute cholecystitis Cholecystectomy Gangrene COVID-19 SARS-CoV-2 Laparoscopy Surgery Medical emergencies. Critical care. Intensive care. First aid Fikri M. Abu-Zidan verfasserin aut Elie Chouillard verfasserin aut Salomone Di Saverio verfasserin aut Massimo Sartelli verfasserin aut Mauro Podda verfasserin aut Carlos Augusto Gomes verfasserin aut Ernest E. Moore verfasserin aut Susan J. Moug verfasserin aut Luca Ansaloni verfasserin aut Yoram Kluger verfasserin aut Federico Coccolini verfasserin aut Aitor Landaluce-Olavarria verfasserin aut Begoña Estraviz-Mateos verfasserin aut Ana Uriguen-Etxeberria verfasserin aut Alessio Giordano verfasserin aut Alfonso Palmieri Luna verfasserin aut Luz Adriana Hernández Amín verfasserin aut Adriana María Palmieri Hernández verfasserin aut Amanda Shabana verfasserin aut Zakaria Andee Dzulkarnaen verfasserin aut Muhammad Asyraf Othman verfasserin aut Mohamad Ikhwan Sani verfasserin aut Andrea Balla verfasserin aut Rosa Scaramuzzo verfasserin aut Pasquale Lepiane verfasserin aut Andrea Bottari verfasserin aut Fabio Staderini verfasserin aut Fabio Cianchi verfasserin aut Andrea Cavallaro verfasserin aut Antonio Zanghì verfasserin aut Alessandro Cappellani verfasserin aut Roberto Campagnacci verfasserin aut Angela Maurizi verfasserin aut Mario Martinotti verfasserin aut Annamaria Ruggieri verfasserin aut Asri Che Jusoh verfasserin aut Karim Abdul Rahman verfasserin aut Anis Suraya M. Zulkifli verfasserin aut Barbara Petronio verfasserin aut Belén Matías-García verfasserin aut Ana Quiroga-Valcárcel verfasserin aut Fernando Mendoza-Moreno verfasserin aut Boyko Atanasov verfasserin aut Fabio Cesare Campanile verfasserin aut Ilaria Vecchioni verfasserin aut Luca Cardinali verfasserin aut Grazia Travaglini verfasserin aut Elisa Sebastiani verfasserin aut Serge Chooklin verfasserin aut Serhii Chuklin verfasserin aut Pasquale Cianci verfasserin aut Enrico Restini verfasserin aut Sabino Capuzzolo verfasserin aut Giuseppe Currò verfasserin aut Rosalinda Filippo verfasserin aut Michele Rispoli verfasserin aut Daniel Aparicio-Sánchez verfasserin aut Virginia Durán Muñóz-Cruzado verfasserin aut Sandra Dios Barbeito verfasserin aut Samir Delibegovic verfasserin aut Amar Kesetovic verfasserin aut Diego Sasia verfasserin aut Felice Borghi verfasserin aut Giorgio Giraudo verfasserin aut Diego Visconti verfasserin aut Emanuele Doria verfasserin aut Mauro Santarelli verfasserin aut Davide Luppi verfasserin aut Stefano Bonilauri verfasserin aut Ugo Grossi verfasserin aut Giacomo Zanus verfasserin aut Alberto Sartori verfasserin aut Giacomo Piatto verfasserin aut Maurizio De Luca verfasserin aut Domenico Vita verfasserin aut Luigi Conti verfasserin aut Patrizio Capelli verfasserin aut Gaetano Maria Cattaneo verfasserin aut Athanasios Marinis verfasserin aut Styliani-Aikaterini Vederaki verfasserin aut Mehmet Bayrak verfasserin aut Yasemin Altıntas verfasserin aut Mustafa Yener Uzunoglu verfasserin aut Iskender Eren Demirbas verfasserin aut Yuksel Altinel verfasserin aut Serhat Meric verfasserin aut Yunus Emre Aktimur verfasserin aut Derya Salim Uymaz verfasserin aut Nail Omarov verfasserin aut Ibrahim Azamat verfasserin aut Eftychios Lostoridis verfasserin aut Eleni-Aikaterini Nagorni verfasserin aut Antonio Pujante verfasserin aut Gabriele Anania verfasserin aut Cristina Bombardini verfasserin aut Francesco Bagolini verfasserin aut Emre Gonullu verfasserin aut Baris Mantoglu verfasserin aut Recayi Capoglu verfasserin aut Stefano Cappato verfasserin aut Elena Muzio verfasserin aut Elif Colak verfasserin aut Suleyman Polat verfasserin aut Zehra Alan Koylu verfasserin aut Fatih Altintoprak verfasserin aut Zülfü Bayhan verfasserin aut Emrah Akin verfasserin aut Enrico Andolfi verfasserin aut Sulce Rezart verfasserin aut Jae Il Kim verfasserin aut Sung Won Jung verfasserin aut Yong Chan Shin verfasserin aut Octavian Enciu verfasserin aut Elena Adelina Toma verfasserin aut Fabio Medas verfasserin aut Gian Luigi Canu verfasserin aut Federico Cappellacci verfasserin aut Fabrizio D’Acapito verfasserin aut Giorgio Ercolani verfasserin aut Leonardo Solaini verfasserin aut Francesco Roscio verfasserin aut Federico Clerici verfasserin aut Roberta Gelmini verfasserin aut Francesco Serra verfasserin aut Elena Giulia Rossi verfasserin aut Francesco Fleres verfasserin aut Guglielmo Clarizia verfasserin aut Alessandro Spolini verfasserin aut Francesco Ferrara verfasserin aut Gabriela Nita verfasserin aut Jlenia Sarnari verfasserin aut Mahir Gachabayov verfasserin aut Abakar Abdullaev verfasserin aut Gaetano Poillucci verfasserin aut Gian Marco Palini verfasserin aut Simone Veneroni verfasserin aut Gianluca Garulli verfasserin aut Micaela Piccoli verfasserin aut Gianmaria Casoni Pattacini verfasserin aut Francesca Pecchini verfasserin aut Giulio Argenio verfasserin aut Mariano Fortunato Armellino verfasserin aut Giuseppe Brisinda verfasserin aut Silvia Tedesco verfasserin aut Pietro Fransvea verfasserin aut Giuseppe Ietto verfasserin aut Caterina Franchi verfasserin aut Giulio Carcano verfasserin aut Gennaro Martines verfasserin aut Giuseppe Trigiante verfasserin aut Giulia Negro verfasserin aut Gustavo Machain Vega verfasserin aut Agustín Rodríguez González verfasserin aut Leonardo Ojeda verfasserin aut Gaetano Piccolo verfasserin aut Andrea Bondurri verfasserin aut Anna Maffioli verfasserin aut Claudio Guerci verfasserin aut Boo Han Sin verfasserin aut Zamri Zuhdi verfasserin aut Azlanudin Azman verfasserin aut Hussam Mousa verfasserin aut Shadi al Bahri verfasserin aut Goran Augustin verfasserin aut Ivan Romic verfasserin aut Trpimir Moric verfasserin aut Ioannis Nikolopoulos verfasserin aut Jacopo Andreuccetti verfasserin aut Giusto Pignata verfasserin aut Rossella D’Alessio verfasserin aut Jakub Kenig verfasserin aut Urszula Skorus verfasserin aut Gustavo Pereira Fraga verfasserin aut Elcio Shiyoiti Hirano verfasserin aut Jackson Vinícius de Lima Bertuol verfasserin aut Arda Isik verfasserin aut Eray Kurnaz verfasserin aut Mohammad Sohail Asghar verfasserin aut Ameer Afzal verfasserin aut Ali Akbar verfasserin aut Taxiarchis Konstantinos Nikolouzakis verfasserin aut Konstantinos Lasithiotakis verfasserin aut Emmanuel Chrysos verfasserin aut Koray Das verfasserin aut Nazmi Özer verfasserin aut Ahmet Seker verfasserin aut Mohamed Ibrahim verfasserin aut Hytham K. S. Hamid verfasserin aut Ahmed Babiker verfasserin aut Konstantinos Bouliaris verfasserin aut George Koukoulis verfasserin aut Chrysoula-Christina Kolla verfasserin aut Andrea Lucchi verfasserin aut Laura Agostinelli verfasserin aut Antonio Taddei verfasserin aut Laura Fortuna verfasserin aut Carlotta Agostini verfasserin aut Leo Licari verfasserin aut Simona Viola verfasserin aut Cosimo Callari verfasserin aut Letizia Laface verfasserin aut Emmanuele Abate verfasserin aut Massimiliano Casati verfasserin aut Alessandro Anastasi verfasserin aut Giuseppe Canonico verfasserin aut Linda Gabellini verfasserin aut Lorenzo Tosi verfasserin aut Anna Guariniello verfasserin aut Federico Zanzi verfasserin aut Lovenish Bains verfasserin aut Larysa Sydorchuk verfasserin aut Oksana Iftoda verfasserin aut Andrii Sydorchuk verfasserin aut Michele Malerba verfasserin aut Federico Costanzo verfasserin aut Raffaele Galleano verfasserin aut Michela Monteleone verfasserin aut Andrea Costanzi verfasserin aut Carlo Riva verfasserin aut Maciej Walędziak verfasserin aut Andrzej Kwiatkowski verfasserin aut Łukasz Czyżykowski verfasserin aut Piotr Major verfasserin aut Marcin Strzałka verfasserin aut Maciej Matyja verfasserin aut Michal Natkaniec verfasserin aut Maria Rosaria Valenti verfasserin aut Maria Domenica Pia Di Vita verfasserin aut Maria Sotiropoulou verfasserin aut Stylianos Kapiris verfasserin aut Damien Massalou verfasserin aut Massimiliano Veroux verfasserin aut Alessio Volpicelli verfasserin aut Rossella Gioco verfasserin aut Matteo Uccelli verfasserin aut Marta Bonaldi verfasserin aut Stefano Olmi verfasserin aut Matteo Nardi verfasserin aut Giada Livadoti verfasserin aut Cristian Mesina verfasserin aut Theodor Viorel Dumitrescu verfasserin aut Mihai Calin Ciorbagiu verfasserin aut Michele Ammendola verfasserin aut Giorgio Ammerata verfasserin aut Roberto Romano verfasserin aut Mihail Slavchev verfasserin aut Evangelos P. Misiakos verfasserin aut Emmanouil Pikoulis verfasserin aut Dimitrios Papaconstantinou verfasserin aut Mohamed Elbahnasawy verfasserin aut Sherief Abdel-elsalam verfasserin aut Daniel M. Felsenreich verfasserin aut Julia Jedamzik verfasserin aut Nikolaos V. Michalopoulos verfasserin aut Theodoros A. Sidiropoulos verfasserin aut Maria Papadoliopoulou verfasserin aut Nicola Cillara verfasserin aut Antonello Deserra verfasserin aut Alessandro Cannavera verfasserin aut Ionuţ Negoi verfasserin aut Dimitrios Schizas verfasserin aut Athanasios Syllaios verfasserin aut Ilias Vagios verfasserin aut Stavros Gourgiotis verfasserin aut Nick Dai verfasserin aut Rekha Gurung verfasserin aut Marcus Norrey verfasserin aut Antonio Pesce verfasserin aut Carlo Vittorio Feo verfasserin aut Nicolo’ Fabbri verfasserin aut Nikolaos Machairas verfasserin aut Panagiotis Dorovinis verfasserin aut Myrto D. Keramida verfasserin aut Francesk Mulita verfasserin aut Georgios Ioannis Verras verfasserin aut Michail Vailas verfasserin aut Omer Yalkin verfasserin aut Nidal Iflazoglu verfasserin aut Direnc Yigit verfasserin aut Oussama Baraket verfasserin aut Karim Ayed verfasserin aut Mohamed hedi Ghalloussi verfasserin aut Parmenion Patias verfasserin aut Georgios Ntokos verfasserin aut Razrim Rahim verfasserin aut Miklosh Bala verfasserin aut Asaf Kedar verfasserin aut Robert G. Sawyer verfasserin aut Anna Trinh verfasserin aut Kelsey Miller verfasserin aut Ruslan Sydorchuk verfasserin aut Ruslan Knut verfasserin aut Oleksandr Plehutsa verfasserin aut Rumeysa Kevser Liman verfasserin aut Zeynep Ozkan verfasserin aut Saleh Abdel Kader verfasserin aut Sanjay Gupta verfasserin aut Monika Gureh verfasserin aut Sara Saeidi verfasserin aut Mohsen Aliakbarian verfasserin aut Amin Dalili verfasserin aut Tomohisa Shoko verfasserin aut Mitsuaki Kojima verfasserin aut Raira Nakamoto verfasserin aut Semra Demirli Atici verfasserin aut Gizem Kilinc Tuncer verfasserin aut Tayfun Kaya verfasserin aut Spiros G. Delis verfasserin aut Stefano Rossi verfasserin aut Biagio Picardi verfasserin aut Simone Rossi del Monte verfasserin aut Tania Triantafyllou verfasserin aut Dimitrios Theodorou verfasserin aut Tadeja Pintar verfasserin aut Jure Salobir verfasserin aut Dimitrios K. Manatakis verfasserin aut Nikolaos Tasis verfasserin aut Vasileios Acheimastos verfasserin aut Orestis Ioannidis verfasserin aut Lydia Loutzidou verfasserin aut Savvas Symeonidis verfasserin aut Tiago Correia de Sá verfasserin aut Mónica Rocha verfasserin aut Tommaso Guagni verfasserin aut Desiré Pantalone verfasserin aut Gherardo Maltinti verfasserin aut Vladimir Khokha verfasserin aut Wafaa Abdel-elsalam verfasserin aut Basma Ghoneim verfasserin aut José Antonio López-Ruiz verfasserin aut Yasin Kara verfasserin aut Syaza Zainudin verfasserin aut Firdaus Hayati verfasserin aut Nornazirah Azizan verfasserin aut Victoria Tan Phooi Khei verfasserin aut Rebecca Choy Xin Yi verfasserin aut Harivinthan Sellappan verfasserin aut Zaza Demetrashvili verfasserin aut Nika Lekiashvili verfasserin aut Ana Tvaladze verfasserin aut Caterina Froiio verfasserin aut Daniele Bernardi verfasserin aut Luigi Bonavina verfasserin aut Angeles Gil-Olarte verfasserin aut Sebastiano Grassia verfasserin aut Estela Romero-Vargas verfasserin aut Francesco Bianco verfasserin aut Andrew A. Gumbs verfasserin aut Agron Dogjani verfasserin aut Ferdinando Agresta verfasserin aut Andrey Litvin verfasserin aut Zsolt J. Balogh verfasserin aut George Gendrikson verfasserin aut Costanza Martino verfasserin aut Dimitrios Damaskos verfasserin aut Nikolaos Pararas verfasserin aut Andrew Kirkpatrick verfasserin aut Mikhail Kurtenkov verfasserin aut Felipe Couto Gomes verfasserin aut Adolfo Pisanu verfasserin aut Oreste Nardello verfasserin aut Fabrizio Gambarini verfasserin aut Hager Aref verfasserin aut Nicola de’ Angelis verfasserin aut Vanni Agnoletti verfasserin aut Antonio Biondi verfasserin aut Marco Vacante verfasserin aut Giulia Griggio verfasserin aut Roberta Tutino verfasserin aut Marco Massani verfasserin aut Giovanni Bisetto verfasserin aut Savino Occhionorelli verfasserin aut Dario Andreotti verfasserin aut Domenico Lacavalla verfasserin aut Walter L. Biffl verfasserin aut Fausto Catena verfasserin aut In World Journal of Emergency Surgery BMC, 2006 17(2022), 1, Seite 16 (DE-627)511639236 (DE-600)2233734-9 17497922 nnns volume:17 year:2022 number:1 pages:16 https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/article/16b272a5a4204c378480f1cd29897edc kostenfrei https://doi.org/10.1186/s13017-022-00466-4 kostenfrei https://doaj.org/toc/1749-7922 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 16 |
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In World Journal of Emergency Surgery 17(2022), 1, Seite 16 volume:17 year:2022 number:1 pages:16 |
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Acute cholecystitis Cholecystectomy Gangrene COVID-19 SARS-CoV-2 Laparoscopy Surgery Medical emergencies. Critical care. Intensive care. First aid |
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Belinda De Simone @@aut@@ Fikri M. Abu-Zidan @@aut@@ Elie Chouillard @@aut@@ Salomone Di Saverio @@aut@@ Massimo Sartelli @@aut@@ Mauro Podda @@aut@@ Carlos Augusto Gomes @@aut@@ Ernest E. Moore @@aut@@ Susan J. Moug @@aut@@ Luca Ansaloni @@aut@@ Yoram Kluger @@aut@@ Federico Coccolini @@aut@@ Aitor Landaluce-Olavarria @@aut@@ Begoña Estraviz-Mateos @@aut@@ Ana Uriguen-Etxeberria @@aut@@ Alessio Giordano @@aut@@ Alfonso Palmieri Luna @@aut@@ Luz Adriana Hernández Amín @@aut@@ Adriana María Palmieri Hernández @@aut@@ Amanda Shabana @@aut@@ Zakaria Andee Dzulkarnaen @@aut@@ Muhammad Asyraf Othman @@aut@@ Mohamad Ikhwan Sani @@aut@@ Andrea Balla @@aut@@ Rosa Scaramuzzo @@aut@@ Pasquale Lepiane @@aut@@ Andrea Bottari @@aut@@ Fabio Staderini @@aut@@ Fabio Cianchi @@aut@@ Andrea Cavallaro @@aut@@ Antonio Zanghì @@aut@@ Alessandro Cappellani @@aut@@ Roberto Campagnacci @@aut@@ Angela Maurizi @@aut@@ Mario Martinotti @@aut@@ Annamaria Ruggieri @@aut@@ Asri Che Jusoh @@aut@@ Karim Abdul Rahman @@aut@@ Anis Suraya M. Zulkifli @@aut@@ Barbara Petronio @@aut@@ Belén Matías-García @@aut@@ Ana Quiroga-Valcárcel @@aut@@ Fernando Mendoza-Moreno @@aut@@ Boyko Atanasov @@aut@@ Fabio Cesare Campanile @@aut@@ Ilaria Vecchioni @@aut@@ Luca Cardinali @@aut@@ Grazia Travaglini @@aut@@ Elisa Sebastiani @@aut@@ Serge Chooklin @@aut@@ Serhii Chuklin @@aut@@ Pasquale Cianci @@aut@@ Enrico Restini @@aut@@ Sabino Capuzzolo @@aut@@ Giuseppe Currò @@aut@@ Rosalinda Filippo @@aut@@ Michele Rispoli @@aut@@ Daniel Aparicio-Sánchez @@aut@@ Virginia Durán Muñóz-Cruzado @@aut@@ Sandra Dios Barbeito @@aut@@ Samir Delibegovic @@aut@@ Amar Kesetovic @@aut@@ Diego Sasia @@aut@@ Felice Borghi @@aut@@ Giorgio Giraudo @@aut@@ Diego Visconti @@aut@@ Emanuele Doria @@aut@@ Mauro Santarelli @@aut@@ Davide Luppi @@aut@@ Stefano Bonilauri @@aut@@ Ugo Grossi @@aut@@ Giacomo Zanus @@aut@@ Alberto Sartori @@aut@@ Giacomo Piatto @@aut@@ Maurizio De Luca @@aut@@ Domenico Vita @@aut@@ Luigi Conti @@aut@@ Patrizio Capelli @@aut@@ Gaetano Maria Cattaneo @@aut@@ Athanasios Marinis @@aut@@ Styliani-Aikaterini Vederaki @@aut@@ Mehmet Bayrak @@aut@@ Yasemin Altıntas @@aut@@ Mustafa Yener Uzunoglu @@aut@@ Iskender Eren Demirbas @@aut@@ Yuksel Altinel @@aut@@ Serhat Meric @@aut@@ Yunus Emre Aktimur @@aut@@ Derya Salim Uymaz @@aut@@ Nail Omarov @@aut@@ Ibrahim Azamat @@aut@@ Eftychios Lostoridis @@aut@@ Eleni-Aikaterini Nagorni @@aut@@ Antonio Pujante @@aut@@ Gabriele Anania @@aut@@ Cristina Bombardini @@aut@@ Francesco Bagolini @@aut@@ Emre Gonullu @@aut@@ Baris Mantoglu @@aut@@ Recayi Capoglu @@aut@@ Stefano Cappato @@aut@@ Elena Muzio @@aut@@ Elif Colak @@aut@@ Suleyman Polat @@aut@@ Zehra Alan Koylu @@aut@@ Fatih Altintoprak @@aut@@ Zülfü Bayhan @@aut@@ Emrah Akin @@aut@@ Enrico Andolfi @@aut@@ Sulce Rezart @@aut@@ Jae Il Kim @@aut@@ Sung Won Jung @@aut@@ Yong Chan Shin @@aut@@ Octavian Enciu @@aut@@ Elena Adelina Toma @@aut@@ Fabio Medas @@aut@@ Gian Luigi Canu @@aut@@ Federico Cappellacci @@aut@@ Fabrizio D’Acapito @@aut@@ Giorgio Ercolani @@aut@@ Leonardo Solaini @@aut@@ Francesco Roscio @@aut@@ Federico Clerici @@aut@@ Roberta Gelmini @@aut@@ Francesco Serra @@aut@@ Elena Giulia Rossi @@aut@@ Francesco Fleres @@aut@@ Guglielmo Clarizia @@aut@@ Alessandro Spolini @@aut@@ Francesco Ferrara @@aut@@ Gabriela Nita @@aut@@ Jlenia Sarnari @@aut@@ Mahir Gachabayov @@aut@@ Abakar Abdullaev @@aut@@ Gaetano Poillucci @@aut@@ Gian Marco Palini @@aut@@ Simone Veneroni @@aut@@ Gianluca Garulli @@aut@@ Micaela Piccoli @@aut@@ Gianmaria Casoni Pattacini @@aut@@ Francesca Pecchini @@aut@@ Giulio Argenio @@aut@@ Mariano Fortunato Armellino @@aut@@ Giuseppe Brisinda @@aut@@ Silvia Tedesco @@aut@@ Pietro Fransvea @@aut@@ Giuseppe Ietto @@aut@@ Caterina Franchi @@aut@@ Giulio Carcano @@aut@@ Gennaro Martines @@aut@@ Giuseppe Trigiante @@aut@@ Giulia Negro @@aut@@ Gustavo Machain Vega @@aut@@ Agustín Rodríguez González @@aut@@ Leonardo Ojeda @@aut@@ Gaetano Piccolo @@aut@@ Andrea Bondurri @@aut@@ Anna Maffioli @@aut@@ Claudio Guerci @@aut@@ Boo Han Sin @@aut@@ Zamri Zuhdi @@aut@@ Azlanudin Azman @@aut@@ Hussam Mousa @@aut@@ Shadi al Bahri @@aut@@ Goran Augustin @@aut@@ Ivan Romic @@aut@@ Trpimir Moric @@aut@@ Ioannis Nikolopoulos @@aut@@ Jacopo Andreuccetti @@aut@@ Giusto Pignata @@aut@@ Rossella D’Alessio @@aut@@ Jakub Kenig @@aut@@ Urszula Skorus @@aut@@ Gustavo Pereira Fraga @@aut@@ Elcio Shiyoiti Hirano @@aut@@ Jackson Vinícius de Lima Bertuol @@aut@@ Arda Isik @@aut@@ Eray Kurnaz @@aut@@ Mohammad Sohail Asghar @@aut@@ Ameer Afzal @@aut@@ Ali Akbar @@aut@@ Taxiarchis Konstantinos Nikolouzakis @@aut@@ Konstantinos Lasithiotakis @@aut@@ Emmanuel Chrysos @@aut@@ Koray Das @@aut@@ Nazmi Özer @@aut@@ Ahmet Seker @@aut@@ Mohamed Ibrahim @@aut@@ Hytham K. S. Hamid @@aut@@ Ahmed Babiker @@aut@@ Konstantinos Bouliaris @@aut@@ George Koukoulis @@aut@@ Chrysoula-Christina Kolla @@aut@@ Andrea Lucchi @@aut@@ Laura Agostinelli @@aut@@ Antonio Taddei @@aut@@ Laura Fortuna @@aut@@ Carlotta Agostini @@aut@@ Leo Licari @@aut@@ Simona Viola @@aut@@ Cosimo Callari @@aut@@ Letizia Laface @@aut@@ Emmanuele Abate @@aut@@ Massimiliano Casati @@aut@@ Alessandro Anastasi @@aut@@ Giuseppe Canonico @@aut@@ Linda Gabellini @@aut@@ Lorenzo Tosi @@aut@@ Anna Guariniello @@aut@@ Federico Zanzi @@aut@@ Lovenish Bains @@aut@@ Larysa Sydorchuk @@aut@@ Oksana Iftoda @@aut@@ Andrii Sydorchuk @@aut@@ Michele Malerba @@aut@@ Federico Costanzo @@aut@@ Raffaele Galleano @@aut@@ Michela Monteleone @@aut@@ Andrea Costanzi @@aut@@ Carlo Riva @@aut@@ Maciej Walędziak @@aut@@ Andrzej Kwiatkowski @@aut@@ Łukasz Czyżykowski @@aut@@ Piotr Major @@aut@@ Marcin Strzałka @@aut@@ Maciej Matyja @@aut@@ Michal Natkaniec @@aut@@ Maria Rosaria Valenti @@aut@@ Maria Domenica Pia Di Vita @@aut@@ Maria Sotiropoulou @@aut@@ Stylianos Kapiris @@aut@@ Damien Massalou @@aut@@ Massimiliano Veroux @@aut@@ Alessio Volpicelli @@aut@@ Rossella Gioco @@aut@@ Matteo Uccelli @@aut@@ Marta Bonaldi @@aut@@ Stefano Olmi @@aut@@ Matteo Nardi @@aut@@ Giada Livadoti @@aut@@ Cristian Mesina @@aut@@ Theodor Viorel Dumitrescu @@aut@@ Mihai Calin Ciorbagiu @@aut@@ Michele Ammendola @@aut@@ Giorgio Ammerata @@aut@@ Roberto Romano @@aut@@ Mihail Slavchev @@aut@@ Evangelos P. Misiakos @@aut@@ Emmanouil Pikoulis @@aut@@ Dimitrios Papaconstantinou @@aut@@ Mohamed Elbahnasawy @@aut@@ Sherief Abdel-elsalam @@aut@@ Daniel M. Felsenreich @@aut@@ Julia Jedamzik @@aut@@ Nikolaos V. Michalopoulos @@aut@@ Theodoros A. Sidiropoulos @@aut@@ Maria Papadoliopoulou @@aut@@ Nicola Cillara @@aut@@ Antonello Deserra @@aut@@ Alessandro Cannavera @@aut@@ Ionuţ Negoi @@aut@@ Dimitrios Schizas @@aut@@ Athanasios Syllaios @@aut@@ Ilias Vagios @@aut@@ Stavros Gourgiotis @@aut@@ Nick Dai @@aut@@ Rekha Gurung @@aut@@ Marcus Norrey @@aut@@ Antonio Pesce @@aut@@ Carlo Vittorio Feo @@aut@@ Nicolo’ Fabbri @@aut@@ Nikolaos Machairas @@aut@@ Panagiotis Dorovinis @@aut@@ Myrto D. Keramida @@aut@@ Francesk Mulita @@aut@@ Georgios Ioannis Verras @@aut@@ Michail Vailas @@aut@@ Omer Yalkin @@aut@@ Nidal Iflazoglu @@aut@@ Direnc Yigit @@aut@@ Oussama Baraket @@aut@@ Karim Ayed @@aut@@ Mohamed hedi Ghalloussi @@aut@@ Parmenion Patias @@aut@@ Georgios Ntokos @@aut@@ Razrim Rahim @@aut@@ Miklosh Bala @@aut@@ Asaf Kedar @@aut@@ Robert G. Sawyer @@aut@@ Anna Trinh @@aut@@ Kelsey Miller @@aut@@ Ruslan Sydorchuk @@aut@@ Ruslan Knut @@aut@@ Oleksandr Plehutsa @@aut@@ Rumeysa Kevser Liman @@aut@@ Zeynep Ozkan @@aut@@ Saleh Abdel Kader @@aut@@ Sanjay Gupta @@aut@@ Monika Gureh @@aut@@ Sara Saeidi @@aut@@ Mohsen Aliakbarian @@aut@@ Amin Dalili @@aut@@ Tomohisa Shoko @@aut@@ Mitsuaki Kojima @@aut@@ Raira Nakamoto @@aut@@ Semra Demirli Atici @@aut@@ Gizem Kilinc Tuncer @@aut@@ Tayfun Kaya @@aut@@ Spiros G. Delis @@aut@@ Stefano Rossi @@aut@@ Biagio Picardi @@aut@@ Simone Rossi del Monte @@aut@@ Tania Triantafyllou @@aut@@ Dimitrios Theodorou @@aut@@ Tadeja Pintar @@aut@@ Jure Salobir @@aut@@ Dimitrios K. Manatakis @@aut@@ Nikolaos Tasis @@aut@@ Vasileios Acheimastos @@aut@@ Orestis Ioannidis @@aut@@ Lydia Loutzidou @@aut@@ Savvas Symeonidis @@aut@@ Tiago Correia de Sá @@aut@@ Mónica Rocha @@aut@@ Tommaso Guagni @@aut@@ Desiré Pantalone @@aut@@ Gherardo Maltinti @@aut@@ Vladimir Khokha @@aut@@ Wafaa Abdel-elsalam @@aut@@ Basma Ghoneim @@aut@@ José Antonio López-Ruiz @@aut@@ Yasin Kara @@aut@@ Syaza Zainudin @@aut@@ Firdaus Hayati @@aut@@ Nornazirah Azizan @@aut@@ Victoria Tan Phooi Khei @@aut@@ Rebecca Choy Xin Yi @@aut@@ Harivinthan Sellappan @@aut@@ Zaza Demetrashvili @@aut@@ Nika Lekiashvili @@aut@@ Ana Tvaladze @@aut@@ Caterina Froiio @@aut@@ Daniele Bernardi @@aut@@ Luigi Bonavina @@aut@@ Angeles Gil-Olarte @@aut@@ Sebastiano Grassia @@aut@@ Estela Romero-Vargas @@aut@@ Francesco Bianco @@aut@@ Andrew A. Gumbs @@aut@@ Agron Dogjani @@aut@@ Ferdinando Agresta @@aut@@ Andrey Litvin @@aut@@ Zsolt J. Balogh @@aut@@ George Gendrikson @@aut@@ Costanza Martino @@aut@@ Dimitrios Damaskos @@aut@@ Nikolaos Pararas @@aut@@ Andrew Kirkpatrick @@aut@@ Mikhail Kurtenkov @@aut@@ Felipe Couto Gomes @@aut@@ Adolfo Pisanu @@aut@@ Oreste Nardello @@aut@@ Fabrizio Gambarini @@aut@@ Hager Aref @@aut@@ Nicola de’ Angelis @@aut@@ Vanni Agnoletti @@aut@@ Antonio Biondi @@aut@@ Marco Vacante @@aut@@ Giulia Griggio @@aut@@ Roberta Tutino @@aut@@ Marco Massani @@aut@@ Giovanni Bisetto @@aut@@ Savino Occhionorelli @@aut@@ Dario Andreotti @@aut@@ Domenico Lacavalla @@aut@@ Walter L. Biffl @@aut@@ Fausto Catena @@aut@@ |
| publishDateDaySort_date |
2022-01-01T00:00:00Z |
| hierarchy_top_id |
511639236 |
| id |
DOAJ085162078 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ085162078</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230311033739.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13017-022-00466-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ085162078</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ16b272a5a4204c378480f1cd29897edc</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RD1-811</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC86-88.9</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Belinda De Simone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Acute cholecystitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cholecystectomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gangrene</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">SARS-CoV-2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Laparoscopy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Surgery</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medical emergencies. Critical care. Intensive care. First aid</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fikri M. Abu-Zidan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elie Chouillard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Salomone Di Saverio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Massimo Sartelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mauro Podda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Augusto Gomes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ernest E. Moore</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susan J. Moug</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luca Ansaloni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoram Kluger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Coccolini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aitor Landaluce-Olavarria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Begoña Estraviz-Mateos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" 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code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elif Colak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Suleyman Polat</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zehra Alan Koylu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fatih Altintoprak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zülfü Bayhan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emrah Akin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Enrico Andolfi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sulce Rezart</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jae Il Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sung Won Jung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yong Chan Shin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Octavian Enciu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elena Adelina Toma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fabio Medas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gian Luigi Canu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Cappellacci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fabrizio D’Acapito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giorgio Ercolani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leonardo Solaini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Roscio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Clerici</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberta Gelmini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Serra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elena Giulia Rossi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Fleres</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Guglielmo Clarizia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Spolini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Ferrara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriela Nita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jlenia Sarnari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mahir Gachabayov</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abakar Abdullaev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gaetano Poillucci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gian Marco Palini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simone Veneroni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gianluca Garulli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Micaela Piccoli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gianmaria Casoni Pattacini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesca Pecchini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giulio Argenio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariano Fortunato Armellino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Brisinda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvia Tedesco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pietro Fransvea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Ietto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Caterina Franchi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giulio Carcano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gennaro Martines</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Trigiante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giulia Negro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gustavo Machain Vega</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Agustín Rodríguez González</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leonardo Ojeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gaetano Piccolo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Bondurri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Maffioli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudio Guerci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Boo Han Sin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zamri Zuhdi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Azlanudin Azman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hussam Mousa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shadi al Bahri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Goran Augustin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ivan Romic</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Trpimir Moric</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioannis Nikolopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jacopo Andreuccetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giusto Pignata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rossella D’Alessio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jakub Kenig</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Urszula Skorus</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gustavo Pereira Fraga</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elcio Shiyoiti Hirano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jackson Vinícius de Lima Bertuol</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Arda Isik</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eray Kurnaz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohammad Sohail Asghar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ameer Afzal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ali Akbar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Taxiarchis Konstantinos Nikolouzakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Konstantinos Lasithiotakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanuel Chrysos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koray Das</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nazmi Özer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmet Seker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohamed Ibrahim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hytham K. S. Hamid</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmed Babiker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Konstantinos Bouliaris</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">George Koukoulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chrysoula-Christina Kolla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Lucchi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Agostinelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Taddei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Fortuna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlotta Agostini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leo Licari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simona Viola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cosimo Callari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Letizia Laface</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanuele Abate</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Massimiliano Casati</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Anastasi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Canonico</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Linda Gabellini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorenzo Tosi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Guariniello</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Zanzi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lovenish Bains</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Larysa Sydorchuk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oksana Iftoda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrii Sydorchuk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michele Malerba</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Costanzo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Raffaele Galleano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michela Monteleone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Costanzi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlo Riva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maciej Walędziak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrzej Kwiatkowski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Łukasz Czyżykowski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Piotr Major</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcin Strzałka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maciej Matyja</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michal Natkaniec</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Rosaria Valenti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Domenica Pia Di Vita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Sotiropoulou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stylianos Kapiris</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Damien Massalou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Massimiliano Veroux</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessio Volpicelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rossella Gioco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matteo Uccelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marta Bonaldi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Olmi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matteo Nardi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giada Livadoti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristian Mesina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Theodor Viorel Dumitrescu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mihai Calin Ciorbagiu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michele Ammendola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giorgio Ammerata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto Romano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mihail Slavchev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Evangelos P. Misiakos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanouil Pikoulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios Papaconstantinou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohamed Elbahnasawy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sherief Abdel-elsalam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel M. Felsenreich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia Jedamzik</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nikolaos V. Michalopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Theodoros A. Sidiropoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Papadoliopoulou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicola Cillara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonello Deserra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Cannavera</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ionuţ Negoi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios Schizas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Athanasios Syllaios</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ilias Vagios</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stavros Gourgiotis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nick Dai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rekha Gurung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcus Norrey</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Pesce</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlo Vittorio Feo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicolo’ Fabbri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nikolaos Machairas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Panagiotis Dorovinis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Myrto D. Keramida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesk Mulita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Ioannis Verras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michail Vailas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Omer Yalkin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nidal Iflazoglu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Direnc Yigit</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oussama Baraket</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karim Ayed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohamed hedi Ghalloussi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Parmenion Patias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Ntokos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Razrim Rahim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miklosh Bala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Asaf Kedar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robert G. Sawyer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Trinh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kelsey Miller</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruslan Sydorchuk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruslan Knut</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oleksandr Plehutsa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rumeysa Kevser Liman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zeynep Ozkan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Saleh Abdel Kader</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sanjay Gupta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monika Gureh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sara Saeidi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohsen Aliakbarian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amin Dalili</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tomohisa Shoko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mitsuaki Kojima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Raira Nakamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Semra Demirli Atici</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gizem Kilinc Tuncer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tayfun Kaya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Spiros G. Delis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Rossi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Biagio Picardi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simone Rossi del Monte</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tania Triantafyllou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios Theodorou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tadeja Pintar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jure Salobir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios K. Manatakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nikolaos Tasis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vasileios Acheimastos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Orestis Ioannidis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lydia Loutzidou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Savvas Symeonidis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tiago Correia de Sá</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mónica Rocha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tommaso Guagni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Desiré Pantalone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gherardo Maltinti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vladimir Khokha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wafaa Abdel-elsalam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Basma Ghoneim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">José Antonio López-Ruiz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasin Kara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Syaza Zainudin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Firdaus Hayati</subfield><subfield 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RD1-811 RC86-88.9 The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? Acute cholecystitis Cholecystectomy Gangrene COVID-19 SARS-CoV-2 Laparoscopy |
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Belinda De Simone Fikri M. Abu-Zidan Elie Chouillard Salomone Di Saverio Massimo Sartelli Mauro Podda Carlos Augusto Gomes Ernest E. Moore Susan J. Moug Luca Ansaloni Yoram Kluger Federico Coccolini Aitor Landaluce-Olavarria Begoña Estraviz-Mateos Ana Uriguen-Etxeberria Alessio Giordano Alfonso Palmieri Luna Luz Adriana Hernández Amín Adriana María Palmieri Hernández Amanda Shabana Zakaria Andee Dzulkarnaen Muhammad Asyraf Othman Mohamad Ikhwan Sani Andrea Balla Rosa Scaramuzzo Pasquale Lepiane Andrea Bottari Fabio Staderini Fabio Cianchi Andrea Cavallaro Antonio Zanghì Alessandro Cappellani Roberto Campagnacci Angela Maurizi Mario Martinotti Annamaria Ruggieri Asri Che Jusoh Karim Abdul Rahman Anis Suraya M. Zulkifli Barbara Petronio Belén Matías-García Ana Quiroga-Valcárcel Fernando Mendoza-Moreno Boyko Atanasov Fabio Cesare Campanile Ilaria Vecchioni Luca Cardinali Grazia Travaglini Elisa Sebastiani Serge Chooklin Serhii Chuklin Pasquale Cianci Enrico Restini Sabino Capuzzolo Giuseppe Currò Rosalinda Filippo Michele Rispoli Daniel Aparicio-Sánchez Virginia Durán Muñóz-Cruzado Sandra Dios Barbeito Samir Delibegovic Amar Kesetovic Diego Sasia Felice Borghi Giorgio Giraudo Diego Visconti Emanuele Doria Mauro Santarelli Davide Luppi Stefano Bonilauri Ugo Grossi Giacomo Zanus Alberto Sartori Giacomo Piatto Maurizio De Luca Domenico Vita Luigi Conti Patrizio Capelli Gaetano Maria Cattaneo Athanasios Marinis Styliani-Aikaterini Vederaki Mehmet Bayrak Yasemin Altıntas Mustafa Yener Uzunoglu Iskender Eren Demirbas Yuksel Altinel Serhat Meric Yunus Emre Aktimur Derya Salim Uymaz Nail Omarov Ibrahim Azamat Eftychios Lostoridis Eleni-Aikaterini Nagorni Antonio Pujante Gabriele Anania Cristina Bombardini Francesco Bagolini Emre Gonullu Baris Mantoglu Recayi Capoglu Stefano Cappato Elena Muzio Elif Colak Suleyman Polat Zehra Alan Koylu Fatih Altintoprak Zülfü Bayhan Emrah Akin Enrico Andolfi Sulce Rezart Jae Il Kim Sung Won Jung Yong Chan Shin Octavian Enciu Elena Adelina Toma Fabio Medas Gian Luigi Canu Federico Cappellacci Fabrizio D’Acapito Giorgio Ercolani Leonardo Solaini Francesco Roscio Federico Clerici Roberta Gelmini Francesco Serra Elena Giulia Rossi Francesco Fleres Guglielmo Clarizia Alessandro Spolini Francesco Ferrara Gabriela Nita Jlenia Sarnari Mahir Gachabayov Abakar Abdullaev Gaetano Poillucci Gian Marco Palini Simone Veneroni Gianluca Garulli Micaela Piccoli Gianmaria Casoni Pattacini Francesca Pecchini Giulio Argenio Mariano Fortunato Armellino Giuseppe Brisinda Silvia Tedesco Pietro Fransvea Giuseppe Ietto Caterina Franchi Giulio Carcano Gennaro Martines Giuseppe Trigiante Giulia Negro Gustavo Machain Vega Agustín Rodríguez González Leonardo Ojeda Gaetano Piccolo Andrea Bondurri Anna Maffioli Claudio Guerci Boo Han Sin Zamri Zuhdi Azlanudin Azman Hussam Mousa Shadi al Bahri Goran Augustin Ivan Romic Trpimir Moric Ioannis Nikolopoulos Jacopo Andreuccetti Giusto Pignata Rossella D’Alessio Jakub Kenig Urszula Skorus Gustavo Pereira Fraga Elcio Shiyoiti Hirano Jackson Vinícius de Lima Bertuol Arda Isik Eray Kurnaz Mohammad Sohail Asghar Ameer Afzal Ali Akbar Taxiarchis Konstantinos Nikolouzakis Konstantinos Lasithiotakis Emmanuel Chrysos Koray Das Nazmi Özer Ahmet Seker Mohamed Ibrahim Hytham K. S. Hamid Ahmed Babiker Konstantinos Bouliaris George Koukoulis Chrysoula-Christina Kolla Andrea Lucchi Laura Agostinelli Antonio Taddei Laura Fortuna Carlotta Agostini Leo Licari Simona Viola Cosimo Callari Letizia Laface Emmanuele Abate Massimiliano Casati Alessandro Anastasi Giuseppe Canonico Linda Gabellini Lorenzo Tosi Anna Guariniello Federico Zanzi Lovenish Bains Larysa Sydorchuk Oksana Iftoda Andrii Sydorchuk Michele Malerba Federico Costanzo Raffaele Galleano Michela Monteleone Andrea Costanzi Carlo Riva Maciej Walędziak Andrzej Kwiatkowski Łukasz Czyżykowski Piotr Major Marcin Strzałka Maciej Matyja Michal Natkaniec Maria Rosaria Valenti Maria Domenica Pia Di Vita Maria Sotiropoulou Stylianos Kapiris Damien Massalou Massimiliano Veroux Alessio Volpicelli Rossella Gioco Matteo Uccelli Marta Bonaldi Stefano Olmi Matteo Nardi Giada Livadoti Cristian Mesina Theodor Viorel Dumitrescu Mihai Calin Ciorbagiu Michele Ammendola Giorgio Ammerata Roberto Romano Mihail Slavchev Evangelos P. Misiakos Emmanouil Pikoulis Dimitrios Papaconstantinou Mohamed Elbahnasawy Sherief Abdel-elsalam Daniel M. Felsenreich Julia Jedamzik Nikolaos V. Michalopoulos Theodoros A. Sidiropoulos Maria Papadoliopoulou Nicola Cillara Antonello Deserra Alessandro Cannavera Ionuţ Negoi Dimitrios Schizas Athanasios Syllaios Ilias Vagios Stavros Gourgiotis Nick Dai Rekha Gurung Marcus Norrey Antonio Pesce Carlo Vittorio Feo Nicolo’ Fabbri Nikolaos Machairas Panagiotis Dorovinis Myrto D. Keramida Francesk Mulita Georgios Ioannis Verras Michail Vailas Omer Yalkin Nidal Iflazoglu Direnc Yigit Oussama Baraket Karim Ayed Mohamed hedi Ghalloussi Parmenion Patias Georgios Ntokos Razrim Rahim Miklosh Bala Asaf Kedar Robert G. Sawyer Anna Trinh Kelsey Miller Ruslan Sydorchuk Ruslan Knut Oleksandr Plehutsa Rumeysa Kevser Liman Zeynep Ozkan Saleh Abdel Kader Sanjay Gupta Monika Gureh Sara Saeidi Mohsen Aliakbarian Amin Dalili Tomohisa Shoko Mitsuaki Kojima Raira Nakamoto Semra Demirli Atici Gizem Kilinc Tuncer Tayfun Kaya Spiros G. Delis Stefano Rossi Biagio Picardi Simone Rossi del Monte Tania Triantafyllou Dimitrios Theodorou Tadeja Pintar Jure Salobir Dimitrios K. Manatakis Nikolaos Tasis Vasileios Acheimastos Orestis Ioannidis Lydia Loutzidou Savvas Symeonidis Tiago Correia de Sá Mónica Rocha Tommaso Guagni Desiré Pantalone Gherardo Maltinti Vladimir Khokha Wafaa Abdel-elsalam Basma Ghoneim José Antonio López-Ruiz Yasin Kara Syaza Zainudin Firdaus Hayati Nornazirah Azizan Victoria Tan Phooi Khei Rebecca Choy Xin Yi Harivinthan Sellappan Zaza Demetrashvili Nika Lekiashvili Ana Tvaladze Caterina Froiio Daniele Bernardi Luigi Bonavina Angeles Gil-Olarte Sebastiano Grassia Estela Romero-Vargas Francesco Bianco Andrew A. Gumbs Agron Dogjani Ferdinando Agresta Andrey Litvin Zsolt J. Balogh George Gendrikson Costanza Martino Dimitrios Damaskos Nikolaos Pararas Andrew Kirkpatrick Mikhail Kurtenkov Felipe Couto Gomes Adolfo Pisanu Oreste Nardello Fabrizio Gambarini Hager Aref Nicola de’ Angelis Vanni Agnoletti Antonio Biondi Marco Vacante Giulia Griggio Roberta Tutino Marco Massani Giovanni Bisetto Savino Occhionorelli Dario Andreotti Domenico Lacavalla Walter L. Biffl Fausto Catena |
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Elektronische Aufsätze |
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Belinda De Simone |
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10.1186/s13017-022-00466-4 |
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verfasserin |
| title_sort |
choco-w prospective observational global study: does covid-19 increase gangrenous cholecystitis? |
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RD1-811 |
| title_auth |
The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? |
| abstract |
Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract |
| abstractGer |
Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract |
| abstract_unstemmed |
Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract |
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The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis? |
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https://doi.org/10.1186/s13017-022-00466-4 https://doaj.org/article/16b272a5a4204c378480f1cd29897edc https://doaj.org/toc/1749-7922 |
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Fikri M. Abu-Zidan Elie Chouillard Salomone Di Saverio Massimo Sartelli Mauro Podda Carlos Augusto Gomes Ernest E. Moore Susan J. Moug Luca Ansaloni Yoram Kluger Federico Coccolini Aitor Landaluce-Olavarria Begoña Estraviz-Mateos Ana Uriguen-Etxeberria Alessio Giordano Alfonso Palmieri Luna Luz Adriana Hernández Amín Adriana María Palmieri Hernández Amanda Shabana Zakaria Andee Dzulkarnaen Muhammad Asyraf Othman Mohamad Ikhwan Sani Andrea Balla Rosa Scaramuzzo Pasquale Lepiane Andrea Bottari Fabio Staderini Fabio Cianchi Andrea Cavallaro Antonio Zanghì Alessandro Cappellani Roberto Campagnacci Angela Maurizi Mario Martinotti Annamaria Ruggieri Asri Che Jusoh Karim Abdul Rahman Anis Suraya M. Zulkifli Barbara Petronio Belén Matías-García Ana Quiroga-Valcárcel Fernando Mendoza-Moreno Boyko Atanasov Fabio Cesare Campanile Ilaria Vecchioni Luca Cardinali Grazia Travaglini Elisa Sebastiani Serge Chooklin Serhii Chuklin Pasquale Cianci Enrico Restini Sabino Capuzzolo Giuseppe Currò Rosalinda Filippo Michele Rispoli Daniel Aparicio-Sánchez Virginia Durán Muñóz-Cruzado Sandra Dios Barbeito Samir Delibegovic Amar Kesetovic Diego Sasia Felice Borghi Giorgio Giraudo Diego Visconti Emanuele Doria Mauro Santarelli Davide Luppi Stefano Bonilauri Ugo Grossi Giacomo Zanus Alberto Sartori Giacomo Piatto Maurizio De Luca Domenico Vita Luigi Conti Patrizio Capelli Gaetano Maria Cattaneo Athanasios Marinis Styliani-Aikaterini Vederaki Mehmet Bayrak Yasemin Altıntas Mustafa Yener Uzunoglu Iskender Eren Demirbas Yuksel Altinel Serhat Meric Yunus Emre Aktimur Derya Salim Uymaz Nail Omarov Ibrahim Azamat Eftychios Lostoridis Eleni-Aikaterini Nagorni Antonio Pujante Gabriele Anania Cristina Bombardini Francesco Bagolini Emre Gonullu Baris Mantoglu Recayi Capoglu Stefano Cappato Elena Muzio Elif Colak Suleyman Polat Zehra Alan Koylu Fatih Altintoprak Zülfü Bayhan Emrah Akin Enrico Andolfi Sulce Rezart Jae Il Kim Sung Won Jung Yong Chan Shin Octavian Enciu Elena Adelina Toma Fabio Medas Gian Luigi Canu Federico Cappellacci Fabrizio D’Acapito Giorgio Ercolani Leonardo Solaini Francesco Roscio Federico Clerici Roberta Gelmini Francesco Serra Elena Giulia Rossi Francesco Fleres Guglielmo Clarizia Alessandro Spolini Francesco Ferrara Gabriela Nita Jlenia Sarnari Mahir Gachabayov Abakar Abdullaev Gaetano Poillucci Gian Marco Palini Simone Veneroni Gianluca Garulli Micaela Piccoli Gianmaria Casoni Pattacini Francesca Pecchini Giulio Argenio Mariano Fortunato Armellino Giuseppe Brisinda Silvia Tedesco Pietro Fransvea Giuseppe Ietto Caterina Franchi Giulio Carcano Gennaro Martines Giuseppe Trigiante Giulia Negro Gustavo Machain Vega Agustín Rodríguez González Leonardo Ojeda Gaetano Piccolo Andrea Bondurri Anna Maffioli Claudio Guerci Boo Han Sin Zamri Zuhdi Azlanudin Azman Hussam Mousa Shadi al Bahri Goran Augustin Ivan Romic Trpimir Moric Ioannis Nikolopoulos Jacopo Andreuccetti Giusto Pignata Rossella D’Alessio Jakub Kenig Urszula Skorus Gustavo Pereira Fraga Elcio Shiyoiti Hirano Jackson Vinícius de Lima Bertuol Arda Isik Eray Kurnaz Mohammad Sohail Asghar Ameer Afzal Ali Akbar Taxiarchis Konstantinos Nikolouzakis Konstantinos Lasithiotakis Emmanuel Chrysos Koray Das Nazmi Özer Ahmet Seker Mohamed Ibrahim Hytham K. S. Hamid Ahmed Babiker Konstantinos Bouliaris George Koukoulis Chrysoula-Christina Kolla Andrea Lucchi Laura Agostinelli Antonio Taddei Laura Fortuna Carlotta Agostini Leo Licari Simona Viola Cosimo Callari Letizia Laface Emmanuele Abate Massimiliano Casati Alessandro Anastasi Giuseppe Canonico Linda Gabellini Lorenzo Tosi Anna Guariniello Federico Zanzi Lovenish Bains Larysa Sydorchuk Oksana Iftoda Andrii Sydorchuk Michele Malerba Federico Costanzo Raffaele Galleano Michela Monteleone Andrea Costanzi Carlo Riva Maciej Walędziak Andrzej Kwiatkowski Łukasz Czyżykowski Piotr Major Marcin Strzałka Maciej Matyja Michal Natkaniec Maria Rosaria Valenti Maria Domenica Pia Di Vita Maria Sotiropoulou Stylianos Kapiris Damien Massalou Massimiliano Veroux Alessio Volpicelli Rossella Gioco Matteo Uccelli Marta Bonaldi Stefano Olmi Matteo Nardi Giada Livadoti Cristian Mesina Theodor Viorel Dumitrescu Mihai Calin Ciorbagiu Michele Ammendola Giorgio Ammerata Roberto Romano Mihail Slavchev Evangelos P. Misiakos Emmanouil Pikoulis Dimitrios Papaconstantinou Mohamed Elbahnasawy Sherief Abdel-elsalam Daniel M. Felsenreich Julia Jedamzik Nikolaos V. Michalopoulos Theodoros A. Sidiropoulos Maria Papadoliopoulou Nicola Cillara Antonello Deserra Alessandro Cannavera Ionuţ Negoi Dimitrios Schizas Athanasios Syllaios Ilias Vagios Stavros Gourgiotis Nick Dai Rekha Gurung Marcus Norrey Antonio Pesce Carlo Vittorio Feo Nicolo’ Fabbri Nikolaos Machairas Panagiotis Dorovinis Myrto D. Keramida Francesk Mulita Georgios Ioannis Verras Michail Vailas Omer Yalkin Nidal Iflazoglu Direnc Yigit Oussama Baraket Karim Ayed Mohamed hedi Ghalloussi Parmenion Patias Georgios Ntokos Razrim Rahim Miklosh Bala Asaf Kedar Robert G. Sawyer Anna Trinh Kelsey Miller Ruslan Sydorchuk Ruslan Knut Oleksandr Plehutsa Rumeysa Kevser Liman Zeynep Ozkan Saleh Abdel Kader Sanjay Gupta Monika Gureh Sara Saeidi Mohsen Aliakbarian Amin Dalili Tomohisa Shoko Mitsuaki Kojima Raira Nakamoto Semra Demirli Atici Gizem Kilinc Tuncer Tayfun Kaya Spiros G. Delis Stefano Rossi Biagio Picardi Simone Rossi del Monte Tania Triantafyllou Dimitrios Theodorou Tadeja Pintar Jure Salobir Dimitrios K. Manatakis Nikolaos Tasis Vasileios Acheimastos Orestis Ioannidis Lydia Loutzidou Savvas Symeonidis Tiago Correia de Sá Mónica Rocha Tommaso Guagni Desiré Pantalone Gherardo Maltinti Vladimir Khokha Wafaa Abdel-elsalam Basma Ghoneim José Antonio López-Ruiz Yasin Kara Syaza Zainudin Firdaus Hayati Nornazirah Azizan Victoria Tan Phooi Khei Rebecca Choy Xin Yi Harivinthan Sellappan Zaza Demetrashvili Nika Lekiashvili Ana Tvaladze Caterina Froiio Daniele Bernardi Luigi Bonavina Angeles Gil-Olarte Sebastiano Grassia Estela Romero-Vargas Francesco Bianco Andrew A. Gumbs Agron Dogjani Ferdinando Agresta Andrey Litvin Zsolt J. Balogh George Gendrikson Costanza Martino Dimitrios Damaskos Nikolaos Pararas Andrew Kirkpatrick Mikhail Kurtenkov Felipe Couto Gomes Adolfo Pisanu Oreste Nardello Fabrizio Gambarini Hager Aref Nicola de’ Angelis Vanni Agnoletti Antonio Biondi Marco Vacante Giulia Griggio Roberta Tutino Marco Massani Giovanni Bisetto Savino Occhionorelli Dario Andreotti Domenico Lacavalla Walter L. Biffl Fausto Catena |
| author2Str |
Fikri M. Abu-Zidan Elie Chouillard Salomone Di Saverio Massimo Sartelli Mauro Podda Carlos Augusto Gomes Ernest E. Moore Susan J. Moug Luca Ansaloni Yoram Kluger Federico Coccolini Aitor Landaluce-Olavarria Begoña Estraviz-Mateos Ana Uriguen-Etxeberria Alessio Giordano Alfonso Palmieri Luna Luz Adriana Hernández Amín Adriana María Palmieri Hernández Amanda Shabana Zakaria Andee Dzulkarnaen Muhammad Asyraf Othman Mohamad Ikhwan Sani Andrea Balla Rosa Scaramuzzo Pasquale Lepiane Andrea Bottari Fabio Staderini Fabio Cianchi Andrea Cavallaro Antonio Zanghì Alessandro Cappellani Roberto Campagnacci Angela Maurizi Mario Martinotti Annamaria Ruggieri Asri Che Jusoh Karim Abdul Rahman Anis Suraya M. Zulkifli Barbara Petronio Belén Matías-García Ana Quiroga-Valcárcel Fernando Mendoza-Moreno Boyko Atanasov Fabio Cesare Campanile Ilaria Vecchioni Luca Cardinali Grazia Travaglini Elisa Sebastiani Serge Chooklin Serhii Chuklin Pasquale Cianci Enrico Restini Sabino Capuzzolo Giuseppe Currò Rosalinda Filippo Michele Rispoli Daniel Aparicio-Sánchez Virginia Durán Muñóz-Cruzado Sandra Dios Barbeito Samir Delibegovic Amar Kesetovic Diego Sasia Felice Borghi Giorgio Giraudo Diego Visconti Emanuele Doria Mauro Santarelli Davide Luppi Stefano Bonilauri Ugo Grossi Giacomo Zanus Alberto Sartori Giacomo Piatto Maurizio De Luca Domenico Vita Luigi Conti Patrizio Capelli Gaetano Maria Cattaneo Athanasios Marinis Styliani-Aikaterini Vederaki Mehmet Bayrak Yasemin Altıntas Mustafa Yener Uzunoglu Iskender Eren Demirbas Yuksel Altinel Serhat Meric Yunus Emre Aktimur Derya Salim Uymaz Nail Omarov Ibrahim Azamat Eftychios Lostoridis Eleni-Aikaterini Nagorni Antonio Pujante Gabriele Anania Cristina Bombardini Francesco Bagolini Emre Gonullu Baris Mantoglu Recayi Capoglu Stefano Cappato Elena Muzio Elif Colak Suleyman Polat Zehra Alan Koylu Fatih Altintoprak Zülfü Bayhan Emrah Akin Enrico Andolfi Sulce Rezart Jae Il Kim Sung Won Jung Yong Chan Shin Octavian Enciu Elena Adelina Toma Fabio Medas Gian Luigi Canu Federico Cappellacci Fabrizio D’Acapito Giorgio Ercolani Leonardo Solaini Francesco Roscio Federico Clerici Roberta Gelmini Francesco Serra Elena Giulia Rossi Francesco Fleres Guglielmo Clarizia Alessandro Spolini Francesco Ferrara Gabriela Nita Jlenia Sarnari Mahir Gachabayov Abakar Abdullaev Gaetano Poillucci Gian Marco Palini Simone Veneroni Gianluca Garulli Micaela Piccoli Gianmaria Casoni Pattacini Francesca Pecchini Giulio Argenio Mariano Fortunato Armellino Giuseppe Brisinda Silvia Tedesco Pietro Fransvea Giuseppe Ietto Caterina Franchi Giulio Carcano Gennaro Martines Giuseppe Trigiante Giulia Negro Gustavo Machain Vega Agustín Rodríguez González Leonardo Ojeda Gaetano Piccolo Andrea Bondurri Anna Maffioli Claudio Guerci Boo Han Sin Zamri Zuhdi Azlanudin Azman Hussam Mousa Shadi al Bahri Goran Augustin Ivan Romic Trpimir Moric Ioannis Nikolopoulos Jacopo Andreuccetti Giusto Pignata Rossella D’Alessio Jakub Kenig Urszula Skorus Gustavo Pereira Fraga Elcio Shiyoiti Hirano Jackson Vinícius de Lima Bertuol Arda Isik Eray Kurnaz Mohammad Sohail Asghar Ameer Afzal Ali Akbar Taxiarchis Konstantinos Nikolouzakis Konstantinos Lasithiotakis Emmanuel Chrysos Koray Das Nazmi Özer Ahmet Seker Mohamed Ibrahim Hytham K. S. Hamid Ahmed Babiker Konstantinos Bouliaris George Koukoulis Chrysoula-Christina Kolla Andrea Lucchi Laura Agostinelli Antonio Taddei Laura Fortuna Carlotta Agostini Leo Licari Simona Viola Cosimo Callari Letizia Laface Emmanuele Abate Massimiliano Casati Alessandro Anastasi Giuseppe Canonico Linda Gabellini Lorenzo Tosi Anna Guariniello Federico Zanzi Lovenish Bains Larysa Sydorchuk Oksana Iftoda Andrii Sydorchuk Michele Malerba Federico Costanzo Raffaele Galleano Michela Monteleone Andrea Costanzi Carlo Riva Maciej Walędziak Andrzej Kwiatkowski Łukasz Czyżykowski Piotr Major Marcin Strzałka Maciej Matyja Michal Natkaniec Maria Rosaria Valenti Maria Domenica Pia Di Vita Maria Sotiropoulou Stylianos Kapiris Damien Massalou Massimiliano Veroux Alessio Volpicelli Rossella Gioco Matteo Uccelli Marta Bonaldi Stefano Olmi Matteo Nardi Giada Livadoti Cristian Mesina Theodor Viorel Dumitrescu Mihai Calin Ciorbagiu Michele Ammendola Giorgio Ammerata Roberto Romano Mihail Slavchev Evangelos P. Misiakos Emmanouil Pikoulis Dimitrios Papaconstantinou Mohamed Elbahnasawy Sherief Abdel-elsalam Daniel M. Felsenreich Julia Jedamzik Nikolaos V. Michalopoulos Theodoros A. Sidiropoulos Maria Papadoliopoulou Nicola Cillara Antonello Deserra Alessandro Cannavera Ionuţ Negoi Dimitrios Schizas Athanasios Syllaios Ilias Vagios Stavros Gourgiotis Nick Dai Rekha Gurung Marcus Norrey Antonio Pesce Carlo Vittorio Feo Nicolo’ Fabbri Nikolaos Machairas Panagiotis Dorovinis Myrto D. Keramida Francesk Mulita Georgios Ioannis Verras Michail Vailas Omer Yalkin Nidal Iflazoglu Direnc Yigit Oussama Baraket Karim Ayed Mohamed hedi Ghalloussi Parmenion Patias Georgios Ntokos Razrim Rahim Miklosh Bala Asaf Kedar Robert G. Sawyer Anna Trinh Kelsey Miller Ruslan Sydorchuk Ruslan Knut Oleksandr Plehutsa Rumeysa Kevser Liman Zeynep Ozkan Saleh Abdel Kader Sanjay Gupta Monika Gureh Sara Saeidi Mohsen Aliakbarian Amin Dalili Tomohisa Shoko Mitsuaki Kojima Raira Nakamoto Semra Demirli Atici Gizem Kilinc Tuncer Tayfun Kaya Spiros G. Delis Stefano Rossi Biagio Picardi Simone Rossi del Monte Tania Triantafyllou Dimitrios Theodorou Tadeja Pintar Jure Salobir Dimitrios K. Manatakis Nikolaos Tasis Vasileios Acheimastos Orestis Ioannidis Lydia Loutzidou Savvas Symeonidis Tiago Correia de Sá Mónica Rocha Tommaso Guagni Desiré Pantalone Gherardo Maltinti Vladimir Khokha Wafaa Abdel-elsalam Basma Ghoneim José Antonio López-Ruiz Yasin Kara Syaza Zainudin Firdaus Hayati Nornazirah Azizan Victoria Tan Phooi Khei Rebecca Choy Xin Yi Harivinthan Sellappan Zaza Demetrashvili Nika Lekiashvili Ana Tvaladze Caterina Froiio Daniele Bernardi Luigi Bonavina Angeles Gil-Olarte Sebastiano Grassia Estela Romero-Vargas Francesco Bianco Andrew A. Gumbs Agron Dogjani Ferdinando Agresta Andrey Litvin Zsolt J. Balogh George Gendrikson Costanza Martino Dimitrios Damaskos Nikolaos Pararas Andrew Kirkpatrick Mikhail Kurtenkov Felipe Couto Gomes Adolfo Pisanu Oreste Nardello Fabrizio Gambarini Hager Aref Nicola de’ Angelis Vanni Agnoletti Antonio Biondi Marco Vacante Giulia Griggio Roberta Tutino Marco Massani Giovanni Bisetto Savino Occhionorelli Dario Andreotti Domenico Lacavalla Walter L. Biffl Fausto Catena |
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10.1186/s13017-022-00466-4 |
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RD1-811 |
| up_date |
2024-07-04T02:04:45.386Z |
| _version_ |
1803612256116670464 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ085162078</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230311033739.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230311s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13017-022-00466-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ085162078</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ16b272a5a4204c378480f1cd29897edc</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RD1-811</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC86-88.9</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Belinda De Simone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Acute cholecystitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cholecystectomy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gangrene</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">SARS-CoV-2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Laparoscopy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Surgery</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medical emergencies. Critical care. Intensive care. First aid</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fikri M. Abu-Zidan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elie Chouillard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Salomone Di Saverio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Massimo Sartelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mauro Podda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Augusto Gomes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ernest E. Moore</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susan J. Moug</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luca Ansaloni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yoram Kluger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Coccolini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aitor Landaluce-Olavarria</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Begoña Estraviz-Mateos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" 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code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elif Colak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Suleyman Polat</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zehra Alan Koylu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fatih Altintoprak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zülfü Bayhan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emrah Akin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Enrico Andolfi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sulce Rezart</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jae Il Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sung Won Jung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yong Chan Shin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Octavian Enciu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elena Adelina Toma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fabio Medas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gian Luigi Canu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Cappellacci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fabrizio D’Acapito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giorgio Ercolani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leonardo Solaini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Roscio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Clerici</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberta Gelmini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Serra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elena Giulia Rossi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Fleres</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Guglielmo Clarizia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Spolini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Ferrara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriela Nita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jlenia Sarnari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mahir Gachabayov</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abakar Abdullaev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gaetano Poillucci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gian Marco Palini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simone Veneroni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gianluca Garulli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Micaela Piccoli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gianmaria Casoni Pattacini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesca Pecchini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giulio Argenio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariano Fortunato Armellino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Brisinda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Silvia Tedesco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pietro Fransvea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Ietto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Caterina Franchi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giulio Carcano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gennaro Martines</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Trigiante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giulia Negro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gustavo Machain Vega</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Agustín Rodríguez González</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leonardo Ojeda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gaetano Piccolo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Bondurri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Maffioli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudio Guerci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Boo Han Sin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zamri Zuhdi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Azlanudin Azman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hussam Mousa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shadi al Bahri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Goran Augustin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ivan Romic</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Trpimir Moric</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ioannis Nikolopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jacopo Andreuccetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giusto Pignata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rossella D’Alessio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jakub Kenig</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Urszula Skorus</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gustavo Pereira Fraga</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elcio Shiyoiti Hirano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jackson Vinícius de Lima Bertuol</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Arda Isik</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eray Kurnaz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohammad Sohail Asghar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ameer Afzal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ali Akbar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Taxiarchis Konstantinos Nikolouzakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Konstantinos Lasithiotakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanuel Chrysos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Koray Das</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nazmi Özer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmet Seker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohamed Ibrahim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hytham K. S. Hamid</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmed Babiker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Konstantinos Bouliaris</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">George Koukoulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chrysoula-Christina Kolla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Lucchi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Agostinelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Taddei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Fortuna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlotta Agostini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leo Licari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simona Viola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cosimo Callari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Letizia Laface</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanuele Abate</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Massimiliano Casati</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Anastasi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Canonico</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Linda Gabellini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorenzo Tosi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Guariniello</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Zanzi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lovenish Bains</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Larysa Sydorchuk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oksana Iftoda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrii Sydorchuk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michele Malerba</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Federico Costanzo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Raffaele Galleano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michela Monteleone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrea Costanzi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlo Riva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maciej Walędziak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrzej Kwiatkowski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Łukasz Czyżykowski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Piotr Major</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcin Strzałka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maciej Matyja</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michal Natkaniec</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Rosaria Valenti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Domenica Pia Di Vita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Sotiropoulou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stylianos Kapiris</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Damien Massalou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Massimiliano Veroux</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessio Volpicelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rossella Gioco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matteo Uccelli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marta Bonaldi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Olmi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matteo Nardi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giada Livadoti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cristian Mesina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Theodor Viorel Dumitrescu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mihai Calin Ciorbagiu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michele Ammendola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giorgio Ammerata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto Romano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mihail Slavchev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Evangelos P. Misiakos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanouil Pikoulis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios Papaconstantinou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohamed Elbahnasawy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sherief Abdel-elsalam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel M. Felsenreich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia Jedamzik</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nikolaos V. Michalopoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Theodoros A. Sidiropoulos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Papadoliopoulou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicola Cillara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonello Deserra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessandro Cannavera</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ionuţ Negoi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios Schizas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Athanasios Syllaios</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ilias Vagios</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stavros Gourgiotis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nick Dai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rekha Gurung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marcus Norrey</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonio Pesce</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlo Vittorio Feo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicolo’ Fabbri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nikolaos Machairas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Panagiotis Dorovinis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Myrto D. Keramida</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesk Mulita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Ioannis Verras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michail Vailas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Omer Yalkin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nidal Iflazoglu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Direnc Yigit</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oussama Baraket</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karim Ayed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohamed hedi Ghalloussi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Parmenion Patias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Georgios Ntokos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Razrim Rahim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miklosh Bala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Asaf Kedar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robert G. Sawyer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna Trinh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kelsey Miller</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruslan Sydorchuk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruslan Knut</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Oleksandr Plehutsa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rumeysa Kevser Liman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zeynep Ozkan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Saleh Abdel Kader</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sanjay Gupta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monika Gureh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sara Saeidi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mohsen Aliakbarian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amin Dalili</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tomohisa Shoko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mitsuaki Kojima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Raira Nakamoto</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Semra Demirli Atici</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gizem Kilinc Tuncer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tayfun Kaya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Spiros G. Delis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Rossi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Biagio Picardi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simone Rossi del Monte</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tania Triantafyllou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios Theodorou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tadeja Pintar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jure Salobir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dimitrios K. Manatakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nikolaos Tasis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vasileios Acheimastos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Orestis Ioannidis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lydia Loutzidou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Savvas Symeonidis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tiago Correia de Sá</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mónica Rocha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tommaso Guagni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Desiré Pantalone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gherardo Maltinti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vladimir Khokha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wafaa Abdel-elsalam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Basma Ghoneim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">José Antonio López-Ruiz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yasin Kara</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Syaza Zainudin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Firdaus Hayati</subfield><subfield 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code="a">Nika Lekiashvili</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Tvaladze</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Caterina Froiio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniele Bernardi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luigi Bonavina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angeles Gil-Olarte</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" 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