Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer
Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healt...
Ausführliche Beschreibung
Autor*in: |
Zhuoqing Xu [verfasserIn] Zeping Lv [verfasserIn] Fangqian Chen [verfasserIn] Yuchen Zhang [verfasserIn] Zifeng Xu [verfasserIn] Jianting Huo [verfasserIn] Wangyi Liu [verfasserIn] Suyue Yu [verfasserIn] Abudumaimaitijiang Tuersun [verfasserIn] Jingkun Zhao [verfasserIn] Yaping Zong [verfasserIn] Xiaonan Shen [verfasserIn] Wenqing Feng [verfasserIn] Aiguo Lu [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022) |
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Übergeordnetes Werk: |
volume:13 ; year:2022 |
Links: |
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DOI / URN: |
10.3389/fimmu.2022.1008975 |
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Katalog-ID: |
DOAJ085271101 |
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520 | |a Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. | ||
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10.3389/fimmu.2022.1008975 doi (DE-627)DOAJ085271101 (DE-599)DOAJ83b2b7d760794de180569d639f4faddb DE-627 ger DE-627 rakwb eng RC581-607 Zhuoqing Xu verfasserin aut Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. young-onset colorectal cancer microbiome Actinomyces TLR2 cancer-associated fibroblasts (CAFs) Immunologic diseases. Allergy Zhuoqing Xu verfasserin aut Zhuoqing Xu verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Wangyi Liu verfasserin aut Wangyi Liu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Jingkun Zhao verfasserin aut Jingkun Zhao verfasserin aut Yaping Zong verfasserin aut Yaping Zong verfasserin aut Xiaonan Shen verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Aiguo Lu verfasserin aut Aiguo Lu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1008975 kostenfrei https://doaj.org/article/83b2b7d760794de180569d639f4faddb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.1008975 doi (DE-627)DOAJ085271101 (DE-599)DOAJ83b2b7d760794de180569d639f4faddb DE-627 ger DE-627 rakwb eng RC581-607 Zhuoqing Xu verfasserin aut Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. young-onset colorectal cancer microbiome Actinomyces TLR2 cancer-associated fibroblasts (CAFs) Immunologic diseases. Allergy Zhuoqing Xu verfasserin aut Zhuoqing Xu verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Wangyi Liu verfasserin aut Wangyi Liu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Jingkun Zhao verfasserin aut Jingkun Zhao verfasserin aut Yaping Zong verfasserin aut Yaping Zong verfasserin aut Xiaonan Shen verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Aiguo Lu verfasserin aut Aiguo Lu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1008975 kostenfrei https://doaj.org/article/83b2b7d760794de180569d639f4faddb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.1008975 doi (DE-627)DOAJ085271101 (DE-599)DOAJ83b2b7d760794de180569d639f4faddb DE-627 ger DE-627 rakwb eng RC581-607 Zhuoqing Xu verfasserin aut Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. young-onset colorectal cancer microbiome Actinomyces TLR2 cancer-associated fibroblasts (CAFs) Immunologic diseases. Allergy Zhuoqing Xu verfasserin aut Zhuoqing Xu verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Wangyi Liu verfasserin aut Wangyi Liu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Jingkun Zhao verfasserin aut Jingkun Zhao verfasserin aut Yaping Zong verfasserin aut Yaping Zong verfasserin aut Xiaonan Shen verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Aiguo Lu verfasserin aut Aiguo Lu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1008975 kostenfrei https://doaj.org/article/83b2b7d760794de180569d639f4faddb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.1008975 doi (DE-627)DOAJ085271101 (DE-599)DOAJ83b2b7d760794de180569d639f4faddb DE-627 ger DE-627 rakwb eng RC581-607 Zhuoqing Xu verfasserin aut Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. young-onset colorectal cancer microbiome Actinomyces TLR2 cancer-associated fibroblasts (CAFs) Immunologic diseases. Allergy Zhuoqing Xu verfasserin aut Zhuoqing Xu verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Wangyi Liu verfasserin aut Wangyi Liu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Jingkun Zhao verfasserin aut Jingkun Zhao verfasserin aut Yaping Zong verfasserin aut Yaping Zong verfasserin aut Xiaonan Shen verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Aiguo Lu verfasserin aut Aiguo Lu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1008975 kostenfrei https://doaj.org/article/83b2b7d760794de180569d639f4faddb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.1008975 doi (DE-627)DOAJ085271101 (DE-599)DOAJ83b2b7d760794de180569d639f4faddb DE-627 ger DE-627 rakwb eng RC581-607 Zhuoqing Xu verfasserin aut Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. young-onset colorectal cancer microbiome Actinomyces TLR2 cancer-associated fibroblasts (CAFs) Immunologic diseases. Allergy Zhuoqing Xu verfasserin aut Zhuoqing Xu verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Zeping Lv verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Fangqian Chen verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Yuchen Zhang verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Zifeng Xu verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Jianting Huo verfasserin aut Wangyi Liu verfasserin aut Wangyi Liu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Suyue Yu verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Abudumaimaitijiang Tuersun verfasserin aut Jingkun Zhao verfasserin aut Jingkun Zhao verfasserin aut Yaping Zong verfasserin aut Yaping Zong verfasserin aut Xiaonan Shen verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Wenqing Feng verfasserin aut Aiguo Lu verfasserin aut Aiguo Lu verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.1008975 kostenfrei https://doaj.org/article/83b2b7d760794de180569d639f4faddb kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008975/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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Zhuoqing Xu @@aut@@ Zeping Lv @@aut@@ Fangqian Chen @@aut@@ Yuchen Zhang @@aut@@ Zifeng Xu @@aut@@ Jianting Huo @@aut@@ Wangyi Liu @@aut@@ Suyue Yu @@aut@@ Abudumaimaitijiang Tuersun @@aut@@ Jingkun Zhao @@aut@@ Yaping Zong @@aut@@ Xiaonan Shen @@aut@@ Wenqing Feng @@aut@@ Aiguo Lu @@aut@@ |
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RC581-607 Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer young-onset colorectal cancer microbiome Actinomyces TLR2 cancer-associated fibroblasts (CAFs) |
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Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer |
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Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. |
abstractGer |
Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. |
abstract_unstemmed |
Colorectal cancer (CRC) is the third most common form of cancer, and the incidence of sporadic young-onset colorectal cancer (yCRC) has been increasing. Microbiota residing in the tumor microenvironment are emerging tumor components. The colonic microbiome differs between patients with CRC and healthy controls; however, few studies have investigated the role of the tumor microbiota in disease diagnosis and tumorigenesis of yCRC. We performed 16S rRNA sequencing analysis to identify the microbiome in CRC and found that tumor microbial diversity decreased in yCRC. Proteobacteria and Firmicutes were the most abundant phyla in all CRC samples, and Actinomyces and Schaalia cardiffensis were the key microbiota in the yCRC group. Correlation analysis revealed that Actinomyces co-occurred with various pro-tumor microbial taxa, including Bacteroidia, Gammaproteobacteria, and Pseudomonas. An independent cohort was used to validate the results. The Actinomyces in CRC was co-localized with cancer-associated fibroblasts and activated the TLR2/NF-κB pathway and reduces CD8+ T lymphocyte infiltration in CRC microenvironment. This study suggests that tumoral microbiota plays an important role in promoting tumorigenesis and therefore has potential as a promising non-invasive tool and intervention target for anti-tumor therapy. |
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Dysbiosis of human tumor microbiome and aberrant residence of Actinomyces in tumor-associated fibroblasts in young-onset colorectal cancer |
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