A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates

Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhi...
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Gespeichert in:

Autor*in:	Dorien De Pooter [verfasserIn] Ellen Van Gulck [verfasserIn] Antony Chen [verfasserIn] Claire F. Evans [verfasserIn] Jean-Marc Neefs [verfasserIn] Helen Horton [verfasserIn] Daniel Boden [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation

Übergeordnetes Werk:	In: Vaccines - MDPI AG, 2013, 9(2021), 9, p 969
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:9, p 969

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/vaccines9090969

Katalog-ID:	DOAJ085554308

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520			\|a Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates.
650		4	\|a therapeutic vaccination
650		4	\|a hepatitis B surface antigen (HBsAg)
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912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_4112
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allfields	10.3390/vaccines9090969 doi (DE-627)DOAJ085554308 (DE-599)DOAJ47a9fd0208164534a56fcca1e29d82a0 DE-627 ger DE-627 rakwb eng Dorien De Pooter verfasserin aut A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates. therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation Medicine R Ellen Van Gulck verfasserin aut Antony Chen verfasserin aut Claire F. Evans verfasserin aut Jean-Marc Neefs verfasserin aut Helen Horton verfasserin aut Daniel Boden verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 9, p 969 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:9, p 969 https://doi.org/10.3390/vaccines9090969 kostenfrei https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0 kostenfrei https://www.mdpi.com/2076-393X/9/9/969 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 9, p 969
spelling	10.3390/vaccines9090969 doi (DE-627)DOAJ085554308 (DE-599)DOAJ47a9fd0208164534a56fcca1e29d82a0 DE-627 ger DE-627 rakwb eng Dorien De Pooter verfasserin aut A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates. therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation Medicine R Ellen Van Gulck verfasserin aut Antony Chen verfasserin aut Claire F. Evans verfasserin aut Jean-Marc Neefs verfasserin aut Helen Horton verfasserin aut Daniel Boden verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 9, p 969 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:9, p 969 https://doi.org/10.3390/vaccines9090969 kostenfrei https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0 kostenfrei https://www.mdpi.com/2076-393X/9/9/969 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 9, p 969
allfields_unstemmed	10.3390/vaccines9090969 doi (DE-627)DOAJ085554308 (DE-599)DOAJ47a9fd0208164534a56fcca1e29d82a0 DE-627 ger DE-627 rakwb eng Dorien De Pooter verfasserin aut A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates. therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation Medicine R Ellen Van Gulck verfasserin aut Antony Chen verfasserin aut Claire F. Evans verfasserin aut Jean-Marc Neefs verfasserin aut Helen Horton verfasserin aut Daniel Boden verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 9, p 969 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:9, p 969 https://doi.org/10.3390/vaccines9090969 kostenfrei https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0 kostenfrei https://www.mdpi.com/2076-393X/9/9/969 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 9, p 969
allfieldsGer	10.3390/vaccines9090969 doi (DE-627)DOAJ085554308 (DE-599)DOAJ47a9fd0208164534a56fcca1e29d82a0 DE-627 ger DE-627 rakwb eng Dorien De Pooter verfasserin aut A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates. therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation Medicine R Ellen Van Gulck verfasserin aut Antony Chen verfasserin aut Claire F. Evans verfasserin aut Jean-Marc Neefs verfasserin aut Helen Horton verfasserin aut Daniel Boden verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 9, p 969 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:9, p 969 https://doi.org/10.3390/vaccines9090969 kostenfrei https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0 kostenfrei https://www.mdpi.com/2076-393X/9/9/969 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 9, p 969
allfieldsSound	10.3390/vaccines9090969 doi (DE-627)DOAJ085554308 (DE-599)DOAJ47a9fd0208164534a56fcca1e29d82a0 DE-627 ger DE-627 rakwb eng Dorien De Pooter verfasserin aut A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates. therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation Medicine R Ellen Van Gulck verfasserin aut Antony Chen verfasserin aut Claire F. Evans verfasserin aut Jean-Marc Neefs verfasserin aut Helen Horton verfasserin aut Daniel Boden verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 9, p 969 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:9, p 969 https://doi.org/10.3390/vaccines9090969 kostenfrei https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0 kostenfrei https://www.mdpi.com/2076-393X/9/9/969 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 9, p 969
language	English
source	In Vaccines 9(2021), 9, p 969 volume:9 year:2021 number:9, p 969
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topic_facet	therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation Medicine R
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authorswithroles_txt_mv	Dorien De Pooter @@aut@@ Ellen Van Gulck @@aut@@ Antony Chen @@aut@@ Claire F. Evans @@aut@@ Jean-Marc Neefs @@aut@@ Helen Horton @@aut@@ Daniel Boden @@aut@@
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author	Dorien De Pooter
spellingShingle	Dorien De Pooter misc therapeutic vaccination misc hepatitis B surface antigen (HBsAg) misc hepatitis B virus (HBV) specific T-cells misc HBV functional cure misc non-human primate misc electroporation misc Medicine misc R A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates
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topic_title	A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates therapeutic vaccination hepatitis B surface antigen (HBsAg) hepatitis B virus (HBV) specific T-cells HBV functional cure non-human primate electroporation
topic	misc therapeutic vaccination misc hepatitis B surface antigen (HBsAg) misc hepatitis B virus (HBV) specific T-cells misc HBV functional cure misc non-human primate misc electroporation misc Medicine misc R
topic_unstemmed	misc therapeutic vaccination misc hepatitis B surface antigen (HBsAg) misc hepatitis B virus (HBV) specific T-cells misc HBV functional cure misc non-human primate misc electroporation misc Medicine misc R
topic_browse	misc therapeutic vaccination misc hepatitis B surface antigen (HBsAg) misc hepatitis B virus (HBV) specific T-cells misc HBV functional cure misc non-human primate misc electroporation misc Medicine misc R
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title	A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates
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title_full	A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates
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title_sort	therapeutic hepatitis b virus dna vaccine induces specific immune responses in mice and non-human primates
title_auth	A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates
abstract	Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates.
abstractGer	Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates.
abstract_unstemmed	Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cirrhosis and liver cancer. Chronic HBV patients exhibit weak, transient, or dysfunctional CD8<sup<+</sup< T-cell responses to HBV, which contrasts with high CD8+ T-cell responses seen for resolvers of acute HBV infection. Therefore, a therapeutic DNA vaccine was designed, expressing both HBV core and polymerase proteins, and was sequence optimized to ensure high protein expression and secretion. Although the vaccine, administered intramuscularly via electroporation, had no effect on plasma viral parameters in a mouse model of persistent HBV infection, it did induce robust HBV-specific immune responses in healthy and adeno-associated hepatitis B virus (AAV-HBV) infected mice as well as in healthy non-human primates.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	9, p 969
title_short	A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates
url	https://doi.org/10.3390/vaccines9090969 https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0 https://www.mdpi.com/2076-393X/9/9/969 https://doaj.org/toc/2076-393X
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up_date	2024-07-03T15:27:05.362Z
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A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates

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