Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity

Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium<...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jiaojiao Zhang [verfasserIn] Rongmei Zhao [verfasserIn] Lu Jin [verfasserIn] Le Pan [verfasserIn] Dongyu Lei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	xanthanolides structures synthesis bioactivity

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 27(2022), 23, p 8136
Übergeordnetes Werk:	volume:27 ; year:2022 ; number:23, p 8136

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules27238136

Katalog-ID:	DOAJ085621501

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allfields	10.3390/molecules27238136 doi (DE-627)DOAJ085621501 (DE-599)DOAJe93c1ee13e7d49a6b4d2ec01e8f68971 DE-627 ger DE-627 rakwb eng QD241-441 Jiaojiao Zhang verfasserin aut Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry. xanthanolides structures synthesis bioactivity Organic chemistry Rongmei Zhao verfasserin aut Lu Jin verfasserin aut Le Pan verfasserin aut Dongyu Lei verfasserin aut In Molecules MDPI AG, 2003 27(2022), 23, p 8136 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:23, p 8136 https://doi.org/10.3390/molecules27238136 kostenfrei https://doaj.org/article/e93c1ee13e7d49a6b4d2ec01e8f68971 kostenfrei https://www.mdpi.com/1420-3049/27/23/8136 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 23, p 8136
spelling	10.3390/molecules27238136 doi (DE-627)DOAJ085621501 (DE-599)DOAJe93c1ee13e7d49a6b4d2ec01e8f68971 DE-627 ger DE-627 rakwb eng QD241-441 Jiaojiao Zhang verfasserin aut Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry. xanthanolides structures synthesis bioactivity Organic chemistry Rongmei Zhao verfasserin aut Lu Jin verfasserin aut Le Pan verfasserin aut Dongyu Lei verfasserin aut In Molecules MDPI AG, 2003 27(2022), 23, p 8136 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:23, p 8136 https://doi.org/10.3390/molecules27238136 kostenfrei https://doaj.org/article/e93c1ee13e7d49a6b4d2ec01e8f68971 kostenfrei https://www.mdpi.com/1420-3049/27/23/8136 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 23, p 8136
allfields_unstemmed	10.3390/molecules27238136 doi (DE-627)DOAJ085621501 (DE-599)DOAJe93c1ee13e7d49a6b4d2ec01e8f68971 DE-627 ger DE-627 rakwb eng QD241-441 Jiaojiao Zhang verfasserin aut Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry. xanthanolides structures synthesis bioactivity Organic chemistry Rongmei Zhao verfasserin aut Lu Jin verfasserin aut Le Pan verfasserin aut Dongyu Lei verfasserin aut In Molecules MDPI AG, 2003 27(2022), 23, p 8136 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:23, p 8136 https://doi.org/10.3390/molecules27238136 kostenfrei https://doaj.org/article/e93c1ee13e7d49a6b4d2ec01e8f68971 kostenfrei https://www.mdpi.com/1420-3049/27/23/8136 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 23, p 8136
allfieldsGer	10.3390/molecules27238136 doi (DE-627)DOAJ085621501 (DE-599)DOAJe93c1ee13e7d49a6b4d2ec01e8f68971 DE-627 ger DE-627 rakwb eng QD241-441 Jiaojiao Zhang verfasserin aut Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry. xanthanolides structures synthesis bioactivity Organic chemistry Rongmei Zhao verfasserin aut Lu Jin verfasserin aut Le Pan verfasserin aut Dongyu Lei verfasserin aut In Molecules MDPI AG, 2003 27(2022), 23, p 8136 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:23, p 8136 https://doi.org/10.3390/molecules27238136 kostenfrei https://doaj.org/article/e93c1ee13e7d49a6b4d2ec01e8f68971 kostenfrei https://www.mdpi.com/1420-3049/27/23/8136 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 23, p 8136
allfieldsSound	10.3390/molecules27238136 doi (DE-627)DOAJ085621501 (DE-599)DOAJe93c1ee13e7d49a6b4d2ec01e8f68971 DE-627 ger DE-627 rakwb eng QD241-441 Jiaojiao Zhang verfasserin aut Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry. xanthanolides structures synthesis bioactivity Organic chemistry Rongmei Zhao verfasserin aut Lu Jin verfasserin aut Le Pan verfasserin aut Dongyu Lei verfasserin aut In Molecules MDPI AG, 2003 27(2022), 23, p 8136 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:23, p 8136 https://doi.org/10.3390/molecules27238136 kostenfrei https://doaj.org/article/e93c1ee13e7d49a6b4d2ec01e8f68971 kostenfrei https://www.mdpi.com/1420-3049/27/23/8136 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 23, p 8136
language	English
source	In Molecules 27(2022), 23, p 8136 volume:27 year:2022 number:23, p 8136
sourceStr	In Molecules 27(2022), 23, p 8136 volume:27 year:2022 number:23, p 8136
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topic_facet	xanthanolides structures synthesis bioactivity Organic chemistry
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authorswithroles_txt_mv	Jiaojiao Zhang @@aut@@ Rongmei Zhao @@aut@@ Lu Jin @@aut@@ Le Pan @@aut@@ Dongyu Lei @@aut@@
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author	Jiaojiao Zhang
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topic_title	QD241-441 Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity xanthanolides structures synthesis bioactivity
topic	misc QD241-441 misc xanthanolides misc structures misc synthesis misc bioactivity misc Organic chemistry
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title	Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity
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title_auth	Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity
abstract	Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry.
abstractGer	Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry.
abstract_unstemmed	Xanthanolides were particularly characteristic of the genus <i<Xanthium</i<, which exhibited broad biological effects and have drawn much attention in pharmacological application. The review surveyed the structures and bioactivities of the xanthanolides in the genus <i<Xanthium</i<, and summarized the synthesis tactics of xanthanolides. The results indicated that over 30 naturally occurring xanthanolides have been isolated from the genus <i<Xanthium</i< in monomeric, dimeric and trimeric forms. The bioassay-guided fractionation studies suggested that the effective fractions on antitumor activities were mostly from weak polar solvents, and xanthatin (<b<1</b<) was the most effective and well-studied xanthanolide. The varieties of structures and structure-activity relationships of the xanthanolides had provided the promising skeleton for the further study. The review aimed at providing guidance for the efficient preparation and the potential prospects of the xanthanolides in the medicinal industry.
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title_short	Xanthanolides in <i<Xanthium</i< L.: Structures, Synthesis and Bioactivity
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