The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Chi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jena V. Lilly [verfasserIn] Jo Lynne Rokita [verfasserIn] Jennifer L. Mason [verfasserIn] Tatiana Patton [verfasserIn] Stephanie Stefankiewiz [verfasserIn] David Higgins [verfasserIn] Gerri Trooskin [verfasserIn] Carina A. Larouci [verfasserIn] Kamnaa Arya [verfasserIn] Elizabeth Appert [verfasserIn] Allison P. Heath [verfasserIn] Yuankun Zhu [verfasserIn] Miguel A. Brown [verfasserIn] Bo Zhang [verfasserIn] Bailey K. Farrow [verfasserIn] Shannon Robins [verfasserIn] Allison M. Morgan [verfasserIn] Thinh Q. Nguyen [verfasserIn] Elizabeth Frenkel [verfasserIn] Kaitlin Lehmann [verfasserIn] Emily Drake [verfasserIn] Catherine Sullivan [verfasserIn] Alexa Plisiewicz [verfasserIn] Noel Coleman [verfasserIn] Luke Patterson [verfasserIn] Mateusz Koptyra [verfasserIn] Zeinab Helili [verfasserIn] Nicholas Van Kuren [verfasserIn] Nathan Young [verfasserIn] Meen Chul Kim [verfasserIn] Christopher Friedman [verfasserIn] Alex Lubneuski [verfasserIn] Christopher Blackden [verfasserIn] Marti Williams [verfasserIn] Valerie Baubet [verfasserIn] Lamiya Tauhid [verfasserIn] Jamie Galanaugh [verfasserIn] Katie Boucher [verfasserIn] Heba Ijaz [verfasserIn] Kristina A. Cole [verfasserIn] Namrata Choudhari [verfasserIn] Mariarita Santi [verfasserIn] Robert W. Moulder [verfasserIn] Jonathan Waller [verfasserIn] Whitney Rife [verfasserIn] Sharon J. Diskin [verfasserIn] Marion Mateos [verfasserIn] Donald W. Parsons [verfasserIn] Ian F. Pollack [verfasserIn] Stewart Goldman [verfasserIn] Sarah Leary [verfasserIn] Chiara Caporalini [verfasserIn] Anna Maria Buccoliero [verfasserIn] Mirko Scagnet [verfasserIn] David Haussler [verfasserIn] Derek Hanson [verfasserIn] Ron Firestein [verfasserIn] Jason Cain [verfasserIn] Joanna J. Phillips [verfasserIn] Nalin Gupta [verfasserIn] Sabine Mueller [verfasserIn] Gerald Grant [verfasserIn] Michelle Monje-Deisseroth [verfasserIn] Sonia Partap [verfasserIn] Jeffrey P. Greenfield [verfasserIn] Rintaro Hashizume [verfasserIn] Amy Smith [verfasserIn] Shida Zhu [verfasserIn] James M. Johnston [verfasserIn] Jason R. Fangusaro [verfasserIn] Matthew Miller [verfasserIn] Matthew D. Wood [verfasserIn] Sharon Gardner [verfasserIn] Claire L. Carter [verfasserIn] Laura M. Prolo [verfasserIn] Jared Pisapia [verfasserIn] Katherine Pehlivan [verfasserIn] Andrea Franson [verfasserIn] Toba Niazi [verfasserIn] Josh Rubin [verfasserIn] Mohamed Abdelbaki [verfasserIn] David S. Ziegler [verfasserIn] Holly B. Lindsay [verfasserIn] Ana Guerreiro Stucklin [verfasserIn] Nicolas Gerber [verfasserIn] Olena M. Vaske [verfasserIn] Carolyn Quinsey [verfasserIn] Brian R. Rood [verfasserIn] Javad Nazarian [verfasserIn] Eric Raabe [verfasserIn] Eric M. Jackson [verfasserIn] Stacie Stapleton [verfasserIn] Robert M. Lober [verfasserIn] David E. Kram [verfasserIn] Carl Koschmann [verfasserIn] Phillip B. Storm [verfasserIn] Rishi R. Lulla [verfasserIn] Michael Prados [verfasserIn] Adam C. Resnick [verfasserIn] Angela J. Waanders [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Neoplasia: An International Journal for Oncology Research - Elsevier, 2008, 35(2023), Seite 100846- |
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| Übergeordnetes Werk: |
volume:35 ; year:2023 ; pages:100846- |
| Links: |
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| DOI / URN: |
10.1016/j.neo.2022.100846 |
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| Katalog-ID: |
DOAJ085330272 |
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| 245 | 1 | 4 | |a The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science |
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| 520 | |a Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. | ||
| 650 | 4 | |a Collaborative international research infrastructure | |
| 650 | 4 | |a Pediatric brain tumors | |
| 650 | 4 | |a Multi-omic data | |
| 650 | 4 | |a Longitudinal clinical data | |
| 650 | 4 | |a Biospecimens | |
| 650 | 4 | |a Molecular clinical trials | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 700 | 0 | |a Jo Lynne Rokita |e verfasserin |4 aut | |
| 700 | 0 | |a Jennifer L. Mason |e verfasserin |4 aut | |
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| 700 | 0 | |a Shannon Robins |e verfasserin |4 aut | |
| 700 | 0 | |a Allison M. Morgan |e verfasserin |4 aut | |
| 700 | 0 | |a Thinh Q. Nguyen |e verfasserin |4 aut | |
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| 700 | 0 | |a Jamie Galanaugh |e verfasserin |4 aut | |
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| 700 | 0 | |a Heba Ijaz |e verfasserin |4 aut | |
| 700 | 0 | |a Kristina A. Cole |e verfasserin |4 aut | |
| 700 | 0 | |a Namrata Choudhari |e verfasserin |4 aut | |
| 700 | 0 | |a Mariarita Santi |e verfasserin |4 aut | |
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| 700 | 0 | |a Sharon J. Diskin |e verfasserin |4 aut | |
| 700 | 0 | |a Marion Mateos |e verfasserin |4 aut | |
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10.1016/j.neo.2022.100846 doi (DE-627)DOAJ085330272 (DE-599)DOAJccba034296a747dd98510c07ca0814c3 DE-627 ger DE-627 rakwb eng RC254-282 Jena V. Lilly verfasserin aut The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. Collaborative international research infrastructure Pediatric brain tumors Multi-omic data Longitudinal clinical data Biospecimens Molecular clinical trials Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jo Lynne Rokita verfasserin aut Jennifer L. Mason verfasserin aut Tatiana Patton verfasserin aut Stephanie Stefankiewiz verfasserin aut David Higgins verfasserin aut Gerri Trooskin verfasserin aut Carina A. Larouci verfasserin aut Kamnaa Arya verfasserin aut Elizabeth Appert verfasserin aut Allison P. Heath verfasserin aut Yuankun Zhu verfasserin aut Miguel A. Brown verfasserin aut Bo Zhang verfasserin aut Bailey K. Farrow verfasserin aut Shannon Robins verfasserin aut Allison M. Morgan verfasserin aut Thinh Q. Nguyen verfasserin aut Elizabeth Frenkel verfasserin aut Kaitlin Lehmann verfasserin aut Emily Drake verfasserin aut Catherine Sullivan verfasserin aut Alexa Plisiewicz verfasserin aut Noel Coleman verfasserin aut Luke Patterson verfasserin aut Mateusz Koptyra verfasserin aut Zeinab Helili verfasserin aut Nicholas Van Kuren verfasserin aut Nathan Young verfasserin aut Meen Chul Kim verfasserin aut Christopher Friedman verfasserin aut Alex Lubneuski verfasserin aut Christopher Blackden verfasserin aut Marti Williams verfasserin aut Valerie Baubet verfasserin aut Lamiya Tauhid verfasserin aut Jamie Galanaugh verfasserin aut Katie Boucher verfasserin aut Heba Ijaz verfasserin aut Kristina A. Cole verfasserin aut Namrata Choudhari verfasserin aut Mariarita Santi verfasserin aut Robert W. Moulder verfasserin aut Jonathan Waller verfasserin aut Whitney Rife verfasserin aut Sharon J. Diskin verfasserin aut Marion Mateos verfasserin aut Donald W. Parsons verfasserin aut Ian F. Pollack verfasserin aut Stewart Goldman verfasserin aut Sarah Leary verfasserin aut Chiara Caporalini verfasserin aut Anna Maria Buccoliero verfasserin aut Mirko Scagnet verfasserin aut David Haussler verfasserin aut Derek Hanson verfasserin aut Ron Firestein verfasserin aut Jason Cain verfasserin aut Joanna J. Phillips verfasserin aut Nalin Gupta verfasserin aut Sabine Mueller verfasserin aut Gerald Grant verfasserin aut Michelle Monje-Deisseroth verfasserin aut Sonia Partap verfasserin aut Jeffrey P. Greenfield verfasserin aut Rintaro Hashizume verfasserin aut Amy Smith verfasserin aut Shida Zhu verfasserin aut James M. Johnston verfasserin aut Jason R. Fangusaro verfasserin aut Matthew Miller verfasserin aut Matthew D. Wood verfasserin aut Sharon Gardner verfasserin aut Claire L. Carter verfasserin aut Laura M. Prolo verfasserin aut Jared Pisapia verfasserin aut Katherine Pehlivan verfasserin aut Andrea Franson verfasserin aut Toba Niazi verfasserin aut Josh Rubin verfasserin aut Mohamed Abdelbaki verfasserin aut David S. Ziegler verfasserin aut Holly B. Lindsay verfasserin aut Ana Guerreiro Stucklin verfasserin aut Nicolas Gerber verfasserin aut Olena M. Vaske verfasserin aut Carolyn Quinsey verfasserin aut Brian R. Rood verfasserin aut Javad Nazarian verfasserin aut Eric Raabe verfasserin aut Eric M. Jackson verfasserin aut Stacie Stapleton verfasserin aut Robert M. Lober verfasserin aut David E. Kram verfasserin aut Carl Koschmann verfasserin aut Phillip B. Storm verfasserin aut Rishi R. Lulla verfasserin aut Michael Prados verfasserin aut Adam C. Resnick verfasserin aut Angela J. Waanders verfasserin aut In Neoplasia: An International Journal for Oncology Research Elsevier, 2008 35(2023), Seite 100846- (DE-627)320468690 (DE-600)2008231-9 14765586 nnns volume:35 year:2023 pages:100846- https://doi.org/10.1016/j.neo.2022.100846 kostenfrei https://doaj.org/article/ccba034296a747dd98510c07ca0814c3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1476558622000720 kostenfrei https://doaj.org/toc/1476-5586 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2023 100846- |
| spelling |
10.1016/j.neo.2022.100846 doi (DE-627)DOAJ085330272 (DE-599)DOAJccba034296a747dd98510c07ca0814c3 DE-627 ger DE-627 rakwb eng RC254-282 Jena V. Lilly verfasserin aut The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. Collaborative international research infrastructure Pediatric brain tumors Multi-omic data Longitudinal clinical data Biospecimens Molecular clinical trials Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jo Lynne Rokita verfasserin aut Jennifer L. Mason verfasserin aut Tatiana Patton verfasserin aut Stephanie Stefankiewiz verfasserin aut David Higgins verfasserin aut Gerri Trooskin verfasserin aut Carina A. Larouci verfasserin aut Kamnaa Arya verfasserin aut Elizabeth Appert verfasserin aut Allison P. Heath verfasserin aut Yuankun Zhu verfasserin aut Miguel A. Brown verfasserin aut Bo Zhang verfasserin aut Bailey K. Farrow verfasserin aut Shannon Robins verfasserin aut Allison M. Morgan verfasserin aut Thinh Q. Nguyen verfasserin aut Elizabeth Frenkel verfasserin aut Kaitlin Lehmann verfasserin aut Emily Drake verfasserin aut Catherine Sullivan verfasserin aut Alexa Plisiewicz verfasserin aut Noel Coleman verfasserin aut Luke Patterson verfasserin aut Mateusz Koptyra verfasserin aut Zeinab Helili verfasserin aut Nicholas Van Kuren verfasserin aut Nathan Young verfasserin aut Meen Chul Kim verfasserin aut Christopher Friedman verfasserin aut Alex Lubneuski verfasserin aut Christopher Blackden verfasserin aut Marti Williams verfasserin aut Valerie Baubet verfasserin aut Lamiya Tauhid verfasserin aut Jamie Galanaugh verfasserin aut Katie Boucher verfasserin aut Heba Ijaz verfasserin aut Kristina A. Cole verfasserin aut Namrata Choudhari verfasserin aut Mariarita Santi verfasserin aut Robert W. Moulder verfasserin aut Jonathan Waller verfasserin aut Whitney Rife verfasserin aut Sharon J. Diskin verfasserin aut Marion Mateos verfasserin aut Donald W. Parsons verfasserin aut Ian F. Pollack verfasserin aut Stewart Goldman verfasserin aut Sarah Leary verfasserin aut Chiara Caporalini verfasserin aut Anna Maria Buccoliero verfasserin aut Mirko Scagnet verfasserin aut David Haussler verfasserin aut Derek Hanson verfasserin aut Ron Firestein verfasserin aut Jason Cain verfasserin aut Joanna J. Phillips verfasserin aut Nalin Gupta verfasserin aut Sabine Mueller verfasserin aut Gerald Grant verfasserin aut Michelle Monje-Deisseroth verfasserin aut Sonia Partap verfasserin aut Jeffrey P. Greenfield verfasserin aut Rintaro Hashizume verfasserin aut Amy Smith verfasserin aut Shida Zhu verfasserin aut James M. Johnston verfasserin aut Jason R. Fangusaro verfasserin aut Matthew Miller verfasserin aut Matthew D. Wood verfasserin aut Sharon Gardner verfasserin aut Claire L. Carter verfasserin aut Laura M. Prolo verfasserin aut Jared Pisapia verfasserin aut Katherine Pehlivan verfasserin aut Andrea Franson verfasserin aut Toba Niazi verfasserin aut Josh Rubin verfasserin aut Mohamed Abdelbaki verfasserin aut David S. Ziegler verfasserin aut Holly B. Lindsay verfasserin aut Ana Guerreiro Stucklin verfasserin aut Nicolas Gerber verfasserin aut Olena M. Vaske verfasserin aut Carolyn Quinsey verfasserin aut Brian R. Rood verfasserin aut Javad Nazarian verfasserin aut Eric Raabe verfasserin aut Eric M. Jackson verfasserin aut Stacie Stapleton verfasserin aut Robert M. Lober verfasserin aut David E. Kram verfasserin aut Carl Koschmann verfasserin aut Phillip B. Storm verfasserin aut Rishi R. Lulla verfasserin aut Michael Prados verfasserin aut Adam C. Resnick verfasserin aut Angela J. Waanders verfasserin aut In Neoplasia: An International Journal for Oncology Research Elsevier, 2008 35(2023), Seite 100846- (DE-627)320468690 (DE-600)2008231-9 14765586 nnns volume:35 year:2023 pages:100846- https://doi.org/10.1016/j.neo.2022.100846 kostenfrei https://doaj.org/article/ccba034296a747dd98510c07ca0814c3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1476558622000720 kostenfrei https://doaj.org/toc/1476-5586 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2023 100846- |
| allfields_unstemmed |
10.1016/j.neo.2022.100846 doi (DE-627)DOAJ085330272 (DE-599)DOAJccba034296a747dd98510c07ca0814c3 DE-627 ger DE-627 rakwb eng RC254-282 Jena V. Lilly verfasserin aut The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. Collaborative international research infrastructure Pediatric brain tumors Multi-omic data Longitudinal clinical data Biospecimens Molecular clinical trials Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jo Lynne Rokita verfasserin aut Jennifer L. Mason verfasserin aut Tatiana Patton verfasserin aut Stephanie Stefankiewiz verfasserin aut David Higgins verfasserin aut Gerri Trooskin verfasserin aut Carina A. Larouci verfasserin aut Kamnaa Arya verfasserin aut Elizabeth Appert verfasserin aut Allison P. Heath verfasserin aut Yuankun Zhu verfasserin aut Miguel A. Brown verfasserin aut Bo Zhang verfasserin aut Bailey K. Farrow verfasserin aut Shannon Robins verfasserin aut Allison M. Morgan verfasserin aut Thinh Q. Nguyen verfasserin aut Elizabeth Frenkel verfasserin aut Kaitlin Lehmann verfasserin aut Emily Drake verfasserin aut Catherine Sullivan verfasserin aut Alexa Plisiewicz verfasserin aut Noel Coleman verfasserin aut Luke Patterson verfasserin aut Mateusz Koptyra verfasserin aut Zeinab Helili verfasserin aut Nicholas Van Kuren verfasserin aut Nathan Young verfasserin aut Meen Chul Kim verfasserin aut Christopher Friedman verfasserin aut Alex Lubneuski verfasserin aut Christopher Blackden verfasserin aut Marti Williams verfasserin aut Valerie Baubet verfasserin aut Lamiya Tauhid verfasserin aut Jamie Galanaugh verfasserin aut Katie Boucher verfasserin aut Heba Ijaz verfasserin aut Kristina A. Cole verfasserin aut Namrata Choudhari verfasserin aut Mariarita Santi verfasserin aut Robert W. Moulder verfasserin aut Jonathan Waller verfasserin aut Whitney Rife verfasserin aut Sharon J. Diskin verfasserin aut Marion Mateos verfasserin aut Donald W. Parsons verfasserin aut Ian F. Pollack verfasserin aut Stewart Goldman verfasserin aut Sarah Leary verfasserin aut Chiara Caporalini verfasserin aut Anna Maria Buccoliero verfasserin aut Mirko Scagnet verfasserin aut David Haussler verfasserin aut Derek Hanson verfasserin aut Ron Firestein verfasserin aut Jason Cain verfasserin aut Joanna J. Phillips verfasserin aut Nalin Gupta verfasserin aut Sabine Mueller verfasserin aut Gerald Grant verfasserin aut Michelle Monje-Deisseroth verfasserin aut Sonia Partap verfasserin aut Jeffrey P. Greenfield verfasserin aut Rintaro Hashizume verfasserin aut Amy Smith verfasserin aut Shida Zhu verfasserin aut James M. Johnston verfasserin aut Jason R. Fangusaro verfasserin aut Matthew Miller verfasserin aut Matthew D. Wood verfasserin aut Sharon Gardner verfasserin aut Claire L. Carter verfasserin aut Laura M. Prolo verfasserin aut Jared Pisapia verfasserin aut Katherine Pehlivan verfasserin aut Andrea Franson verfasserin aut Toba Niazi verfasserin aut Josh Rubin verfasserin aut Mohamed Abdelbaki verfasserin aut David S. Ziegler verfasserin aut Holly B. Lindsay verfasserin aut Ana Guerreiro Stucklin verfasserin aut Nicolas Gerber verfasserin aut Olena M. Vaske verfasserin aut Carolyn Quinsey verfasserin aut Brian R. Rood verfasserin aut Javad Nazarian verfasserin aut Eric Raabe verfasserin aut Eric M. Jackson verfasserin aut Stacie Stapleton verfasserin aut Robert M. Lober verfasserin aut David E. Kram verfasserin aut Carl Koschmann verfasserin aut Phillip B. Storm verfasserin aut Rishi R. Lulla verfasserin aut Michael Prados verfasserin aut Adam C. Resnick verfasserin aut Angela J. Waanders verfasserin aut In Neoplasia: An International Journal for Oncology Research Elsevier, 2008 35(2023), Seite 100846- (DE-627)320468690 (DE-600)2008231-9 14765586 nnns volume:35 year:2023 pages:100846- https://doi.org/10.1016/j.neo.2022.100846 kostenfrei https://doaj.org/article/ccba034296a747dd98510c07ca0814c3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1476558622000720 kostenfrei https://doaj.org/toc/1476-5586 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2023 100846- |
| allfieldsGer |
10.1016/j.neo.2022.100846 doi (DE-627)DOAJ085330272 (DE-599)DOAJccba034296a747dd98510c07ca0814c3 DE-627 ger DE-627 rakwb eng RC254-282 Jena V. Lilly verfasserin aut The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. Collaborative international research infrastructure Pediatric brain tumors Multi-omic data Longitudinal clinical data Biospecimens Molecular clinical trials Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jo Lynne Rokita verfasserin aut Jennifer L. Mason verfasserin aut Tatiana Patton verfasserin aut Stephanie Stefankiewiz verfasserin aut David Higgins verfasserin aut Gerri Trooskin verfasserin aut Carina A. Larouci verfasserin aut Kamnaa Arya verfasserin aut Elizabeth Appert verfasserin aut Allison P. Heath verfasserin aut Yuankun Zhu verfasserin aut Miguel A. Brown verfasserin aut Bo Zhang verfasserin aut Bailey K. Farrow verfasserin aut Shannon Robins verfasserin aut Allison M. Morgan verfasserin aut Thinh Q. Nguyen verfasserin aut Elizabeth Frenkel verfasserin aut Kaitlin Lehmann verfasserin aut Emily Drake verfasserin aut Catherine Sullivan verfasserin aut Alexa Plisiewicz verfasserin aut Noel Coleman verfasserin aut Luke Patterson verfasserin aut Mateusz Koptyra verfasserin aut Zeinab Helili verfasserin aut Nicholas Van Kuren verfasserin aut Nathan Young verfasserin aut Meen Chul Kim verfasserin aut Christopher Friedman verfasserin aut Alex Lubneuski verfasserin aut Christopher Blackden verfasserin aut Marti Williams verfasserin aut Valerie Baubet verfasserin aut Lamiya Tauhid verfasserin aut Jamie Galanaugh verfasserin aut Katie Boucher verfasserin aut Heba Ijaz verfasserin aut Kristina A. Cole verfasserin aut Namrata Choudhari verfasserin aut Mariarita Santi verfasserin aut Robert W. Moulder verfasserin aut Jonathan Waller verfasserin aut Whitney Rife verfasserin aut Sharon J. Diskin verfasserin aut Marion Mateos verfasserin aut Donald W. Parsons verfasserin aut Ian F. Pollack verfasserin aut Stewart Goldman verfasserin aut Sarah Leary verfasserin aut Chiara Caporalini verfasserin aut Anna Maria Buccoliero verfasserin aut Mirko Scagnet verfasserin aut David Haussler verfasserin aut Derek Hanson verfasserin aut Ron Firestein verfasserin aut Jason Cain verfasserin aut Joanna J. Phillips verfasserin aut Nalin Gupta verfasserin aut Sabine Mueller verfasserin aut Gerald Grant verfasserin aut Michelle Monje-Deisseroth verfasserin aut Sonia Partap verfasserin aut Jeffrey P. Greenfield verfasserin aut Rintaro Hashizume verfasserin aut Amy Smith verfasserin aut Shida Zhu verfasserin aut James M. Johnston verfasserin aut Jason R. Fangusaro verfasserin aut Matthew Miller verfasserin aut Matthew D. Wood verfasserin aut Sharon Gardner verfasserin aut Claire L. Carter verfasserin aut Laura M. Prolo verfasserin aut Jared Pisapia verfasserin aut Katherine Pehlivan verfasserin aut Andrea Franson verfasserin aut Toba Niazi verfasserin aut Josh Rubin verfasserin aut Mohamed Abdelbaki verfasserin aut David S. Ziegler verfasserin aut Holly B. Lindsay verfasserin aut Ana Guerreiro Stucklin verfasserin aut Nicolas Gerber verfasserin aut Olena M. Vaske verfasserin aut Carolyn Quinsey verfasserin aut Brian R. Rood verfasserin aut Javad Nazarian verfasserin aut Eric Raabe verfasserin aut Eric M. Jackson verfasserin aut Stacie Stapleton verfasserin aut Robert M. Lober verfasserin aut David E. Kram verfasserin aut Carl Koschmann verfasserin aut Phillip B. Storm verfasserin aut Rishi R. Lulla verfasserin aut Michael Prados verfasserin aut Adam C. Resnick verfasserin aut Angela J. Waanders verfasserin aut In Neoplasia: An International Journal for Oncology Research Elsevier, 2008 35(2023), Seite 100846- (DE-627)320468690 (DE-600)2008231-9 14765586 nnns volume:35 year:2023 pages:100846- https://doi.org/10.1016/j.neo.2022.100846 kostenfrei https://doaj.org/article/ccba034296a747dd98510c07ca0814c3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1476558622000720 kostenfrei https://doaj.org/toc/1476-5586 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2023 100846- |
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10.1016/j.neo.2022.100846 doi (DE-627)DOAJ085330272 (DE-599)DOAJccba034296a747dd98510c07ca0814c3 DE-627 ger DE-627 rakwb eng RC254-282 Jena V. Lilly verfasserin aut The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. Collaborative international research infrastructure Pediatric brain tumors Multi-omic data Longitudinal clinical data Biospecimens Molecular clinical trials Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jo Lynne Rokita verfasserin aut Jennifer L. Mason verfasserin aut Tatiana Patton verfasserin aut Stephanie Stefankiewiz verfasserin aut David Higgins verfasserin aut Gerri Trooskin verfasserin aut Carina A. Larouci verfasserin aut Kamnaa Arya verfasserin aut Elizabeth Appert verfasserin aut Allison P. Heath verfasserin aut Yuankun Zhu verfasserin aut Miguel A. Brown verfasserin aut Bo Zhang verfasserin aut Bailey K. Farrow verfasserin aut Shannon Robins verfasserin aut Allison M. Morgan verfasserin aut Thinh Q. Nguyen verfasserin aut Elizabeth Frenkel verfasserin aut Kaitlin Lehmann verfasserin aut Emily Drake verfasserin aut Catherine Sullivan verfasserin aut Alexa Plisiewicz verfasserin aut Noel Coleman verfasserin aut Luke Patterson verfasserin aut Mateusz Koptyra verfasserin aut Zeinab Helili verfasserin aut Nicholas Van Kuren verfasserin aut Nathan Young verfasserin aut Meen Chul Kim verfasserin aut Christopher Friedman verfasserin aut Alex Lubneuski verfasserin aut Christopher Blackden verfasserin aut Marti Williams verfasserin aut Valerie Baubet verfasserin aut Lamiya Tauhid verfasserin aut Jamie Galanaugh verfasserin aut Katie Boucher verfasserin aut Heba Ijaz verfasserin aut Kristina A. Cole verfasserin aut Namrata Choudhari verfasserin aut Mariarita Santi verfasserin aut Robert W. Moulder verfasserin aut Jonathan Waller verfasserin aut Whitney Rife verfasserin aut Sharon J. Diskin verfasserin aut Marion Mateos verfasserin aut Donald W. Parsons verfasserin aut Ian F. Pollack verfasserin aut Stewart Goldman verfasserin aut Sarah Leary verfasserin aut Chiara Caporalini verfasserin aut Anna Maria Buccoliero verfasserin aut Mirko Scagnet verfasserin aut David Haussler verfasserin aut Derek Hanson verfasserin aut Ron Firestein verfasserin aut Jason Cain verfasserin aut Joanna J. Phillips verfasserin aut Nalin Gupta verfasserin aut Sabine Mueller verfasserin aut Gerald Grant verfasserin aut Michelle Monje-Deisseroth verfasserin aut Sonia Partap verfasserin aut Jeffrey P. Greenfield verfasserin aut Rintaro Hashizume verfasserin aut Amy Smith verfasserin aut Shida Zhu verfasserin aut James M. Johnston verfasserin aut Jason R. Fangusaro verfasserin aut Matthew Miller verfasserin aut Matthew D. Wood verfasserin aut Sharon Gardner verfasserin aut Claire L. Carter verfasserin aut Laura M. Prolo verfasserin aut Jared Pisapia verfasserin aut Katherine Pehlivan verfasserin aut Andrea Franson verfasserin aut Toba Niazi verfasserin aut Josh Rubin verfasserin aut Mohamed Abdelbaki verfasserin aut David S. Ziegler verfasserin aut Holly B. Lindsay verfasserin aut Ana Guerreiro Stucklin verfasserin aut Nicolas Gerber verfasserin aut Olena M. Vaske verfasserin aut Carolyn Quinsey verfasserin aut Brian R. Rood verfasserin aut Javad Nazarian verfasserin aut Eric Raabe verfasserin aut Eric M. Jackson verfasserin aut Stacie Stapleton verfasserin aut Robert M. Lober verfasserin aut David E. Kram verfasserin aut Carl Koschmann verfasserin aut Phillip B. Storm verfasserin aut Rishi R. Lulla verfasserin aut Michael Prados verfasserin aut Adam C. Resnick verfasserin aut Angela J. Waanders verfasserin aut In Neoplasia: An International Journal for Oncology Research Elsevier, 2008 35(2023), Seite 100846- (DE-627)320468690 (DE-600)2008231-9 14765586 nnns volume:35 year:2023 pages:100846- https://doi.org/10.1016/j.neo.2022.100846 kostenfrei https://doaj.org/article/ccba034296a747dd98510c07ca0814c3 kostenfrei http://www.sciencedirect.com/science/article/pii/S1476558622000720 kostenfrei https://doaj.org/toc/1476-5586 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 35 2023 100846- |
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Jena V. Lilly @@aut@@ Jo Lynne Rokita @@aut@@ Jennifer L. Mason @@aut@@ Tatiana Patton @@aut@@ Stephanie Stefankiewiz @@aut@@ David Higgins @@aut@@ Gerri Trooskin @@aut@@ Carina A. Larouci @@aut@@ Kamnaa Arya @@aut@@ Elizabeth Appert @@aut@@ Allison P. Heath @@aut@@ Yuankun Zhu @@aut@@ Miguel A. Brown @@aut@@ Bo Zhang @@aut@@ Bailey K. Farrow @@aut@@ Shannon Robins @@aut@@ Allison M. Morgan @@aut@@ Thinh Q. Nguyen @@aut@@ Elizabeth Frenkel @@aut@@ Kaitlin Lehmann @@aut@@ Emily Drake @@aut@@ Catherine Sullivan @@aut@@ Alexa Plisiewicz @@aut@@ Noel Coleman @@aut@@ Luke Patterson @@aut@@ Mateusz Koptyra @@aut@@ Zeinab Helili @@aut@@ Nicholas Van Kuren @@aut@@ Nathan Young @@aut@@ Meen Chul Kim @@aut@@ Christopher Friedman @@aut@@ Alex Lubneuski @@aut@@ Christopher Blackden @@aut@@ Marti Williams @@aut@@ Valerie Baubet @@aut@@ Lamiya Tauhid @@aut@@ Jamie Galanaugh @@aut@@ Katie Boucher @@aut@@ Heba Ijaz @@aut@@ Kristina A. Cole @@aut@@ Namrata Choudhari @@aut@@ Mariarita Santi @@aut@@ Robert W. Moulder @@aut@@ Jonathan Waller @@aut@@ Whitney Rife @@aut@@ Sharon J. Diskin @@aut@@ Marion Mateos @@aut@@ Donald W. Parsons @@aut@@ Ian F. Pollack @@aut@@ Stewart Goldman @@aut@@ Sarah Leary @@aut@@ Chiara Caporalini @@aut@@ Anna Maria Buccoliero @@aut@@ Mirko Scagnet @@aut@@ David Haussler @@aut@@ Derek Hanson @@aut@@ Ron Firestein @@aut@@ Jason Cain @@aut@@ Joanna J. Phillips @@aut@@ Nalin Gupta @@aut@@ Sabine Mueller @@aut@@ Gerald Grant @@aut@@ Michelle Monje-Deisseroth @@aut@@ Sonia Partap @@aut@@ Jeffrey P. Greenfield @@aut@@ Rintaro Hashizume @@aut@@ Amy Smith @@aut@@ Shida Zhu @@aut@@ James M. Johnston @@aut@@ Jason R. Fangusaro @@aut@@ Matthew Miller @@aut@@ Matthew D. Wood @@aut@@ Sharon Gardner @@aut@@ Claire L. Carter @@aut@@ Laura M. Prolo @@aut@@ Jared Pisapia @@aut@@ Katherine Pehlivan @@aut@@ Andrea Franson @@aut@@ Toba Niazi @@aut@@ Josh Rubin @@aut@@ Mohamed Abdelbaki @@aut@@ David S. Ziegler @@aut@@ Holly B. Lindsay @@aut@@ Ana Guerreiro Stucklin @@aut@@ Nicolas Gerber @@aut@@ Olena M. Vaske @@aut@@ Carolyn Quinsey @@aut@@ Brian R. Rood @@aut@@ Javad Nazarian @@aut@@ Eric Raabe @@aut@@ Eric M. Jackson @@aut@@ Stacie Stapleton @@aut@@ Robert M. Lober @@aut@@ David E. Kram @@aut@@ Carl Koschmann @@aut@@ Phillip B. Storm @@aut@@ Rishi R. Lulla @@aut@@ Michael Prados @@aut@@ Adam C. Resnick @@aut@@ Angela J. Waanders @@aut@@ |
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Jena V. Lilly Jo Lynne Rokita Jennifer L. Mason Tatiana Patton Stephanie Stefankiewiz David Higgins Gerri Trooskin Carina A. Larouci Kamnaa Arya Elizabeth Appert Allison P. Heath Yuankun Zhu Miguel A. Brown Bo Zhang Bailey K. Farrow Shannon Robins Allison M. Morgan Thinh Q. Nguyen Elizabeth Frenkel Kaitlin Lehmann Emily Drake Catherine Sullivan Alexa Plisiewicz Noel Coleman Luke Patterson Mateusz Koptyra Zeinab Helili Nicholas Van Kuren Nathan Young Meen Chul Kim Christopher Friedman Alex Lubneuski Christopher Blackden Marti Williams Valerie Baubet Lamiya Tauhid Jamie Galanaugh Katie Boucher Heba Ijaz Kristina A. Cole Namrata Choudhari Mariarita Santi Robert W. Moulder Jonathan Waller Whitney Rife Sharon J. Diskin Marion Mateos Donald W. Parsons Ian F. Pollack Stewart Goldman Sarah Leary Chiara Caporalini Anna Maria Buccoliero Mirko Scagnet David Haussler Derek Hanson Ron Firestein Jason Cain Joanna J. Phillips Nalin Gupta Sabine Mueller Gerald Grant Michelle Monje-Deisseroth Sonia Partap Jeffrey P. Greenfield Rintaro Hashizume Amy Smith Shida Zhu James M. Johnston Jason R. Fangusaro Matthew Miller Matthew D. Wood Sharon Gardner Claire L. Carter Laura M. Prolo Jared Pisapia Katherine Pehlivan Andrea Franson Toba Niazi Josh Rubin Mohamed Abdelbaki David S. Ziegler Holly B. Lindsay Ana Guerreiro Stucklin Nicolas Gerber Olena M. Vaske Carolyn Quinsey Brian R. Rood Javad Nazarian Eric Raabe Eric M. Jackson Stacie Stapleton Robert M. Lober David E. Kram Carl Koschmann Phillip B. Storm Rishi R. Lulla Michael Prados Adam C. Resnick Angela J. Waanders |
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The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science |
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Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. |
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Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. |
| abstract_unstemmed |
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for < 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors. |
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| score |
7.400872 |