Modulated Raman Spectroscopy for Enhanced Cancer Diagnosis at the Cellular Level

Raman spectroscopy is emerging as a promising and novel biophotonics tool for non-invasive, real-time diagnosis of tissue and cell abnormalities. However, the presence of a strong fluorescence background is a key issue that can detract from the use of Raman spectroscopy in routine clinical care. The...
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Autor*in:	Anna Chiara De Luca [verfasserIn] Kishan Dholakia [verfasserIn] Michael Mazilu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Raman spectroscopy cancer detection cell sensor fluorescence background

Übergeordnetes Werk:	In: Sensors - MDPI AG, 2003, 15(2015), 6, Seite 13680-13704
Übergeordnetes Werk:	volume:15 ; year:2015 ; number:6 ; pages:13680-13704

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/s150613680

Katalog-ID:	DOAJ085331465

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language	English
source	In Sensors 15(2015), 6, Seite 13680-13704 volume:15 year:2015 number:6 pages:13680-13704
sourceStr	In Sensors 15(2015), 6, Seite 13680-13704 volume:15 year:2015 number:6 pages:13680-13704
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Raman spectroscopy cancer detection cell sensor fluorescence background Chemical technology
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container_title	Sensors
authorswithroles_txt_mv	Anna Chiara De Luca @@aut@@ Kishan Dholakia @@aut@@ Michael Mazilu @@aut@@
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callnumber-first	T - Technology
author	Anna Chiara De Luca
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topic_title	TP1-1185 Modulated Raman Spectroscopy for Enhanced Cancer Diagnosis at the Cellular Level Raman spectroscopy cancer detection cell sensor fluorescence background
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title	Modulated Raman Spectroscopy for Enhanced Cancer Diagnosis at the Cellular Level
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title_auth	Modulated Raman Spectroscopy for Enhanced Cancer Diagnosis at the Cellular Level
abstract	Raman spectroscopy is emerging as a promising and novel biophotonics tool for non-invasive, real-time diagnosis of tissue and cell abnormalities. However, the presence of a strong fluorescence background is a key issue that can detract from the use of Raman spectroscopy in routine clinical care. The review summarizes the state-of-the-art methods to remove the fluorescence background and explores recent achievements to address this issue obtained with modulated Raman spectroscopy. This innovative approach can be used to extract the Raman spectral component from the fluorescence background and improve the quality of the Raman signal. We describe the potential of modulated Raman spectroscopy as a rapid, inexpensive and accurate clinical tool to detect the presence of bladder cancer cells. Finally, in a broader context, we show how this approach can greatly enhance the sensitivity of integrated Raman spectroscopy and microfluidic systems, opening new prospects for portable higher throughput Raman cell sorting.
abstractGer	Raman spectroscopy is emerging as a promising and novel biophotonics tool for non-invasive, real-time diagnosis of tissue and cell abnormalities. However, the presence of a strong fluorescence background is a key issue that can detract from the use of Raman spectroscopy in routine clinical care. The review summarizes the state-of-the-art methods to remove the fluorescence background and explores recent achievements to address this issue obtained with modulated Raman spectroscopy. This innovative approach can be used to extract the Raman spectral component from the fluorescence background and improve the quality of the Raman signal. We describe the potential of modulated Raman spectroscopy as a rapid, inexpensive and accurate clinical tool to detect the presence of bladder cancer cells. Finally, in a broader context, we show how this approach can greatly enhance the sensitivity of integrated Raman spectroscopy and microfluidic systems, opening new prospects for portable higher throughput Raman cell sorting.
abstract_unstemmed	Raman spectroscopy is emerging as a promising and novel biophotonics tool for non-invasive, real-time diagnosis of tissue and cell abnormalities. However, the presence of a strong fluorescence background is a key issue that can detract from the use of Raman spectroscopy in routine clinical care. The review summarizes the state-of-the-art methods to remove the fluorescence background and explores recent achievements to address this issue obtained with modulated Raman spectroscopy. This innovative approach can be used to extract the Raman spectral component from the fluorescence background and improve the quality of the Raman signal. We describe the potential of modulated Raman spectroscopy as a rapid, inexpensive and accurate clinical tool to detect the presence of bladder cancer cells. Finally, in a broader context, we show how this approach can greatly enhance the sensitivity of integrated Raman spectroscopy and microfluidic systems, opening new prospects for portable higher throughput Raman cell sorting.
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title_short	Modulated Raman Spectroscopy for Enhanced Cancer Diagnosis at the Cellular Level
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