Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor

Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery we...
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Autor*in:	Can Cui [verfasserIn] Dengwen Zhang [verfasserIn] Ke Sun [verfasserIn] Yi Zhu [verfasserIn] Jindong Xu [verfasserIn] Yin Kang [verfasserIn] Guangyan Zhang [verfasserIn] Yujin Cai [verfasserIn] Songsong Mao [verfasserIn] Ruichun Long [verfasserIn] Jue Ma [verfasserIn] Song Dong [verfasserIn] Yi Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis

Übergeordnetes Werk:	In: BMC Immunology - BMC, 2003, 23(2022), 1, Seite 15
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12865-022-00490-8

Katalog-ID:	DOAJ085575259

Internformat


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245	1	0	\|a Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor
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520			\|a Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer.
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allfields	10.1186/s12865-022-00490-8 doi (DE-627)DOAJ085575259 (DE-599)DOAJ4937b1b161e049399eeba13ea59e66d3 DE-627 ger DE-627 rakwb eng RC581-607 Can Cui verfasserin aut Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer. Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis Immunologic diseases. Allergy Dengwen Zhang verfasserin aut Ke Sun verfasserin aut Yi Zhu verfasserin aut Jindong Xu verfasserin aut Yin Kang verfasserin aut Guangyan Zhang verfasserin aut Yujin Cai verfasserin aut Songsong Mao verfasserin aut Ruichun Long verfasserin aut Jue Ma verfasserin aut Song Dong verfasserin aut Yi Sun verfasserin aut In BMC Immunology BMC, 2003 23(2022), 1, Seite 15 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:23 year:2022 number:1 pages:15 https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/article/4937b1b161e049399eeba13ea59e66d3 kostenfrei https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 15
spelling	10.1186/s12865-022-00490-8 doi (DE-627)DOAJ085575259 (DE-599)DOAJ4937b1b161e049399eeba13ea59e66d3 DE-627 ger DE-627 rakwb eng RC581-607 Can Cui verfasserin aut Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer. Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis Immunologic diseases. Allergy Dengwen Zhang verfasserin aut Ke Sun verfasserin aut Yi Zhu verfasserin aut Jindong Xu verfasserin aut Yin Kang verfasserin aut Guangyan Zhang verfasserin aut Yujin Cai verfasserin aut Songsong Mao verfasserin aut Ruichun Long verfasserin aut Jue Ma verfasserin aut Song Dong verfasserin aut Yi Sun verfasserin aut In BMC Immunology BMC, 2003 23(2022), 1, Seite 15 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:23 year:2022 number:1 pages:15 https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/article/4937b1b161e049399eeba13ea59e66d3 kostenfrei https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 15
allfields_unstemmed	10.1186/s12865-022-00490-8 doi (DE-627)DOAJ085575259 (DE-599)DOAJ4937b1b161e049399eeba13ea59e66d3 DE-627 ger DE-627 rakwb eng RC581-607 Can Cui verfasserin aut Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer. Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis Immunologic diseases. Allergy Dengwen Zhang verfasserin aut Ke Sun verfasserin aut Yi Zhu verfasserin aut Jindong Xu verfasserin aut Yin Kang verfasserin aut Guangyan Zhang verfasserin aut Yujin Cai verfasserin aut Songsong Mao verfasserin aut Ruichun Long verfasserin aut Jue Ma verfasserin aut Song Dong verfasserin aut Yi Sun verfasserin aut In BMC Immunology BMC, 2003 23(2022), 1, Seite 15 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:23 year:2022 number:1 pages:15 https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/article/4937b1b161e049399eeba13ea59e66d3 kostenfrei https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 15
allfieldsGer	10.1186/s12865-022-00490-8 doi (DE-627)DOAJ085575259 (DE-599)DOAJ4937b1b161e049399eeba13ea59e66d3 DE-627 ger DE-627 rakwb eng RC581-607 Can Cui verfasserin aut Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer. Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis Immunologic diseases. Allergy Dengwen Zhang verfasserin aut Ke Sun verfasserin aut Yi Zhu verfasserin aut Jindong Xu verfasserin aut Yin Kang verfasserin aut Guangyan Zhang verfasserin aut Yujin Cai verfasserin aut Songsong Mao verfasserin aut Ruichun Long verfasserin aut Jue Ma verfasserin aut Song Dong verfasserin aut Yi Sun verfasserin aut In BMC Immunology BMC, 2003 23(2022), 1, Seite 15 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:23 year:2022 number:1 pages:15 https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/article/4937b1b161e049399eeba13ea59e66d3 kostenfrei https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 15
allfieldsSound	10.1186/s12865-022-00490-8 doi (DE-627)DOAJ085575259 (DE-599)DOAJ4937b1b161e049399eeba13ea59e66d3 DE-627 ger DE-627 rakwb eng RC581-607 Can Cui verfasserin aut Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer. Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis Immunologic diseases. Allergy Dengwen Zhang verfasserin aut Ke Sun verfasserin aut Yi Zhu verfasserin aut Jindong Xu verfasserin aut Yin Kang verfasserin aut Guangyan Zhang verfasserin aut Yujin Cai verfasserin aut Songsong Mao verfasserin aut Ruichun Long verfasserin aut Jue Ma verfasserin aut Song Dong verfasserin aut Yi Sun verfasserin aut In BMC Immunology BMC, 2003 23(2022), 1, Seite 15 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:23 year:2022 number:1 pages:15 https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/article/4937b1b161e049399eeba13ea59e66d3 kostenfrei https://doi.org/10.1186/s12865-022-00490-8 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 15
language	English
source	In BMC Immunology 23(2022), 1, Seite 15 volume:23 year:2022 number:1 pages:15
sourceStr	In BMC Immunology 23(2022), 1, Seite 15 volume:23 year:2022 number:1 pages:15
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	BMC Immunology
authorswithroles_txt_mv	Can Cui @@aut@@ Dengwen Zhang @@aut@@ Ke Sun @@aut@@ Yi Zhu @@aut@@ Jindong Xu @@aut@@ Yin Kang @@aut@@ Guangyan Zhang @@aut@@ Yujin Cai @@aut@@ Songsong Mao @@aut@@ Ruichun Long @@aut@@ Jue Ma @@aut@@ Song Dong @@aut@@ Yi Sun @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	326644962
id	DOAJ085575259
language_de	englisch
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callnumber-first	R - Medicine
author	Can Cui
spellingShingle	Can Cui misc RC581-607 misc Lung cancer misc Propofol misc Elderly misc Th17/Treg misc γ-aminobutyric acid A receptor misc Metastasis misc Immunologic diseases. Allergy Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor
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topic_title	RC581-607 Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor Lung cancer Propofol Elderly Th17/Treg γ-aminobutyric acid A receptor Metastasis
topic	misc RC581-607 misc Lung cancer misc Propofol misc Elderly misc Th17/Treg misc γ-aminobutyric acid A receptor misc Metastasis misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc Lung cancer misc Propofol misc Elderly misc Th17/Treg misc γ-aminobutyric acid A receptor misc Metastasis misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc Lung cancer misc Propofol misc Elderly misc Th17/Treg misc γ-aminobutyric acid A receptor misc Metastasis misc Immunologic diseases. Allergy
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title	Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor
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title_full	Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor
author_sort	Can Cui
journal	BMC Immunology
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author_browse	Can Cui Dengwen Zhang Ke Sun Yi Zhu Jindong Xu Yin Kang Guangyan Zhang Yujin Cai Songsong Mao Ruichun Long Jue Ma Song Dong Yi Sun
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title_sort	propofol maintains th17/treg cell balance in elderly patients undergoing lung cancer surgery through gabaa receptor
callnumber	RC581-607
title_auth	Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor
abstract	Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer.
abstractGer	Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer.
abstract_unstemmed	Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer.
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container_issue	1
title_short	Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor
url	https://doi.org/10.1186/s12865-022-00490-8 https://doaj.org/article/4937b1b161e049399eeba13ea59e66d3 https://doaj.org/toc/1471-2172
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Propofol maintains Th17/Treg cell balance in elderly patients undergoing lung cancer surgery through GABAA receptor

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