MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis

Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord lesions in MS patients and examined how it influences the fulfi...
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Autor*in:	Esben Nyborg Poulsen [verfasserIn] Anna Olsson [verfasserIn] Stefan Gustavsen [verfasserIn] Annika Reynberg Langkilde [verfasserIn] Annette Bang Oturai [verfasserIn] Jonathan Frederik Carlsen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	MRI multiple sclerosis spinal cord dissemination in time dissemination in space

Übergeordnetes Werk:	In: Diagnostics - MDPI AG, 2012, 11(2021), 8, p 1424
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:8, p 1424

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/diagnostics11081424

Katalog-ID:	DOAJ085555444

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allfieldsGer	10.3390/diagnostics11081424 doi (DE-627)DOAJ085555444 (DE-599)DOAJ8838856c592a4b62a84548cdfa0784df DE-627 ger DE-627 rakwb eng R5-920 Esben Nyborg Poulsen verfasserin aut MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord lesions in MS patients and examined how it influences the fulfillment of the 2017 McDonald Criteria. Seventy-four patients with relapsing-remitting MS were examined with brain and entire spinal cord MRI. Sixty-five patients received contrast. The number and anatomical location of MS lesions were assessed along with the Expanded Disability Status Scale (EDSS). A Chi-square test, Fischer’s exact test, and one-sided McNemar’s test were used to test distributions. MS lesions were distributed throughout the spinal cord. Diagnosis of dissemination in space (DIS) was increased from 58/74 (78.4%) to 67/74 (90.5%) when adding cervical spinal cord MRI to brain MRI alone (<i<p</i< = 0.004). Diagnosis of dissemination in time (DIT) was not significantly increased when adding entire spinal cord MRI to brain MRI alone (<i<p</i< = 0.04). There was no association between the number of spinal cord lesions and the EDSS score (<i<p</i< = 0.71). MS lesions are present throughout the spinal cord, and spinal cord MRI may play an important role in the diagnosis and follow-up of MS patients. MRI multiple sclerosis spinal cord dissemination in time dissemination in space Medicine (General) Anna Olsson verfasserin aut Stefan Gustavsen verfasserin aut Annika Reynberg Langkilde verfasserin aut Annette Bang Oturai verfasserin aut Jonathan Frederik Carlsen verfasserin aut In Diagnostics MDPI AG, 2012 11(2021), 8, p 1424 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:11 year:2021 number:8, p 1424 https://doi.org/10.3390/diagnostics11081424 kostenfrei https://doaj.org/article/8838856c592a4b62a84548cdfa0784df kostenfrei https://www.mdpi.com/2075-4418/11/8/1424 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 8, p 1424
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authorswithroles_txt_mv	Esben Nyborg Poulsen @@aut@@ Anna Olsson @@aut@@ Stefan Gustavsen @@aut@@ Annika Reynberg Langkilde @@aut@@ Annette Bang Oturai @@aut@@ Jonathan Frederik Carlsen @@aut@@
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callnumber-first	R - Medicine
author	Esben Nyborg Poulsen
spellingShingle	Esben Nyborg Poulsen misc R5-920 misc MRI misc multiple sclerosis misc spinal cord misc dissemination in time misc dissemination in space misc Medicine (General) MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis
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topic_title	R5-920 MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis MRI multiple sclerosis spinal cord dissemination in time dissemination in space
topic	misc R5-920 misc MRI misc multiple sclerosis misc spinal cord misc dissemination in time misc dissemination in space misc Medicine (General)
topic_unstemmed	misc R5-920 misc MRI misc multiple sclerosis misc spinal cord misc dissemination in time misc dissemination in space misc Medicine (General)
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title	MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis
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title_full	MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis
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author_browse	Esben Nyborg Poulsen Anna Olsson Stefan Gustavsen Annika Reynberg Langkilde Annette Bang Oturai Jonathan Frederik Carlsen
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title_sort	mri of the entire spinal cord—worth the while or waste of time? a retrospective study of 74 patients with multiple sclerosis
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title_auth	MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis
abstract	Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord lesions in MS patients and examined how it influences the fulfillment of the 2017 McDonald Criteria. Seventy-four patients with relapsing-remitting MS were examined with brain and entire spinal cord MRI. Sixty-five patients received contrast. The number and anatomical location of MS lesions were assessed along with the Expanded Disability Status Scale (EDSS). A Chi-square test, Fischer’s exact test, and one-sided McNemar’s test were used to test distributions. MS lesions were distributed throughout the spinal cord. Diagnosis of dissemination in space (DIS) was increased from 58/74 (78.4%) to 67/74 (90.5%) when adding cervical spinal cord MRI to brain MRI alone (<i<p</i< = 0.004). Diagnosis of dissemination in time (DIT) was not significantly increased when adding entire spinal cord MRI to brain MRI alone (<i<p</i< = 0.04). There was no association between the number of spinal cord lesions and the EDSS score (<i<p</i< = 0.71). MS lesions are present throughout the spinal cord, and spinal cord MRI may play an important role in the diagnosis and follow-up of MS patients.
abstractGer	Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord lesions in MS patients and examined how it influences the fulfillment of the 2017 McDonald Criteria. Seventy-four patients with relapsing-remitting MS were examined with brain and entire spinal cord MRI. Sixty-five patients received contrast. The number and anatomical location of MS lesions were assessed along with the Expanded Disability Status Scale (EDSS). A Chi-square test, Fischer’s exact test, and one-sided McNemar’s test were used to test distributions. MS lesions were distributed throughout the spinal cord. Diagnosis of dissemination in space (DIS) was increased from 58/74 (78.4%) to 67/74 (90.5%) when adding cervical spinal cord MRI to brain MRI alone (<i<p</i< = 0.004). Diagnosis of dissemination in time (DIT) was not significantly increased when adding entire spinal cord MRI to brain MRI alone (<i<p</i< = 0.04). There was no association between the number of spinal cord lesions and the EDSS score (<i<p</i< = 0.71). MS lesions are present throughout the spinal cord, and spinal cord MRI may play an important role in the diagnosis and follow-up of MS patients.
abstract_unstemmed	Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord lesions in MS patients and examined how it influences the fulfillment of the 2017 McDonald Criteria. Seventy-four patients with relapsing-remitting MS were examined with brain and entire spinal cord MRI. Sixty-five patients received contrast. The number and anatomical location of MS lesions were assessed along with the Expanded Disability Status Scale (EDSS). A Chi-square test, Fischer’s exact test, and one-sided McNemar’s test were used to test distributions. MS lesions were distributed throughout the spinal cord. Diagnosis of dissemination in space (DIS) was increased from 58/74 (78.4%) to 67/74 (90.5%) when adding cervical spinal cord MRI to brain MRI alone (<i<p</i< = 0.004). Diagnosis of dissemination in time (DIT) was not significantly increased when adding entire spinal cord MRI to brain MRI alone (<i<p</i< = 0.04). There was no association between the number of spinal cord lesions and the EDSS score (<i<p</i< = 0.71). MS lesions are present throughout the spinal cord, and spinal cord MRI may play an important role in the diagnosis and follow-up of MS patients.
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title_short	MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis
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MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis

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