Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated...
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Autor*in:	Yong-Jun Lu [verfasserIn] Zhi-Gang She [verfasserIn] Yong-Cheng Lin [verfasserIn] Miao Yu [verfasserIn] Cai-Huan Huang [verfasserIn] Xun Zhu [verfasserIn] Hong-Bo Huang [verfasserIn] Bin Chen [verfasserIn] Jia-Hui Pan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	endophytic fungus Alternaria sp. bianthraquinone alterporriol cytotoxicity

Übergeordnetes Werk:	In: Marine Drugs - MDPI AG, 2005, 9(2011), 5, Seite 832-843
Übergeordnetes Werk:	volume:9 ; year:2011 ; number:5 ; pages:832-843

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/md9050832

Katalog-ID:	DOAJ085175161

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language	English
source	In Marine Drugs 9(2011), 5, Seite 832-843 volume:9 year:2011 number:5 pages:832-843
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callnumber-first	Q - Science
author	Yong-Jun Lu
spellingShingle	Yong-Jun Lu misc QH301-705.5 misc endophytic fungus misc Alternaria sp. misc bianthraquinone misc alterporriol misc cytotoxicity misc Biology (General) Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea
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topic_title	QH301-705.5 Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea endophytic fungus Alternaria sp bianthraquinone alterporriol cytotoxicity
topic	misc QH301-705.5 misc endophytic fungus misc Alternaria sp. misc bianthraquinone misc alterporriol misc cytotoxicity misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc endophytic fungus misc Alternaria sp. misc bianthraquinone misc alterporriol misc cytotoxicity misc Biology (General)
topic_browse	misc QH301-705.5 misc endophytic fungus misc Alternaria sp. misc bianthraquinone misc alterporriol misc cytotoxicity misc Biology (General)
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title	Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea
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title_full	Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea
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title_sort	three bianthraquinone derivatives from the mangrove endophytic fungus alternaria sp. zj9-6b from the south china sea
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title_auth	Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea
abstract	Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.
abstractGer	Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.
abstract_unstemmed	Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.
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title_short	Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea
url	https://doi.org/10.3390/md9050832 https://doaj.org/article/a109efd409ef4f66aaf49d1d31ea714c http://www.mdpi.com/1660-3397/9/5/832/ https://doaj.org/toc/1660-3397
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up_date	2024-07-04T02:07:34.804Z
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Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

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