Epigenetic Mechanisms of HIV-1 Persistence

Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Roxane Verdikt [verfasserIn] Olivier Hernalsteens [verfasserIn] Carine Van Lint [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	HIV-1 latency HIV-1 persistence reservoirs epigenetics

Übergeordnetes Werk:	In: Vaccines - MDPI AG, 2013, 9(2021), 5, p 514
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:5, p 514

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/vaccines9050514

Katalog-ID:	DOAJ085567493

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520			\|a Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to <i<cis</i<-regulatory proviral regions. Furthermore, the complex repertoire of HIV-1 repression mechanisms varies depending on the nature of the viral reservoir, although, so far, few studies have addressed the specific regulatory mechanisms of HIV-1 persistence in other reservoirs than the well-studied latently infected CD4<sup<+</sup< T cells. Here, we present an exhaustive and updated picture of the heterochromatinization of the HIV-1 promoter in its different reservoirs. We highlight the complexity, heterogeneity and dynamics of the epigenetic mechanisms of HIV-1 persistence, while discussing the importance of further understanding HIV-1 gene regulation for the rational design of novel HIV-1 cure strategies.
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spelling	10.3390/vaccines9050514 doi (DE-627)DOAJ085567493 (DE-599)DOAJdd0886cb3bb54f84a5d1ac2f0bfcc9c8 DE-627 ger DE-627 rakwb eng Roxane Verdikt verfasserin aut Epigenetic Mechanisms of HIV-1 Persistence 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to <i<cis</i<-regulatory proviral regions. Furthermore, the complex repertoire of HIV-1 repression mechanisms varies depending on the nature of the viral reservoir, although, so far, few studies have addressed the specific regulatory mechanisms of HIV-1 persistence in other reservoirs than the well-studied latently infected CD4<sup<+</sup< T cells. Here, we present an exhaustive and updated picture of the heterochromatinization of the HIV-1 promoter in its different reservoirs. We highlight the complexity, heterogeneity and dynamics of the epigenetic mechanisms of HIV-1 persistence, while discussing the importance of further understanding HIV-1 gene regulation for the rational design of novel HIV-1 cure strategies. HIV-1 latency HIV-1 persistence reservoirs epigenetics Medicine R Olivier Hernalsteens verfasserin aut Carine Van Lint verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 5, p 514 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:5, p 514 https://doi.org/10.3390/vaccines9050514 kostenfrei https://doaj.org/article/dd0886cb3bb54f84a5d1ac2f0bfcc9c8 kostenfrei https://www.mdpi.com/2076-393X/9/5/514 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 5, p 514
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allfieldsGer	10.3390/vaccines9050514 doi (DE-627)DOAJ085567493 (DE-599)DOAJdd0886cb3bb54f84a5d1ac2f0bfcc9c8 DE-627 ger DE-627 rakwb eng Roxane Verdikt verfasserin aut Epigenetic Mechanisms of HIV-1 Persistence 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to <i<cis</i<-regulatory proviral regions. Furthermore, the complex repertoire of HIV-1 repression mechanisms varies depending on the nature of the viral reservoir, although, so far, few studies have addressed the specific regulatory mechanisms of HIV-1 persistence in other reservoirs than the well-studied latently infected CD4<sup<+</sup< T cells. Here, we present an exhaustive and updated picture of the heterochromatinization of the HIV-1 promoter in its different reservoirs. We highlight the complexity, heterogeneity and dynamics of the epigenetic mechanisms of HIV-1 persistence, while discussing the importance of further understanding HIV-1 gene regulation for the rational design of novel HIV-1 cure strategies. HIV-1 latency HIV-1 persistence reservoirs epigenetics Medicine R Olivier Hernalsteens verfasserin aut Carine Van Lint verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 5, p 514 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:5, p 514 https://doi.org/10.3390/vaccines9050514 kostenfrei https://doaj.org/article/dd0886cb3bb54f84a5d1ac2f0bfcc9c8 kostenfrei https://www.mdpi.com/2076-393X/9/5/514 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 5, p 514
allfieldsSound	10.3390/vaccines9050514 doi (DE-627)DOAJ085567493 (DE-599)DOAJdd0886cb3bb54f84a5d1ac2f0bfcc9c8 DE-627 ger DE-627 rakwb eng Roxane Verdikt verfasserin aut Epigenetic Mechanisms of HIV-1 Persistence 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to <i<cis</i<-regulatory proviral regions. Furthermore, the complex repertoire of HIV-1 repression mechanisms varies depending on the nature of the viral reservoir, although, so far, few studies have addressed the specific regulatory mechanisms of HIV-1 persistence in other reservoirs than the well-studied latently infected CD4<sup<+</sup< T cells. Here, we present an exhaustive and updated picture of the heterochromatinization of the HIV-1 promoter in its different reservoirs. We highlight the complexity, heterogeneity and dynamics of the epigenetic mechanisms of HIV-1 persistence, while discussing the importance of further understanding HIV-1 gene regulation for the rational design of novel HIV-1 cure strategies. HIV-1 latency HIV-1 persistence reservoirs epigenetics Medicine R Olivier Hernalsteens verfasserin aut Carine Van Lint verfasserin aut In Vaccines MDPI AG, 2013 9(2021), 5, p 514 (DE-627)736559205 (DE-600)2703319-3 2076393X nnns volume:9 year:2021 number:5, p 514 https://doi.org/10.3390/vaccines9050514 kostenfrei https://doaj.org/article/dd0886cb3bb54f84a5d1ac2f0bfcc9c8 kostenfrei https://www.mdpi.com/2076-393X/9/5/514 kostenfrei https://doaj.org/toc/2076-393X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 5, p 514
language	English
source	In Vaccines 9(2021), 5, p 514 volume:9 year:2021 number:5, p 514
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topic_facet	HIV-1 latency HIV-1 persistence reservoirs epigenetics Medicine R
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author	Roxane Verdikt
spellingShingle	Roxane Verdikt misc HIV-1 latency misc HIV-1 persistence misc reservoirs misc epigenetics misc Medicine misc R Epigenetic Mechanisms of HIV-1 Persistence
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topic_title	Epigenetic Mechanisms of HIV-1 Persistence HIV-1 latency HIV-1 persistence reservoirs epigenetics
topic	misc HIV-1 latency misc HIV-1 persistence misc reservoirs misc epigenetics misc Medicine misc R
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title	Epigenetic Mechanisms of HIV-1 Persistence
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title_sort	epigenetic mechanisms of hiv-1 persistence
title_auth	Epigenetic Mechanisms of HIV-1 Persistence
abstract	Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to <i<cis</i<-regulatory proviral regions. Furthermore, the complex repertoire of HIV-1 repression mechanisms varies depending on the nature of the viral reservoir, although, so far, few studies have addressed the specific regulatory mechanisms of HIV-1 persistence in other reservoirs than the well-studied latently infected CD4<sup<+</sup< T cells. Here, we present an exhaustive and updated picture of the heterochromatinization of the HIV-1 promoter in its different reservoirs. We highlight the complexity, heterogeneity and dynamics of the epigenetic mechanisms of HIV-1 persistence, while discussing the importance of further understanding HIV-1 gene regulation for the rational design of novel HIV-1 cure strategies.
abstractGer	Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to <i<cis</i<-regulatory proviral regions. Furthermore, the complex repertoire of HIV-1 repression mechanisms varies depending on the nature of the viral reservoir, although, so far, few studies have addressed the specific regulatory mechanisms of HIV-1 persistence in other reservoirs than the well-studied latently infected CD4<sup<+</sup< T cells. Here, we present an exhaustive and updated picture of the heterochromatinization of the HIV-1 promoter in its different reservoirs. We highlight the complexity, heterogeneity and dynamics of the epigenetic mechanisms of HIV-1 persistence, while discussing the importance of further understanding HIV-1 gene regulation for the rational design of novel HIV-1 cure strategies.
abstract_unstemmed	Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized therapeutic interventions. HIV-1 gene expression relies on the redundant and cooperative recruitment of cellular epigenetic machineries to <i<cis</i<-regulatory proviral regions. Furthermore, the complex repertoire of HIV-1 repression mechanisms varies depending on the nature of the viral reservoir, although, so far, few studies have addressed the specific regulatory mechanisms of HIV-1 persistence in other reservoirs than the well-studied latently infected CD4<sup<+</sup< T cells. Here, we present an exhaustive and updated picture of the heterochromatinization of the HIV-1 promoter in its different reservoirs. We highlight the complexity, heterogeneity and dynamics of the epigenetic mechanisms of HIV-1 persistence, while discussing the importance of further understanding HIV-1 gene regulation for the rational design of novel HIV-1 cure strategies.
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title_short	Epigenetic Mechanisms of HIV-1 Persistence
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