Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer

To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to clust...
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Autor*in:	Xiaobo Wu [verfasserIn] Xingbo Long [verfasserIn] Chenkai Ma [verfasserIn] Yin Celeste Cheuk [verfasserIn] Mengbo Hu [verfasserIn] Jimeng Hu [verfasserIn] Haowen Jiang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	prostate cancer UBE2C TP53 biomarkers

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 22, p 13873
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:22, p 13873

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms232213873

Katalog-ID:	DOAJ085528420

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allfields	10.3390/ijms232213873 doi (DE-627)DOAJ085528420 (DE-599)DOAJ534f041d539e453090b255d9097ec980 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Xiaobo Wu verfasserin aut Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to cluster patients and to screen genes that play a vital role in PCa progression (hub gene). Immunohistochemistry staining was used to evaluate the protein level of UBE2C in prostatic tissues. Through WGCNA, we found a gene co-expression module (named the purple module) that is strongly associated with the Gleason score, pathologic T stage, and biochemical recurrent status. Genes in the purple module are enriched in cell cycle and <i<P53</i< signaling and help us to cluster patients into two groups with distinctive biochemical recurrent survival rates and <i<TP53</i< mutation statuses. Further analysis showed UBE2C served as a hub gene in the purple module. The expression of UBE2C in PCa was significantly higher than that in paracancerous tissues and was remarkably associated with pathologic grade, Gleason score, and prognosis in PCa patients. To conclude, UBE2C is a PCa-progress-related gene and a biomarker for PCa patients. Therapy targeting UBE2C may serve as a promising treatment of PCa in the future. prostate cancer UBE2C TP53 biomarkers Biology (General) Chemistry Xingbo Long verfasserin aut Chenkai Ma verfasserin aut Yin Celeste Cheuk verfasserin aut Mengbo Hu verfasserin aut Jimeng Hu verfasserin aut Haowen Jiang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 22, p 13873 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:22, p 13873 https://doi.org/10.3390/ijms232213873 kostenfrei https://doaj.org/article/534f041d539e453090b255d9097ec980 kostenfrei https://www.mdpi.com/1422-0067/23/22/13873 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 22, p 13873
spelling	10.3390/ijms232213873 doi (DE-627)DOAJ085528420 (DE-599)DOAJ534f041d539e453090b255d9097ec980 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Xiaobo Wu verfasserin aut Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to cluster patients and to screen genes that play a vital role in PCa progression (hub gene). Immunohistochemistry staining was used to evaluate the protein level of UBE2C in prostatic tissues. Through WGCNA, we found a gene co-expression module (named the purple module) that is strongly associated with the Gleason score, pathologic T stage, and biochemical recurrent status. Genes in the purple module are enriched in cell cycle and <i<P53</i< signaling and help us to cluster patients into two groups with distinctive biochemical recurrent survival rates and <i<TP53</i< mutation statuses. Further analysis showed UBE2C served as a hub gene in the purple module. The expression of UBE2C in PCa was significantly higher than that in paracancerous tissues and was remarkably associated with pathologic grade, Gleason score, and prognosis in PCa patients. To conclude, UBE2C is a PCa-progress-related gene and a biomarker for PCa patients. Therapy targeting UBE2C may serve as a promising treatment of PCa in the future. prostate cancer UBE2C TP53 biomarkers Biology (General) Chemistry Xingbo Long verfasserin aut Chenkai Ma verfasserin aut Yin Celeste Cheuk verfasserin aut Mengbo Hu verfasserin aut Jimeng Hu verfasserin aut Haowen Jiang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 22, p 13873 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:22, p 13873 https://doi.org/10.3390/ijms232213873 kostenfrei https://doaj.org/article/534f041d539e453090b255d9097ec980 kostenfrei https://www.mdpi.com/1422-0067/23/22/13873 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 22, p 13873
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allfieldsGer	10.3390/ijms232213873 doi (DE-627)DOAJ085528420 (DE-599)DOAJ534f041d539e453090b255d9097ec980 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Xiaobo Wu verfasserin aut Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to cluster patients and to screen genes that play a vital role in PCa progression (hub gene). Immunohistochemistry staining was used to evaluate the protein level of UBE2C in prostatic tissues. Through WGCNA, we found a gene co-expression module (named the purple module) that is strongly associated with the Gleason score, pathologic T stage, and biochemical recurrent status. Genes in the purple module are enriched in cell cycle and <i<P53</i< signaling and help us to cluster patients into two groups with distinctive biochemical recurrent survival rates and <i<TP53</i< mutation statuses. Further analysis showed UBE2C served as a hub gene in the purple module. The expression of UBE2C in PCa was significantly higher than that in paracancerous tissues and was remarkably associated with pathologic grade, Gleason score, and prognosis in PCa patients. To conclude, UBE2C is a PCa-progress-related gene and a biomarker for PCa patients. Therapy targeting UBE2C may serve as a promising treatment of PCa in the future. prostate cancer UBE2C TP53 biomarkers Biology (General) Chemistry Xingbo Long verfasserin aut Chenkai Ma verfasserin aut Yin Celeste Cheuk verfasserin aut Mengbo Hu verfasserin aut Jimeng Hu verfasserin aut Haowen Jiang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 22, p 13873 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:22, p 13873 https://doi.org/10.3390/ijms232213873 kostenfrei https://doaj.org/article/534f041d539e453090b255d9097ec980 kostenfrei https://www.mdpi.com/1422-0067/23/22/13873 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 22, p 13873
allfieldsSound	10.3390/ijms232213873 doi (DE-627)DOAJ085528420 (DE-599)DOAJ534f041d539e453090b255d9097ec980 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Xiaobo Wu verfasserin aut Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to cluster patients and to screen genes that play a vital role in PCa progression (hub gene). Immunohistochemistry staining was used to evaluate the protein level of UBE2C in prostatic tissues. Through WGCNA, we found a gene co-expression module (named the purple module) that is strongly associated with the Gleason score, pathologic T stage, and biochemical recurrent status. Genes in the purple module are enriched in cell cycle and <i<P53</i< signaling and help us to cluster patients into two groups with distinctive biochemical recurrent survival rates and <i<TP53</i< mutation statuses. Further analysis showed UBE2C served as a hub gene in the purple module. The expression of UBE2C in PCa was significantly higher than that in paracancerous tissues and was remarkably associated with pathologic grade, Gleason score, and prognosis in PCa patients. To conclude, UBE2C is a PCa-progress-related gene and a biomarker for PCa patients. Therapy targeting UBE2C may serve as a promising treatment of PCa in the future. prostate cancer UBE2C TP53 biomarkers Biology (General) Chemistry Xingbo Long verfasserin aut Chenkai Ma verfasserin aut Yin Celeste Cheuk verfasserin aut Mengbo Hu verfasserin aut Jimeng Hu verfasserin aut Haowen Jiang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 22, p 13873 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:22, p 13873 https://doi.org/10.3390/ijms232213873 kostenfrei https://doaj.org/article/534f041d539e453090b255d9097ec980 kostenfrei https://www.mdpi.com/1422-0067/23/22/13873 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 22, p 13873
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source	In International Journal of Molecular Sciences 23(2022), 22, p 13873 volume:23 year:2022 number:22, p 13873
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callnumber-first	Q - Science
author	Xiaobo Wu
spellingShingle	Xiaobo Wu misc QH301-705.5 misc QD1-999 misc prostate cancer misc UBE2C misc TP53 misc biomarkers misc Biology (General) misc Chemistry Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer
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topic_title	QH301-705.5 QD1-999 Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer prostate cancer UBE2C TP53 biomarkers
topic	misc QH301-705.5 misc QD1-999 misc prostate cancer misc UBE2C misc TP53 misc biomarkers misc Biology (General) misc Chemistry
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title	Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer
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title_full	Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer
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title_sort	overexpression of ubiquitin-conjugating enzyme e2c is associated with worsened prognosis in prostate cancer
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title_auth	Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer
abstract	To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to cluster patients and to screen genes that play a vital role in PCa progression (hub gene). Immunohistochemistry staining was used to evaluate the protein level of UBE2C in prostatic tissues. Through WGCNA, we found a gene co-expression module (named the purple module) that is strongly associated with the Gleason score, pathologic T stage, and biochemical recurrent status. Genes in the purple module are enriched in cell cycle and <i<P53</i< signaling and help us to cluster patients into two groups with distinctive biochemical recurrent survival rates and <i<TP53</i< mutation statuses. Further analysis showed UBE2C served as a hub gene in the purple module. The expression of UBE2C in PCa was significantly higher than that in paracancerous tissues and was remarkably associated with pathologic grade, Gleason score, and prognosis in PCa patients. To conclude, UBE2C is a PCa-progress-related gene and a biomarker for PCa patients. Therapy targeting UBE2C may serve as a promising treatment of PCa in the future.
abstractGer	To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to cluster patients and to screen genes that play a vital role in PCa progression (hub gene). Immunohistochemistry staining was used to evaluate the protein level of UBE2C in prostatic tissues. Through WGCNA, we found a gene co-expression module (named the purple module) that is strongly associated with the Gleason score, pathologic T stage, and biochemical recurrent status. Genes in the purple module are enriched in cell cycle and <i<P53</i< signaling and help us to cluster patients into two groups with distinctive biochemical recurrent survival rates and <i<TP53</i< mutation statuses. Further analysis showed UBE2C served as a hub gene in the purple module. The expression of UBE2C in PCa was significantly higher than that in paracancerous tissues and was remarkably associated with pathologic grade, Gleason score, and prognosis in PCa patients. To conclude, UBE2C is a PCa-progress-related gene and a biomarker for PCa patients. Therapy targeting UBE2C may serve as a promising treatment of PCa in the future.
abstract_unstemmed	To evaluate the role of ubiquitin-conjugating enzyme E2C (UBE2C) in prostate cancer (PCa) progression and prognosis, the TCGA and our PCa tissue microarray cohort were included in the study. Weighted gene co-expression network analysis (WGCNA) and non-negative matrix factorization were used to cluster patients and to screen genes that play a vital role in PCa progression (hub gene). Immunohistochemistry staining was used to evaluate the protein level of UBE2C in prostatic tissues. Through WGCNA, we found a gene co-expression module (named the purple module) that is strongly associated with the Gleason score, pathologic T stage, and biochemical recurrent status. Genes in the purple module are enriched in cell cycle and <i<P53</i< signaling and help us to cluster patients into two groups with distinctive biochemical recurrent survival rates and <i<TP53</i< mutation statuses. Further analysis showed UBE2C served as a hub gene in the purple module. The expression of UBE2C in PCa was significantly higher than that in paracancerous tissues and was remarkably associated with pathologic grade, Gleason score, and prognosis in PCa patients. To conclude, UBE2C is a PCa-progress-related gene and a biomarker for PCa patients. Therapy targeting UBE2C may serve as a promising treatment of PCa in the future.
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title_short	Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer
url	https://doi.org/10.3390/ijms232213873 https://doaj.org/article/534f041d539e453090b255d9097ec980 https://www.mdpi.com/1422-0067/23/22/13873 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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