Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome
Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
I. M. Bykov [verfasserIn] D. A. Lubchenko [verfasserIn] K. A. Popov [verfasserIn] Ya. Ye. Denisova [verfasserIn] A. N. Stolyarova [verfasserIn] M. A. Popova [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
In: Инновационная медицина Кубани - Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1, 2021, (2020), 4, Seite 20-26 |
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| Übergeordnetes Werk: |
year:2020 ; number:4 ; pages:20-26 |
| Links: |
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| DOI / URN: |
10.35401/2500-0268-2020-20-4-20-26 |
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| Katalog-ID: |
DOAJ085521779 |
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| 520 | |a Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. | ||
| 650 | 4 | |a oxidative stress | |
| 650 | 4 | |a laboratory markers | |
| 650 | 4 | |a antioxidant system | |
| 650 | 4 | |a drug abuse | |
| 650 | 4 | |a opioids | |
| 650 | 4 | |a psychostimulants | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 653 | 0 | |a Diseases of the circulatory (Cardiovascular) system | |
| 653 | 0 | |a Surgery | |
| 653 | 0 | |a Medical emergencies. Critical care. Intensive care. First aid | |
| 700 | 0 | |a D. A. Lubchenko |e verfasserin |4 aut | |
| 700 | 0 | |a K. A. Popov |e verfasserin |4 aut | |
| 700 | 0 | |a Ya. Ye. Denisova |e verfasserin |4 aut | |
| 700 | 0 | |a A. N. Stolyarova |e verfasserin |4 aut | |
| 700 | 0 | |a M. A. Popova |e verfasserin |4 aut | |
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10.35401/2500-0268-2020-20-4-20-26 doi (DE-627)DOAJ085521779 (DE-599)DOAJd8dd91d38e01464d9bdb33dcf19e6dfe DE-627 ger DE-627 rakwb rus RC254-282 RC666-701 RD1-811 RC86-88.9 I. M. Bykov verfasserin aut Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. oxidative stress laboratory markers antioxidant system drug abuse opioids psychostimulants Neoplasms. Tumors. Oncology. Including cancer and carcinogens Diseases of the circulatory (Cardiovascular) system Surgery Medical emergencies. Critical care. Intensive care. First aid D. A. Lubchenko verfasserin aut K. A. Popov verfasserin aut Ya. Ye. Denisova verfasserin aut A. N. Stolyarova verfasserin aut M. A. Popova verfasserin aut In Инновационная медицина Кубани Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1, 2021 (2020), 4, Seite 20-26 (DE-627)1760593621 25419897 nnns year:2020 number:4 pages:20-26 https://doi.org/10.35401/2500-0268-2020-20-4-20-26 kostenfrei https://doaj.org/article/d8dd91d38e01464d9bdb33dcf19e6dfe kostenfrei https://www.innovmedkub.ru/jour/article/view/329 kostenfrei https://doaj.org/toc/2541-9897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2020 4 20-26 |
| spelling |
10.35401/2500-0268-2020-20-4-20-26 doi (DE-627)DOAJ085521779 (DE-599)DOAJd8dd91d38e01464d9bdb33dcf19e6dfe DE-627 ger DE-627 rakwb rus RC254-282 RC666-701 RD1-811 RC86-88.9 I. M. Bykov verfasserin aut Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. oxidative stress laboratory markers antioxidant system drug abuse opioids psychostimulants Neoplasms. Tumors. Oncology. Including cancer and carcinogens Diseases of the circulatory (Cardiovascular) system Surgery Medical emergencies. Critical care. Intensive care. First aid D. A. Lubchenko verfasserin aut K. A. Popov verfasserin aut Ya. Ye. Denisova verfasserin aut A. N. Stolyarova verfasserin aut M. A. Popova verfasserin aut In Инновационная медицина Кубани Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1, 2021 (2020), 4, Seite 20-26 (DE-627)1760593621 25419897 nnns year:2020 number:4 pages:20-26 https://doi.org/10.35401/2500-0268-2020-20-4-20-26 kostenfrei https://doaj.org/article/d8dd91d38e01464d9bdb33dcf19e6dfe kostenfrei https://www.innovmedkub.ru/jour/article/view/329 kostenfrei https://doaj.org/toc/2541-9897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2020 4 20-26 |
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10.35401/2500-0268-2020-20-4-20-26 doi (DE-627)DOAJ085521779 (DE-599)DOAJd8dd91d38e01464d9bdb33dcf19e6dfe DE-627 ger DE-627 rakwb rus RC254-282 RC666-701 RD1-811 RC86-88.9 I. M. Bykov verfasserin aut Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. oxidative stress laboratory markers antioxidant system drug abuse opioids psychostimulants Neoplasms. Tumors. Oncology. Including cancer and carcinogens Diseases of the circulatory (Cardiovascular) system Surgery Medical emergencies. Critical care. Intensive care. First aid D. A. Lubchenko verfasserin aut K. A. Popov verfasserin aut Ya. Ye. Denisova verfasserin aut A. N. Stolyarova verfasserin aut M. A. Popova verfasserin aut In Инновационная медицина Кубани Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1, 2021 (2020), 4, Seite 20-26 (DE-627)1760593621 25419897 nnns year:2020 number:4 pages:20-26 https://doi.org/10.35401/2500-0268-2020-20-4-20-26 kostenfrei https://doaj.org/article/d8dd91d38e01464d9bdb33dcf19e6dfe kostenfrei https://www.innovmedkub.ru/jour/article/view/329 kostenfrei https://doaj.org/toc/2541-9897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2020 4 20-26 |
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10.35401/2500-0268-2020-20-4-20-26 doi (DE-627)DOAJ085521779 (DE-599)DOAJd8dd91d38e01464d9bdb33dcf19e6dfe DE-627 ger DE-627 rakwb rus RC254-282 RC666-701 RD1-811 RC86-88.9 I. M. Bykov verfasserin aut Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. oxidative stress laboratory markers antioxidant system drug abuse opioids psychostimulants Neoplasms. Tumors. Oncology. Including cancer and carcinogens Diseases of the circulatory (Cardiovascular) system Surgery Medical emergencies. Critical care. Intensive care. First aid D. A. Lubchenko verfasserin aut K. A. Popov verfasserin aut Ya. Ye. Denisova verfasserin aut A. N. Stolyarova verfasserin aut M. A. Popova verfasserin aut In Инновационная медицина Кубани Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1, 2021 (2020), 4, Seite 20-26 (DE-627)1760593621 25419897 nnns year:2020 number:4 pages:20-26 https://doi.org/10.35401/2500-0268-2020-20-4-20-26 kostenfrei https://doaj.org/article/d8dd91d38e01464d9bdb33dcf19e6dfe kostenfrei https://www.innovmedkub.ru/jour/article/view/329 kostenfrei https://doaj.org/toc/2541-9897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2020 4 20-26 |
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10.35401/2500-0268-2020-20-4-20-26 doi (DE-627)DOAJ085521779 (DE-599)DOAJd8dd91d38e01464d9bdb33dcf19e6dfe DE-627 ger DE-627 rakwb rus RC254-282 RC666-701 RD1-811 RC86-88.9 I. M. Bykov verfasserin aut Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. oxidative stress laboratory markers antioxidant system drug abuse opioids psychostimulants Neoplasms. Tumors. Oncology. Including cancer and carcinogens Diseases of the circulatory (Cardiovascular) system Surgery Medical emergencies. Critical care. Intensive care. First aid D. A. Lubchenko verfasserin aut K. A. Popov verfasserin aut Ya. Ye. Denisova verfasserin aut A. N. Stolyarova verfasserin aut M. A. Popova verfasserin aut In Инновационная медицина Кубани Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1, 2021 (2020), 4, Seite 20-26 (DE-627)1760593621 25419897 nnns year:2020 number:4 pages:20-26 https://doi.org/10.35401/2500-0268-2020-20-4-20-26 kostenfrei https://doaj.org/article/d8dd91d38e01464d9bdb33dcf19e6dfe kostenfrei https://www.innovmedkub.ru/jour/article/view/329 kostenfrei https://doaj.org/toc/2541-9897 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2020 4 20-26 |
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M. Bykov</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. 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I. M. Bykov misc RC254-282 misc RC666-701 misc RD1-811 misc RC86-88.9 misc oxidative stress misc laboratory markers misc antioxidant system misc drug abuse misc opioids misc psychostimulants misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Diseases of the circulatory (Cardiovascular) system misc Surgery misc Medical emergencies. Critical care. Intensive care. First aid Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome |
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RC254-282 RC666-701 RD1-811 RC86-88.9 Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome oxidative stress laboratory markers antioxidant system drug abuse opioids psychostimulants |
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misc RC254-282 misc RC666-701 misc RD1-811 misc RC86-88.9 misc oxidative stress misc laboratory markers misc antioxidant system misc drug abuse misc opioids misc psychostimulants misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Diseases of the circulatory (Cardiovascular) system misc Surgery misc Medical emergencies. Critical care. Intensive care. First aid |
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misc RC254-282 misc RC666-701 misc RD1-811 misc RC86-88.9 misc oxidative stress misc laboratory markers misc antioxidant system misc drug abuse misc opioids misc psychostimulants misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Diseases of the circulatory (Cardiovascular) system misc Surgery misc Medical emergencies. Critical care. Intensive care. First aid |
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I. M. Bykov D. A. Lubchenko K. A. Popov Ya. Ye. Denisova A. N. Stolyarova M. A. Popova |
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oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome |
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Oxidative stress markers in patients suffering from opioid and psychostimulant dependence syndrome |
| abstract |
Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. |
| abstractGer |
Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. |
| abstract_unstemmed |
Background. The available data from clinical studies suggest the essential role of free radical processes in the pathogenesis of drug dependence syndrome. At the same time, there is a limited understanding of using markers of oxidative stress in laboratory monitoring and prediction of drug pathology.Objective. To characterize changes in promising indicators of oxidative stress in patients with psychostimulant and opioid dependence syndrome.Material and Methods. The total study population was divided into three groups of men aged 23–35: healthy controls (n = 20), patients with the opioid (n = 20) and psychostimulant (n = 20) dependence syndrome. Patients were analyzed for the oxidative stress markers while being in therapy for addiction syndrome aimed at treating mental disorders and detoxification.Results. The study of antioxidant activity and blood plasma thiol groups did not reveal any significant differences between patients suffering from opioid and psychostimulant addiction. The values of the parameters mentioned above were maintained by 20–30% lower than the control indices throughout the entire study. The nature of changes in erythrocyte suspension parameters was not so unambiguous. Thus, patients with opioid dependence syndrome were characterized by a 91% increase in thiobarbituric acid (TBA)-reactive materials in the setting of a slightly altered state of the glutathione system parameters. Psychostimulant dependent patients revealed relatively low level of the products of biomolecule oxidative modifications in the erythrocytes that is 52% higher compared to the control values. It decreased during the therapy, but glutathione concentration reduction by 33% and an imbalance of glutathione metabolism were determined.Conclusion. The course of the opioid dependence syndrome is characterized by a pronounced intensification of free radical processes while the common trait for psychostimulant abusers is significant changes in the antioxidant defense system. Therefore, in the first case, it is most justified to conduct a laboratory assessment of indicators of oxidative damage, and in the second one, it is also advisable to determine the markers of the state of individual links of the antioxidant system. |
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