Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups

Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivaleno...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Leif Sundheim [verfasserIn] Inger Therese Lillegaard [verfasserIn] Christiane Kruse Fæste [verfasserIn] Anne-Lise Brantsæter [verfasserIn] Guro Brodal [verfasserIn] Gunnar Sundstøl Eriksen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	deoxynivalenol DON risk assessment chronic exposure Fusarium graminearum

Übergeordnetes Werk:	In: Toxins - MDPI AG, 2010, 9(2017), 2, p 46
Übergeordnetes Werk:	volume:9 ; year:2017 ; number:2, p 46

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/toxins9020046

Katalog-ID:	DOAJ085251402

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allfields	10.3390/toxins9020046 doi (DE-627)DOAJ085251402 (DE-599)DOAJ27183af838aa4cc5b076bdf81d772e8e DE-627 ger DE-627 rakwb eng Leif Sundheim verfasserin aut Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivalenol (DON) in different age groups of the domestic population. This review presents the main results from the risk assessment, supplemented with some recently published data. Impairment of the immune system together with reduced feed intake and weight gain are the critical effects of DON in experimental animals on which the current tolerable daily intake was established. Based on food consumption and occurrence data, the mean exposure to DON in years with low and high levels of DON in the flour, respectively, were in the range of or up to two times the Tolerable Daily Intake (TDI) in 1-year-old infants and 2-year-old children. In years with high mean DON concentration, the high (95th-percentile) exposure exceeded the TDI by up to 3.5 times in 1-, 2- , 4-, and 9-year-old children. The assessment concluded that exceeding the TDI in infants and children is of concern. The estimated dietary DON intakes in adolescent and adult populations are in the range of the TDI or below, and are not a health concern. Acute human exposure to DON is not of concern in any age group. deoxynivalenol DON risk assessment chronic exposure Fusarium graminearum Medicine R Inger Therese Lillegaard verfasserin aut Christiane Kruse Fæste verfasserin aut Anne-Lise Brantsæter verfasserin aut Guro Brodal verfasserin aut Gunnar Sundstøl Eriksen verfasserin aut In Toxins MDPI AG, 2010 9(2017), 2, p 46 (DE-627)610604236 (DE-600)2518395-3 20726651 nnns volume:9 year:2017 number:2, p 46 https://doi.org/10.3390/toxins9020046 kostenfrei https://doaj.org/article/27183af838aa4cc5b076bdf81d772e8e kostenfrei http://www.mdpi.com/2072-6651/9/2/46 kostenfrei https://doaj.org/toc/2072-6651 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 2, p 46
spelling	10.3390/toxins9020046 doi (DE-627)DOAJ085251402 (DE-599)DOAJ27183af838aa4cc5b076bdf81d772e8e DE-627 ger DE-627 rakwb eng Leif Sundheim verfasserin aut Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivalenol (DON) in different age groups of the domestic population. This review presents the main results from the risk assessment, supplemented with some recently published data. Impairment of the immune system together with reduced feed intake and weight gain are the critical effects of DON in experimental animals on which the current tolerable daily intake was established. Based on food consumption and occurrence data, the mean exposure to DON in years with low and high levels of DON in the flour, respectively, were in the range of or up to two times the Tolerable Daily Intake (TDI) in 1-year-old infants and 2-year-old children. In years with high mean DON concentration, the high (95th-percentile) exposure exceeded the TDI by up to 3.5 times in 1-, 2- , 4-, and 9-year-old children. The assessment concluded that exceeding the TDI in infants and children is of concern. The estimated dietary DON intakes in adolescent and adult populations are in the range of the TDI or below, and are not a health concern. Acute human exposure to DON is not of concern in any age group. deoxynivalenol DON risk assessment chronic exposure Fusarium graminearum Medicine R Inger Therese Lillegaard verfasserin aut Christiane Kruse Fæste verfasserin aut Anne-Lise Brantsæter verfasserin aut Guro Brodal verfasserin aut Gunnar Sundstøl Eriksen verfasserin aut In Toxins MDPI AG, 2010 9(2017), 2, p 46 (DE-627)610604236 (DE-600)2518395-3 20726651 nnns volume:9 year:2017 number:2, p 46 https://doi.org/10.3390/toxins9020046 kostenfrei https://doaj.org/article/27183af838aa4cc5b076bdf81d772e8e kostenfrei http://www.mdpi.com/2072-6651/9/2/46 kostenfrei https://doaj.org/toc/2072-6651 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 2, p 46
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allfieldsGer	10.3390/toxins9020046 doi (DE-627)DOAJ085251402 (DE-599)DOAJ27183af838aa4cc5b076bdf81d772e8e DE-627 ger DE-627 rakwb eng Leif Sundheim verfasserin aut Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivalenol (DON) in different age groups of the domestic population. This review presents the main results from the risk assessment, supplemented with some recently published data. Impairment of the immune system together with reduced feed intake and weight gain are the critical effects of DON in experimental animals on which the current tolerable daily intake was established. Based on food consumption and occurrence data, the mean exposure to DON in years with low and high levels of DON in the flour, respectively, were in the range of or up to two times the Tolerable Daily Intake (TDI) in 1-year-old infants and 2-year-old children. In years with high mean DON concentration, the high (95th-percentile) exposure exceeded the TDI by up to 3.5 times in 1-, 2- , 4-, and 9-year-old children. The assessment concluded that exceeding the TDI in infants and children is of concern. The estimated dietary DON intakes in adolescent and adult populations are in the range of the TDI or below, and are not a health concern. Acute human exposure to DON is not of concern in any age group. deoxynivalenol DON risk assessment chronic exposure Fusarium graminearum Medicine R Inger Therese Lillegaard verfasserin aut Christiane Kruse Fæste verfasserin aut Anne-Lise Brantsæter verfasserin aut Guro Brodal verfasserin aut Gunnar Sundstøl Eriksen verfasserin aut In Toxins MDPI AG, 2010 9(2017), 2, p 46 (DE-627)610604236 (DE-600)2518395-3 20726651 nnns volume:9 year:2017 number:2, p 46 https://doi.org/10.3390/toxins9020046 kostenfrei https://doaj.org/article/27183af838aa4cc5b076bdf81d772e8e kostenfrei http://www.mdpi.com/2072-6651/9/2/46 kostenfrei https://doaj.org/toc/2072-6651 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 2, p 46
allfieldsSound	10.3390/toxins9020046 doi (DE-627)DOAJ085251402 (DE-599)DOAJ27183af838aa4cc5b076bdf81d772e8e DE-627 ger DE-627 rakwb eng Leif Sundheim verfasserin aut Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivalenol (DON) in different age groups of the domestic population. This review presents the main results from the risk assessment, supplemented with some recently published data. Impairment of the immune system together with reduced feed intake and weight gain are the critical effects of DON in experimental animals on which the current tolerable daily intake was established. Based on food consumption and occurrence data, the mean exposure to DON in years with low and high levels of DON in the flour, respectively, were in the range of or up to two times the Tolerable Daily Intake (TDI) in 1-year-old infants and 2-year-old children. In years with high mean DON concentration, the high (95th-percentile) exposure exceeded the TDI by up to 3.5 times in 1-, 2- , 4-, and 9-year-old children. The assessment concluded that exceeding the TDI in infants and children is of concern. The estimated dietary DON intakes in adolescent and adult populations are in the range of the TDI or below, and are not a health concern. Acute human exposure to DON is not of concern in any age group. deoxynivalenol DON risk assessment chronic exposure Fusarium graminearum Medicine R Inger Therese Lillegaard verfasserin aut Christiane Kruse Fæste verfasserin aut Anne-Lise Brantsæter verfasserin aut Guro Brodal verfasserin aut Gunnar Sundstøl Eriksen verfasserin aut In Toxins MDPI AG, 2010 9(2017), 2, p 46 (DE-627)610604236 (DE-600)2518395-3 20726651 nnns volume:9 year:2017 number:2, p 46 https://doi.org/10.3390/toxins9020046 kostenfrei https://doaj.org/article/27183af838aa4cc5b076bdf81d772e8e kostenfrei http://www.mdpi.com/2072-6651/9/2/46 kostenfrei https://doaj.org/toc/2072-6651 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 2, p 46
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author	Leif Sundheim
spellingShingle	Leif Sundheim misc deoxynivalenol misc DON misc risk assessment misc chronic exposure misc Fusarium graminearum misc Medicine misc R Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups
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topic_title	Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups deoxynivalenol DON risk assessment chronic exposure Fusarium graminearum
topic	misc deoxynivalenol misc DON misc risk assessment misc chronic exposure misc Fusarium graminearum misc Medicine misc R
topic_unstemmed	misc deoxynivalenol misc DON misc risk assessment misc chronic exposure misc Fusarium graminearum misc Medicine misc R
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title	Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups
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title_sort	deoxynivalenol exposure in norway, risk assessments for different human age groups
title_auth	Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups
abstract	Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivalenol (DON) in different age groups of the domestic population. This review presents the main results from the risk assessment, supplemented with some recently published data. Impairment of the immune system together with reduced feed intake and weight gain are the critical effects of DON in experimental animals on which the current tolerable daily intake was established. Based on food consumption and occurrence data, the mean exposure to DON in years with low and high levels of DON in the flour, respectively, were in the range of or up to two times the Tolerable Daily Intake (TDI) in 1-year-old infants and 2-year-old children. In years with high mean DON concentration, the high (95th-percentile) exposure exceeded the TDI by up to 3.5 times in 1-, 2- , 4-, and 9-year-old children. The assessment concluded that exceeding the TDI in infants and children is of concern. The estimated dietary DON intakes in adolescent and adult populations are in the range of the TDI or below, and are not a health concern. Acute human exposure to DON is not of concern in any age group.
abstractGer	Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivalenol (DON) in different age groups of the domestic population. This review presents the main results from the risk assessment, supplemented with some recently published data. Impairment of the immune system together with reduced feed intake and weight gain are the critical effects of DON in experimental animals on which the current tolerable daily intake was established. Based on food consumption and occurrence data, the mean exposure to DON in years with low and high levels of DON in the flour, respectively, were in the range of or up to two times the Tolerable Daily Intake (TDI) in 1-year-old infants and 2-year-old children. In years with high mean DON concentration, the high (95th-percentile) exposure exceeded the TDI by up to 3.5 times in 1-, 2- , 4-, and 9-year-old children. The assessment concluded that exceeding the TDI in infants and children is of concern. The estimated dietary DON intakes in adolescent and adult populations are in the range of the TDI or below, and are not a health concern. Acute human exposure to DON is not of concern in any age group.
abstract_unstemmed	Deoxynivalenol (DON) is the most common mycotoxin in Norwegian cereals, and DON is detected in most samples of crude cereal grain and cereal food commodities such as flour, bran, and oat flakes. The Norwegian Scientific Committee for Food Safety assessed the risk for adverse effects of deoxynivalenol (DON) in different age groups of the domestic population. This review presents the main results from the risk assessment, supplemented with some recently published data. Impairment of the immune system together with reduced feed intake and weight gain are the critical effects of DON in experimental animals on which the current tolerable daily intake was established. Based on food consumption and occurrence data, the mean exposure to DON in years with low and high levels of DON in the flour, respectively, were in the range of or up to two times the Tolerable Daily Intake (TDI) in 1-year-old infants and 2-year-old children. In years with high mean DON concentration, the high (95th-percentile) exposure exceeded the TDI by up to 3.5 times in 1-, 2- , 4-, and 9-year-old children. The assessment concluded that exceeding the TDI in infants and children is of concern. The estimated dietary DON intakes in adolescent and adult populations are in the range of the TDI or below, and are not a health concern. Acute human exposure to DON is not of concern in any age group.
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title_short	Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups
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Deoxynivalenol Exposure in Norway, Risk Assessments for Different Human Age Groups

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